Detailed information for compound 839808

Basic information

Technical information
  • TDR Targets ID: 839808
  • Name: N-(3,5-dimethoxyphenyl)-3-(hydroxymethyl)pyra zine-2-carboxamide
  • MW: 289.287 | Formula: C14H15N3O4
  • H donors: 2 H acceptors: 4 LogP: 0.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1)OC)NC(=O)c1nccnc1CO
  • InChi: 1S/C14H15N3O4/c1-20-10-5-9(6-11(7-10)21-2)17-14(19)13-12(8-18)15-3-4-16-13/h3-7,18H,8H2,1-2H3,(H,17,19)
  • InChiKey: GFMHZCVWYONSBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,5-dimethoxyphenyl)-3-(hydroxymethyl)-2-pyrazinecarboxamide
  • N-(3,5-dimethoxyphenyl)-3-methylol-pyrazinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0115 0.0785
Plasmodium falciparum ataxin-2 like protein, putative 0.0123 0.0629 0.2169
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0164 0.0908
Toxoplasma gondii helicase, putative 0.0033 0.0072 0.0024
Onchocerca volvulus 0.0251 0.1418 0.1401
Trypanosoma cruzi PAB1-binding protein , putative 0.0123 0.0629 0.2169
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0066 0.1049
Schistosoma mansoni bromodomain containing protein 0.0059 0.0233 0.3688
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0631 0.5047
Brugia malayi TAR-binding protein 0.0123 0.0631 0.0855
Entamoeba histolytica hypothetical protein 0.0101 0.0493 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0164 0.2593
Schistosoma mansoni DNA polymerase I 0.0033 0.0072 0.1148
Loa Loa (eye worm) hypothetical protein 0.0046 0.0154 0.1106
Echinococcus multilocularis twinkle protein, mitochondrial 0.0024 0.002 0.011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0101 0.0493 0.274
Trichomonas vaginalis set domain proteins, putative 0.0251 0.1418 1
Brugia malayi MH2 domain containing protein 0.0114 0.0572 0.0774
Loa Loa (eye worm) transcription factor SMAD2 0.0114 0.0572 0.4564
Schistosoma mansoni ferritin light chain 0.0025 0.0027 0.0427
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0066 0.0368
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0055 0.0211 0.1172
Mycobacterium ulcerans DNA polymerase I 0.0113 0.0566 1
Onchocerca volvulus 0.0032 0.0066 0.0046
Schistosoma mansoni ferritin 0.0025 0.0027 0.0427
Echinococcus multilocularis expressed protein 0.0025 0.0027 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0164 0.2593
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0365 0.114
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0055 0.0211 0.1172
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0435
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.008 0.0365 0.1162
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0631 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0629 0.5031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0101 0.0493 0.274
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0631 0.3503
Schistosoma mansoni ferritin 0.0025 0.0027 0.0427
Entamoeba histolytica hypothetical protein 0.0101 0.0493 1
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0113 0.0566 1
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0314
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0631 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0076 0.0425
Echinococcus multilocularis tumor protein p63 0.0314 0.1801 1
Brugia malayi Bromodomain containing protein 0.007 0.03 0.0396
Schistosoma mansoni ferritin 0.0025 0.0027 0.0427
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.008 0.0365 0.114
Schistosoma mansoni hypothetical protein 0.0101 0.0493 0.7822
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0365 0.114
Echinococcus granulosus expressed protein 0.0025 0.0027 0.0149
Brugia malayi DNA polymerase I family protein 0.0033 0.0072 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0114 0.0572 0.4564
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0583
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0039 0.0113 0.0182
Schistosoma mansoni hypothetical protein 0.0055 0.0211 0.3346
Loa Loa (eye worm) hypothetical protein 0.0066 0.0275 0.2109
Trypanosoma brucei PAB1-binding protein , putative 0.0123 0.0629 0.2169
Echinococcus granulosus ferritin 0.0025 0.0027 0.0149
Trypanosoma brucei telomerase reverse transcriptase 0.045 0.2638 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0123 0.0629 0.2169
Leishmania major hypothetical protein, conserved 0.0123 0.0629 0.2169
Plasmodium vivax plastid replication-repair enzyme, putative 0.0033 0.0072 0.0024
Brugia malayi Pre-SET motif family protein 0.0221 0.1231 0.1686
Entamoeba histolytica hypothetical protein 0.0101 0.0493 1
Brugia malayi hypothetical protein 0.0123 0.0629 0.0852
Toxoplasma gondii RNA-directed DNA polymerase 0.045 0.2638 1
Echinococcus granulosus tar DNA binding protein 0.0123 0.0631 0.3503
Leishmania major telomerase reverse transcriptase, putative 0.045 0.2638 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0164 0.0908
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0695
Brugia malayi Telomerase reverse transcriptase 0.1196 0.7233 1
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0365 0.114
Plasmodium vivax ataxin-2 like protein, putative 0.0123 0.0629 0.2188
Brugia malayi RNA binding protein 0.0123 0.0631 0.0855
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.008 0.0365 0.114
Echinococcus granulosus twinkle protein mitochondrial 0.0024 0.002 0.011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1231 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0059 0.0328
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0631 1
Echinococcus granulosus tumor protein p63 0.0314 0.1801 1
Schistosoma mansoni ferritin light chain 0.0025 0.0027 0.0427
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.008 0.0365 0.6269
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0314
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0631 1
Trichomonas vaginalis DNA polymerase I, putative 0.0033 0.0072 0.0327
Chlamydia trachomatis DNA polymerase I 0.0113 0.0566 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0123 0.0629 0.2169
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.045 0.2638 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.045 0.2638 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0066 0.1049
Giardia lamblia Telomerase catalytic subunit 0.045 0.2638 0.5
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.045 0.2638 1
Schistosoma mansoni transcription factor LCR-F1 0.0101 0.0493 0.7822
Toxoplasma gondii LsmAD domain-containing protein 0.0123 0.0629 0.2188
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0055 0.0212 0.1178
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0113 0.0566 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0076 0.0425
Onchocerca volvulus 0.0046 0.0154 0.0134
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0113 0.0566 1
Mycobacterium ulcerans 5'-3' exonuclease 0.008 0.0365 0.6269
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0631 0.5047
Treponema pallidum DNA polymerase I (polA) 0.0113 0.0566 1
Schistosoma mansoni ferritin 0.0025 0.0027 0.0427
Brugia malayi hypothetical protein 0.0079 0.036 0.048
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0033 0.0072 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0055 0.0212 0.1178
Schistosoma mansoni apoferritin-2 0.0025 0.0027 0.0427
Schistosoma mansoni apoferritin-2 0.0025 0.0027 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0164 0.1188
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0631 0.0855
Plasmodium falciparum telomerase reverse transcriptase 0.045 0.2638 1
Entamoeba histolytica hypothetical protein 0.0101 0.0493 1
Loa Loa (eye worm) RNA binding protein 0.0123 0.0631 0.5047
Brugia malayi Pre-SET motif family protein 0.0032 0.0066 0.0073
Brugia malayi Bromodomain containing protein 0.0036 0.009 0.0106
Brugia malayi hypothetical protein 0.0101 0.0493 0.0665
Echinococcus multilocularis ferritin 0.0025 0.0027 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0631 1
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0154 0.2436

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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