TDR Targets

Basic information

Technical information

TDR Targets ID: 84429
Name: 6-chloro-2-(3-nitrophenyl)chromen-4-one
MW: 301.681 | Formula: C15H8ClNO4
H donors: 0 H acceptors: 3 LogP: 3.64 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)c(=O)cc(o2)c1cccc(c1)[N+](=O)[O-]
InChi: 1S/C15H8ClNO4/c16-10-4-5-14-12(7-10)13(18)8-15(21-14)9-2-1-3-11(6-9)17(19)20/h1-8H
InChiKey: DKCAUMRZSZVJCP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-chloro-2-(3-nitrophenyl)-1-benzopyran-4-one
6-chloro-2-(3-nitrophenyl)chromone
6-chloro-2-(3-nitrophenyl)-4-chromenone
EU-0068162

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0444	0.1299
Onchocerca volvulus		0.0038	0.0508	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0243	0.5182
Echinococcus granulosus	short transient receptor potential channel 6	0.0062	0.1038	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0015	0.0028	0.0133
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.003	0.0004
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0042	0.0199
Plasmodium falciparum	protein kinase 7	0.032	0.6557	0.6542
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0042	0.0067
Schistosoma mansoni	nAChR subunit	0.0017	0.0074	0.0141
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0042	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Schistosoma mansoni	nAChR subunit	0.0038	0.0508	0.1499
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0136	0.0513
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0445	0.0404
Brugia malayi	major facilitator superfamily protein	0.0016	0.0042	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	hypothetical protein	0.0016	0.004	0.0056
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0445	0.0404
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0038	0.0508	0.2286
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0074	0.0215
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0444	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Onchocerca volvulus		0.0038	0.0508	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0429	0.1252
Brugia malayi	hypothetical protein	0.0016	0.0042	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Plasmodium falciparum	hexose transporter	0.0113	0.2128	0.2094
Onchocerca volvulus		0.0016	0.0042	0.0292
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Schistosoma mansoni	glucose transporter	0.0016	0.0042	0.0044
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0508	0.2286
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0454	0.1973
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0508	0.1499
Schistosoma mansoni	acetylcholine receptor-related	0.0017	0.0074	0.0141
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0038	0.0508	0.2389
Echinococcus multilocularis	General substrate transporter	0.0097	0.1787	0.5492
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0183	0.3622	0.3595
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0454	0.8107
Schistosoma mansoni	hypothetical protein	0.0165	0.323	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2128	0.6557
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0454	0.8107
Schistosoma mansoni	nAChR subunit	0.0017	0.0074	0.0141
Trypanosoma cruzi	hexose transporter	0.0035	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.0508	0.1499
Onchocerca volvulus		0.0038	0.0508	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0015	0.0028	0.0133
Brugia malayi	Sugar transporter family protein	0.0016	0.0042	0.0067
Echinococcus multilocularis	short transient receptor potential channel 6	0.0062	0.1038	0.3154
Brugia malayi	Cation transporter family protein	0.0038	0.0508	0.2286
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0017	0.0074	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Echinococcus multilocularis	transient receptor potential ion channel A	0.0091	0.1655	0.5081
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0454	0.1973
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0042	0.0044
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0445	0.0404
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.002	0.0136	0.0336
Schistosoma mansoni	transient receptor potential channel	0.0094	0.1722	0.5291
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0161	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0508	0.1499
Onchocerca volvulus		0.0016	0.0042	0.0292
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0445	0.0404
Brugia malayi	major facilitator superfamily protein	0.0016	0.0042	0.0067
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0226	0.1063
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0508	0.2286
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0454	0.8107
Schistosoma mansoni	transient receptor potential channel	0.0062	0.1038	0.3154
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.055	0.051
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0038	0.0508	0.1499
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0183	0.3622	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0508	0.2286
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0042	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.2128	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Schistosoma mansoni	neurotransmitter gated ion channel	0.002	0.0136	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.0004
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0429	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Onchocerca volvulus		0.002	0.0136	0.2243
Brugia malayi	hypothetical protein	0.0016	0.0042	0.0067
Onchocerca volvulus		0.002	0.0136	0.2243
Onchocerca volvulus		0.0016	0.0042	0.0292
Onchocerca volvulus		0.0016	0.0042	0.0292
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0429	0.9512
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0042	0.0067
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.003	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0411	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	Cam kinase protein 1	0.0035	0.0444	0.1981
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0035	0.0453	0.1326
