TDR Targets

Basic information

Technical information

TDR Targets ID: 830330
Name: N-(4-ethylphenyl)-2-(5-methyl-4,5,6,7-tetrahy droindazol-2-yl)acetamide
MW: 297.395 | Formula: C18H23N3O
H donors: 1 H acceptors: 2 LogP: 3.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)NC(=O)Cn1cc2c(n1)CCC(C2)C
InChi: 1S/C18H23N3O/c1-3-14-5-7-16(8-6-14)19-18(22)12-21-11-15-10-13(2)4-9-17(15)20-21/h5-8,11,13H,3-4,9-10,12H2,1-2H3,(H,19,22)
InChiKey: DPUMBGRXLGMCMU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-ethylphenyl)-2-(5-methyl-4,5,6,7-tetrahydroindazol-2-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0035	0.0035
Onchocerca volvulus		0.0124	0.0312	0.7815
Brugia malayi	hypothetical protein	0.0013	0.0009	0.0248
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0048	0.0106	0.0106
Entamoeba histolytica	hypothetical protein	0.0042	0.009	0.1986
Onchocerca volvulus		0.0124	0.0312	0.7815
Loa Loa (eye worm)	glutathione reductase	0.0056	0.0127	0.0127
Trichomonas vaginalis	glutathione reductase, putative	0.0019	0.0027	0.0471
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Brugia malayi	reverse transcriptase	0.0013	0.0009	0.0248
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Brugia malayi	Pre-SET motif family protein	0.002	0.0028	0.0799
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0019	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0127	0.0322	0.8898
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.009	0.009
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0124	0.0312	0.0312
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0124	0.0312	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.009	0.009
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0019	0.0027	0.0027
Brugia malayi	hypothetical protein	0.0124	0.0312	0.898
Loa Loa (eye worm)	IRE protein kinase	0.0022	0.0035	0.0035
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0142	0.036	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0958	0.2586	0.2586
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0124	0.0312	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0124	0.0312	0.898
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0124	0.0312	0.898
Mycobacterium tuberculosis	Probable dehydrogenase	0.0127	0.0322	0.8898
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.002	0.0028	0.0028
Trichomonas vaginalis	serine threonine-protein kinase, putative	0.0022	0.0034	0.0655
Leishmania major	potassium channel subunit-like protein	0.0124	0.0312	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0028	0.0028
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0019	0.0027	0.0606
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Treponema pallidum	NADH oxidase	0.0019	0.0027	0.5
Brugia malayi	glutathione reductase	0.0056	0.0127	0.3639
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0027	0.0124
Schistosoma mansoni	calcium-activated potassium channel	0.3676	1	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Onchocerca volvulus		0.0124	0.0312	0.7815
Echinococcus granulosus	histone lysine methyltransferase setb	0.002	0.0028	0.0028
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.002	0.0028	0.0028
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0124	0.0312	0.898
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0013	0.0009	0.0009
Brugia malayi	Zinc knuckle family protein	0.0013	0.0009	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Trypanosoma cruzi	trypanothione reductase, putative	0.0019	0.0027	0.0606
Plasmodium falciparum	potassium channel	0.0124	0.0312	1
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0009	0.0000000057401	0.0000000057401
Schistosoma mansoni	hypothetical protein	0.0013	0.0009	0.0009
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0013	0.0009	0.0009
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0127	0.0322	0.8898
Mycobacterium ulcerans	ion transport protein	0.0124	0.0312	1
Echinococcus multilocularis	potassium channel subfamily K 8	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.002	0.0028	0.0028
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0003
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.002	0.0028	0.0027
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0019	0.0027	0.0522
Mycobacterium ulcerans	transmembrane cation transporter	0.0124	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0027	0.0124
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0124	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.1073	0.29	0.29
Plasmodium vivax	potassium channel, putative	0.0124	0.0312	1
Brugia malayi	reverse transcriptase	0.0013	0.0009	0.0248
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0014	0.0013	0.0373
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0027	0.0606
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0019	0.0027	0.5
Onchocerca volvulus		0.0124	0.0312	0.7815
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0009	0.0000000057401	0.0000000057401
Echinococcus granulosus	Ankyrin	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Echinococcus multilocularis	small conductance calcium activated potassium	0.3676	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0027	0.0606
Brugia malayi	Uncoordinated protein 44	0.001	0.0003	0.0082
Echinococcus multilocularis	RNA directed DNA polymerase	0.0013	0.0009	0.0009
