TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.485 | Formula: C22H32O8
H donors: 0 H acceptors: 2 LogP: 3.41 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C(=C[C@@]1(C)O[C@H]2[C@@]34C1CC[C@@H](C4CC[C@](O2)(OO3)C)C)C(=O)OCC
InChi: 1S/C22H32O8/c1-6-25-17(23)14(18(24)26-7-2)12-20(4)16-9-8-13(3)15-10-11-21(5)28-19(27-20)22(15,16)30-29-21/h12-13,15-16,19H,6-11H2,1-5H3/t13-,15?,16?,19-,20-,21-,22-/m1/s1
InChiKey: GTWWRLLZIRZVAW-ATIACKARSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Furin-like cysteine rich region family protein	0.0058	0.1129	0.2443
Schistosoma mansoni	glucose transport protein	0.022	0.462	1
Echinococcus granulosus	epidermal growth factor receptor	0.0058	0.1129	0.2443
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0534	0.1156
Brugia malayi	hypothetical protein	0.0031	0.0534	0.1156
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0119	1
Schistosoma mansoni	tyrosine kinase	0.0057	0.1106	0.2394
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.1292
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Plasmodium vivax	sugar transporter, putative	0.0031	0.0534	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.022	0.462	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0033	0.0582	0.126
Echinococcus granulosus	epidermal growth factor receptor	0.0058	0.1129	0.2443
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0534	0.3986
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0034	0.0597	0.1292
Leishmania major	glucose transporter, lmgt3	0.0068	0.134	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0034	0.0597	0.0903
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.022	0.462	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0068	0.134	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0399	0.0863
Onchocerca volvulus		0.0031	0.0534	0.5
Echinococcus granulosus	solute carrier family 22	0.0031	0.0534	0.1156
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.2975
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Echinococcus multilocularis	insulin receptor	0.0128	0.2642	0.5718
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0534	0.3986
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.134	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.1129	0.2443
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.022	0.462	1
Trichomonas vaginalis	conserved hypothetical protein	0.022	0.462	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Echinococcus granulosus	solute carrier family 22	0.0031	0.0534	0.1156
Trypanosoma brucei	glucose transporter 2A	0.0068	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.134	0.2901
Toxoplasma gondii	facilitative glucose transporter GT1	0.022	0.462	0.6987
Toxoplasma gondii	protein kinase, putative	0.0312	0.6612	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.134	0.2901
Leishmania major	protein kinase, putative	0.0034	0.0597	0.4454
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0034	0.0597	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.1292
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Schistosoma mansoni	tyrosine kinase	0.0128	0.2642	0.5718
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.1292
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.1292
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0701	0.5229
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0318	0.5959
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0534	0.0808
Schistosoma mansoni	tyrosine kinase	0.0128	0.2642	0.5718
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Onchocerca volvulus		0.0031	0.0534	0.5
Brugia malayi	hypothetical protein	0.0031	0.0534	0.1156
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0058	0.1129	0.2443
Echinococcus multilocularis	General substrate transporter	0.0189	0.3951	0.8553
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0034	0.0597	0.0597
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0034	0.0597	0.1292
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0318	0.5469
Echinococcus granulosus	General substrate transporter	0.0189	0.3951	0.8553
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.022	0.462	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.134	0.2901
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Schistosoma mansoni	protein kinase	0.0034	0.0597	0.1292
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0582	0.126
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0034	0.0597	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0534	0.1156
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.0863
Onchocerca volvulus		0.0031	0.0534	0.5
Onchocerca volvulus		0.0031	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.2975
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0034	0.0597	0.0597
Plasmodium vivax	hexose transporter	0.022	0.462	0.462
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Onchocerca volvulus		0.0031	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0534	0.1156
Echinococcus multilocularis		0.0017	0.0228	0.0494
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0399	0.0863
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	0.7463
Onchocerca volvulus		0.0031	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0582	0.126
Trypanosoma cruzi	hexose transporter	0.0068	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0534	0.1156
Plasmodium falciparum	proline--tRNA ligase	0.0039	0.0701	0.0701
Schistosoma mansoni	sugar transporter	0.0031	0.0534	0.1156
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0534	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0178	0.3724	0.3724
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0034	0.0597	0.1292
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.134	0.2901
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0534	0.1156
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.134	1
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.134	0.2901
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0597	0.1292
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0534	0.0534
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0534	0.1156
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0863
Entamoeba histolytica	protein kinase, putative	0.0034	0.0597	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.1129	0.2443
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0534	1
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0033	0.0582	0.126
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.126
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0399	0.6849
Schistosoma mansoni	sugar transporter	0.0031	0.0534	0.1156
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1401	0.3033
Entamoeba histolytica	hypothetical protein	0.0025	0.0399	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0534	0.1156
Schistosoma mansoni	tyrosine kinase	0.0058	0.1129	0.2443
Leishmania major	glucose transporter, lmgt2	0.0068	0.134	1
Onchocerca volvulus		0.0031	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0534	0.3986
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.2975
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0034	0.0597	0.0903
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0034	0.0597	0.0903
Brugia malayi	Sugar transporter family protein	0.0031	0.0534	0.1156
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0534	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0534	1
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0672	0.5012
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.022	0.462	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0701	0.5229
Giardia lamblia	Sugar-proton symporter	0.0031	0.0534	0.9177
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0534	0.1156
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.1292
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0034	0.0597	0.0597
