Detailed information for compound 839362

Basic information

Technical information
  • TDR Targets ID: 839362
  • Name: naphthalen-1-yl-[4-(6-nitro-1,3-benzothiazol- 2-yl)piperazin-1-yl]methanone
  • MW: 418.468 | Formula: C22H18N4O3S
  • H donors: 0 H acceptors: 4 LogP: 4.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc2c1cccc2)N1CCN(CC1)c1nc2c(s1)cc(cc2)[N+](=O)[O-]
  • InChi: 1S/C22H18N4O3S/c27-21(18-7-3-5-15-4-1-2-6-17(15)18)24-10-12-25(13-11-24)22-23-19-9-8-16(26(28)29)14-20(19)30-22/h1-9,14H,10-13H2
  • InChiKey: GSAFIWMOHIFDIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-naphthyl-[4-(6-nitro-1,3-benzothiazol-2-yl)piperazin-1-yl]methanone
  • 1-naphthyl-[4-(6-nitro-1,3-benzothiazol-2-yl)-1-piperazinyl]methanone
  • 5960-28-1
  • Oprea1_563788
  • CBMicro_020905
  • BIM-0021001.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.3404 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0189 0.0526 0.0526
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0014 0.5
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.052 0.1501 0.1501
Plasmodium falciparum cGMP-specific phosphodiesterase 0.052 0.1501 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0033 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.052 0.1501 0.1501
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0033 0.0035
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0578 0.3793
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.0301 0.0301
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.052 0.1501 0.1489
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Echinococcus granulosus intermediate filament protein 0.0022 0.0033 0.0033
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.052 0.1501 0.1489
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3404 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0189 0.0526 0.0526
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0112 0.0099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Plasmodium falciparum cGMP-specific phosphodiesterase 0.052 0.1501 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0014 0.0014
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis conserved hypothetical protein 0.052 0.1501 1
Trichomonas vaginalis glucosylceramidase, putative 0.0143 0.039 0.2531
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.052 0.1501 0.1489
Schistosoma mansoni patched 1 0.0034 0.0069 0.0055
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.052 0.1501 0.1501
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.052 0.1501 0.1501
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0112 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0014 0.0012
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.052 0.1501 0.1806
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0003 0.0003
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.052 0.1501 0.1489
Echinococcus granulosus Niemann Pick C1 protein 0.0079 0.0201 0.0201
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.052 0.1501 0.1806
Trichomonas vaginalis glucosylceramidase, putative 0.0143 0.039 0.2531
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1501 0.1806
Loa Loa (eye worm) hypothetical protein 0.052 0.1501 0.1501
Schistosoma mansoni niemann-pick C1 (NPC1) 0.008 0.0205 0.0191
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.052 0.1501 0.1501
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.052 0.1501 0.1489
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.3404 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Loa Loa (eye worm) hypothetical protein 0.3404 1 1
Loa Loa (eye worm) hypothetical protein 0.052 0.1501 0.1501
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.052 0.1501 0.1806
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0049 0.0112 0.0112
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1501 0.1806
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.052 0.1501 0.1501
Plasmodium falciparum phosphodiesterase delta, putative 0.052 0.1501 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2885 0.8469 0.8469
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0033 0.0033
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.052 0.1501 0.1501
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0369 0.2386
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.3404 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.2885 0.8469 1
Brugia malayi intermediate filament protein 0.0022 0.0033 0.0035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.3404 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0369 0.2386
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus multilocularis lamin 0.0022 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0578 0.3793
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.052 0.1501 0.1806
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0033 0.0033
Brugia malayi CHE-14 protein 0.0034 0.0069 0.0077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Echinococcus multilocularis Niemann Pick C1 protein 0.0079 0.0201 0.0201
Schistosoma mansoni lamin 0.0022 0.0033 0.0019
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0049 0.0112 0.012
Onchocerca volvulus Glucosylceramidase homolog 0.0135 0.0369 1
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0369 0.2386
Schistosoma mansoni lamin 0.0022 0.0033 0.0019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Schistosoma mansoni hypothetical protein 0.0039 0.0083 0.0069
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.052 0.1501 0.1769
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0034 0.0069 0.0069
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0039 0.0083 0.0094
Echinococcus granulosus sterol regulatory element binding protein 0.0034 0.0069 0.0069
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Loa Loa (eye worm) PDE1B protein 0.052 0.1501 0.1501
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.2885 0.8469 0.8469
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0369 0.2386
Giardia lamblia hypothetical protein 0.052 0.1501 0.1489
Giardia lamblia Hypothetical protein 0.052 0.1501 0.1489
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.052 0.1501 0.1769
Brugia malayi hypothetical protein 0.0189 0.0526 0.0618
