Detailed information for compound 845305

Basic information

Technical information
  • TDR Targets ID: 845305
  • Name: 4-dimethoxyphosphoryl-N-[(4-methylphenyl)meth yl]-2-(3-nitrophenyl)-1,3-oxazol-5-amine
  • MW: 417.352 | Formula: C19H20N3O6P
  • H donors: 1 H acceptors: 4 LogP: 4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COP(=O)(c1nc(oc1NCc1ccc(cc1)C)c1cccc(c1)[N+](=O)[O-])OC
  • InChi: 1S/C19H20N3O6P/c1-13-7-9-14(10-8-13)12-20-18-19(29(25,26-2)27-3)21-17(28-18)15-5-4-6-16(11-15)22(23)24/h4-11,20H,12H2,1-3H3
  • InChiKey: PCXHVAGLMAKNQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-dimethoxyphosphoryl-N-[(4-methylphenyl)methyl]-2-(3-nitrophenyl)oxazol-5-amine
  • 4-dimethoxyphosphoryl-N-[(4-methylphenyl)methyl]-2-(3-nitrophenyl)-5-oxazolamine
  • [4-dimethoxyphosphoryl-2-(3-nitrophenyl)oxazol-5-yl]-(4-methylbenzyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0196 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0542 0.1002
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0489 0.5414 1
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0489 0.5414 0.5414
Brugia malayi jmjC domain containing protein 0.0064 0.0542 0.1002
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1119 0.2068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0417 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0196 0.0363
Loa Loa (eye worm) hypothetical protein 0.0115 0.1118 0.2065
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0288 0.3113 0.5739
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.1118 0.2065
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0196 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0417 0.0417
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0013 0.0013
Brugia malayi nuclear receptor NHR-88 0.0034 0.0196 0.0363
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0196 0.0363
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0542 0.064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0219 0.0219
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0489 0.5414 0.6384
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0196 0.0363
Schistosoma mansoni hypothetical protein 0.0186 0.1934 0.228
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0196 0.0232
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0011 0.002
Echinococcus granulosus geminin 0.0186 0.1934 0.228
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0013 0.0025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0196 0.0363
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0013 0.0025
Loa Loa (eye worm) ctsf protein 0.0018 0.0013 0.0025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0196 0.0232
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0025
Toxoplasma gondii cathepsin CPL 0.0018 0.0013 0.0025
Onchocerca volvulus 0.0034 0.0196 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Loa Loa (eye worm) cysteine protease 0.0018 0.0013 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0196 0.0363
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0489 0.5414 0.6384
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0196 0.0232
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0001 0.0003
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0013 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0196 0.0591
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0196 0.0232
Brugia malayi jmjC domain containing protein 0.0064 0.0542 0.1002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0001 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0196 0.0363
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0001 0.0003
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0013 0.0025
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0013 0.0016
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0489 0.5414 0.7342
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0196 0.0363
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0196 0.0232
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0605 0.1118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0196 0.0363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0417 0.0491
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0196 0.0363
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.002
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0001 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0002
Leishmania major cathepsin L-like protease 0.007 0.0605 0.1118
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0288 0.3113 0.4214
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0001
Echinococcus multilocularis geminin 0.0186 0.1934 0.1934
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0196 0.0363
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0288 0.3113 0.575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0013 0.0025
Schistosoma mansoni coup transcription factor 0.0034 0.0196 0.0232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Onchocerca volvulus 0.0288 0.3113 1
Echinococcus granulosus GPCR family 2 0.0036 0.0219 0.0258
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0219 0.0404
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0489 0.5414 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0001 0.0003
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0219 0.0404
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0258
Plasmodium vivax vivapain-2 0.0018 0.0013 0.0025
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0489 0.5414 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Schistosoma mansoni hypothetical protein 0.0078 0.0702 0.0827
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0001 0.0003
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0288 0.3113 0.4214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0196 0.0363
Schistosoma mansoni hypothetical protein 0.0186 0.1934 0.228
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0011 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0542 0.064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0196 0.0232
Brugia malayi MH2 domain containing protein 0.0135 0.135 0.2493
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0489 0.5414 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0196 0.0232
Trichomonas vaginalis Sialidase-1 precursor, putative 0.0659 0.7368 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0013 0.0016
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0025
Echinococcus granulosus cathepsin l1 0.0018 0.0013 0.0016
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0489 0.5414 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.1118 0.2065
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0196 0.0196
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0011 0.002
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0489 0.5414 0.7342
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0196 0.0363
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0196 0.0196
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0605 0.1118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0196 0.0363
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0011 0.0013
Echinococcus granulosus microtubule associated protein 2 0.0756 0.8481 1
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1119 0.2068
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0025
Brugia malayi ecdysteroid receptor 0.0034 0.0196 0.0363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0196 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0196 0.0196