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0017	0.0074	0.0215
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0183	0.3622	0.5495
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0429	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0038	0.0508	0.2286
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0015	0.0028	0.0133
Loa Loa (eye worm)	TYRA-2 protein	0.0015	0.0028	0.0133
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0508	0.1499
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0243	0.1141
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0015	0.0028	0.0133
Echinococcus granulosus	solute carrier family 22	0.0016	0.0042	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Loa Loa (eye worm)	GABA receptor subunit	0.002	0.0136	0.0639
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0508	0.1499
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0017	0.0074	0.0215
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2128	0.6557
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0215
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0444	0.1299
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0243	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2128	0.6557
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0243	0.395
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.003	0.0004
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0411	0.1822
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Plasmodium vivax	CDK-related protein kinase 6, putative	0.048	1	1
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0454	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0429	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Echinococcus granulosus	General substrate transporter	0.0097	0.1787	0.5492
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0445	0.0404
Schistosoma mansoni	nAChR subunit	0.0038	0.0508	0.1499
Loa Loa (eye worm)	sugar transporter	0.0113	0.2128	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0042	0.0067
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Brugia malayi	Sugar transporter family protein	0.0113	0.2128	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Onchocerca volvulus		0.0016	0.0042	0.0292
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0161	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0243	0.395
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0444	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0226	0.0185
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0243	0.067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Schistosoma mansoni	nAChR subunit	0.0038	0.0508	0.1499
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0508	0.2286
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.055	0.0779
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0017	0.0074	0.0345
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0739	0.3475
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0444	0.1299
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0454	0.8107
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0508	0.2389
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0508	0.1499
Echinococcus granulosus	solute carrier family 22	0.0016	0.0042	0.0044
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0398	0.1155
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0038	0.0508	0.2286
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0444	0.1981
Onchocerca volvulus		0.0017	0.0074	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Onchocerca volvulus		0.0016	0.0042	0.0292
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.003	0.0004
Echinococcus multilocularis	nAChR subunit	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Onchocerca volvulus		0.0016	0.0042	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Loa Loa (eye worm)	sugar transporter	0.0016	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Onchocerca volvulus		0.0038	0.0508	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0038	0.0508	0.2286
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Schistosoma mansoni	protein kinase	0.0035	0.0444	0.1299
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0444	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0429	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Echinococcus granulosus	GPCR family 2	0.0015	0.003	0.0004
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Echinococcus granulosus	nAChR subunit	0.0038	0.0508	0.1499
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0017	0.0074	0.0215
Echinococcus granulosus	TRP transient receptor potential channel	0.0035	0.0453	0.1326
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0243	0.1021
Entamoeba histolytica	protein kinase, putative	0.0035	0.0444	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0508	0.1499
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0454	0.8107
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.0004
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0508	0.1499
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0445	0.0404
Onchocerca volvulus		0.0016	0.0042	0.0292
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2128	0.6557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0508	0.2286
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2128	0.6557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0508	0.1499
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0243	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0411	0.1195
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0444	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0453	0.2129
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0038	0.0508	0.2389
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0113	0.1383
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2128	0.6557
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0038	0.0508	0.2389
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0444	0.1299
Echinococcus multilocularis	GPCR, family 2	0.0015	0.003	0.0004
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0243	0.5
