Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0039 | 0.0616 | 0.0616 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Onchocerca volvulus | 0.0031 | 0.0367 | 0.5955 | |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.013 | 0.3462 | 0.3033 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0339 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0939 | 0.0939 |
Schistosoma mansoni | lamin | 0.0031 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0039 | 0.0616 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0939 | 0.0939 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0339 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.013 | 0.3462 | 0.3462 |
Echinococcus granulosus | methionine synthase reductase | 0.021 | 0.595 | 0.595 |
Brugia malayi | diaphorase | 0.0039 | 0.0616 | 0.0616 |
Echinococcus granulosus | geminin | 0.0192 | 0.541 | 0.541 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.013 | 0.3462 | 0.3462 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.021 | 0.595 | 0.595 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0039 | 0.0616 | 0.5 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0367 | 0.0367 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0367 | 0.0367 |
Schistosoma mansoni | cytochrome B5 | 0.0039 | 0.0616 | 0.0616 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0039 | 0.0616 | 0.0616 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0939 | 0.0939 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0339 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0301 | 0.8796 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0339 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0339 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.541 | 0.541 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0939 | 0.0939 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0939 | 0.0939 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0367 | 0.0367 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0301 | 0.8796 | 0.8159 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0171 | 0.4746 | 0.4746 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0349 | 0.0349 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0339 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0339 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0367 | 0.0367 |
Brugia malayi | FAD binding domain containing protein | 0.0339 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0339 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0339 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0939 | 0.0939 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0301 | 0.8796 | 0.8717 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0339 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.0367 | 0.0367 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0301 | 0.8796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0.0367 | 0.5955 | |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.013 | 0.3462 | 0.3033 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.013 | 0.3462 | 0.3033 |
Leishmania major | hypothetical protein, conserved | 0.013 | 0.3462 | 0.3033 |
Treponema pallidum | flavodoxin | 0.013 | 0.3462 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0168 | 0.4666 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0939 | 0.0939 |
Schistosoma mansoni | lamin | 0.0031 | 0.0367 | 0.0367 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0367 | 0.0367 |
Chlamydia trachomatis | Na(+)-translocating NADH-quinone reductase subunit F | 0.0039 | 0.0616 | 0.1035 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0939 | 0.0939 |
Echinococcus multilocularis | methionine synthase reductase | 0.021 | 0.595 | 0.595 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.541 | 0.541 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0367 | 0.0367 |
Leishmania major | p450 reductase, putative | 0.0339 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.013 | 0.3462 | 0.3033 |
Echinococcus multilocularis | geminin | 0.0192 | 0.541 | 0.541 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0039 | 0.0616 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.021 | 0.595 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0039 | 0.0616 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0339 | 1 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0039 | 0.0616 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0367 | 0.0367 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0339 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.021 | 0.595 | 0.595 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0367 | 0.0367 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0339 | 1 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.013 | 0.3462 | 0.3033 |
Brugia malayi | FAD binding domain containing protein | 0.021 | 0.595 | 0.595 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Leishmania major | cytochrome P450 reductase, putative | 0.0301 | 0.8796 | 0.8717 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.013 | 0.3462 | 0.3033 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0339 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0168 | 0.4666 | 0.4666 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0168 | 0.4666 | 1 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0039 | 0.0616 | 0.0616 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0039 | 0.0616 | 0.0616 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0367 | 0.0367 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0039 | 0.0616 | 0.0616 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0939 | 0.0939 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0367 | 0.0367 |
Onchocerca volvulus | 0.0039 | 0.0616 | 1 | |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.013 | 0.3462 | 0.3033 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0367 | 0.0367 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.