Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0056 | 0.0332 |
Schistosoma mansoni | hypothetical protein | 0.0752 | 0.0733 | 0.1517 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0003 | 0.0005 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0724 | 0.0705 | 0.4344 |
Echinococcus multilocularis | GPCR, family 2 | 0.007 | 0.0056 | 0.0348 |
Echinococcus granulosus | carbonic anhydrase II | 0.1647 | 0.1621 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0056 | 0.0042 | 0.0261 |
Echinococcus multilocularis | Smad4 | 0.0016 | 0.0003 | 0.0016 |
Loa Loa (eye worm) | glutaminase 2 | 0.0251 | 0.0236 | 0.1443 |
Echinococcus granulosus | geminin | 0.0509 | 0.0492 | 0.3036 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0033 | 0.0206 |
Schistosoma mansoni | glutaminase | 0.0251 | 0.0236 | 0.0489 |
Brugia malayi | CXXC zinc finger family protein | 0.0053 | 0.0039 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0056 | 0.0117 |
Mycobacterium ulcerans | integral membrane transporter | 0.026 | 0.0244 | 0.014 |
Schistosoma mansoni | cpg binding protein | 0.0056 | 0.0042 | 0.0088 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.006 | 0.0047 | 0.1574 |
Echinococcus granulosus | smad | 0.0016 | 0.0003 | 0.0016 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0003 | 0.0005 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0724 | 0.0705 | 0.1459 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0151 | 0.0137 | 0.0835 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0221 | 0.0206 | 0.1264 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.007 | 0.0056 | 0.0337 |
Echinococcus granulosus | Smad4 | 0.0016 | 0.0003 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.0137 | 0.0283 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0033 | 0.0206 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0053 | 0.0039 | 0.0227 |
Mycobacterium ulcerans | glutaminase | 0.0251 | 0.0236 | 0.0131 |
Echinococcus granulosus | carbonic anhydrase | 0.0724 | 0.0705 | 0.435 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0639 | 0.0621 | 0.3829 |
Chlamydia trachomatis | sulfate transporter | 0.026 | 0.0244 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0724 | 0.0705 | 0.4344 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0033 | 0.019 |
Toxoplasma gondii | hypothetical protein | 0.0724 | 0.0705 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0221 | 0.0206 | 0.1259 |
Echinococcus multilocularis | cpg binding protein | 0.0056 | 0.0042 | 0.0261 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0056 | 0.0117 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0639 | 0.0621 | 0.3829 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0003 | 0.0005 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0033 | 0.0206 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1647 | 0.1621 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.012 | 0.0106 | 0.022 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0112 | 0.0098 | 0.0203 |
Schistosoma mansoni | carbonic anhydrase | 0.4887 | 0.4834 | 1 |
Brugia malayi | Smad1 | 0.0016 | 0.0003 | 0.0005 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0724 | 0.0705 | 0.1459 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.012 | 0.0106 | 0.0078 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.006 | 0.0047 | 0.0076 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1647 | 0.1621 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0016 | 0.0003 | 0.0003 |
Brugia malayi | Latrophilin receptor protein 2 | 0.007 | 0.0056 | 0.0337 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 0.0139 | 0.0856 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0639 | 0.0621 | 0.1284 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 0.0139 | 0.0856 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0861 | 0.0841 | 0.5189 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0033 | 0.0195 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0003 | 0.0005 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0232 | 0.0217 | 0.1325 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0024 | 0.0145 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0289 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0033 | 0.0069 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.007 | 0.0056 | 0.0332 |
Echinococcus multilocularis | carbonic anhydrase | 0.0724 | 0.0705 | 0.435 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.1882 | 0.1853 | 0.2366 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0273 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.007 | 0.0056 | 0.0348 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.006 | 0.0047 | 0.0531 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0024 | 0.0145 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.007 | 0.0056 | 0.0348 |
Echinococcus multilocularis | smad | 0.0016 | 0.0003 | 0.0016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0033 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.0492 | 0.1018 |
Loa Loa (eye worm) | glutaminase | 0.0251 | 0.0236 | 0.1443 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0056 | 0.0117 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0033 | 0.0069 |
Brugia malayi | hypothetical protein | 0.0294 | 0.0278 | 0.1707 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0003 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0206 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0139 | 0.0841 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.012 | 0.0106 | 0.0656 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1647 | 0.1621 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1647 | 0.1621 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.012 | 0.0106 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.1267 | 0.1244 | 0.767 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.012 | 0.0106 | 0.022 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0289 |
Echinococcus granulosus | GPCR family 2 | 0.007 | 0.0056 | 0.0348 |
Echinococcus multilocularis | carbonic anhydrase | 0.0724 | 0.0705 | 0.435 |
Schistosoma mansoni | smad | 0.0016 | 0.0003 | 0.0006 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1647 | 0.1621 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0097 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0531 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.4218 | 0.4171 | 0.54 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0056 | 0.0117 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0289 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0024 | 0.0049 |
