Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0083 | 0.0536 | 0.0869 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.138 | 0.137 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0032 | 0.0052 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0641 | 0.6547 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0045 | 0.013 | 0.0196 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.0456 | 0.0736 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0102 | 0.0749 | 0.0964 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0045 | 0.0136 | 0.0349 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0102 | 0.0749 | 0.0964 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.0456 | 0.1245 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.0146 | 0.1761 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0456 | 0.0731 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0045 | 0.013 | 0.0414 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0045 | 0.0136 | 0.0125 |
Mycobacterium tuberculosis | Probable reductase | 0.0102 | 0.0749 | 0.0964 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0641 | 0.6547 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0594 | 0.6045 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.1168 | 0.4058 |
Loa Loa (eye worm) | glutathione reductase | 0.0045 | 0.013 | 0.0196 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0198 | 0.0652 |
Plasmodium falciparum | importin beta, putative | 0.0034 | 0.0015 | 0.0005 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 0.0872 | 0.1156 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.0536 | 0.0887 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.0536 | 0.0865 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0099 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0146 | 0.0221 |
Trypanosoma brucei | trypanothione reductase | 0.0045 | 0.013 | 0.0414 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.0456 | 0.0736 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0099 | 0.0305 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0032 | 0.0052 |
Brugia malayi | chromobox protein homolog 3 | 0.0046 | 0.0146 | 0.0221 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.0543 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0032 | 0.0055 |
Brugia malayi | glutathione reductase | 0.0045 | 0.013 | 0.0196 |
Echinococcus multilocularis | snurportin 1 | 0.0365 | 0.3577 | 0.3569 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.0456 | 0.0736 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0102 | 0.0749 | 0.0964 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0183 | 0.0303 |
Leishmania major | trypanothione reductase | 0.0045 | 0.013 | 0.0414 |
Echinococcus granulosus | snurportin 1 | 0.0365 | 0.3577 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0641 | 0.6547 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.286 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.0536 | 0.1471 |
Onchocerca volvulus | 0.0093 | 0.065 | 1 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.0045 | 0.013 | 0.0181 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.0536 | 0.0887 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0641 | 0.6547 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0594 | 0.6045 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0032 | 0.002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0146 | 0.0241 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0032 | 0.0069 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.286 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0594 | 0.6045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0456 | 0.0731 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.0456 | 0.0444 |
Brugia malayi | Heterochromatin protein 1 | 0.0083 | 0.0536 | 0.0869 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0114 | 0.0872 | 0.1156 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.145 | 0.2379 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.145 | 0.2379 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0102 | 0.0749 | 0.0964 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0032 | 0.0052 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.0536 | 0.0865 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0032 | 0.0069 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0032 | 0.0052 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.0456 | 0.0736 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.0543 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.0543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0015 | 0.0005 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0015 | 0.0011 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.138 | 0.137 |
Plasmodium falciparum | glutathione reductase | 0.0045 | 0.013 | 0.0181 |
Toxoplasma gondii | thioredoxin reductase | 0.0045 | 0.013 | 0.7697 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.0456 | 0.0736 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1168 | 0.4058 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0032 | 0.0052 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0032 | 0.0033 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0015 | 0.0011 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0032 | 0.0052 |
Brugia malayi | RNA, U transporter 1 | 0.0097 | 0.0694 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0038 | 0.0043 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.1139 | 0.1864 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.286 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0641 | 0.6547 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0032 | 0.0052 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0032 | 0.0069 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.286 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0114 | 0.0872 | 0.1156 |
Plasmodium vivax | importin-beta 2, putative | 0.0034 | 0.0015 | 0.0005 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 0.138 | 0.2268 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0032 | 0.0069 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0032 | 0.0033 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0032 | 0.0027 |
Plasmodium falciparum | thioredoxin reductase | 0.0045 | 0.013 | 0.0181 |
Plasmodium vivax | glutathione reductase, putative | 0.0045 | 0.013 | 0.0181 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.1339 | 0.1885 |
Mycobacterium ulcerans | glutaminase | 0.0594 | 0.6045 | 0.9037 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 0.138 | 0.3838 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0456 | 0.0731 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0099 | 0.0305 |
Echinococcus multilocularis | geminin | 0.0167 | 0.145 | 0.144 |
Echinococcus granulosus | geminin | 0.0167 | 0.145 | 0.4033 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.0543 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.0536 | 0.0525 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0456 | 0.0731 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0146 | 0.0241 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0641 | 0.6547 | 1 |
Schistosoma mansoni | glutaminase | 0.0594 | 0.6045 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0365 | 0.3577 | 0.5909 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0114 | 0.0872 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0641 | 0.6547 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0034 | 0.0015 | 0.0009 |
Brugia malayi | RNA binding protein | 0.0075 | 0.0456 | 0.0736 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0456 | 0.0731 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.0536 | 0.1471 |
Brugia malayi | Thioredoxin reductase | 0.0045 | 0.013 | 0.0196 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0099 | 0.0305 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.005 | 0.0183 | 0.238 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0032 | 0.1283 |
Brugia malayi | glutaminase DH11.1 | 0.0594 | 0.6045 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1168 | 0.4058 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0032 | 0.0052 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0102 | 0.0749 | 0.0964 |
Schistosoma mansoni | hypothetical protein | 0.0365 | 0.3577 | 0.5907 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.1139 | 0.1864 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0641 | 0.6547 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0034 | 0.0015 | 0.0206 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0032 | 0.0052 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0034 | 0.0015 | 0.0003 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0161 | 0.138 | 0.2268 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0165 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.0536 | 0.0525 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0183 | 0.0303 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0083 | 0.0543 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0034 | 0.0015 | 0.0005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.