Detailed information for compound 832181

Basic information

Technical information
  • TDR Targets ID: 832181
  • Name: N-(2-chloro-4-methylphenyl)-2-[2-[(4-methylph enyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-y l]acetamide
  • MW: 436.957 | Formula: C23H21ClN4OS
  • H donors: 1 H acceptors: 3 LogP: 5.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CSc1nc2c(n1CC(=O)Nc1ccc(cc1Cl)C)cncc2
  • InChi: 1S/C23H21ClN4OS/c1-15-3-6-17(7-4-15)14-30-23-27-20-9-10-25-12-21(20)28(23)13-22(29)26-19-8-5-16(2)11-18(19)24/h3-12H,13-14H2,1-2H3,(H,26,29)
  • InChiKey: HEMWSSPILDZBGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chloro-4-methyl-phenyl)-2-[2-[(4-methylphenyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-yl]acetamide
  • N-(2-chloro-4-methylphenyl)-2-[2-[(4-methylphenyl)methylthio]-3-imidazo[5,4-c]pyridinyl]acetamide
  • N-(2-chloro-4-methyl-phenyl)-2-[2-[(4-methylbenzyl)thio]imidazo[5,4-c]pyridin-3-yl]acetamide
  • N-(2-chloro-4-methyl-phenyl)-2-[2-[(4-methylphenyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0025 0.0159 0.1892
Leishmania major basic transcription factor 3a, putative 0.0035 0.0304 0.3831
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.016 0.0142
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0159 0.4939
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.016 0.0498
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0304 0.3831
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.016 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.016 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.016 0.0498
Schistosoma mansoni thyroid hormone receptor 0.0025 0.016 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.016 0.0498
Brugia malayi nuclear hormone receptor 0.0025 0.016 0.0498
Echinococcus multilocularis microtubule associated protein 2 0.0693 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0352 0.0334
Schistosoma mansoni hypothetical protein 0.007 0.0822 0.0805
Schistosoma mansoni coup transcription factor 0.0025 0.016 0.0142
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0185 0.0577
Schistosoma mansoni thyroid hormone receptor 0.0025 0.016 0.0142
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0635 0.1976
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0239 0.3313 0.33
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0159 0.1892
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.016 0.0498
Schistosoma mansoni hypothetical protein 0.0254 0.3525 0.3513
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0657 0.2043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.016 0.0498
Echinococcus multilocularis lamin 0.0027 0.0185 0.0167
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0657 0.064
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0578 0.1799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.016 0.0498
Schistosoma mansoni lamin 0.0027 0.0185 0.0167
Entamoeba histolytica hypothetical protein 0.007 0.0822 1
Echinococcus granulosus lamin 0.0027 0.0185 0.0167
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0657 0.064
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0185 0.0577
Brugia malayi nuclear receptor NHR-88 0.0025 0.016 0.0498
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0102 0.1285 0.3999
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.016 0.0142
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0657 0.064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0822 0.0805
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0822 0.0805
Loa Loa (eye worm) hypothetical protein 0.0025 0.0159 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.016 0.0498
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0635 0.0618
Brugia malayi steroid hormone receptor 0.0025 0.016 0.0498
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0159 0.1892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.016 0.0498
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0352 0.0334
Schistosoma mansoni nuclear hormone receptor 0.0025 0.016 0.0142
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0822 0.0805
Brugia malayi follicle stimulating hormone receptor 0.0233 0.3214 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.016 0.0498
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.016 0.0142
Echinococcus multilocularis transcription factor btf3 0.0035 0.0304 0.0286
Brugia malayi jmjC domain containing protein 0.0016 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0763 1
Echinococcus granulosus muscleblind protein 0.015 0.1997 0.1982
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0304 1
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0304 0.3831
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.016 0.0142
Brugia malayi jmjC domain containing protein 0.0059 0.0657 0.2043
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Loa Loa (eye worm) hypothetical protein 0.015 0.1997 0.6213
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.016 0.0498
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0159 0.4939
Loa Loa (eye worm) hypothetical protein 0.015 0.1997 0.6213
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0304 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.016 0.0142
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.016 0.0498
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.016 0.0142
Echinococcus granulosus intermediate filament protein 0.0027 0.0185 0.0167
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.016 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0018 0.0057
Brugia malayi ecdysteroid receptor 0.0025 0.016 0.0498
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.016 0.0142
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.016 0.0142
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0304 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.016 0.0498
