TDR Targets

Basic information

Technical information

TDR Targets ID: 831609
Name: 3-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimid in-6-yl)-N-propan-2-ylpropanamide
MW: 261.323 | Formula: C13H19N5O
H donors: 1 H acceptors: 4 LogP: 1.21 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(NC(=O)CCc1c(C)nc2n(c1C)ncn2)C
InChi: 1S/C13H19N5O/c1-8(2)16-12(19)6-5-11-9(3)17-13-14-7-15-18(13)10(11)4/h7-8H,5-6H2,1-4H3,(H,16,19)
InChiKey: LJMCCXHSLMMDGA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-isopropyl-propanamide
3-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-isopropylpropanamide
3-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-isopropyl-propionamide
3-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-propan-2-yl-propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0047	0.0341
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0111	0.0959	0.0959
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0057	0.046	0.046
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0111	0.0959	0.0959
Schistosoma mansoni	glutamate receptor NMDA	0.0866	0.79	1
Loa Loa (eye worm)	glutamate receptor 2	0.0111	0.0959	1
Trypanosoma cruzi	extracellular receptor, putative	0.0057	0.046	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0169	0.1484	0.1484
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0047	0.034
Schistosoma mansoni	protein kinase	0.0057	0.046	0.0582
Schistosoma mansoni	hypothetical protein	0.0404	0.3653	0.4624
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0286	0.256	0.5
Schistosoma mansoni	hypothetical protein	0.0111	0.0959	0.1214
Echinococcus granulosus	nmda type glutamate receptor	0.0755	0.6876	0.6876
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0111	0.0959	0.0959
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0294	0.0294
Echinococcus multilocularis	glutamate receptor 2	0.0111	0.0959	0.0959
Plasmodium vivax	multidomain scavenger receptor, putative	0.0039	0.0294	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0057	0.046	0.046
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0057	0.046	0.4716
Leishmania major	extracellular receptor, putative	0.0057	0.046	1
Schistosoma mansoni	tyrosine kinase	0.0057	0.046	0.0582
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0286	0.256	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0169	0.1484	0.1484
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0057	0.046	0.046
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0047	0.0341
Schistosoma mansoni	tyrosine kinase	0.0057	0.046	0.0582
Echinococcus multilocularis	cpg binding protein	0.003	0.0211	0.0211
Schistosoma mansoni	glutamate receptor AMPA	0.0111	0.0959	0.1214
Brugia malayi	Receptor family ligand binding region containing protein	0.0057	0.046	0.4715
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0057	0.046	0.046
Schistosoma mansoni	cpg binding protein	0.003	0.0211	0.0267
Schistosoma mansoni	glutamate receptor kainate	0.0111	0.0959	0.1214
Schistosoma mansoni	glutamate receptor AMPA	0.0111	0.0959	0.1214
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0286	0.256	0.5
Onchocerca volvulus		0.0039	0.0294	0.3689
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0196	0.192
Schistosoma mansoni	lipoxygenase	0.0109	0.0939	0.1188
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0111	0.0959	0.0959
Schistosoma mansoni	microtubule-associated protein tau	0.0682	0.6207	0.7857
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Onchocerca volvulus		0.0039	0.0294	0.3689
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0057	0.046	0.046
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0111	0.0959	0.0959
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0057	0.046	0.4716
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0057	0.046	0.046
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0169	0.1484	0.1484
Schistosoma mansoni	glutamate receptor kainate	0.0111	0.0959	0.1214
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0397	0.3584	0.3584
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0294	0.0294
Echinococcus multilocularis	glutamate receptor NMDA	0.0698	0.6351	0.6351
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Onchocerca volvulus		0.0057	0.046	1
Echinococcus multilocularis	tyrosine kinase	0.0057	0.046	0.046
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.046	0.4716
Loa Loa (eye worm)	glutamate receptor	0.0057	0.046	0.4716
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0057	0.046	0.046
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0286	0.256	0.5
Echinococcus granulosus	tyrosine kinase	0.0057	0.046	0.046
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0294	0.0294
Brugia malayi	Glutamate receptor 1 precursor	0.0111	0.0959	1
Brugia malayi	Guanylyl cyclase protein 23	0.0057	0.046	0.4715
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0057	0.046	0.4716
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0169	0.1484	0.1484