Brugia malayi	hypothetical protein	0.0016	0.0042	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Schistosoma mansoni	nAChR subunit	0.0038	0.0508	0.1499
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0042	0.0044
Loa Loa (eye worm)	LGC-31 protein	0.0038	0.0508	0.2389
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0445	0.0617
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0508	0.2389
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0398	0.1155
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0508	0.1499
Onchocerca volvulus		0.0016	0.0042	0.0292
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2128	0.6557
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0136	0.0336
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0429	0.1909
Echinococcus multilocularis	transient receptor potential gamma protein	0.0094	0.1722	0.5291
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Entamoeba histolytica	protein kinase, putative	0.0035	0.0444	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0226	0.3621
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0508	0.1499
Schistosoma mansoni	hypothetical protein	0.0113	0.2128	0.6557
Schistosoma mansoni	nAChR subunit	0.0038	0.0508	0.1499
Onchocerca volvulus		0.0016	0.0042	0.0292
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0243	0.3046
Schistosoma mansoni	sugar transporter	0.0016	0.0042	0.0044
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0739	0.3387
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0739	0.3387
Echinococcus multilocularis	geminin	0.0165	0.323	1
Toxoplasma gondii	protein kinase, putative	0.032	0.6557	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0445	0.0617
Echinococcus granulosus	transient receptor potential ion channel A	0.0091	0.1655	0.5081
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0226	0.3621
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0445	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0017	0.0074	0.0141
Schistosoma mansoni	hypothetical protein	0.0165	0.323	1
Schistosoma mansoni	glucose transport protein	0.0113	0.2128	0.6557
Schistosoma mansoni	nAChR subunit	0.0038	0.0508	0.1499
Schistosoma mansoni	transient receptor potential channel	0.0062	0.1038	0.3154
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0215
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0042	0.0044
Onchocerca volvulus		0.0016	0.0042	0.0292
Leishmania major	hypothetical protein, conserved	0.0024	0.0226	0.3621
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0074	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1722	0.8095
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0038	0.0508	0.1499
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0038	0.0508	0.1499
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0508	0.1499
Onchocerca volvulus		0.0038	0.0508	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0028	0.0133
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0508	0.1499
Echinococcus granulosus	solute carrier family 22	0.0016	0.0042	0.0044
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0042	0.0044
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0508	0.1499
Echinococcus granulosus	solute carrier family 22	0.0016	0.0042	0.0044
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.003	0.0006
Schistosoma mansoni	glucose transport protein	0.0113	0.2128	0.6557
Onchocerca volvulus		0.0016	0.0042	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0017	0.0074	0.0141
Leishmania major	glucose transporter, lmgt2	0.0035	0.0454	0.8107
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0243	0.0201
Onchocerca volvulus		0.0038	0.0508	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0028	0.0133
Schistosoma mansoni	sugar transporter	0.0016	0.0042	0.0044
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0454	0.8107
Schistosoma mansoni	transient receptor potential channel 4	0.0094	0.1722	0.5291
Onchocerca volvulus		0.0016	0.0042	0.0292
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0243	0.0201
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0042	0.0044
Onchocerca volvulus		0.0016	0.0042	0.0292
Leishmania major	glucose transporter, lmgt3	0.0035	0.0454	0.8107
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0042	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0136	0.0513
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0038	0.0508	0.2286
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0508	0.1499
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0038	0.0508	0.1499
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0444	0.1299
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.055	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0017	0.0074	0.0345
Echinococcus granulosus	nAChR subunit	0.002	0.0136	0.0336
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.0074	0.0141
Schistosoma mansoni	glucose transport protein	0.0113	0.2128	0.6557
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Plasmodium vivax	hexose transporter	0.0113	0.2128	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0226	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Brugia malayi	Sugar transporter family protein	0.0016	0.0042	0.0067
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0042	0.0044
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0739	0.3475
Echinococcus granulosus	geminin	0.0165	0.323	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Entamoeba histolytica	hypothetical protein	0.0025	0.0243	0.3465
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0444	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	hypothetical protein	0.0024	0.0226	0.0942
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.055	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0243	0.0961
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0454	0.8107
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.002	0.0136	0.0513
Onchocerca volvulus	Putative nachr subunit	0.0038	0.0508	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0243	0.395
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0017	0.0074	0.0141
