TDR Targets

Basic information

Technical information

TDR Targets ID: 832589
Name: N-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]m ethyl]-2-(4-methylphenoxy)acetamide
MW: 357.791 | Formula: C18H16ClN3O3
H donors: 1 H acceptors: 3 LogP: 3.64 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NCc1onc(n1)c1ccc(cc1)Cl)COc1ccc(cc1)C
InChi: 1S/C18H16ClN3O3/c1-12-2-8-15(9-3-12)24-11-16(23)20-10-17-21-18(22-25-17)13-4-6-14(19)7-5-13/h2-9H,10-11H2,1H3,(H,20,23)
InChiKey: QXULMWYEFKDXJS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]-2-(4-methylphenoxy)ethanamide
ZINC04850475
STK322233

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase, CMGC CDK	0.0218	0.0603	0.0856
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0385	0.1379	0.112
Echinococcus granulosus	protein kinase c epsilon type	0.07	0.2841	0.2627
Echinococcus multilocularis	serine threonine protein kinase	0.1978	0.8766	0.8729
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0385	0.1379	0.112
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0936	0.3933	0.3752
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0385	0.1379	0.112
Entamoeba histolytica	cell division protein kinase 2, putative	0.0218	0.0603	0.2867
Schistosoma mansoni	serine/threonine protein kinase	0.0283	0.0905	0.0632
Echinococcus multilocularis	cyclin dependent kinase	0.0218	0.0603	0.0321
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Echinococcus multilocularis	myotubularin protein 13	0.0266	0.0828	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1056	0.1322
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Echinococcus granulosus	N chimaerin	0.0266	0.0828	0.0553
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0218	0.0603	1
Entamoeba histolytica	hypothetical protein	0.0266	0.0828	0.4936
Entamoeba histolytica	diacylglycerol kinase, putative	0.0266	0.0828	0.4936
Loa Loa (eye worm)	hypothetical protein	0.054	0.2096	0.2625
Echinococcus granulosus	protein kinase C gamma type	0.1978	0.8766	0.8729
Echinococcus granulosus	NDR protein kinase	0.0385	0.1379	0.112
Trypanosoma brucei	cdc2-related kinase 3	0.0218	0.0603	0.2867
Schistosoma mansoni	serine/threonine protein kinase	0.0266	0.0828	0.0553
Schistosoma mansoni	serine/threonine kinase	0.0385	0.1379	0.112
Toxoplasma gondii	AGC kinase	0.0385	0.1379	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0283	0.0905	0.0767
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0385	0.1379	0.112
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0385	0.1379	0.1726
Trichomonas vaginalis	cyclin B, putative	0.015	0.0291	0.0571
Loa Loa (eye worm)	hypothetical protein	0.015	0.0291	0.0364
Trichomonas vaginalis	CMGC family protein kinase	0.0218	0.0603	0.1378
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0936	0.3933	1
Echinococcus granulosus	cyclin dependent kinase 1	0.0218	0.0603	0.0321
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.1544	0.6752	0.6655
Trypanosoma cruzi	cdc2-related kinase 3	0.0218	0.0603	1
Onchocerca volvulus		0.0266	0.0828	0.1474
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0385	0.1379	0.1726
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0266	0.0828	0.1036
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0368	0.1302	0.3188
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Echinococcus granulosus	cyclin dependent kinase 5	0.0218	0.0603	0.0321
Echinococcus multilocularis	protein kinase c iota type	0.0651	0.2613	0.2392
Echinococcus multilocularis	cyclin dependent kinase 1	0.0218	0.0603	0.0321
Brugia malayi	Protein kinase domain containing protein	0.0385	0.1379	0.136
Brugia malayi	Protein kinase domain containing protein	0.0218	0.0603	0.039
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.161	0.7057	0.8836
Brugia malayi	Hr1 repeat family protein	0.0385	0.1379	0.136
Trypanosoma brucei	cdc2-related kinase 1	0.0218	0.0603	0.2867
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0218	0.0603	1
Loa Loa (eye worm)	TTK protein kinase	0.0936	0.3933	0.4925
Echinococcus granulosus	Diacylglycerol kinase theta	0.0266	0.0828	0.0553
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0936	0.3933	0.3752
Echinococcus multilocularis	unc 13 (munc13)	0.0315	0.1056	0.0788
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.07	0.2841	0.3557
Brugia malayi	RhoGAP domain containing protein	0.0266	0.0828	0.0671
Brugia malayi	Protein kinase domain containing protein	0.0283	0.0905	0.0767