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0124	0.0312	0.0312
Brugia malayi	Death domain containing protein	0.0009	0.0000000057401	0.00000016514
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Toxoplasma gondii	ion channel protein	0.0124	0.0312	1
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Trypanosoma brucei	RNA helicase, putative	0.0557	0.1493	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0019	0.0027	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0124	0.0312	1
Plasmodium falciparum	potassium channel	0.0124	0.0312	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0124	0.0312	0.898
Giardia lamblia	Hypothetical protein	0.0124	0.0312	1
Echinococcus multilocularis	twik family of potassium channels	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0027	0.0606
Trypanosoma cruzi	ion transport protein, putative	0.0124	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.3676	1	1
Schistosoma mansoni	hypothetical protein	0.0124	0.0312	0.0312
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0027	0.0606
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0028	0.0028
Loa Loa (eye worm)	TWK-28 protein	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Protein kinase domain containing protein	0.001	0	0.0011
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0013	0.0009	0.0009
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0142	0.036	1
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0013	0.0009	0.0215
Entamoeba histolytica	hypothetical protein	0.0042	0.009	0.1986
Brugia malayi	Ribonuclease 2-5A family protein	0.0022	0.0035	0.0995
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0019	0.0027	0.0124
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0013	0.0009	0.0009
Trypanosoma cruzi	ion transport protein, putative	0.0124	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.1205	0.3261	0.3261
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0124	0.0312	0.898
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0124	0.0312	0.0312
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0009	0.0009
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0124	0.0312	0.898
Mycobacterium tuberculosis	Probable oxidoreductase	0.0142	0.036	1
Onchocerca volvulus		0.002	0.0028	0.0695
Echinococcus granulosus	twik family of potassium channels	0.0124	0.0312	0.0312
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0124	0.0312	0.7771
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0124	0.0312	1
Brugia malayi	Pre-SET motif family protein	0.0137	0.0348	1
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0124	0.0312	0.2045
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Thioredoxin reductase	0.0056	0.0127	0.3639
Echinococcus multilocularis	calcium activated potassium channel variant	0.0124	0.0312	0.0312
Leishmania major	hypothetical protein, conserved	0.0124	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0013	0.0009	0.0009
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.0027	0.0776
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0142	0.036	1
Trypanosoma brucei	trypanothione reductase	0.0056	0.0127	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Toxoplasma gondii	thioredoxin reductase	0.0056	0.0127	0.349
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0124	0.0312	0.2045
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Brugia malayi	hypothetical protein	0.0013	0.0009	0.0248
Schistosoma mansoni	calcium-activated potassium channel	0.0124	0.0312	0.0312
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0124	0.0312	0.7771
Plasmodium vivax	potassium channel, putative	0.0124	0.0312	1
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0124	0.0312	0.898
Brugia malayi	hypothetical protein	0.0013	0.0009	0.0248
Schistosoma mansoni	calcium-activated potassium channel	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Plasmodium vivax	thioredoxin reductase, putative	0.0056	0.0127	0.349
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Echinococcus multilocularis	potassium channel subfamily K	0.0124	0.0312	0.0312
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0027	0.0606
Trypanosoma cruzi	trypanothione reductase, putative	0.0056	0.0127	0.3884
Brugia malayi	hypothetical protein	0.0013	0.0009	0.0248
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0019	0.0027	0.0027
Trichomonas vaginalis	mercuric reductase, putative	0.0019	0.0027	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0124	0.0312	0.898
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.1274	0.3449	0.3449
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0014	0.0013	0.0373
Schistosoma mansoni	hypothetical protein	0.3676	1	1
Schistosoma mansoni	hypothetical protein	0.0557	0.1493	0.1493
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0124	0.0312	0.898
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0124	0.0312	0.898
Onchocerca volvulus		0.0124	0.0312	0.7815
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0124	0.0312	0.7771
Schistosoma mansoni	ankyrin 23/unc44	0.0009	0.0000000057401	0.0000000057401
Plasmodium vivax	glutathione reductase, putative	0.0056	0.0127	0.349
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0124	0.0312	0.898
Mycobacterium tuberculosis	Probable reductase	0.0127	0.0322	0.8898
