Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Homo sapiens | platelet-activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Echinococcus granulosus | g-protein coupled receptor | platelet-activating factor receptor | 342 aa | 302 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0025 | 0.043 | 0.064 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0053 | 0.2207 | 0.2065 |
Loa Loa (eye worm) | glutathione reductase | 0.0065 | 0.2996 | 0.2983 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0158 | 0.9033 | 1 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0053 | 0.2207 | 0.2224 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0025 | 0.043 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0065 | 0.2996 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0025 | 0.043 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0022 | 0.0254 | 0.5916 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.043 | 0.02 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0025 | 0.043 | 0.064 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.043 | 0.02 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0065 | 0.2996 | 1 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0025 | 0.043 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0025 | 0.043 | 0.064 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0053 | 0.2207 | 0.2065 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0025 | 0.043 | 0.064 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0065 | 0.2996 | 0.3123 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0025 | 0.043 | 0.064 |
Plasmodium falciparum | thioredoxin reductase | 0.0065 | 0.2996 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0025 | 0.043 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0065 | 0.2996 | 0.2813 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0053 | 0.2207 | 0.2003 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.043 | 0.02 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0065 | 0.2996 | 1 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0025 | 0.043 | 0.064 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0065 | 0.2996 | 1 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0025 | 0.043 | 0.064 |
Trypanosoma brucei | trypanothione reductase | 0.0065 | 0.2996 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0158 | 0.9033 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0025 | 0.043 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0025 | 0.043 | 0.064 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0053 | 0.2207 | 0.2224 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0065 | 0.2996 | 0.3123 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.043 | 0.018 |
Leishmania major | trypanothione reductase | 0.0065 | 0.2996 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.043 | 1 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0025 | 0.043 | 1 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0025 | 0.043 | 0.02 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0053 | 0.2207 | 0.2224 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0025 | 0.043 | 0.02 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0158 | 0.9033 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0025 | 0.043 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0173 | 1 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.004 | 0.1397 | 0.4166 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.043 | 0.064 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.043 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.9033 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0158 | 0.9033 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0173 | 1 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.043 | 0.02 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0148 | 0.8371 | 0.923 |
Brugia malayi | glycyl-tRNA synthetase | 0.0053 | 0.2207 | 0.2003 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.043 | 0.018 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.043 | 0.064 |
Plasmodium falciparum | glutathione reductase | 0.0065 | 0.2996 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0022 | 0.0254 | 0.5916 |
Brugia malayi | glutathione reductase | 0.0065 | 0.2996 | 0.2813 |
Toxoplasma gondii | thioredoxin reductase | 0.0065 | 0.2996 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0065 | 0.2996 | 0.2983 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.043 | 0.018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets | ChEMBL. | 2879917 |
IC50 (binding) | = 0.2 uM | Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets | ChEMBL. | 2879917 |
IC50 (binding) | = 0.45 uM | Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand | ChEMBL. | 3339617 |
IC50 (binding) | = 0.45 uM | Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand | ChEMBL. | 3339617 |
IC50 (functional) | = 5 uM | Evaluated for inhibition of slow reacting substance of anaphylaxis (SRS-A) induced contractions in guinea pig ileum strips | ChEMBL. | 2879917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.