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0001 0.0002
Brugia malayi hypothetical protein 0.0018 0.0011 0.002
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0702 0.1296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0196 0.0363
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0288 0.3113 0.8758
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0219 0.0258
Echinococcus multilocularis GPCR, family 2 0.0036 0.0219 0.0219
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0001
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0288 0.3113 0.4214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0258
Plasmodium vivax vivapain-2 0.0018 0.0013 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1119 0.2068
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.135 0.2493
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0288 0.3113 0.5
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0489 0.5414 1
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0219 0.0404
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0417 0.077
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0196 0.0363
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0433 0.08
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0196 0.0196
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0196 0.0363
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0288 0.3113 0.5739
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0196 0.0232
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0196 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0196 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Brugia malayi steroid hormone receptor 0.0034 0.0196 0.0363
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0196 0.0232
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0417 0.077
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0011 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0417 0.0491
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0013 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0196 0.0196
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0196 0.0232
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0535 0.0989
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0013 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0659 0.7368 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0417 0.0491
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0025
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0013 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0196 0.0363
Brugia malayi nuclear hormone receptor 0.0034 0.0196 0.0363
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0417 0.0491
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0025
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0288 0.3113 0.5
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0288 0.3113 0.4214
Schistosoma mansoni microtubule-associated protein tau 0.0756 0.8481 1
Echinococcus multilocularis cysteine protease 0.0018 0.0013 0.0013
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0489 0.5414 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0001 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.1118 0.2065
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0288 0.3113 0.4214
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0013 0.0025
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0196 0.0363
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0489 0.5414 1
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0258
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0001 0.0001
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0115 0.1119 0.2068
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0219 0.0404
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0489 0.5414 1
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0196 0.0232
Brugia malayi hypothetical protein 0.0018 0.0011 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0196 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0196 0.0232
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0702 0.1296
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1119 0.2068
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0605 0.1118
Brugia malayi isocitrate dehydrogenase 0.0017 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0196 0.0363
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0196 0.0232
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0542 0.064
Loa Loa (eye worm) fibroinase 0.0018 0.0013 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0219 0.0219
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0001 0.0003
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0196 0.0363
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0196 0.0591
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0363
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0258
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0196 0.0196
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0196 0.0196
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0025
Echinococcus multilocularis cysteine protease 0.0018 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0288 0.3113 0.575
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0219 0.0258
Leishmania major cathepsin L-like protease 0.007 0.0605 0.1118
Echinococcus multilocularis microtubule associated protein 2 0.0756 0.8481 0.8481
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0542 0.0542
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0196 0.0196
Mycobacterium tuberculosis Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) 0.0327 0.3554 1
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1119 0.2068
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0489 0.5414 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0288 0.3113 0.4214
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1119 0.2068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0196 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0605 0.1118
Leishmania major cathepsin L-like protease 0.007 0.0605 0.1118
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0605 0.1118
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0115 0.1119 0.2068
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0196 0.0232
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0001 0.0003
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0489 0.5414 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0196 0.0232
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0196 0.0232
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0196 0.0232
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0542 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0196 0.0363
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.002
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0542 0.064
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0489 0.5414 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0542 0.064
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.135 0.2493
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0013 0.0025
Brugia malayi nuclear receptor RXR 0.0018 0.0011 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0196 0.0591
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0417 0.0417

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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