Detailed information for compound 840122

Basic information

Technical information
  • TDR Targets ID: 840122
  • Name: 1-(4-bromophenyl)sulfonyl-4-[5-(4-methoxyphen yl)-1,3,4-oxadiazol-2-yl]piperidine
  • MW: 478.36 | Formula: C20H20BrN3O4S
  • H donors: 0 H acceptors: 4 LogP: 3.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nnc(o1)C1CCN(CC1)S(=O)(=O)c1ccc(cc1)Br
  • InChi: 1S/C20H20BrN3O4S/c1-27-17-6-2-14(3-7-17)19-22-23-20(28-19)15-10-12-24(13-11-15)29(25,26)18-8-4-16(21)5-9-18/h2-9,15H,10-13H2,1H3
  • InChiKey: SQGBAAHJAUWCTF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus orexin receptor type 2 0.004 0.0257 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0147 0.0147
Onchocerca volvulus 0.004 0.0257 0.0406
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.072 0.072
Echinococcus granulosus neuropeptide s receptor 0.004 0.0257 0.0257
Trichomonas vaginalis glutaminase, putative 0.0281 0.3187 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus serotonin receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0257 0.0406
Brugia malayi ORL1-like opioid receptor 0.004 0.0257 0.0605
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0257 0.0257
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0257 0.0257
Echinococcus multilocularis serotonin receptor 0.004 0.0257 0.0257
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0257 0.0257
Echinococcus granulosus GPCR family 2 0.0031 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.015 0.015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.015 0.015
Mycobacterium tuberculosis Conserved protein 0.0078 0.072 0.1235
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0257 0.0257
Schistosoma mansoni hypothetical protein 0.004 0.0257 0.0257
Schistosoma mansoni amine GPCR 0.004 0.0257 0.0257
Brugia malayi beta-lactamase 0.0078 0.072 0.1694
Schistosoma mansoni hypothetical protein 0.0041 0.027 0.027
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.072 0.2258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0887 0.0887
Brugia malayi Serotonin receptor 0.004 0.0257 0.0605
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0257 0.0257
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0977 0.0977
Schistosoma mansoni opsin-like receptor 0.004 0.0257 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.072 0.2258
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.015 0.1157
Loa Loa (eye worm) glutaminase 2 0.0281 0.3187 0.7505
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0179
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus sex peptide receptor 0.004 0.0257 0.0257
Schistosoma mansoni biogenic amine receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0346
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.1055
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0995 0.0995
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0257 0.0257
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0257 0.0257
Echinococcus granulosus neuropeptide receptor 0.004 0.0257 0.0257
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0257 0.0257
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0257 0.0257
Echinococcus granulosus g protein coupled receptor 0.004 0.0257 0.0257
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0498 0.5826 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0289 0.0289
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0257 0.0257
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Brugia malayi hypothetical protein 0.0025 0.0076 0.0179
Echinococcus granulosus expressed conserved protein 0.0093 0.0904 0.0904
Schistosoma mansoni biogenic amine receptor 0.004 0.0257 0.0257
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0257 0.0257
Plasmodium vivax SET domain protein, putative 0.0031 0.015 0.1157
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni hypothetical protein 0.004 0.0257 0.0257
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0257 0.0257
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0257 0.0257
Echinococcus granulosus neuropeptide receptor 0.004 0.0257 0.0257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0257 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0887 0.0887
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0257 0.0257
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0289 0.0289
Brugia malayi neuropeptide F receptor 0.004 0.0257 0.0605
Echinococcus multilocularis GPCR, family 2 0.0031 0.0147 0.0147
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0257 0.0257
Schistosoma mansoni hypothetical protein 0.0041 0.027 0.027
Mycobacterium leprae conserved hypothetical protein 0.0078 0.072 0.5
Echinococcus multilocularis fmrfamide receptor 0.004 0.0257 0.0257
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Brugia malayi Melatonin receptor type 1A 0.004 0.0257 0.0605
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 0.5
Brugia malayi neuropeptide F receptor 0.004 0.0257 0.0605
Brugia malayi hypothetical protein 0.0086 0.0823 0.1937
Brugia malayi Dopamine receptor protein 2 0.004 0.0257 0.0605
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0067 0.0582 0.137
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Onchocerca volvulus 0.004 0.0257 0.0406
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0257 0.0257
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0977 0.0977
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0257 0.0257
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0257 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.1055
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0257 0.0605
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0257 0.0257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0147 0.0346
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0097 0.0957 0.2253
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0257 0.0257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.072 0.072
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0957 0.2253
Schistosoma mansoni neuropeptide receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0078 0.072 0.1694
Echinococcus granulosus g protein coupled receptor 0.004 0.0257 0.0257
Schistosoma mansoni adenoreceptor 0.004 0.0257 0.0257
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 0.5
Trichomonas vaginalis esterase, putative 0.0078 0.072 0.2258
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0257 0.0257
Brugia malayi Dopamine receptor protein 1 0.004 0.0257 0.0605
Onchocerca volvulus 0.0078 0.072 0.2169
Onchocerca volvulus 0.0247 0.2774 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0257 0.0257
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0257 0.0605
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0257 0.0257
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0257 0.0257