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.0312	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0027	0.5
Loa Loa (eye worm)	TWK-7 protein	0.0124	0.0312	0.0312
Echinococcus multilocularis	twik family of potassium channels	0.0124	0.0312	0.0312
Entamoeba histolytica	hypothetical protein	0.0042	0.009	0.1986
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0127	0.0322	0.8898
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0027	0.5
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0137	0.0348	0.0348
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0124	0.0312	0.898
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0013	0.0009	0.0009
Plasmodium falciparum	glutathione reductase	0.0056	0.0127	0.349
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0022	0.0035	0.0035
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0028	0.0028
Leishmania major	ion transport protein-like protein	0.0124	0.0312	1
Echinococcus granulosus	KRAB A domain containing protein	0.0013	0.0009	0.0009
Brugia malayi	Zinc knuckle family protein	0.0013	0.0009	0.0248
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0022	0.0035	0.0035
Echinococcus granulosus	calcium activated potassium channel variant	0.0124	0.0312	0.0312
Schistosoma mansoni	calcium-activated potassium channel	0.2347	0.6375	0.6375
Brugia malayi	hypothetical protein	0.0124	0.0312	0.898
Plasmodium falciparum	thioredoxin reductase	0.0056	0.0127	0.349
Echinococcus granulosus	thioredoxin glutathione reductase	0.0056	0.0127	0.0127
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Trichomonas vaginalis	set domain proteins, putative	0.0156	0.0399	1
Echinococcus multilocularis	potassium channel subfamily K 8	0.0124	0.0312	0.0312
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0027	0.0606
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0124	0.0312	0.7771
Loa Loa (eye worm)	uncoordinated protein 58	0.0124	0.0312	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0124	0.0312	0.898
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0048	0.0106	0.0106
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0056	0.0127	0.0127
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.009	0.009
Entamoeba histolytica	hypothetical protein	0.0042	0.009	0.1986
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0027	0.0606
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0124	0.0312	0.8628
Loa Loa (eye worm)	thioredoxin reductase	0.0056	0.0127	0.0127
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0124	0.0312	1
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0124	0.0312	0.0312
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0127	0.0322	0.8898
Onchocerca volvulus		0.0124	0.0312	0.7815
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Onchocerca volvulus		0.0124	0.0312	0.7815
Schistosoma mansoni	twik family of potassium channels-related	0.0124	0.0312	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0124	0.0312	0.898
Echinococcus granulosus	potassium channel subfamily K	0.0124	0.0312	0.0312
Echinococcus granulosus	potassium channel subfamily K 8	0.0124	0.0312	0.0312
Echinococcus granulosus	potassium channel subfamily K 8	0.0124	0.0312	0.0312
Onchocerca volvulus		0.0156	0.0399	1
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0124	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Echinococcus granulosus	RNA directed DNA polymerase	0.0013	0.0009	0.0009
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.0312	1
Echinococcus multilocularis	Ankyrin	0.0011	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0042	0.009	0.009
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0013	0.0009	0.0009
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0124	0.0312	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0124	0.0312	0.898
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Leishmania major	hypothetical protein, conserved	0.0124	0.0312	1
Schistosoma mansoni	protein kinase	0.0013	0.0009	0.0009
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0019	0.0027	0.0027
Leishmania major	calcium/potassium channel (CAKC), putative	0.0124	0.0312	1
Onchocerca volvulus		0.0013	0.0009	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Toxoplasma gondii	ion channel protein	0.0124	0.0312	1
Echinococcus granulosus	twik family of potassium channels	0.0124	0.0312	0.0312
Onchocerca volvulus		0.0013	0.0009	0.0215
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0013	0.0009	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0034	0.0655
Plasmodium vivax	SET domain protein, putative	0.002	0.0028	0.0027
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0056	0.0127	0.3352
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.002	0.0028	0.0028
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0124	0.0312	0.898
Leishmania major	trypanothione reductase	0.0056	0.0127	0.349
Brugia malayi	reverse transcriptase	0.0013	0.0009	0.0248
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0027	0.0606
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0312	0.0312
Brugia malayi	hypothetical protein	0.0042	0.009	0.258
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0124	0.0312	0.898
Brugia malayi	Pao retrotransposon peptidase family protein	0.0013	0.0009	0.0248
Onchocerca volvulus		0.0124	0.0312	0.7815

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 830330