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0315	0.1056	0.0788
Trichomonas vaginalis	cyclin B, putative	0.015	0.0291	0.0571
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0385	0.1379	0.112
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Schistosoma mansoni	unc-13 (munc13)	0.0315	0.1056	0.0788
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0385	0.1379	0.1726
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Brugia malayi	Protein kinase domain containing protein	0.0936	0.3933	0.4553
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0266	0.0828	0.1036
Trichomonas vaginalis	CMGC family protein kinase	0.0218	0.0603	0.1378
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0266	0.0828	0.0553
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0283	0.0905	0.0632
Trichomonas vaginalis	CAMK family protein kinase	0.0936	0.3933	1
Echinococcus granulosus	RNA directed DNA polymerase	0.1544	0.6752	0.6655
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0806	0.3331	0.417
Schistosoma mansoni	serine/threonine protein kinase	0.2244	1	1
Brugia malayi	protein kinase C II.	0.07	0.2841	0.3187
Trypanosoma cruzi	cdc2-related kinase 1	0.0218	0.0603	1
Brugia malayi	diacylglycerol kinase	0.0266	0.0828	0.0671
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0266	0.0828	0.0553
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0385	0.1379	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0385	0.1379	0.1726
Schistosoma mansoni	rac gtpase activating protein	0.0266	0.0828	0.0553
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0283	0.0905	0.0632
Brugia malayi	Protein kinase domain containing protein	0.0385	0.1379	0.136
Echinococcus multilocularis	cyclin dependent kinase 1	0.0218	0.0603	0.0321
Onchocerca volvulus		0.054	0.2096	0.4957
Echinococcus multilocularis	protein kinase c eta type	0.0266	0.0828	0.0553
Trichomonas vaginalis	cyclins, putative	0.015	0.0291	0.0571
Giardia lamblia	Kinase, TTK	0.0936	0.3933	1
Giardia lamblia	Kinase, CMGC CDK	0.0218	0.0603	0.0856
Trichomonas vaginalis	cyclins, putative	0.015	0.0291	0.0571
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0266	0.0828	0.0553
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0385	0.1379	0.1726
Echinococcus granulosus	raf serine:threonine protein kinase	0.0266	0.0828	0.0553
Schistosoma mansoni	serine/threonine protein kinase	0.0218	0.0603	0.0321
Trypanosoma cruzi	cdc2-related kinase 1	0.0218	0.0603	1
Schistosoma mansoni	serine/threonine protein kinase	0.0385	0.1379	0.112
Schistosoma mansoni	protein kinase C	0.0315	0.1056	0.0788
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0283	0.0905	0.1133
Brugia malayi	Protein kinase c protein 2	0.1876	0.8292	1
Entamoeba histolytica	protein kinase, putative	0.0385	0.1379	1
Schistosoma mansoni	hypothetical protein	0.0266	0.0828	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0526	0.0658
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.2244	1	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0218	0.0603	0.0321
Brugia malayi	diacylglycerol kinase	0.0266	0.0828	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0925	0.3882	0.486
Echinococcus multilocularis	cyclin dependent kinase 5	0.0218	0.0603	0.0321
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Plasmodium vivax	protein kinase Crk2	0.0218	0.0603	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0218	0.0603	0.0755
Onchocerca volvulus		0.0266	0.0828	0.1474
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Schistosoma mansoni	vav2	0.0266	0.0828	0.0553
Loa Loa (eye worm)	hypothetical protein	0.015	0.0291	0.0364
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Onchocerca volvulus		0.0315	0.1056	0.21
Schistosoma mansoni	protein kinase C mu	0.0266	0.0828	0.0553
Loa Loa (eye worm)	hypothetical protein	0.054	0.2096	0.2625
Brugia malayi	protein kinase C3,putative	0.0283	0.0905	0.0767
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0266	0.0828	0.0553
Brugia malayi	cell division control protein 2 homolog	0.0218	0.0603	0.039
Loa Loa (eye worm)	raf kinase	0.0266	0.0828	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0315	0.1056	0.0788
Schistosoma mansoni	serine/threonine protein kinase	0.2244	1	1
Echinococcus multilocularis	RNA directed DNA polymerase	0.1544	0.6752	0.6655
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0385	0.1379	0.112
Echinococcus multilocularis	protein kinase c epsilon type	0.07	0.2841	0.2627
