Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0.0173 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.0033 | 0.0173 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.0173 | 1 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0411 | 1 | 1 |
Onchocerca volvulus | 0.0194 | 0.4372 | 0.4274 | |
Loa Loa (eye worm) | norepinephrine transporter | 0.0194 | 0.4372 | 0.4372 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0194 | 0.4372 | 0.5 |
Onchocerca volvulus | Galectin homolog | 0.0411 | 1 | 1 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0033 | 0.0173 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.4372 | 0.4372 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.4372 | 0.4372 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | galectin | 0.0411 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3078 | 0.2957 |
Brugia malayi | galectin | 0.0411 | 1 | 1 |
Echinococcus multilocularis | Galectin, carbohydrate recognition domain | 0.0411 | 1 | 1 |
Brugia malayi | galectin | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Onchocerca volvulus | Galectin homolog | 0.0411 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0033 | 0.0173 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0194 | 0.4372 | 0.4274 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 0.0173 |
Echinococcus granulosus | serotonin transporter | 0.0194 | 0.4372 | 0.4274 |
Echinococcus granulosus | Galectin carbohydrate recognition domain | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0411 | 1 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0194 | 0.4372 | 0.4372 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0411 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.4372 | 0.4372 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 0.0173 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0194 | 0.4372 | 0.4274 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0.0173 | 1 |
Echinococcus multilocularis | geminin | 0.0145 | 0.3078 | 0.2957 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0194 | 0.4372 | 0.4372 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 0.0173 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0145 | 0.3078 | 0.2957 |
Schistosoma mansoni | galectin | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | galectin | 0.0411 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3078 | 0.2957 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0033 | 0.0173 | 0.0173 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0194 | 0.4372 | 0.4274 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0033 | 0.0173 | 0.0173 |
Plasmodium vivax | amine transporter, putative | 0.0033 | 0.0173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.4372 | 0.4372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.