TDR Targets

Basic information

Technical information

TDR Targets ID: 839629
Name: 1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzim idazole
MW: 284.763 | Formula: C15H9ClN2S
H donors: 0 H acceptors: 1 LogP: 4.76 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1csc2n1c1ccccc1n2
InChi: 1S/C15H9ClN2S/c16-11-7-5-10(6-8-11)14-9-19-15-17-12-3-1-2-4-13(12)18(14)15/h1-9H
InChiKey: KVGAIKBYWWKQKF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-chlorophenyl)thiazolo[3,2-a]benzimidazole
ZINC00275832
BIM-0020161.P001
CBMicro_020247

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Heterochromatin protein 1	0.0083	0.0536	0.0869
Schistosoma mansoni	chromobox protein	0.0083	0.0536	0.0865
Mycobacterium ulcerans	glutaminase	0.0594	0.6045	0.9037
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0032	0.0055
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0032	0.0069
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.005	0.0183	0.238
Echinococcus multilocularis	geminin	0.0167	0.145	0.144
Plasmodium vivax	glutathione reductase, putative	0.0045	0.013	0.0181
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0032	0.0052
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0015	0.0011
Echinococcus granulosus	lysosomal alpha glucosidase	0.0161	0.138	0.3838
Loa Loa (eye worm)	glutaminase	0.0594	0.6045	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.286	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0099	0.0305
Trichomonas vaginalis	chromobox protein, putative	0.005	0.0183	0.0303
Echinococcus multilocularis	chromobox protein 1	0.0083	0.0536	0.0525
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0032	0.0052
Echinococcus multilocularis	tar DNA binding protein	0.0075	0.0456	0.0444
Brugia malayi	RNA recognition motif domain containing protein	0.0075	0.0456	0.0736
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0641	0.6547	0.5
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.1168	0.4058
Mycobacterium tuberculosis	Probable dehydrogenase	0.0102	0.0749	0.0964
Echinococcus multilocularis	chromobox protein 1	0.0083	0.0536	0.0525
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0641	0.6547	1
Brugia malayi	RNA, U transporter 1	0.0097	0.0694	0.113
Brugia malayi	glutathione reductase	0.0045	0.013	0.0196
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0102	0.0749	0.0964
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.138	0.137
Trichomonas vaginalis	chromobox protein, putative	0.005	0.0183	0.0303
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0146	0.0241
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.138	0.137
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0032	0.0069
Brugia malayi	RNA binding protein	0.0075	0.0456	0.0736
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0641	0.6547	1
Leishmania major	trypanothione reductase	0.0045	0.013	0.0414
Brugia malayi	chromobox protein homolog 3	0.0046	0.0146	0.0221
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0456	0.0731
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0114	0.0872	0.1156
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0102	0.0749	0.0964
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0456	0.0731
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0032	0.1283
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0099	0.0305
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0045	0.0136	0.0125
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0456	0.0731
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0015	0.0206
Schistosoma mansoni	glutaminase	0.0594	0.6045	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0032	0.0033
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0099	0.0305
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0641	0.6547	0.5
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0641	0.6547	1
Loa Loa (eye worm)	RNA binding protein	0.0075	0.0456	0.0736
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0641	0.6547	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0032	0.002
Schistosoma mansoni	chromobox protein	0.0083	0.0536	0.0865
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0102	0.0749	0.0964
Trypanosoma brucei	trypanothione reductase	0.0045	0.013	0.0414
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0114	0.0872	0.1156
Schistosoma mansoni	alpha-glucosidase	0.0139	0.1139	0.1864
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0641	0.6547	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.1339	0.1885
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0146	0.0221
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0298	0.286	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0198	0.0652
