Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | STE family protein kinase | 0.0184 | 0.0768 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0183 | 0.0764 | 0.9188 |
Echinococcus multilocularis | plexin a4 | 0.0067 | 0.0206 | 0.0225 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0184 | 0.0768 | 0.084 |
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.018 | 0.0751 | 0.0822 |
Brugia malayi | Protein kinase domain | 0.0184 | 0.0768 | 0.0768 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.018 | 0.0751 | 0.0822 |
Trichomonas vaginalis | STE family protein kinase | 0.0184 | 0.0768 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.2115 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0184 | 0.0768 | 0.9234 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0184 | 0.0768 | 0.084 |
Echinococcus multilocularis | geminin | 0.0197 | 0.0831 | 0.091 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.1934 | 0.9137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0831 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0184 | 0.0768 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.1934 | 0.9137 | 1 |
Echinococcus granulosus | geminin | 0.0197 | 0.0831 | 0.091 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.018 | 0.0751 | 0.0822 |
Brugia malayi | WH1 domain containing protein | 0.018 | 0.0751 | 0.0751 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0184 | 0.0768 | 0.084 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0751 | 0.903 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.018 | 0.0751 | 0.0751 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.0768 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0751 | 0.903 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0157 | 0.0157 |
Trichomonas vaginalis | STE family protein kinase | 0.0184 | 0.0768 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0184 | 0.0768 | 0.084 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0184 | 0.0768 | 0.084 |
Schistosoma mansoni | protein kinase | 0.0184 | 0.0768 | 0.9234 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.018 | 0.0751 | 0.0822 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.018 | 0.0751 | 0.903 |
Entamoeba histolytica | p21-activated kinase | 0.0184 | 0.0768 | 1 |
Schistosoma mansoni | plexin | 0.0056 | 0.0157 | 0.1883 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.0768 | 1 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.018 | 0.0751 | 0.0822 |
Brugia malayi | Plexin repeat family protein | 0.0056 | 0.0157 | 0.0157 |
Trichomonas vaginalis | STE family protein kinase | 0.0184 | 0.0768 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0184 | 0.0768 | 0.084 |
Brugia malayi | plexin A | 0.0067 | 0.0206 | 0.0206 |
Trichomonas vaginalis | STE family protein kinase | 0.0184 | 0.0768 | 1 |
Echinococcus granulosus | plexin a4 | 0.0067 | 0.0206 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0751 | 0.0751 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.0768 | 1 |
Onchocerca volvulus | 0.0056 | 0.0157 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0184 | 0.0768 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.018 | 0.0751 | 0.0751 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0751 | 0.903 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.0768 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0183 | 0.0764 | 0.9188 |
Schistosoma mansoni | protein kinase | 0.0184 | 0.0768 | 0.9234 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0044 | 0.0531 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.018 | 0.0751 | 0.0751 |
Schistosoma mansoni | plexin | 0.0033 | 0.0044 | 0.0531 |
Loa Loa (eye worm) | plexin A | 0.0067 | 0.0206 | 0.0206 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0831 | 1 |
Schistosoma mansoni | protein kinase | 0.018 | 0.0751 | 0.903 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.68 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | = 7.2 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 102 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 109 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.