TDR Targets

Basic information

Technical information

TDR Targets ID: 835905
Name: 4-diethoxyphosphoryl-N-(furan-2-ylmethyl)-2-( 4-methoxyphenyl)-1,3-oxazol-5-amine
MW: 406.369 | Formula: C19H23N2O6P
H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOP(=O)(c1nc(oc1NCc1ccco1)c1ccc(cc1)OC)OCC
InChi: 1S/C19H23N2O6P/c1-4-25-28(22,26-5-2)19-18(20-13-16-7-6-12-24-16)27-17(21-19)14-8-10-15(23-3)11-9-14/h6-12,20H,4-5,13H2,1-3H3
InChiKey: ZWOXDXANMSRVFE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-diethoxyphosphoryl-N-(2-furylmethyl)-2-(4-methoxyphenyl)oxazol-5-amine
4-diethoxyphosphoryl-N-(2-furylmethyl)-2-(4-methoxyphenyl)-5-oxazolamine
[4-diethoxyphosphoryl-2-(4-methoxyphenyl)oxazol-5-yl]-(2-furylmethyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0357	0.1392	0.1714
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.2215	1	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0414	0.1655	0.2039
Brugia malayi	Ras association domain family 1 isoform A	0.026	0.0941	0.0858
Echinococcus granulosus	protein kinase c iota type	0.0617	0.2597	0.2412
Echinococcus multilocularis	RNA directed DNA polymerase	0.1548	0.6911	0.6834
Brugia malayi	Hr1 repeat family protein	0.0357	0.1392	0.1412
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0357	0.1392	0.1714
Echinococcus granulosus	protein kinase c eta type	0.026	0.0941	0.0716
Brugia malayi	protein kinase C II.	0.0667	0.2825	0.3174
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0357	0.1392	0.1714
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Brugia malayi	protein kinase C3,putative	0.0268	0.0977	0.0902
Entamoeba histolytica	protein kinase, putative	0.0357	0.1392	1
Echinococcus multilocularis	Diacylglycerol kinase theta	0.026	0.0941	0.0716
Brugia malayi	Pleckstrin Homology Domain	0.026	0.0941	0.0858
Schistosoma mansoni	hypothetical protein	0.026	0.0941	0.0814
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.026	0.0941	0.0716
Echinococcus granulosus	geminin	0.0194	0.0635	0.0402
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.0977	0.085
Echinococcus multilocularis	protein kinase c iota type	0.0617	0.2597	0.2412
Entamoeba histolytica	hypothetical protein	0.026	0.0941	0.6761
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.026	0.0941	0.0814
Schistosoma mansoni	protein kinase C	0.0309	0.1169	0.1045
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0268	0.0977	0.1202
Echinococcus granulosus	unc 13 munc13	0.0309	0.1169	0.095
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.1605	0.7175	0.8841
Schistosoma mansoni	serine/threonine protein kinase	0.0357	0.1392	0.1271
Schistosoma mansoni	serine/threonine protein kinase	0.0667	0.2825	0.2724
Schistosoma mansoni	serine/threonine protein kinase	0.2215	1	1
Brugia malayi	RhoGAP domain containing protein	0.026	0.0941	0.0858
Loa Loa (eye worm)	jmjC domain-containing protein	0.0069	0.0055	0.0067
Loa Loa (eye worm)	raf kinase	0.026	0.0941	0.1158
Brugia malayi	Protein kinase c protein 2	0.1865	0.838	1
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0357	0.1392	0.1178
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Schistosoma mansoni	hypothetical protein	0.0194	0.0635	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0539	0.2235	0.2753
Brugia malayi	diacylglycerol kinase	0.026	0.0941	0.0858
Echinococcus granulosus	serine:threonine protein kinase N2	0.0357	0.1392	0.1178
Brugia malayi	Protein kinase domain containing protein	0.0268	0.0977	0.0902
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0357	0.1392	0.1178
Echinococcus granulosus	protein kinase c epsilon type	0.0667	0.2825	0.2647
Schistosoma mansoni	diacylglycerol kinase theta	0.026	0.0941	0.0814
Brugia malayi	Protein kinase domain containing protein	0.0357	0.1392	0.1412
Echinococcus multilocularis	Rac GTPase activating protein 1	0.026	0.0941	0.0716
Entamoeba histolytica	diacylglycerol kinase, putative	0.026	0.0941	0.6761
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0357	0.1392	0.1178
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Toxoplasma gondii	AGC kinase	0.0357	0.1392	1
Echinococcus granulosus	protein kinase C gamma type	0.1955	0.8795	0.8765
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0357	0.1392	0.1178
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.0977	0.085
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.026	0.0941	0.0814
Entamoeba histolytica	protein kinase, putative	0.0357	0.1392	1
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.026	0.0941	0.1158
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0667	0.2825	0.348
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0357	0.1392	0.1178
Echinococcus multilocularis	raf serine:threonine protein kinase	0.026	0.0941	0.0716
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0357	0.1392	0.1714
Schistosoma mansoni	unc-13 (munc13)	0.0309	0.1169	0.1045
Echinococcus multilocularis	serine threonine protein kinase	0.1955	0.8795	0.8765
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Loa Loa (eye worm)	hypothetical protein	0.0279	0.103	0.1268
