TDR Targets

Basic information

Technical information

TDR Targets ID: 865832
Name: 2-(1-methylbenzimidazol-2-yl)sulfanyl-N-(pyri din-2-ylmethylideneamino)acetamide
MW: 325.388 | Formula: C16H15N5OS
H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CSc1nc2c(n1C)cccc2)N/N=C/c1ccccn1
InChi: 1S/C16H15N5OS/c1-21-14-8-3-2-7-13(14)19-16(21)23-11-15(22)20-18-10-12-6-4-5-9-17-12/h2-10H,11H2,1H3,(H,20,22)/b18-10+
InChiKey: SUCXEYNDNBTLKW-VCHYOVAHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(1-methylbenzimidazol-2-yl)sulfanyl-N-(2-pyridylmethyleneamino)acetamide
2-[(1-methyl-2-benzimidazolyl)thio]-N-(2-pyridylmethyleneamino)acetamide
2-[(1-methylbenzimidazol-2-yl)thio]-N-(2-pyridylmethyleneamino)acetamide
2-(1-methylbenzimidazol-2-yl)sulfanyl-N-(pyridin-2-ylmethylideneamino)ethanamide
ST021847

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Echinococcus multilocularis	cathepsin b	0.0045	0.2851	0.2848
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0008	0.0311	0.1082
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0008	0.0311	0.4086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0016	0.0853	0.1703
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0038	0.2326	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0311	0.1082
Echinococcus multilocularis	cathepsin L cysteine protease	0.0008	0.0311	0.0308
Trypanosoma cruzi	trypanothione reductase, putative	0.0015	0.0757	0.2647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0007	0.0194	0.2241
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0311	0.0708
Schistosoma mansoni	hypothetical protein	0.0096	0.6388	1
Echinococcus multilocularis	neuropeptide s receptor	0.0149	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0008	0.0311	0.3624
Mycobacterium tuberculosis	Probable oxidoreductase	0.0038	0.2326	1
Echinococcus granulosus	neuropeptide receptor A26	0.0149	1	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0005	0.0089	0.114
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0005	0.0089	0.5
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0005	0.0089	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0149	1	1
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0008	0.0311	0.0308
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0007	0.0194	0.2241
Trypanosoma brucei	importin beta-1 subunit, putative	0.0009	0.0358	0.4177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Toxoplasma gondii	NADPH-glutathione reductase	0.0005	0.0089	0.1011
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0007	0.024	0.0475
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0004	0.0003	0.0005
Echinococcus multilocularis	cathepsin b	0.0045	0.2851	0.2848
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0005	0.0089	0.1011
Giardia lamblia	Cathepsin B precursor	0.0016	0.0853	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0008	0.0311	0.4086
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0034	0.2066	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0311	0.1082
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0311	1
Trichomonas vaginalis	mercuric reductase, putative	0.0005	0.0089	0.0172
Plasmodium falciparum	importin beta, putative	0.0009	0.0358	0.471
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Loa Loa (eye worm)	glutathione reductase	0.0015	0.0757	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0311	0.0487
Echinococcus granulosus	cathepsin b	0.0045	0.2851	0.2848
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0311	0.1082
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0311	1
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Entamoeba histolytica	hypothetical protein	0.0007	0.024	0.7701
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0007	0.0194	0.2527
Brugia malayi	Pre-SET motif family protein	0.001	0.0398	0.0906
Leishmania major	importin beta-1 subunit, putative	0.0007	0.024	0.279
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Echinococcus multilocularis	cysteine protease	0.0008	0.0311	0.0308
Trypanosoma brucei	trypanothione reductase	0.0015	0.0757	0.8869
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0005	0.0089	0.1011
Echinococcus multilocularis	cysteine protease	0.0008	0.0311	0.0308
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0016	0.0853	1
Trichomonas vaginalis	ran, putative	0.0007	0.0194	0.0382
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0016	0.0853	0.2985
Toxoplasma gondii	thioredoxin reductase	0.0015	0.0757	0.8869
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Echinococcus multilocularis	cathepsin L cysteine protease	0.0008	0.0311	0.0308
Brugia malayi	glutathione reductase	0.0015	0.0757	0.1732
Trypanosoma brucei	importin beta-1 subunit, putative	0.0009	0.0358	0.4177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0005	0.0089	0.114
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0005	0.0089	0.5
Plasmodium vivax	SET domain protein, putative	0.001	0.0398	0.5233
Plasmodium vivax	importin-beta 2, putative	0.0009	0.0358	0.471
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0008	0.0311	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0008	0.0311	0.0487
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.0302
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.0302
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0004	0.0003	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0008	0.0311	0.0617
Mycobacterium tuberculosis	Probable dehydrogenase	0.0034	0.2066	0.8837
Echinococcus granulosus	importin subunit beta 1	0.0009	0.0358	0.0355
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0005	0.0089	0.1011
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0034	0.2066	0.8837
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.001	0.0398	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0005	0.0089	0.5
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0034	0.2066	0.8837
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0007	0.0194	0.0669
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0005	0.0089	0.1011
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0005	0.0089	0.0198
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0007	0.0194	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0311	0.1082
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0007	0.0194	0.0191
Toxoplasma gondii	cathepsin CPL	0.0008	0.0311	0.3624
Plasmodium falciparum	thioredoxin reductase	0.0005	0.0089	0.114
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0016	0.0853	0.1336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Leishmania major	trypanothione reductase	0.0015	0.0757	0.8869
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Loa Loa (eye worm)	hypothetical protein	0.001	0.0398	0.0623
Mycobacterium tuberculosis	Probable reductase	0.0034	0.2066	0.8837
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.001	0.0398	0.0395
Loa Loa (eye worm)	thioredoxin reductase	0.0015	0.0757	0.1185
Loa Loa (eye worm)	ctsf protein	0.0008	0.0311	0.0487
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0045	0.2851	0.4463
Brugia malayi	RNA, U transporter 1	0.0026	0.1507	0.3456
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0008	0.0311	0.0308
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0311	0.0487