Entamoeba histolytica hypothetical protein 0.007 0.0822 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1285 0.3999
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.016 0.0498
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0635 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.016 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0304 0.5
Brugia malayi Muscleblind-like protein 0.015 0.1997 0.6213
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0635 0.0618
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.016 0.0498
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0657 0.064
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0159 0.1892
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.016 0.0142
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.3214 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0763 1
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.016 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0018 0.0057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0635 0.5
Brugia malayi hypothetical protein 0.0016 0.0027 0.0084
Echinococcus multilocularis lamin dm0 0.0027 0.0185 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.016 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.016 0.0498
Brugia malayi jmjC domain containing protein 0.0016 0.0018 0.0057
Schistosoma mansoni transcription factor btf3 0.0035 0.0304 0.0286
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0763 0.8874
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.016 0.0142
Echinococcus granulosus FTZ F1 alpha 0.0025 0.016 0.0142
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.016 0.0142
Onchocerca volvulus 0.0027 0.0185 0.0224
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0018 0.0057
Entamoeba histolytica hypothetical protein 0.007 0.0822 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.016 0.0142
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0657 0.064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.016 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0057
Echinococcus multilocularis muscleblind protein 0.015 0.1997 0.1982
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.016 0.0498
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.016 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0304 0.5
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0239 0.3313 0.33
Brugia malayi beta-NAC-like protein 0.0035 0.0304 0.0945
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0304 0.3831
Echinococcus granulosus lamin dm0 0.0027 0.0185 0.0167
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0304 0.0945
Onchocerca volvulus 0.0102 0.1285 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0178 0.0554
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0635 0.8282
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.016 0.0142
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.016 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.016 0.0498
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0763 0.0746
Schistosoma mansoni lamin 0.0027 0.0185 0.0167
Loa Loa (eye worm) hypothetical protein 0.0027 0.0185 0.0577
Brugia malayi intermediate filament protein 0.0027 0.0185 0.0577
Brugia malayi jmjC domain containing protein 0.0059 0.0657 0.2043
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0763 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.016 0.0498
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0657 0.064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.016 0.0142
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0763 1
Brugia malayi jmjC domain containing protein 0.0016 0.0018 0.0057
Schistosoma mansoni microtubule-associated protein tau 0.0693 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.016 0.0142
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0763 0.0746
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0763 0.2374
Echinococcus multilocularis musashi 0.0027 0.0185 0.0167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.016 0.0498
Echinococcus multilocularis muscleblind protein 1 0.015 0.1997 0.1982
Brugia malayi hypothetical protein 0.007 0.0822 0.2556
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.016 0.0142
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0635 0.5
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0254 0.3525 0.3513
Brugia malayi jmjC domain containing protein 0.0016 0.0018 0.0057
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0657 0.064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.016 0.0142
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.016 0.0498
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.016 0.0142
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0498
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0635 0.0618
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0057
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.016 0.0142
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0185 0.0577
Schistosoma mansoni intermediate filament proteins 0.0027 0.0185 0.0167
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0304 1
Echinococcus granulosus transcription factor btf3 0.0035 0.0304 0.0286
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0763 0.0746
Entamoeba histolytica hypothetical protein 0.007 0.0822 1
Brugia malayi hypothetical protein 0.0025 0.0159 0.0495
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.016 0.0142
Onchocerca volvulus 0.0027 0.0185 0.0224
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0159 0.4939
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.016 0.0142
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0159 0.4939
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0763 0.2374

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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