Echinococcus granulosus	Polycystic kidney disease protein	0.0039	0.0294	0.0294
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0111	0.0959	0.0959
Echinococcus multilocularis	glutamate receptor 2	0.0057	0.046	0.046
Echinococcus multilocularis	NMDA receptor	0.0111	0.0959	0.0959
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0169	0.1484	0.1484
Echinococcus multilocularis	microtubule associated protein 2	0.0682	0.6207	0.6207
Brugia malayi	hypothetical protein	0.0057	0.046	0.4715
Schistosoma mansoni	loxhd1	0.0039	0.0294	0.0372
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.046	0.4716
Echinococcus multilocularis	Polycystic kidney disease protein	0.0039	0.0294	0.0294
Loa Loa (eye worm)	glutamate receptor 1	0.0111	0.0959	1
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.3653	0.3653
Onchocerca volvulus		0.0057	0.046	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0111	0.0959	0.0959
Echinococcus granulosus	RUN	0.0039	0.0294	0.0294
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.3653	0.3653
Brugia malayi	hypothetical protein	0.0039	0.0294	0.2951
Echinococcus granulosus	microtubule associated protein 2	0.0682	0.6207	0.6207
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0294	0.2952
Echinococcus multilocularis	RUN	0.0039	0.0294	0.0294
Brugia malayi	metabotropic glutamate receptor type 2	0.0057	0.046	0.4715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Brugia malayi	Doublecortin family protein	0.0039	0.0294	0.2951
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0057	0.046	0.4715
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0047	0.0341
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.043	0.5
Loa Loa (eye worm)	doublecortin family protein	0.0039	0.0294	0.2952
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0286	0.256	0.5
Echinococcus multilocularis	glutamate receptor 2	0.0169	0.1484	0.1484
Echinococcus granulosus	cpg binding protein	0.003	0.0211	0.0211
Brugia malayi	Glutamate receptor 2 precursor	0.0111	0.0959	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.046	0.4716
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0196	0.1921
Brugia malayi	hypothetical protein	0.0039	0.0294	0.2951
Schistosoma mansoni	polycystin 1-related	0.0039	0.0294	0.0372
Schistosoma mansoni	rab6-interacting	0.0039	0.0294	0.0372
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0057	0.046	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0294	0.0372
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0047	0.034
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0047	0.5
Echinococcus multilocularis	nmda type glutamate receptor	0.1095	1	1
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0057	0.046	0.046
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0016	0.0012
Brugia malayi	Receptor family ligand binding region containing protein	0.0057	0.046	0.4715
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0169	0.1484	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0294	0.2952
Echinococcus granulosus	glutamate receptor NMDA	0.0698	0.6351	0.6351
Schistosoma mansoni	ATP-binding cassette transporter	0.0111	0.0959	0.1214
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0111	0.0959	0.0959
Echinococcus multilocularis	nmda type glutamate receptor	0.0755	0.6876	0.6876
Echinococcus granulosus	glutamate receptor 2	0.0057	0.046	0.046
Schistosoma mansoni	metabotropic glutamate receptor	0.0057	0.046	0.0582
Entamoeba histolytica	hypothetical protein	0.0057	0.046	0.5
Schistosoma mansoni	glutamate receptor kainate	0.0111	0.0959	0.1214
Schistosoma mansoni	metabotropic glutamate receptor	0.0057	0.046	0.0582
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0109	0.0939	0.0939
Echinococcus granulosus	glutamate receptor 2	0.0169	0.1484	0.1484
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0057	0.046	0.4715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0111	0.0959	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.4716
Chlamydia trachomatis	glutamine binding protein	0.0286	0.256	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0016
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0169	0.1484	0.1484
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0169	0.1484	0.1484
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0294	0.0294
Schistosoma mansoni	glutamate receptor NMDA	0.0111	0.0959	0.1214
Schistosoma mansoni	rab6-interacting	0.0039	0.0294	0.0372
Schistosoma mansoni	lipoxygenase	0.0039	0.0294	0.0372
Schistosoma mansoni	cpg binding protein	0.0028	0.0196	0.0248
Plasmodium falciparum	LCCL domain-containing protein	0.0039	0.0294	0.5
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0109	0.0939	0.0939
Schistosoma mansoni	cpg binding protein	0.003	0.0211	0.0267
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0016
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0489	0.0619

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 831609