Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.013 | 0.3462 | 0.3033 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0039 | 0.0616 | 0.0616 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Loa Loa (eye worm) | flavodoxin family protein | 0.013 | 0.3462 | 0.3462 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0339 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.541 | 0.541 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0301 | 0.8796 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.021 | 0.595 | 0.595 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0339 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.013 | 0.3462 | 0.3033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0339 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0367 | 0.0367 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.013 | 0.3462 | 0.3033 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0339 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0339 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0367 | 0.0367 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0168 | 0.4666 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0039 | 0.0616 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0939 | 0.0939 |
Leishmania major | cytochrome P450 reductase, putative | 0.0301 | 0.8796 | 0.8717 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0367 | 0.0367 |
Brugia malayi | FAD binding domain containing protein | 0.021 | 0.595 | 0.595 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0939 | 0.0939 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0367 | 0.0367 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0339 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0301 | 0.8796 | 0.8159 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0367 | 0.0367 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0339 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0.0367 | 0.5955 | |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.013 | 0.3462 | 0.3462 |
Schistosoma mansoni | lamin | 0.0031 | 0.0367 | 0.0367 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0939 | 0.0939 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0367 | 0.0367 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0171 | 0.4746 | 0.4746 |
Onchocerca volvulus | 0.0031 | 0.0367 | 0.5955 | |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0339 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0367 | 0.0367 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0339 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.0367 | 0.0367 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0168 | 0.4666 | 0.4666 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.013 | 0.3462 | 0.3033 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0939 | 0.0939 |
Echinococcus granulosus | methionine synthase reductase | 0.021 | 0.595 | 0.595 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0039 | 0.0616 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0939 | 0.0939 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0367 | 0.0367 |
Trypanosoma cruzi | p450 reductase, putative | 0.0339 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0168 | 0.4666 | 1 |
Chlamydia trachomatis | Na(+)-translocating NADH-quinone reductase subunit F | 0.0039 | 0.0616 | 0.1035 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0939 | 0.0939 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.013 | 0.3462 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0367 | 0.0367 |
Giardia lamblia | Hypothetical protein | 0.0301 | 0.8796 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0339 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.013 | 0.3462 | 0.3033 |
Loa Loa (eye worm) | diaphorase | 0.0039 | 0.0616 | 0.0616 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0349 | 0.0349 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0039 | 0.0616 | 0.5 |
Echinococcus multilocularis | geminin | 0.0192 | 0.541 | 0.541 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0939 | 0.0939 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.013 | 0.3462 | 0.3033 |
Chlamydia trachomatis | sulfite reductase | 0.021 | 0.595 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0367 | 0.0367 |
Leishmania major | p450 reductase, putative | 0.0339 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0339 | 1 | 1 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0039 | 0.0616 | 0.0616 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0039 | 0.0616 | 0.0616 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0939 | 0.0939 |
Schistosoma mansoni | cytochrome B5 | 0.0039 | 0.0616 | 0.0616 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0339 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0339 | 1 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0301 | 0.8796 | 0.8717 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0039 | 0.0616 | 0.0616 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.021 | 0.595 | 0.595 |
Onchocerca volvulus | 0.0039 | 0.0616 | 1 | |
Brugia malayi | diaphorase | 0.0039 | 0.0616 | 0.0616 |
Echinococcus granulosus | geminin | 0.0192 | 0.541 | 0.541 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0939 | 0.0939 |
Treponema pallidum | flavodoxin | 0.013 | 0.3462 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0039 | 0.0616 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.541 | 0.541 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.021 | 0.595 | 0.595 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0367 | 0.0367 |
Entamoeba histolytica | type A flavoprotein, putative | 0.013 | 0.3462 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0339 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0039 | 0.0616 | 0.5 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0039 | 0.0616 | 0.0616 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.013 | 0.3462 | 0.3033 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0339 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.