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Entamoeba histolytica	cell division protein kinase 2, putative	0.0218	0.0603	0.2867
Trichomonas vaginalis	cyclin B, putative	0.015	0.0291	0.0571
Schistosoma mansoni	serine/threonine protein kinase	0.0385	0.1379	0.112
Loa Loa (eye worm)	hypothetical protein	0.181	0.7987	1
Schistosoma mansoni	serine/threonine protein kinase	0.07	0.2841	0.2627
Schistosoma mansoni	serine/threonine protein kinase	0.0283	0.0905	0.0632
Brugia malayi	RhoGAP domain containing protein	0.0266	0.0828	0.0671
Schistosoma mansoni	serine/threonine protein kinase	0.0385	0.1379	0.112
Toxoplasma gondii	diacylglycerol kinase, putative	0.0266	0.0828	0.2901
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0266	0.0828	0.0553
Schistosoma mansoni	unc-13 (munc13)	0.0315	0.1056	0.0788
Schistosoma mansoni	atypical protein kinase C	0.0651	0.2613	0.2392
Plasmodium falciparum	protein kinase 5	0.0218	0.0603	0.5
Trichomonas vaginalis	cyclins, putative	0.015	0.0291	0.0571
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0218	0.0603	0.0755
Schistosoma mansoni	diacylglycerol kinase theta	0.0266	0.0828	0.0553
Trichomonas vaginalis	CMGC family protein kinase	0.0218	0.0603	0.1378
Schistosoma mansoni	protein kinase C mu	0.0283	0.0905	0.0632
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0266	0.0828	0.0553
Entamoeba histolytica	protein kinase, putative	0.0385	0.1379	1
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0283	0.0905	0.1133
Echinococcus granulosus	cyclin dependent kinase	0.0218	0.0603	0.0321
Brugia malayi	Pleckstrin Homology Domain	0.0266	0.0828	0.0671
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0266	0.0828	0.1036
Brugia malayi	Variant SH3 domain containing protein	0.0266	0.0828	0.0671
Loa Loa (eye worm)	hypothetical protein	0.054	0.2096	0.2625
Brugia malayi	Ras association domain family 1 isoform A	0.0266	0.0828	0.0671
Echinococcus multilocularis	N chimaerin	0.0266	0.0828	0.0553
Trichomonas vaginalis	CAMK family protein kinase	0.0936	0.3933	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0218	0.0603	0.0755
Loa Loa (eye worm)	hypothetical protein	0.1544	0.6752	0.8454
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0266	0.0828	0.0553
Schistosoma mansoni	diacylglycerol kinase theta	0.0266	0.0828	0.0553
Trichomonas vaginalis	cyclin B, putative	0.015	0.0291	0.0571
Brugia malayi	Protein kinase domain containing protein	0.0385	0.1379	0.136
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0385	0.1379	0.112
Entamoeba histolytica	diacylglycerol kinase, putative	0.0266	0.0828	0.4936
Trichomonas vaginalis	cyclins, putative	0.015	0.0291	0.0571
Brugia malayi	RhoGEF domain containing protein	0.0266	0.0828	0.0671
Echinococcus granulosus	myotubularin protein 13	0.0266	0.0828	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Echinococcus granulosus	serine:threonine protein kinase N2	0.0385	0.1379	0.112
Trichomonas vaginalis	cyclin A, putative	0.015	0.0291	0.0571
Echinococcus granulosus	protein kinase c iota type	0.0651	0.2613	0.2392
Schistosoma mansoni	serine/threonine protein kinase	0.0218	0.0603	0.0321
Trypanosoma cruzi	cdc2-related kinase 3	0.0218	0.0603	1
Echinococcus granulosus	Rac GTPase activating protein 1	0.0266	0.0828	0.0553
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0385	0.1379	0.1726
Brugia malayi	p70 ribosomal S6 kinase beta	0.0385	0.1379	0.136
Trichomonas vaginalis	AGC family protein kinase	0.0385	0.1379	0.3387
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0936	0.3933	0.3752
Schistosoma mansoni	serine/threonine protein kinase	0.0385	0.1379	0.112
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Entamoeba histolytica	protein kinase, putative	0.0385	0.1379	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0266	0.0828	0.1036
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0385	0.1379	0.112
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0385	0.1379	0.1726
Echinococcus granulosus	protein kinase c eta type	0.0266	0.0828	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0828	0.1036
Entamoeba histolytica	protein kinase, putative	0.0385	0.1379	1
Echinococcus granulosus	unc 13 munc13	0.0315	0.1056	0.0788
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0385	0.1379	0.112
Brugia malayi	C1-like domain containing protein	0.0283	0.0905	0.0767

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 832589