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.052 0.1501 0.1489
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0578 0.3793
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.052 0.1501 0.1501
Trypanosoma brucei hypothetical protein, conserved 0.052 0.1501 0.1806
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.052 0.1501 0.1806
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus granulosus lamin 0.0022 0.0033 0.0033
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.052 0.1501 0.1501
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0369 0.2386
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0578 0.3793
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1501 0.1806
Echinococcus multilocularis protein patched 0.0034 0.0069 0.0069
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0049 0.0112 0.0112
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 0.1806
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.052 0.1501 0.1489
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2885 0.8469 0.8469
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Echinococcus multilocularis expressed conserved protein 0.0074 0.0187 0.0187
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.281 0.8248 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.0301 0.0301
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.052 0.1501 0.1769
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.052 0.1501 0.1806
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1501 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0069 0.0371
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus granulosus expressed conserved protein 0.0074 0.0187 0.0187
Leishmania major hypothetical protein, conserved 0.281 0.8248 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.052 0.1501 0.1769
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1501 0.1806
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.052 0.1501 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.052 0.1501 0.1806
Loa Loa (eye worm) hypothetical protein 0.052 0.1501 0.1501
Echinococcus multilocularis musashi 0.0022 0.0033 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.281 0.8248 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.052 0.1501 0.1769
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.052 0.1501 0.1501
Plasmodium vivax phosphodiesterase gamma, putative 0.052 0.1501 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0578 0.3793
Toxoplasma gondii aldehyde dehydrogenase 0.0049 0.0112 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0112 1
Schistosoma mansoni hypothetical protein 0.0033 0.0065 0.0052
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Leishmania major hypothetical protein, conserved 0.052 0.1501 0.1806
Onchocerca volvulus 0.0039 0.0083 0.1492
Schistosoma mansoni hypothetical protein 0.0033 0.0065 0.0052
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0112 0.0099
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.052 0.1501 0.1501
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Echinococcus multilocularis lamin dm0 0.0022 0.0033 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Trypanosoma brucei cAMP-specific phosphodiesterase 0.052 0.1501 0.1806
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0049 0.0112 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.052 0.1501 0.1501
Brugia malayi Niemann-Pick C1 protein precursor 0.0079 0.0201 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0369 0.2386
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.052 0.1501 0.1501
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0648 0.188 0.188
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.052 0.1501 0.1489
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.052 0.1501 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.052 0.1501 0.1806
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.052 0.1501 0.1806
Echinococcus multilocularis protein dispatched 1 0.0039 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0079 0.0201 0.0201
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.052 0.1501 0.1489
Schistosoma mansoni hypothetical protein 0.0033 0.0065 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.052 0.1501 1
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0578 0.3793
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0079 0.0201 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0032
Plasmodium falciparum phosphodiesterase gamma, putative 0.052 0.1501 1
Schistosoma mansoni intermediate filament proteins 0.0022 0.0033 0.0019
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0206 0.0578 0.0678
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.052 0.1501 0.1489
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.052 0.1501 0.1806
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Echinococcus granulosus Protein patched homolog 1 0.0034 0.0069 0.0069
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.052 0.1501 1
Schistosoma mansoni hypothetical protein 0.0033 0.0065 0.0052
Echinococcus multilocularis sterol regulatory element binding protein 0.0034 0.0069 0.0069
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.052 0.1501 0.1806
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3404 1 1
Echinococcus granulosus lamin dm0 0.0022 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1501 0.1806
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0014 0.0014
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0014 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0112 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.052 0.1501 0.1806
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0206 0.0578 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0369 0.2386
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.052 0.1501 0.1769
Schistosoma mansoni survival motor neuron protein 0.0039 0.0083 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.052 0.1501 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.052 0.1501 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.052 0.1501 0.1489

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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