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni hypothetical protein 0.0031 0.0147 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0257 0.0257
Schistosoma mansoni amine GPCR 0.004 0.0257 0.0257
Schistosoma mansoni serine/threonine protein kinase 0.0368 0.4247 0.4247
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0257 0.0257
Schistosoma mansoni amine GPCR 0.004 0.0257 0.0257
Schistosoma mansoni hypothetical protein 0.0841 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0257 0.0257
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0257 0.0257
Brugia malayi Pre-SET motif family protein 0.0217 0.241 0.5675
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.015 0.015
Brugia malayi CHE-14 protein 0.0043 0.0289 0.068
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0257 0.0605
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.0099 0.0977 0.23
Loa Loa (eye worm) hypothetical protein 0.0086 0.0823 0.1937
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.072 0.1694
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0887 0.2089
Onchocerca volvulus 0.004 0.0257 0.0406
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0257 0.0257
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0257 0.0257
Mycobacterium ulcerans glutaminase 0.0281 0.3187 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0977 0.23
Onchocerca volvulus 0.004 0.0257 0.0406
Echinococcus multilocularis somatostatin receptor 0.004 0.0257 0.0257
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0257 0.0257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.072 0.2258
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni hypothetical protein 0.0041 0.027 0.027
Onchocerca volvulus 0.004 0.0257 0.0406
Echinococcus granulosus allatostatin A receptor 0.004 0.0257 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0887 0.0887
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Brugia malayi Serotonin receptor 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus multilocularis allatostatin A receptor 0.004 0.0257 0.0257
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.072 0.1235
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0257 0.0605
Schistosoma mansoni eyes absent homolog 0.0086 0.0823 0.0823
Echinococcus granulosus somatostatin receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.072 0.1694
Brugia malayi follicle stimulating hormone receptor 0.004 0.0257 0.0605
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0257 0.0257
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Onchocerca volvulus 0.0078 0.072 0.2169
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0257 0.0257
Brugia malayi Dopamine receptor 0.004 0.0257 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0289 0.0907
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0147 0.0147
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0257 0.0257
Echinococcus multilocularis fmrfamide receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.072 1
Schistosoma mansoni myosin xvIII 0.004 0.0257 0.0257
Brugia malayi AKH receptor 0.004 0.0257 0.0605
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Onchocerca volvulus 0.0078 0.072 0.2169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0147 0.0147
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0289 0.068
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0257 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.072 1
Echinococcus multilocularis g protein coupled receptor 0.004 0.0257 0.0257
Brugia malayi G-protein coupled receptor 0.004 0.0257 0.0605
Echinococcus multilocularis sex peptide receptor 0.004 0.0257 0.0257
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.072 0.1235
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1494 0.1494
Schistosoma mansoni glutaminase 0.0281 0.3187 0.3187
Loa Loa (eye worm) hypothetical protein 0.0078 0.072 0.1694
Onchocerca volvulus 0.004 0.0257 0.0406
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0257 0.0605
Brugia malayi hypothetical protein 0.0368 0.4247 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0887 0.0887
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0257 0.0605
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0887 0.2089
Schistosoma mansoni patched 1 0.0043 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.072 0.072
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni neuropeptide receptor 0.004 0.0257 0.0257
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.072 0.1235
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0257 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.072 0.2258
Mycobacterium tuberculosis Conserved protein 0.0078 0.072 0.1235
Onchocerca volvulus 0.004 0.0257 0.0406
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0257 0.0257
Brugia malayi sulfakinin receptor protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0257 0.0605
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.072 0.1235
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0147 0.0346
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0257 0.0605
Loa Loa (eye worm) glutaminase 0.0281 0.3187 0.7505
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0257 0.0605
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0257 0.0406
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0405 0.0954
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0368 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni neuropeptide receptor 0.004 0.0257 0.0257
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0257 0.0257
Echinococcus multilocularis neuropeptide receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0257 0.0605
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0147 0.0346
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.0257 0.0605
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0257 0.0257
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0368 0.4247 0.4247
Schistosoma mansoni amine GPCR 0.004 0.0257 0.0257
Leishmania major hypothetical protein, conserved 0.0078 0.072 1
Echinococcus granulosus g protein coupled receptor 0.004 0.0257 0.0257
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1494 0.1494
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.015 0.015
Mycobacterium tuberculosis Conserved protein 0.0078 0.072 0.1235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Onchocerca volvulus 0.004 0.0257 0.0406
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Brugia malayi G protein-coupled receptor 0.004 0.0257 0.0605
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0257 0.0257
Echinococcus multilocularis orexin receptor type 2 0.004 0.0257 0.0257
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0368 0.4247 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0257 0.0605
