Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1379 | 0.663 | 0.6622 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0427 | 0.1819 | 0.2723 |
Brugia malayi | protein kinase C II. | 0.0682 | 0.3104 | 0.3091 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0682 | 0.3104 | 0.4667 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0085 | 0.0087 | 0.0103 |
Entamoeba histolytica | protein kinase, putative | 0.2046 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.1322 | 0.6341 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0124 | 0.0285 | 0.0403 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0682 | 0.3104 | 0.3091 |
Echinococcus granulosus | protein kinase c iota type | 0.0682 | 0.3104 | 0.4667 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0682 | 0.3104 | 0.4682 |
Echinococcus multilocularis | nervana 2 | 0.1307 | 0.6266 | 0.945 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0682 | 0.3104 | 0.3091 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0682 | 0.3104 | 0.4667 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0124 | 0.0285 | 0.043 |
Trichomonas vaginalis | AGC family protein kinase | 0.0682 | 0.3104 | 0.3088 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.1322 | 0.6341 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0682 | 0.3104 | 0.3091 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0427 | 0.1819 | 0.1804 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0085 | 0.0087 | 0.0103 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0072 | 0.0023 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0124 | 0.0285 | 0.0403 |
Entamoeba histolytica | protein kinase, putative | 0.2046 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1307 | 0.6266 | 0.945 |
Trichomonas vaginalis | AGC family protein kinase | 0.0682 | 0.3104 | 0.3088 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0399 | 0.1677 | 0.1658 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0085 | 0.0087 | 0.0131 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0072 | 0.0023 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0739 | 0.3393 | 0.3378 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.1322 | 0.6341 | 0.9563 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0085 | 0.0087 | 0.0103 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0682 | 0.3104 | 0.4682 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0682 | 0.3104 | 0.4667 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0682 | 0.3104 | 0.4667 |
Brugia malayi | Protein kinase domain containing protein | 0.0682 | 0.3104 | 0.3091 |
Echinococcus multilocularis | nervana 2 | 0.1307 | 0.6266 | 0.945 |
Schistosoma mansoni | serine/threonine kinase | 0.0682 | 0.3104 | 0.4682 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0072 | 0.0023 | 0.0004 |
Leishmania major | folate/biopterin transporter, putative | 0.0072 | 0.0023 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0682 | 0.3104 | 0.4667 |
Leishmania major | protein kinase, putative | 0.0072 | 0.0023 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2046 | 1 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.2046 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0682 | 0.3104 | 0.3091 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0467 | 0.2018 | 0.3043 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0085 | 0.0087 | 0.0068 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0427 | 0.1819 | 0.2723 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0087 | 0.0068 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0682 | 0.3104 | 0.4667 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0072 | 0.0023 | 0.0006 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.1307 | 0.6266 | 0.945 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0667 | 0.303 | 0.3014 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.1322 | 0.6341 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0682 | 0.3104 | 0.3088 |
Trichomonas vaginalis | AGC family protein kinase | 0.0682 | 0.3104 | 0.3088 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0085 | 0.0087 | 0.0131 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0085 | 0.0087 | 0.0064 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0085 | 0.0087 | 0.0103 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0682 | 0.3104 | 0.4682 |
Echinococcus granulosus | nervana 2 | 0.1307 | 0.6266 | 0.945 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0085 | 0.0087 | 0.0064 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.1322 | 0.6341 | 0.9563 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1989 | 0.9711 | 0.971 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0124 | 0.0285 | 0.0403 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.1322 | 0.6341 | 0.9563 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0124 | 0.0285 | 0.043 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0085 | 0.0087 | 0.0103 |
Trichomonas vaginalis | AGC family protein kinase | 0.2046 | 1 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0085 | 0.0087 | 0.0068 |
Entamoeba histolytica | protein kinase 2, putative | 0.1322 | 0.6341 | 0.6332 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0085 | 0.0087 | 0.0103 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0085 | 0.0087 | 0.0103 |
Brugia malayi | Hr1 repeat family protein | 0.0682 | 0.3104 | 0.3091 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0085 | 0.0087 | 0.0131 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0085 | 0.0087 | 0.0103 |
Echinococcus multilocularis | protein kinase c iota type | 0.0682 | 0.3104 | 0.4667 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1379 | 0.663 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2046 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.1307 | 0.6266 | 0.945 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0682 | 0.3104 | 0.4682 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0682 | 0.3104 | 0.4667 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.2046 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2046 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0682 | 0.3104 | 0.4682 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1379 | 0.663 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0682 | 0.3104 | 0.4667 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0682 | 0.3104 | 0.4667 |
Schistosoma mansoni | atypical protein kinase C | 0.0682 | 0.3104 | 0.4682 |
Echinococcus granulosus | NDR protein kinase | 0.0682 | 0.3104 | 0.4667 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.0019 | 0.0029 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0124 | 0.0285 | 0.0403 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1379 | 0.663 | 0.6622 |
Entamoeba histolytica | protein kinase, putative | 0.1989 | 0.9711 | 0.971 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0682 | 0.3104 | 0.4682 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0682 | 0.3104 | 0.4667 |
Brugia malayi | Protein kinase domain containing protein | 0.0682 | 0.3104 | 0.3091 |
Trichomonas vaginalis | AGC family protein kinase | 0.2046 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2046 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0682 | 0.3104 | 0.3091 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0682 | 0.3104 | 0.4667 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0682 | 0.3104 | 0.4667 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0399 | 0.1677 | 0.1658 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0682 | 0.3104 | 0.3091 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0072 | 0.0023 | 0.0004 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0682 | 0.3104 | 0.4667 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1379 | 0.663 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0085 | 0.0087 | 0.0131 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1322 | 0.6341 | 0.9562 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.0019 | 0.0029 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0467 | 0.2018 | 0.3043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0085 | 0.0087 | 0.0131 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0427 | 0.1819 | 0.1804 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0085 | 0.0087 | 0.0103 |
Trypanosoma cruzi | Protein kinase B | 0.1379 | 0.663 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0682 | 0.3104 | 0.4667 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.0019 | 0.0029 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.1307 | 0.6266 | 0.945 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0682 | 0.3104 | 0.4667 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0085 | 0.0087 | 0.0068 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0085 | 0.0087 | 0.0103 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0682 | 0.3104 | 0.4667 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0285 | 0.0267 |
Toxoplasma gondii | AGC kinase | 0.1989 | 0.9711 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0682 | 0.3104 | 0.4682 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1989 | 0.9711 | 0.971 |
Loa Loa (eye worm) | hypothetical protein | 0.0682 | 0.3104 | 0.3091 |
Leishmania major | protein kinase, putative | 0.0072 | 0.0023 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0085 | 0.0087 | 0.0131 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1379 | 0.663 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2046 | 1 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0085 | 0.0087 | 0.0103 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0072 | 0.0023 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0124 | 0.0285 | 0.0267 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1379 | 0.663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1534 | 0.1518 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1307 | 0.6266 | 0.945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.