Onchocerca volvulus		0.0031	0.0534	0.5
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0119	0.2978
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0034	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.126
Echinococcus granulosus	calcium dependent protein kinase	0.0032	0.0552	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0034	0.0597	0.0597
Schistosoma mansoni	sugar transporter	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Plasmodium vivax	proline--tRNA ligase, putative	0.0039	0.0701	0.0701
Plasmodium falciparum	protein kinase 7	0.0312	0.6612	0.6612
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0534	0.1156
Loa Loa (eye worm)	sugar transporter	0.0031	0.0534	0.1156
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0534	0.1156
Onchocerca volvulus		0.0031	0.0534	0.5
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	0.7463
Schistosoma mansoni	tyrosine kinase	0.0057	0.1106	0.2394
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.022	0.462	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0534	0.1156
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0534	0.3986
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0033	0.0582	0.126
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0033	0.0582	0.9752
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0178	0.3724	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Onchocerca volvulus		0.0031	0.0534	0.5
Brugia malayi	Sugar transporter family protein	0.022	0.462	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0034	0.0597	0.1292
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0058	0.1129	0.2443
Schistosoma mansoni	glucose transport protein	0.022	0.462	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0128	0.2642	0.5718
Mycobacterium ulcerans	sugar transporter	0.0031	0.0534	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0399	0.0863
Loa Loa (eye worm)	hypothetical protein	0.007	0.1379	0.2985
Leishmania major	glucose transporter, lmgt1	0.0068	0.134	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0032	0.0552	0.1194
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.134	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0582	0.126
Giardia lamblia	Prolyl-tRNA synthetase	0.0033	0.0582	1
Schistosoma mansoni	protein kinase	0.0034	0.0597	0.1292
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0128	0.2642	0.5718
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0333	0.0721
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0399	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0534	1
Brugia malayi	Sugar transporter family protein	0.0031	0.0534	0.1156
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.022	0.462	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0701	0.5229
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.134	0.2901
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Onchocerca volvulus		0.0031	0.0534	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0058	0.1129	0.2443
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0399	0.0399
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0399	0.0399
Schistosoma mansoni	tyrosine kinase	0.0057	0.1106	0.2394
Echinococcus granulosus	solute carrier family 22	0.0031	0.0534	0.1156
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0399	0.0603
Schistosoma mansoni	hypothetical protein	0.022	0.462	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Schistosoma mansoni	glucose transport protein	0.022	0.462	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0534	0.1156
Onchocerca volvulus		0.0031	0.0534	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0534	0.0808
Schistosoma mansoni	sugar transporter	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Plasmodium falciparum	hexose transporter	0.022	0.462	0.462
Onchocerca volvulus		0.0031	0.0534	0.5
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0034	0.0597	0.0597
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0399	0.6849
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0039	0.0701	0.106
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0701	0.5229
Brugia malayi	hypothetical protein	0.0031	0.0534	0.1156
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0534	0.0808
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.134	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0178	0.3724	0.5632
Onchocerca volvulus		0.0031	0.0534	0.5
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0468	1	1
Echinococcus granulosus	insulin receptor	0.0128	0.2642	0.5718
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0534	0.0808
Giardia lamblia	Hexose transporter	0.0031	0.0534	0.9177
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0534	0.1156
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.022	0.462	1
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0119	0.2222
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0597	0.1292
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0033	0.0582	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0863
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0448	0.0969
Loa Loa (eye worm)	sugar transporter	0.022	0.462	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0534	0.1156
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0534	0.3986
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0034	0.0597	0.4454
Echinococcus granulosus	solute carrier family 22	0.0031	0.0534	0.1156
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.016	0.0346
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0534	0.3986
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0534	0.1156
Trypanosoma brucei	glucose transporter, putative	0.0068	0.134	1
Brugia malayi	major facilitator superfamily protein	0.0031	0.0534	0.1156
Trypanosoma brucei	glucose transporter 1E	0.0068	0.134	1
Onchocerca volvulus		0.0031	0.0534	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.134	0.2901
Schistosoma mansoni	glucose transporter	0.0031	0.0534	0.1156
Onchocerca volvulus	Putative transporter	0.0031	0.0534	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0.0534	0.3986
Echinococcus multilocularis	epidermal growth factor receptor	0.0058	0.1129	0.2443
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0582	0.126
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0034	0.0597	0.0597
Brugia malayi	Cam kinase protein 1	0.0034	0.0597	0.1292
Onchocerca volvulus		0.0031	0.0534	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.1292
Schistosoma mansoni	protein kinase	0.0034	0.0597	0.1292
Entamoeba histolytica	protein kinase, putative	0.0034	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0597	0.1292
Brugia malayi	major facilitator superfamily protein	0.0031	0.0534	0.1156
Loa Loa (eye worm)	TK/INSR protein kinase	0.0128	0.2642	0.5718
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0534	0.1156
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.1292
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0534	0.1156
Brugia malayi	Protein kinase domain containing protein	0.0128	0.2642	0.5718
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0318	0.5959
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0534	0.1156
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0399	0.0863
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0701	0.5229
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0534	1
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0534	0.1156

Activities

Activity type	Activity value	Assay description	Source	Reference
Cured/treated (functional)	= 0	Antimalarial activity was determined by Blood schizonticidal activity in mouse infected with Plasmodium berghei(K-173 strain) at 10 (mg/kgx5) subcutaneous dosage; Cured/treated = 0/5 on day 7	ChEMBL.	7783124

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 189239

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 83686