Onchocerca volvulus 0.004 0.0257 0.0406
Onchocerca volvulus 0.004 0.0257 0.0406
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.072 0.2258
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0257 0.0257
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0582 0.137
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0257 0.0257
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0257 0.0257
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0957 0.2253
Onchocerca volvulus 0.004 0.0257 0.0406
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0078 0.072 0.1694
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0031 0.0147 0.0147
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0257 0.0605
Brugia malayi Serine/threonine-protein kinase SULU 0.0368 0.4247 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0257 0.0257
Toxoplasma gondii ABC1 family protein 0.0078 0.072 1
Echinococcus granulosus fmrfamide receptor 0.004 0.0257 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0257 0.0257
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0257 0.0605
Trichomonas vaginalis set domain proteins, putative 0.0247 0.2774 0.8705
Brugia malayi larval opioid receptor 0.004 0.0257 0.0605
Mycobacterium ulcerans hypothetical protein 0.0078 0.072 0.2258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Schistosoma mansoni amine GPCR 0.004 0.0257 0.0257
Onchocerca volvulus 0.004 0.0257 0.0406
Schistosoma mansoni hypothetical protein 0.004 0.0257 0.0257
Mycobacterium ulcerans lipase LipD 0.0078 0.072 0.2258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Brugia malayi beta-lactamase family protein 0.0078 0.072 0.1694
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0257 0.0257
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0076 0.1055
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.072 0.1235
Brugia malayi beta-lactamase family protein 0.0078 0.072 0.1694
Loa Loa (eye worm) hypothetical protein 0.0086 0.0823 0.1937
Schistosoma mansoni hypothetical protein 0.0067 0.0582 0.0582
Loa Loa (eye worm) hypothetical protein 0.0078 0.072 0.1694
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.072 0.1235
Brugia malayi putative neuropeptide receptor 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.072 0.072
Echinococcus multilocularis g protein coupled receptor 0.004 0.0257 0.0257
Plasmodium vivax hypothetical protein, conserved 0.0078 0.072 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0257 0.0257
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0257 0.0257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0887 0.0887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0887 0.0887
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.072 0.2258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Brugia malayi GnHR receptor homolog 0.004 0.0257 0.0605
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0257 0.0257
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Brugia malayi RE15519p 0.004 0.0257 0.0605
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0957 0.2253
Schistosoma mansoni biogenic amine receptor 0.004 0.0257 0.0257
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni opsin-like receptor 0.004 0.0257 0.0257
Echinococcus multilocularis serotonin receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.0078 0.072 0.1694
Schistosoma mansoni hypothetical protein 0.004 0.0257 0.0257
Schistosoma mansoni neuropeptide receptor 0.004 0.0257 0.0257
Echinococcus multilocularis protein dispatched 1 0.0049 0.0362 0.0362
Schistosoma mansoni opsin-like receptor 0.004 0.0257 0.0257
Mycobacterium ulcerans beta-lactamase 0.0078 0.072 0.2258
Echinococcus multilocularis protein patched 0.0043 0.0289 0.0289
Echinococcus multilocularis expressed conserved protein 0.0093 0.0904 0.0904
Brugia malayi glutaminase DH11.1 0.0281 0.3187 0.7505
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.072 1
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Echinococcus multilocularis neuropeptide receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0257 0.0605
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0257 0.0257
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0257 0.0257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0887 0.0887
Echinococcus granulosus g-protein coupled receptor 0.004 0.0257 0.0257
Schistosoma mansoni hypothetical protein 0.0041 0.027 0.027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0136 0.0136
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0257 0.0257
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0257 0.0257
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0257 0.0257
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.072 0.2258
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0257 0.0257
Schistosoma mansoni histamine h1 receptor 0.004 0.0257 0.0257
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0257 0.0257
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0257 0.0257
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0257 0.0257
Onchocerca volvulus 0.004 0.0257 0.0406
Onchocerca volvulus 0.004 0.0257 0.0406
Schistosoma mansoni hypothetical protein 0.0031 0.0147 0.0147
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0257 0.0257
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Brugia malayi G-protein coupled receptor 0.004 0.0257 0.0605
Leishmania major hypothetical protein, conserved 0.0025 0.0076 0.1055
Onchocerca volvulus 0.004 0.0257 0.0406
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0257 0.0257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0257 0.0257
Brugia malayi hypothetical protein 0.004 0.0257 0.0605
Brugia malayi Pre-SET motif family protein 0.0031 0.015 0.0354
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0257 0.0257
Schistosoma mansoni hypothetical protein 0.0841 1 1
Loa Loa (eye worm) beta-lactamase 0.0078 0.072 0.1694
Loa Loa (eye worm) hypothetical protein 0.0078 0.072 0.1694
Echinococcus multilocularis geminin 0.0841 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Schistosoma mansoni hypothetical protein 0.0031 0.0147 0.0147
Mycobacterium leprae Probable lipase LipE 0.0078 0.072 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.072 0.1235
Echinococcus granulosus hypothetical protein 0.004 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0257 0.0257
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0977 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0605
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.241 0.5675
Echinococcus multilocularis g protein coupled receptor 0.004 0.0257 0.0257
Onchocerca volvulus 0.004 0.0257 0.0406
Onchocerca volvulus 0.004 0.0257 0.0406

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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