Detailed information for compound 834444

Basic information

Technical information
  • TDR Targets ID: 834444
  • Name: N-(3-chlorophenyl)-7-methyl-4-oxopyrido[1,2-a ]pyrimidine-3-carboxamide
  • MW: 313.738 | Formula: C16H12ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 1.71 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)NC(=O)c1cnc2n(c1=O)cc(cc2)C
  • InChi: 1S/C16H12ClN3O2/c1-10-5-6-14-18-8-13(16(22)20(14)9-10)15(21)19-12-4-2-3-11(17)7-12/h2-9H,1H3,(H,19,21)
  • InChiKey: BVGSEFWDUOKHOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chlorophenyl)-7-methyl-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxamide
  • N-(3-chlorophenyl)-7-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinecarboxamide
  • N-(3-chlorophenyl)-4-keto-7-methyl-pyrido[1,2-a]pyrimidine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0585 0.0807
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0998 0.149
Brugia malayi Importin beta-1 subunit 0.003 0.0753 0.1112
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1816 0.1789
Schistosoma mansoni hypothetical protein 0.0338 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.1343 0.1279
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.1343 0.2022
Brugia malayi MAP kinase sur-1 0.0049 0.1343 0.2022
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0087 0.2474 0.3187
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.1343 0.1314
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.4069 0.405
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.1343 0.1279
Loa Loa (eye worm) RNA binding protein 0.0065 0.1816 0.1915
Entamoeba histolytica Thymidylate kinase, putative 0.0221 0.6512 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0748 0.1149
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1343 0.1914
Onchocerca volvulus Putative thymidylate kinase 0.0221 0.6512 0.9405
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0748 0.0718
Brugia malayi Pre-SET motif family protein 0.0205 0.6025 0.9249
Entamoeba histolytica hypothetical protein 0.0024 0.0585 0.0852
Schistosoma mansoni thymidylate kinase 0.0221 0.6512 0.6501
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1343 0.1914
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0087 0.2474 0.3187
Plasmodium falciparum importin beta, putative 0.003 0.0753 0.1112
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0748 0.0718
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1343 0.1914
Echinococcus granulosus snurportin 1 0.0316 0.9347 0.9344
Trichomonas vaginalis set domain proteins, putative 0.0234 0.6877 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1816 0.1789
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0748 0.0718
Echinococcus multilocularis geminin 0.0338 1 1
Trichomonas vaginalis thymidylate kinase, putative 0.0221 0.6512 0.9467
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.1101 0.1561
Echinococcus multilocularis thymidylate kinase 0.0221 0.6512 0.6501
Loa Loa (eye worm) acetyltransferase 0.014 0.4069 0.4334
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.1343 0.1279
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.4069 0.623
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.1343 0.2022
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0006 0.0046 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0748 0.0718
Leishmania major hypothetical protein, conserved 0.0087 0.2474 0.3767
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.6025 0.6434
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.4069 0.405
Schistosoma mansoni hypothetical protein 0.0316 0.9347 0.9344
Trypanosoma cruzi thymidylate kinase, putative 0.0221 0.6512 1
Toxoplasma gondii thymidylate kinase 0.0221 0.6512 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.9347 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1816 0.1915
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.1343 0.1314
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.1101 0.1561
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0998 0.149
Schistosoma mansoni hypothetical protein 0.0221 0.6512 0.6501
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1816 0.2752
Mycobacterium ulcerans thymidylate kinase 0.0221 0.6512 0.5
Schistosoma mansoni thymidylate kinase 0.0221 0.6512 0.6501
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.1343 0.1314
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0748 0.0718
Loa Loa (eye worm) thymidylate kinase 0.0221 0.6512 0.6957
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0585 0.0807
Schistosoma mansoni importin beta-1 0.003 0.0753 0.0723
Plasmodium vivax thymidylate kinase, putative 0.0221 0.6512 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1816 0.1789
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.1343 0.0625
Leishmania major importin beta-1 subunit, putative 0.0024 0.0585 0.0852
Echinococcus granulosus thymidylate kinase 0.0221 0.6512 0.6501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0748 0.0768
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.1343 0.1279
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0716 0.0685
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0032 0.005
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0753 0.1156
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0753 0.1112
Giardia lamblia CDC8 0.0221 0.6512 1
Leishmania major thymidylate kinase-like protein 0.0221 0.6512 1
Onchocerca volvulus 0.0234 0.6877 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1816 0.1915
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0748 0.0718
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0585 0.0807
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.1101 0.1691
Trypanosoma cruzi thymidylate kinase, putative 0.0221 0.6512 1
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0221 0.6512 0.5
Plasmodium vivax importin-beta 2, putative 0.003 0.0753 0.1156
Brugia malayi Pre-SET motif family protein 0.0029 0.0748 0.1105
Brugia malayi RNA binding protein 0.0065 0.1816 0.2752
Schistosoma mansoni hypothetical protein 0.0338 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.1343 0.1407
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1343 0.1914
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0032 0.005
Echinococcus granulosus tar DNA binding protein 0.0065 0.1816 0.1789
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.1101 0.1691
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.1343 0.1314
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1816 0.1789
Brugia malayi TAR-binding protein 0.0065 0.1816 0.2752
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1816 0.1789
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0221 0.6512 0.5
Plasmodium falciparum thymidylate kinase 0.0221 0.6512 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1816 0.1789
Echinococcus multilocularis snurportin 1 0.0316 0.9347 0.9344
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.3951 0.3932
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.1343 0.2062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0748 0.0718
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.1343 0.2022
Trichomonas vaginalis thymidylate kinase, putative 0.0221 0.6512 0.9467
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0221 0.6512 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.1343 0.1314
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.1101 0.1691
Brugia malayi RNA, U transporter 1 0.0084 0.239 0.3639
Plasmodium vivax SET domain protein, putative 0.0029 0.0748 0.1149
Trypanosoma brucei thymidylate kinase, putative 0.0221 0.6512 1
Treponema pallidum thymidylate kinase (tmk) 0.0221 0.6512 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.1101 0.1072
Echinococcus multilocularis importin subunit beta 1 0.003 0.0753 0.0723
Brugia malayi thymidylate kinase 0.0221 0.6512 1
Trypanosoma brucei thymidylate kinase, putative 0.0221 0.6512 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0753 0.0723
Loa Loa (eye worm) hypothetical protein 0.003 0.0753 0.0773
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0753 0.1112
Plasmodium vivax transportin, putative 0.0006 0.0032 0.005
Trypanosoma brucei protein kinase, putative 0.0049 0.1343 0.2022
Chlamydia trachomatis thymidylate kinase 0.0221 0.6512 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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