Detailed information for compound 831128

Basic information

Technical information
  • TDR Targets ID: 831128
  • Name: 6-(3-bromophenyl)-2-propylimidazo[2,1-b][1,3, 4]thiadiazole
  • MW: 322.223 | Formula: C13H12BrN3S
  • H donors: 0 H acceptors: 2 LogP: 4.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nn2c(s1)nc(c2)c1cccc(c1)Br
  • InChi: 1S/C13H12BrN3S/c1-2-4-12-16-17-8-11(15-13(17)18-12)9-5-3-6-10(14)7-9/h3,5-8H,2,4H2,1H3
  • InChiKey: TZPRSMXAHWCCKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(3-bromophenyl)-2-propyl-imidazo[2,1-b][1,3,4]thiadiazole
  • ZINC07994989

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0572
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0039 0.0068
Onchocerca volvulus 0.0043 0.0328 0.029
Trypanosoma cruzi katanin, putative 0.0036 0.0214 0.0000043848
Toxoplasma gondii katanin-like family protein 0.0036 0.0214 0.0175
Loa Loa (eye worm) vps4b-prov protein 0.0036 0.0214 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0328 0.0123
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0079 0.0851 0.0815
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0107 0.0183
Echinococcus granulosus jumonji domain containing protein 0.0033 0.0179 0.014
Brugia malayi beta-lactamase 0.0043 0.0328 0.0507
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3805 0.6497
Echinococcus multilocularis lysine specific demethylase 5A 0.0029 0.0114 0.0075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0328 0.056
Brugia malayi RNA binding protein 0.0076 0.0818 0.1367
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0328 0.029
Trypanosoma cruzi katanin, putative 0.0036 0.0214 0.0000043848
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0416 0.5857 0.5841
Entamoeba histolytica hypothetical protein 0.0043 0.0327 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0187
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0569 0.0532
Giardia lamblia Topoisomerase II 0.0036 0.0214 0.03
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0576 0.0943
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0328 0.056
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0818 0.1427
Echinococcus granulosus vacuolar protein sorting associated protein 4A 0.0036 0.0214 0.0175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0328 0.029
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0036 0.0214 0.0113
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1822 0.3178
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0328 0.0117
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0107 0.0183
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0611 0.0574
Brugia malayi vps4b-prov protein 0.0036 0.0214 0.0306
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0328 1
Entamoeba histolytica cdc48-like protein, putative 0.0659 0.9469 1
Toxoplasma gondii cell division protein CDC48AP 0.0416 0.5857 0.5841
Mycobacterium leprae Probable lipase LipE 0.0043 0.0328 1
Brugia malayi beta-lactamase family protein 0.0043 0.0328 0.0507
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0107 0.012
Leishmania major katanin, putative,serine peptidase, Clan SJ, family S16, putative 0.0036 0.0214 0.0113
Onchocerca volvulus 0.0043 0.0328 0.029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0572
Brugia malayi fidgetin protein 0.0036 0.0214 0.0306
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0818 0.0782
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0328 0.056
Loa Loa (eye worm) beta-lactamase 0.0043 0.0328 0.0572
Giardia lamblia SKD1 protein 0.0036 0.0214 0.03
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0287 0.3949 0.6867
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0107 0.0183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0572
Onchocerca volvulus 0.006 0.0569 0.0532
Trypanosoma cruzi katanin-like protein, putative 0.0036 0.0214 0.0000043848
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0079 0.0851 0.0815
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0327 0.0289
Brugia malayi SAP1 protein 0.0036 0.0214 0.0306
Schistosoma mansoni hypothetical protein 0.0036 0.0214 0.0175
Loa Loa (eye worm) hypothetical protein 0.0041 0.0294 0.0513
Trypanosoma cruzi katanin, putative 0.0036 0.0214 0.0000043848
Trypanosoma brucei Valosin-containing protein 0.0659 0.9469 1
Trypanosoma cruzi katanin, putative 0.0036 0.0214 0.0000043848
Onchocerca volvulus 0.0043 0.0328 0.029
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0039 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0327 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0818 0.0782
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0328 0.0346
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0107 0.012
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0659 0.9469 1
Loa Loa (eye worm) fidgetin protein 0.0036 0.0214 0.0373
Mycobacterium ulcerans hypothetical protein 0.0029 0.0107 0.0183
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0328 0.0117
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0327 0.0289
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0419 0.0731
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0328 0.0123
Leishmania major hypothetical protein, conserved 0.0043 0.0328 0.0235
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0659 0.9469 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0107 0.0183
Trichomonas vaginalis esterase, putative 0.0043 0.0328 0.0117
Echinococcus multilocularis vacuolar protein sorting associated protein 4A 0.0036 0.0214 0.0175
Mycobacterium tuberculosis Conserved protein 0.0043 0.0328 0.056
Toxoplasma gondii ABC1 family protein 0.0043 0.0328 0.029
Giardia lamblia AAA family ATPase 0.0416 0.5857 1
Loa Loa (eye worm) VCP protein 0.0287 0.3949 0.6888
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0328 0.029
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0164 0.2122 0.195
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0576 0.0943
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0107 0.0183
Echinococcus granulosus lysine specific demethylase 5A 0.0029 0.0114 0.0075
Trypanosoma cruzi katanin, putative 0.0036 0.0214 0.0000043848
Mycobacterium tuberculosis Conserved protein 0.0043 0.0328 0.056
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0107 0.0183
Schistosoma mansoni hypothetical protein 0.0043 0.0327 0.0289
