Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminase | 0.0572 | 0.2737 | 1 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.0032 | 0.0116 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0041 | 0.0148 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0094 | 0.033 | 0.0291 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0076 | 0.0239 | 0.0873 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0042 | 0.0068 | 0.0233 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0076 | 0.0239 | 0.0873 |
Plasmodium falciparum | thioredoxin reductase | 0.0041 | 0.0065 | 0.0033 |
Schistosoma mansoni | alpha-glucosidase | 0.0294 | 0.1335 | 0.4801 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0108 | 0.0251 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0041 | 0.0065 | 0.0238 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0262 | 0.1175 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0036 | 0.0041 | 0.0009 |
Schistosoma mansoni | alpha glucosidase | 0.0076 | 0.0239 | 0.0735 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.019 | 0.1371 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0094 | 0.033 | 0.8461 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.012 | 0.0867 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0041 | 0.0477 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0104 | 0.0383 | 0.0344 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.0041 | 0.0148 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0076 | 0.0239 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0094 | 0.033 | 0.0291 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0094 | 0.033 | 0.0291 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0076 | 0.0239 | 0.2033 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0076 | 0.0239 | 0.0873 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0041 | 0.0148 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0041 | 0.0065 | 0.0025 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.016 | 0.0664 | 0.0626 |
Loa Loa (eye worm) | glutaminase 2 | 0.0572 | 0.2737 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.019 | 0.015 |
Echinococcus multilocularis | geminin | 0.0171 | 0.0716 | 0.1664 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0304 | 0.1387 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0036 | 0.0041 | 0.0148 |
Mycobacterium ulcerans | hypothetical protein | 0.016 | 0.0664 | 0.0626 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0076 | 0.0239 | 0.1722 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0881 | 0.4293 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.2016 | 1 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.019 | 0.1027 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.019 | 0.7648 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0076 | 0.0239 | 0.0552 |
Loa Loa (eye worm) | glutathione reductase | 0.0041 | 0.0065 | 0.0238 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0262 | 0.1175 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0094 | 0.033 | 0.0291 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0041 | 0.0148 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.0582 | 0.4194 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.2016 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0108 | 0.0247 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0262 | 0.1175 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0041 | 0.0477 |
Trypanosoma brucei | glucosidase, putative | 0.0076 | 0.0239 | 0.1722 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0262 | 0.1175 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0036 | 0.0041 | 0.0421 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0341 | 0.1574 | 0.3664 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0716 | 0.2505 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.0032 | 0.0116 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.019 | 0.0555 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.0032 | 0.023 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0076 | 0.0239 | 0.1343 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.019 | 0.015 |
Leishmania major | trypanothione reductase | 0.0041 | 0.0065 | 0.0469 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0341 | 0.1574 | 0.3664 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0105 | 0.3523 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0144 | 0.0582 | 0.4194 |
Plasmodium falciparum | pyruvate kinase | 0.0036 | 0.0041 | 0.0009 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0104 | 0.0383 | 1 |
Leishmania major | pyruvate kinase | 0.0036 | 0.0041 | 0.0293 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0041 | 0.0065 | 0.0469 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0108 | 0.0496 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0032 | 0.023 |
Plasmodium vivax | glutathione reductase, putative | 0.0041 | 0.0065 | 0.0033 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0104 | 0.0383 | 0.0344 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0108 | 0.0251 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.0032 | 0.023 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2016 | 1 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0043 | 0.0073 | 0.0528 |
Onchocerca volvulus | 0.0197 | 0.0851 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0716 | 0.2505 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0076 | 0.0239 | 0.0873 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.0041 | 0.0293 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.019 | 0.0438 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0094 | 0.033 | 0.0291 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0036 | 0.0041 | 0.0293 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0036 | 0.0041 | 0.0148 |
Brugia malayi | glutaminase DH11.1 | 0.0572 | 0.2737 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0108 | 0.0247 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0076 | 0.0239 | 0.2033 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0041 | 0.009 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.2016 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0239 | 0.1722 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0341 | 0.1574 | 0.5751 |
Mycobacterium ulcerans | glutaminase | 0.0572 | 0.2737 | 0.2708 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0076 | 0.0239 | 0.0873 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0094 | 0.033 | 0.0291 |
Giardia lamblia | Pyruvate kinase | 0.0036 | 0.0041 | 0.5 |
Echinococcus granulosus | geminin | 0.0171 | 0.0716 | 0.4437 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0073 | 0.0528 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0041 | 0.0065 | 0.0033 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0239 | 0.1722 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.019 | 0.015 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.0041 | 0.0057 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.019 | 0.015 |
Brugia malayi | Thioredoxin reductase | 0.0041 | 0.0065 | 0.0238 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.019 | 0.0555 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0076 | 0.0239 | 0.0873 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0341 | 0.1574 | 0.5751 |
Leishmania major | pyruvate kinase | 0.0036 | 0.0041 | 0.0293 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0042 | 0.0068 | 0.0153 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0032 | 0.023 |
Plasmodium falciparum | glutathione reductase | 0.0041 | 0.0065 | 0.0033 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.0041 | 0.0293 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 0.1387 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0304 | 0.1387 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0108 | 0.0396 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0032 | 0.0069 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0076 | 0.0239 | 0.0873 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.2016 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0041 | 0.0065 | 0.0469 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0108 | 0.0496 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0262 | 0.1175 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0294 | 0.1335 | 0.4801 |
Brugia malayi | glutathione reductase | 0.0041 | 0.0065 | 0.0238 |
Trichomonas vaginalis | glutaminase, putative | 0.0572 | 0.2737 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0104 | 0.0383 | 0.0344 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0076 | 0.0239 | 0.0873 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 0.1387 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0041 | 0.0065 | 0.1602 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0076 | 0.0239 | 0.0873 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0032 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0041 | 0.0148 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0076 | 0.0239 | 0.0873 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0108 | 0.0396 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0036 | 0.0041 | 0.0293 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0341 | 0.1574 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0572 | 0.2737 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0108 | 0.0251 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.0582 | 0.4194 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0073 | 0.0528 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0041 | 0.009 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.2016 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0076 | 0.0239 | 0.0873 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.0041 | 0.0148 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0041 | 0.0477 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2016 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.0041 | 0.0057 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0073 | 0.0528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.