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0007	0.0194	0.0438
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0311	0.0487
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0007	0.0194	0.2241
Plasmodium vivax	vivapain-2	0.0008	0.0311	0.4086
Loa Loa (eye worm)	cysteine protease	0.0008	0.0311	0.0487
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.0302
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0007	0.0194	0.2527
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0045	0.2851	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0015	0.0757	0.2985
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.0302
Trypanosoma cruzi	trypanothione reductase, putative	0.0005	0.0089	0.0302
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0007	0.0194	0.0191
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0067	0.4355	0.6818
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0311	0.0487
Entamoeba histolytica	Ran family GTPase	0.0007	0.0194	0.6185
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0003	0.0005
Plasmodium vivax	vivapain-2	0.0008	0.0311	0.4086
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0005	0.0089	0.1011
Plasmodium falciparum	thioredoxin reductase	0.0015	0.0757	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Echinococcus multilocularis	snurportin 1	0.0096	0.6388	0.6387
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Onchocerca volvulus		0.0076	0.4993	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0311	0.0487
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0096	0.6388	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.1011
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.001	0.0398	0.0623
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.001	0.0398	0.0623
Giardia lamblia	Cathepsin B precursor	0.0016	0.0853	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0045	0.2851	0.6543
Plasmodium falciparum	glutathione reductase	0.0005	0.0089	0.114
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Echinococcus granulosus	snurportin 1	0.0096	0.6388	0.6387
Echinococcus multilocularis	importin subunit beta 1	0.0009	0.0358	0.0355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Plasmodium falciparum	glutathione reductase	0.0015	0.0757	1
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0005	0.0089	0.0086
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0005	0.0089	0.014
Echinococcus granulosus	cathepsin l1	0.0008	0.0311	0.0308
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0034	0.2066	0.8837
Trichomonas vaginalis	importin beta-1, putative	0.0007	0.024	0.0475
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0311	0.0487
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0007	0.024	0.0833
Echinococcus granulosus	thioredoxin glutathione reductase	0.0015	0.0757	0.0754
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0009	0.0373	0.037
Brugia malayi	Thioredoxin reductase	0.0015	0.0757	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0358	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2851	0.4463
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0005	0.0089	0.1011
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.1011
Giardia lamblia	Cathepsin B precursor	0.0016	0.0853	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0007	0.024	0.0475
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0005	0.0089	0.0302
Brugia malayi	Importin beta-1 subunit	0.0009	0.0358	0.0816
Schistosoma mansoni	ran	0.0007	0.0194	0.0303
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.001	0.0398	0.4641
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Schistosoma mansoni	importin beta-1	0.0009	0.0358	0.0561
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0005	0.0089	0.1011
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0005	0.0089	0.114
Toxoplasma gondii	HEAT repeat-containing protein	0.0009	0.0358	0.4177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0008	0.0311	0.0708
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0045	0.2851	0.4463
Brugia malayi	cathepsin L-like precursor	0.0008	0.0311	0.0708
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0005	0.0089	0.0302
Trichomonas vaginalis	glutathione reductase, putative	0.0005	0.0089	0.0172
Onchocerca volvulus		0.001	0.0398	0.0185
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0005	0.0089	0.0302
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Echinococcus granulosus	cathepsin b	0.0045	0.2851	0.2848
Loa Loa (eye worm)	fibroinase	0.0008	0.0311	0.0487
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0005	0.0089	0.0086
Schistosoma mansoni	ran	0.0007	0.0194	0.0303
Leishmania major	GTP-binding protein, putative	0.0007	0.0194	0.2241
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0008	0.0311	0.4086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0045	0.2851	0.4463
Echinococcus granulosus	cathepsin l1	0.0008	0.0311	0.0308
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0007	0.0194	0.0669
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0311	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0311	0.0487
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Trypanosoma cruzi	cruzipain precursor, putative	0.0008	0.0311	0.1082
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0015	0.0757	0.0754
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0005	0.0089	0.114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0005	0.0089	0.1011
Echinococcus granulosus	histone lysine methyltransferase setb	0.001	0.0398	0.0395
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0008	0.0311	0.0308
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0311	0.3624
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0005	0.0089	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.001	0.0398	0.0623
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0008	0.0311	0.0308
Plasmodium vivax	thioredoxin reductase, putative	0.0015	0.0757	1
Trichomonas vaginalis	set domain proteins, putative	0.0076	0.4993	1
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Toxoplasma gondii	cathepsin B	0.0016	0.0853	1
Loa Loa (eye worm)	cathepsin B	0.0016	0.0853	0.1336
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0005	0.0089	0.5
Treponema pallidum	NADH oxidase	0.0005	0.0089	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0045	0.2851	0.4463
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0038	0.2326	1
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0311	0.0708
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.001	0.0398	0.0623
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0311	0.0617
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0016	0.0853	1
Plasmodium vivax	glutathione reductase, putative	0.0015	0.0757	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0008	0.0311	0.0617
Leishmania major	cathepsin L-like protease	0.0008	0.0311	0.3624
Brugia malayi	Pre-SET motif family protein	0.0067	0.4355	1
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0311	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0038	0.2326	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0311	0.0617

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 865832