Loa Loa (eye worm)	glutaminase 2	0.0594	0.6045	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0161	0.138	0.2268
Echinococcus granulosus	chromobox protein 1	0.0083	0.0536	0.1471
Brugia malayi	glutaminase DH11.1	0.0594	0.6045	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0045	0.0136	0.0349
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0032	0.0052
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0032	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0038	0.0043
Loa Loa (eye worm)	thioredoxin reductase	0.0045	0.013	0.0196
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0032	0.0033
Plasmodium falciparum	glutathione reductase	0.0045	0.013	0.0181
Loa Loa (eye worm)	heterochromatin protein 1	0.0083	0.0536	0.0869
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0032	0.0052
Schistosoma mansoni	alpha glucosidase	0.0036	0.0032	0.0027
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1168	0.4058
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.0146	0.1761
Trichomonas vaginalis	chromobox protein, putative	0.0083	0.0536	0.0887
Brugia malayi	Thioredoxin reductase	0.0045	0.013	0.0196
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0015	0.0009
Leishmania major	mitochondrial DNA polymerase beta	0.0298	0.286	1
Onchocerca volvulus		0.0093	0.065	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0005
Entamoeba histolytica	fatty acid elongase, putative	0.0083	0.0543	1
Brugia malayi	TAR-binding protein	0.0075	0.0456	0.0736
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0102	0.0749	0.0964
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1168	0.4058
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0365	0.3577	0.5909
Entamoeba histolytica	fatty acid elongase, putative	0.0083	0.0543	1
Trypanosoma brucei	glucosidase, putative	0.0036	0.0032	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0146	0.0241
Echinococcus granulosus	snurportin 1	0.0365	0.3577	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0161	0.138	0.2268
Trypanosoma cruzi	trypanothione reductase, putative	0.0045	0.013	0.0414
Plasmodium falciparum	importin beta, putative	0.0034	0.0015	0.0005
Plasmodium vivax	thioredoxin reductase, putative	0.0045	0.013	0.0181
Echinococcus granulosus	geminin	0.0167	0.145	0.4033
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0075	0.0456	0.0736
Loa Loa (eye worm)	glutathione reductase	0.0045	0.013	0.0196
Plasmodium falciparum	thioredoxin reductase	0.0045	0.013	0.0181
Echinococcus granulosus	tar DNA binding protein	0.0075	0.0456	0.1245
Trichomonas vaginalis	chromobox protein, putative	0.0083	0.0536	0.0887
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0032	0.0069
Entamoeba histolytica	fatty acid elongase, putative	0.0083	0.0543	1
Schistosoma mansoni	hypothetical protein	0.0167	0.145	0.2379
Entamoeba histolytica	fatty acid elongase, putative	0.0083	0.0543	1
Schistosoma mansoni	alpha-glucosidase	0.0139	0.1139	0.1864
Schistosoma mansoni	hypothetical protein	0.0365	0.3577	0.5907
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0015	0.0003
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0032	0.0052
Entamoeba histolytica	fatty acid elongase, putative	0.0083	0.0543	1
Mycobacterium tuberculosis	Probable reductase	0.0102	0.0749	0.0964
Brugia malayi	Importin beta-1 subunit	0.0034	0.0015	0.0005
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0015	0.0005
Toxoplasma gondii	hypothetical protein	0.0048	0.0165	1
Schistosoma mansoni	hypothetical protein	0.0167	0.145	0.2379
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0114	0.0872	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0032	0.0052
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.286	1
Loa Loa (eye worm)	TAR-binding protein	0.0075	0.0456	0.0736
Mycobacterium tuberculosis	Probable oxidoreductase	0.0114	0.0872	0.1156
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0456	0.0731
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0032	0.0052
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0032	0.0052
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0641	0.6547	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0015	0.0011
Echinococcus granulosus	chromobox protein 1	0.0083	0.0536	0.1471
Echinococcus multilocularis	snurportin 1	0.0365	0.3577	0.3569
Trichomonas vaginalis	glutaminase, putative	0.0594	0.6045	1
Toxoplasma gondii	thioredoxin reductase	0.0045	0.013	0.7697
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0456	0.0731
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0099	0.0305

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 839629