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0357	0.1392	0.1178
Echinococcus granulosus	myotubularin protein 13	0.026	0.0941	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0637	0.2686	0.3309
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Schistosoma mansoni	serine/threonine kinase	0.0357	0.1392	0.1271
Loa Loa (eye worm)	hypothetical protein	0.1548	0.6911	0.8515
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0357	0.1392	0.1178
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Echinococcus granulosus	Diacylglycerol kinase theta	0.026	0.0941	0.0716
Echinococcus multilocularis	protein kinase c eta type	0.026	0.0941	0.0716
Schistosoma mansoni	serine/threonine protein kinase	0.0357	0.1392	0.1271
Brugia malayi	Protein kinase domain containing protein	0.0357	0.1392	0.1412
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.1548	0.6911	0.6834
Entamoeba histolytica	protein kinase, putative	0.0357	0.1392	1
Schistosoma mansoni	unc-13 (munc13)	0.0309	0.1169	0.1045
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Brugia malayi	p70 ribosomal S6 kinase beta	0.0357	0.1392	0.1412
Schistosoma mansoni	hypothetical protein	0.0194	0.0635	0.0504
Schistosoma mansoni	atypical protein kinase C	0.0617	0.2597	0.2493
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Echinococcus granulosus	Rac GTPase activating protein 1	0.026	0.0941	0.0716
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Echinococcus multilocularis	geminin	0.0194	0.0635	0.0402
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0357	0.1392	0.1178
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0268	0.0977	0.0902
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.026	0.0941	0.1158
Schistosoma mansoni	serine/threonine protein kinase	0.0357	0.1392	0.1271
Brugia malayi	diacylglycerol kinase	0.026	0.0941	0.0858
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.026	0.0941	0.1158
Brugia malayi	RhoGAP domain containing protein	0.026	0.0941	0.0858
Brugia malayi	Protein kinase domain containing protein	0.0357	0.1392	0.1412
Brugia malayi	C1-like domain containing protein	0.0268	0.0977	0.0902
Echinococcus multilocularis	N chimaerin	0.026	0.0941	0.0716
Echinococcus multilocularis	unc 13 (munc13)	0.0309	0.1169	0.095
Schistosoma mansoni	serine/threonine protein kinase	0.0357	0.1392	0.1271
Onchocerca volvulus		0.0279	0.103	0.391
Echinococcus multilocularis	protein kinase c epsilon type	0.0667	0.2825	0.2647
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0309	0.1169	0.095
Loa Loa (eye worm)	hypothetical protein	0.0279	0.103	0.1268
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0357	0.1392	0.5
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Schistosoma mansoni	protein kinase C mu	0.026	0.0941	0.0814
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0357	0.1392	0.1714
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0309	0.1169	0.095
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Entamoeba histolytica	diacylglycerol kinase, putative	0.026	0.0941	0.6761
Schistosoma mansoni	diacylglycerol kinase theta	0.026	0.0941	0.0814
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0357	0.1392	0.1714
Onchocerca volvulus		0.0309	0.1169	1
Echinococcus granulosus	RNA directed DNA polymerase	0.1548	0.6911	0.6834
Schistosoma mansoni	serine/threonine protein kinase	0.2215	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0357	0.1392	1
Schistosoma mansoni	protein kinase C mu	0.0268	0.0977	0.085
Schistosoma mansoni	vav2	0.026	0.0941	0.0814
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0268	0.0977	0.0752
Brugia malayi	Variant SH3 domain containing protein	0.026	0.0941	0.0858
Echinococcus multilocularis	myotubularin protein 13	0.026	0.0941	0.0716
Schistosoma mansoni	rac gtpase activating protein	0.026	0.0941	0.0814
Echinococcus granulosus	NDR protein kinase	0.0357	0.1392	0.1178
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.026	0.0941	0.0716
Loa Loa (eye worm)	hypothetical protein	0.026	0.0941	0.1158
Entamoeba histolytica	protein kinase, putative	0.0357	0.1392	1
Schistosoma mansoni	serine/threonine protein kinase	0.026	0.0941	0.0814
Brugia malayi	RhoGEF domain containing protein	0.026	0.0941	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0279	0.103	0.1268
Echinococcus granulosus	raf serine:threonine protein kinase	0.026	0.0941	0.0716
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0357	0.1392	0.1178
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0268	0.0977	0.0752
Echinococcus granulosus	N chimaerin	0.026	0.0941	0.0716
Brugia malayi	RasGEF domain containing protein	0.0154	0.045	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0309	0.1169	0.144
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0268	0.0977	0.1202
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0357	0.1392	0.1714
Loa Loa (eye worm)	hypothetical protein	0.1808	0.8116	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 835905