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0444	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.002	0.0136	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Plasmodium falciparum	proline--tRNA ligase	0.004	0.055	0.051
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0454	0.8107
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0293	0.1375
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.055	1
Brugia malayi	Cation transporter family protein	0.0038	0.0508	0.2286
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.055	1
Leishmania major	protein kinase, putative	0.0035	0.0444	0.7919
Toxoplasma gondii	facilitative glucose transporter GT1	0.0113	0.2128	0.3201
Schistosoma mansoni	sugar transporter	0.0016	0.0042	0.0044
Echinococcus granulosus	short transient receptor potential channel 6	0.0062	0.1038	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0429	0.1909
Brugia malayi	Cation transporter family protein	0.0038	0.0508	0.2286
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0508	0.1499
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0226	0.3621
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0454	0.1973
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0454	0.1973
Onchocerca volvulus		0.0017	0.0074	0.0941
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0454	0.1973
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Schistosoma mansoni	protein kinase	0.0035	0.0444	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0508	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.0004
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0136	0.0513
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0243	0.067
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0454	0.8107
Schistosoma mansoni	protein kinase	0.0035	0.0444	0.1299
Echinococcus multilocularis	short transient receptor potential channel 6	0.0062	0.1038	0.3154
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0508	0.1499
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0243	0.067
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Echinococcus granulosus	transient receptor potential gamma protein	0.0094	0.1722	0.5291
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0429	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0226	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0508	0.2286
Onchocerca volvulus		0.0017	0.0074	0.0941
Echinococcus multilocularis	nAChR subunit	0.002	0.0136	0.0336
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0038	0.0508	0.2286
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.003	0.0139
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0042	0.0044
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0074	0.0215
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0176	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Onchocerca volvulus		0.0016	0.0042	0.0292
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0444	0.1299
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0429	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0971	0.4562
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0444	0.7919
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0243	0.0308
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0454	0.8107
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0017	0.0074	0.0141
Loa Loa (eye worm)	acetylcholine receptor protein	0.0017	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0226	0.0185
Onchocerca volvulus	Putative transporter	0.0016	0.0042	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0508	0.2389
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0508	0.1499
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0113	0.2128	0.6557
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0454	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0386	0.1812
Brugia malayi	Transient-receptor-potential like protein	0.0035	0.0453	0.2022
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0038	0.0508	0.2286
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0429	0.1252
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0508	0.2286
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0444	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0215
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0038	0.0508	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0199
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.0508	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.0074	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Leishmania major	glucose transporter, lmgt1	0.0035	0.0454	0.8107
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0508	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0508	0.2286
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.0508	0.1499
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0429	0.1252
Schistosoma mansoni	nAChR subunit	0.0038	0.0508	0.1499
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0243	0.067
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0508	0.2286
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0017	0.0074	0.0141
Loa Loa (eye worm)	melatonin receptor type 1A	0.0015	0.0028	0.0133
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0508	0.1499
Brugia malayi	excitatory GABA receptor EXP-1A	0.0038	0.0508	0.2286
Schistosoma mansoni	sugar transporter	0.0016	0.0042	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0133
Onchocerca volvulus		0.0016	0.0042	0.0292

Activities

Activity type	Activity value	Assay description	Source	Reference
-Log Ki (binding)	= 8.1	Binding affinity towards benzodiazepine site in GABAA receptor	ChEMBL.	11384234
Ki (binding)	= 8.1	Binding affinity towards benzodiazepine site in GABAA receptor	ChEMBL.	11384234
Ki (binding)	= 0.008 uM	Displacement of [3H]-flunitrazepine binding from GABA-A central benzodiazepine receptor of rat cerebral cortical membrane	ChEMBL.	No reference
Ki (binding)	= 0.008 uM	Displacement of [3H]-flunitrazepine binding from GABA-A central benzodiazepine receptor of rat cerebral cortical membrane	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 5011228
Search by Saint Jude

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 84429