Plasmodium falciparum vacuolar protein sorting-associated protein 4 0.0036 0.0214 0.0226
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0818 0.1427
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0695 1 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0328 0.056
Echinococcus multilocularis tumor protein p63 0.0408 0.5739 0.5722
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1822 0.3178
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0164 0.2122 0.195
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0114 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0328 0.0117
Loa Loa (eye worm) hypothetical protein 0.006 0.0569 0.0992
Echinococcus multilocularis jumonji domain containing protein 0.0033 0.0179 0.014
Brugia malayi beta-lactamase family protein 0.0043 0.0328 0.0507
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0328 0.0572
Plasmodium falciparum phd finger protein, putative 0.0024 0.0039 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0328 0.0117
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0695 1 1
Brugia malayi jmjC domain containing protein 0.0079 0.0851 0.1426
Loa Loa (eye worm) RNA binding protein 0.0076 0.0818 0.1427
Onchocerca volvulus 0.0029 0.0107 0.0068
Mycobacterium tuberculosis Putative conserved ATPase 0.0416 0.5857 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0328 0.056
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0659 0.9469 1
Echinococcus granulosus fidgetin protein 1 0.0036 0.0214 0.0175
Loa Loa (eye worm) hypothetical protein 0.0041 0.0293 0.0512
Trypanosoma cruzi vacuolar transport protein 4A, putative 0.0036 0.0214 0.0000043848
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0328 0.029
Mycobacterium tuberculosis Conserved protein 0.0043 0.0328 0.056
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0114 0.0199
Toxoplasma gondii cell division protein CDC48CY 0.0695 1 1
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0659 0.9469 1
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0695 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0187
Schistosoma mansoni hypothetical protein 0.0041 0.0293 0.0255
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0187
Loa Loa (eye worm) ATPase 0.0036 0.0214 0.0373
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0328 0.056
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0287 0.3949 0.3925
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0818 0.1367
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0114 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0107 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0107 0.012
Mycobacterium ulcerans ATPase 0.0416 0.5857 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0659 0.9469 0.9467
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0287 0.3949 0.3925
Echinococcus granulosus katanin p60 ATPase containing subunit A1 0.0036 0.0214 0.0175
Brugia malayi TAR-binding protein 0.0076 0.0818 0.1367
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0572
Entamoeba histolytica ATPase, Vps4 oligomerisation domain containing protein 0.0036 0.0214 0.0113
Entamoeba histolytica hypothetical protein 0.0043 0.0327 0.0235
Giardia lamblia Katanin 0.0036 0.0214 0.03
Echinococcus granulosus tumor protein p63 0.0408 0.5739 0.5722
Schistosoma mansoni skd/vacuolar sorting 0.0036 0.0214 0.0175
Loa Loa (eye worm) hypothetical protein 0.0408 0.5733 1
Brugia malayi valosin containing protein 0.0408 0.5733 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0818 0.0782
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0818 0.0782
Mycobacterium ulcerans lipase LipD 0.0043 0.0328 0.056
Trypanosoma cruzi vacuolar protein sorting-associated protein 4, putative 0.0036 0.0214 0.0000043848
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0695 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0576 0.1005
Brugia malayi jmjC domain containing protein 0.0029 0.0114 0.0132
Echinococcus granulosus tar DNA binding protein 0.0076 0.0818 0.0782
Brugia malayi vesicle-fusing ATPase 0.0408 0.5733 1
Trypanosoma cruzi vesicular transport protein (CDC48 homologue), putative 0.0036 0.0214 0.0000043848
Loa Loa (eye worm) vesicle-fusing ATPase 0.0408 0.5733 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0328 0.056
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0818 0.0782
Entamoeba histolytica hypothetical protein 0.0043 0.0327 0.0235
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0576 0.1005
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0328 0.0123
Entamoeba histolytica hypothetical protein 0.0043 0.0327 0.0235
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0328 0.056
Echinococcus multilocularis katanin p60 ATPase containing subunit A1 0.0036 0.0214 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0107 0.0183
Trypanosoma cruzi metalloprotease, putative 0.0036 0.0214 0.0000043848
Giardia lamblia SKD1 protein 0.0036 0.0214 0.03
Trypanosoma cruzi Valosin-containing protein, putative 0.0659 0.9469 1
Entamoeba histolytica vacuolar sorting protein-associating protein 4A (VPS4), putative 0.0036 0.0214 0.0113
Echinococcus multilocularis fidgetin protein 1 0.0036 0.0214 0.0175
Brugia malayi MH2 domain containing protein 0.0144 0.1822 0.3131
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0293 0.0446
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0328 0.0507
Brugia malayi ATPase, AAA family protein 0.0036 0.0214 0.0306
Leishmania major vacuolar protein sorting-associated protein 4 0.0036 0.0214 0.0113
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0036 0.0214 0.0113
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0572
Mycobacterium ulcerans beta-lactamase 0.0043 0.0328 0.056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0572
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0068
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0328 0.056
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0818 0.0782
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0328 0.0117
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0328 0.056
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0107 0.0183
Plasmodium vivax cell division cycle ATPase, putative 0.0252 0.3418 0.361
Brugia malayi hypothetical protein 0.0043 0.0327 0.0506

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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