Leishmania major | carbonic anhydrase family protein, putative | 0.4887 | 0.4834 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 1.0096 | 1 | 1 |
Trypanosoma brucei | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.026 | 0.0244 | 0.1455 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0003 | 0.0006 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.4887 | 0.4834 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.7759 | 0.7683 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.1629 | 0.1603 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 0.0139 | 0.0856 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0724 | 0.0705 | 0.4341 |
Echinococcus granulosus | carbonic anhydrase | 0.0724 | 0.0705 | 0.435 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.0278 | 0.1703 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0016 | 0.0003 | 0.0016 |
Schistosoma mansoni | Smad4 | 0.0016 | 0.0003 | 0.0006 |
Echinococcus granulosus | carbonic anhydrase | 0.0724 | 0.0705 | 0.435 |
Brugia malayi | Muscleblind-like protein | 0.0153 | 0.0139 | 0.0846 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.01 | 0.0086 | 0.1097 |
Toxoplasma gondii | inorganic anion transporter, sulfate permease (SulP) family protein | 0.026 | 0.0244 | 0.3372 |
Loa Loa (eye worm) | hypothetical protein | 0.0724 | 0.0705 | 0.4341 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.4887 | 0.4834 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0724 | 0.0705 | 0.435 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0139 | 0.0841 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0016 | 0.0003 | 0.0006 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1647 | 0.1621 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0056 | 0.0042 | 0.0088 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.2551 | 0.2517 | 0.3235 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0752 | 0.0733 | 0.4523 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0724 | 0.0705 | 0.4344 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0232 | 0.0217 | 0.1325 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0137 | 0.083 |
Brugia malayi | hypothetical protein | 0.0023 | 0.001 | 0.005 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1647 | 0.1621 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.006 | 0.0047 | 0.0289 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0003 | 0.0006 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.006 | 0.0047 | 0.0229 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.012 | 0.0106 | 0.02 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0724 | 0.0705 | 0.4344 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0016 | 0.0003 | 0.0016 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0016 | 0.0003 | 0.0016 |
Onchocerca volvulus | 0.1629 | 0.1603 | 1 | |
Plasmodium falciparum | inorganic anion exchanger, inorganic anion antiporter | 0.026 | 0.0244 | 0.3372 |
Onchocerca volvulus | 0.0294 | 0.0278 | 0.1528 | |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.0492 | 0.1018 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.006 | 0.0047 | 0.0229 |
Plasmodium vivax | sulfate transporter, putative | 0.026 | 0.0244 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0024 | 0.0049 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0016 | 0.0003 | 0.0007 |
Schistosoma mansoni | cpg binding protein | 0.0053 | 0.0039 | 0.0081 |
Brugia malayi | isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0278 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.006 | 0.0047 | 0.0229 |
Mycobacterium ulcerans | carbonic anhydrase | 0.4887 | 0.4834 | 0.4779 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0724 | 0.0705 | 0.1459 |
Mycobacterium ulcerans | transmembrane carbonic anhydrase, SulP | 0.026 | 0.0244 | 0.014 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1647 | 0.1621 | 0.3353 |
Schistosoma mansoni | carbonic anhydrase | 0.0724 | 0.0705 | 0.1459 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1647 | 0.1621 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0033 | 0.0206 |
Echinococcus multilocularis | geminin | 0.0509 | 0.0492 | 0.3036 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.001 | 0.0045 |
Trichomonas vaginalis | conserved hypothetical protein | 1.0096 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0724 | 0.0705 | 1 |
Trypanosoma cruzi | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.026 | 0.0244 | 0.1455 |
Leishmania major | carbonic anhydrase-like protein | 0.1647 | 0.1621 | 0.3339 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0003 | 0.0006 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0724 | 0.0705 | 0.4344 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0024 | 0.0134 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1647 | 0.1621 | 0.3353 |
Trypanosoma cruzi | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.026 | 0.0244 | 0.1455 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.012 | 0.0106 | 0.1386 |
Brugia malayi | glutaminase DH11.1 | 0.0251 | 0.0236 | 0.1447 |
Loa Loa (eye worm) | hypothetical protein | 0.0724 | 0.0705 | 0.4341 |
Echinococcus granulosus | dnaJ subfamily B | 0.0752 | 0.0733 | 0.4523 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.007 | 0.0056 | 0.0348 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0003 | 0.002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0221 | 0.0206 | 0.1264 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.006 | 0.0047 | 0.0229 |
Schistosoma mansoni | hypothetical protein | 0.0724 | 0.0705 | 0.1459 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.007 | 0.0056 | 0.0348 |
Brugia malayi | Isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0278 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0289 |
Brugia malayi | MH2 domain containing protein | 0.0232 | 0.0217 | 0.1329 |
Mycobacterium ulcerans | transmembrane carbonic anhydrase, SulP | 0.026 | 0.0244 | 0.014 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.006 | 0.0047 | 0.0531 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0016 | 0.0003 | 0.0016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.