Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0851 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0099 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0043 | 0.3341 | 1 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.0094 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.003 | 0.1647 | 0.4931 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0099 | 0.0297 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0043 | 0.3341 | 0.3341 |
Schistosoma mansoni | DNA polymerase eta | 0.0043 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0851 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0099 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0099 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0099 | 0.0297 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0094 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0851 | 0.0851 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0099 | 0.0297 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0851 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0043 | 0.3341 | 0.3341 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0094 | 1 | 1 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.0094 | 1 | 1 |
Mycobacterium leprae | probable conserved integral membrane transport protein | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0099 | 0.0099 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0851 | 0.2547 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0099 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0094 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0099 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0094 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0099 | 0.0099 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 (nhe2) | 0.0076 | 0.7643 | 0.7643 |
Wolbachia endosymbiont of Brugia malayi | Kef-type K+ transport system, membrane component | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3341 | 0.3341 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.0094 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0094 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0851 | 0.2319 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0094 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0099 | 0.0297 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.003 | 0.1647 | 0.4931 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0099 | 0.0099 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0099 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0094 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0043 | 0.3341 | 0.3341 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0094 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0099 | 0.0297 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0099 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0094 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0094 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0099 | 0.0099 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0043 | 0.3341 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | NHE-3 | 0.0094 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.0094 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0094 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0099 | 0.0099 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0043 | 0.3341 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0099 | 0.0099 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0851 | 0.5167 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0076 | 0.7643 | 0.7643 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.003 | 0.1647 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0851 | 0.2547 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0094 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0851 | 0.0851 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0099 | 0.0297 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0851 | 0.2547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.