Detailed information for compound 870656

Basic information

Technical information
  • TDR Targets ID: 870656
  • Name: ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-4,6,7, 8-tetrahydrochromene-3-carboxylate
  • MW: 347.793 | Formula: C18H18ClNO4
  • H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(N)OC2=C(C1c1ccc(cc1)Cl)C(=O)CCC2
  • InChi: 1S/C18H18ClNO4/c1-2-23-18(22)16-14(10-6-8-11(19)9-7-10)15-12(21)4-3-5-13(15)24-17(16)20/h6-9,14H,2-5,20H2,1H3
  • InChiKey: NAOZUHXAJDKWOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(4-chlorophenyl)-5-oxo-4,6,7,8-tetrahydrochromene-3-carboxylic acid ethyl ester
  • 2-amino-4-(4-chlorophenyl)-5-keto-4,6,7,8-tetrahydrochromene-3-carboxylic acid ethyl ester
  • Oprea1_500609
  • Oprea1_791582
  • ST5005732
  • BAS 00898967

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Toxoplasma gondii hypothetical protein 0.002 0.2113 0.2205
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.4321 0.4205
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0023 0.2769 0.2769
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0322 0.0322
Trichomonas vaginalis abcb9, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) AGC/AKT protein kinase 0.0037 0.5389 0.8397
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.4321 0.4321
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0665 0.0475
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.4321 0.4321
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0012 0.0665 0.0665
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0665 0.0665
Brugia malayi protein kinase C II. 0.0012 0.0665 0.1036
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0665 0.0665
Schistosoma mansoni multidrug resistance protein 0.0031 0.4321 0.4321
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0012 0.0665 0.0665
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0012 0.0665 0.0665
Trichomonas vaginalis abcb9, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Entamoeba histolytica P-glycoprotein-2 0.0031 0.4321 0.6627
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis nervana 2 0.0023 0.2721 0.2721
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.4321 0.4321
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.3199 0.3199
Trypanosoma cruzi ABC transporter, putative 0.001 0.0322 0.0038
Echinococcus multilocularis multidrug resistance associated protein 1 0.001 0.0285 0.0285
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.3536 0.3536
Entamoeba histolytica protein kinase, putative 0.0012 0.0665 0.0748
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0012 0.0665 0.0665
Trypanosoma brucei ATP-binding cassette protein, putative 0.001 0.0322 0.0038
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.0665 0.1036
Loa Loa (eye worm) hypothetical protein 0.002 0.2113 0.3293
Entamoeba histolytica protein kinase, putative 0.0037 0.5389 0.8345
Echinococcus multilocularis serine:threonine protein kinase 38 0.0012 0.0665 0.0665
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Toxoplasma gondii hypothetical protein 0.002 0.2113 0.2205
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.3199 0.4823
Loa Loa (eye worm) ABC transporter 0.0009 0.0043 0.0067
Echinococcus granulosus serine:threonine protein kinase N2 0.0012 0.0665 0.0665
Schistosoma mansoni multidrug resistance protein 0.0009 0.02 0.02
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0012 0.0665 0.0665
Entamoeba histolytica P-glycoprotein-5 0.0031 0.4321 0.6627
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0322 0.0322
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0042 0.6418 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.001 0.0285 0.0285
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus nervana 2 0.0023 0.2721 0.2721
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0023 0.2721 0.2721
Brugia malayi Hr1 repeat family protein 0.0012 0.0665 0.1036
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.3536 0.5509
Trichomonas vaginalis AGC family protein kinase 0.0014 0.1095 0.0914
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.001 0.0285 0.0285
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.3536 0.3536
Echinococcus granulosus ATP binding cassette sub family B 0.001 0.0285 0.0285
Echinococcus multilocularis Glutaredoxin protein 5 0.0023 0.2721 0.2721
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0322 0.0322
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Trichomonas vaginalis taga, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) AGC/NDR protein kinase 0.0012 0.0665 0.1036
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0012 0.0665 0.1036
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.2547 0.2547
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0012 0.0665 0.0665
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.3199 0.3199
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0042 0.6418 0.6418
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0012 0.0665 0.1036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0665 0.1036
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.4235 0.4235
Schistosoma mansoni smdr2 0.0031 0.4321 0.4321
Brugia malayi ABC transporter family protein 0.0009 0.0043 0.0067
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Toxoplasma gondii GAF domain-containing protein 0.002 0.2113 0.2205
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.4321 0.4205
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.3199 0.4823
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.4321 0.4867
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0322 0.02
Loa Loa (eye worm) hypothetical protein 0.0031 0.4235 0.6599
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.4235 0.4235
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Giardia lamblia ABC transporter 0.001 0.0236 0.0142
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.001 0.0285 0.0285
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Entamoeba histolytica protein kinase, putative 0.0037 0.5389 0.8345
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.2769 0.2557
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6345
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.8577 0.8548
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.4321 0.4867
Loa Loa (eye worm) hypothetical protein 0.001 0.0285 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.8577 0.8548
Brugia malayi ABC transporter family protein 0.001 0.0285 0.0444
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 1 1
Toxoplasma gondii AGC kinase 0.0035 0.496 0.5637
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.3536 0.3404
Giardia lamblia Kinase, AGC PKA 0.0023 0.2769 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.3536 0.5509
Plasmodium vivax hypothetical protein, conserved 0.002 0.2113 0.2981
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0042 0.6418 0.6418
Trichomonas vaginalis conserved hypothetical protein 0.002 0.2113 0.1953
Trypanosoma brucei rac serine-threonine kinase, putative 0.0037 0.5389 0.5254
Trypanosoma cruzi Protein kinase B 0.0025 0.3199 0.2999
Giardia lamblia Multidrug resistance-associated protein 1 0.001 0.0285 0.0333
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.4321 0.658
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 1 1
Mycobacterium ulcerans putative regulatory protein 0.002 0.2113 1
Schistosoma mansoni multidrug resistance protein 0.0031 0.4321 0.4321
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Schistosoma mansoni ABC transporter 0.0009 0.0043 0.0043
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.6313 0.6238
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0042 0.6418 0.7397
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0042 0.6418 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Loa Loa (eye worm) hypothetical protein 0.0009 0.02 0.0311
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) hypothetical protein 0.0031 0.4321 0.6732
Giardia lamblia ABC transporter, putative 0.001 0.0285 0.0333
Giardia lamblia Multidrug resistance-associated protein 1 0.001 0.0285 0.0333
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0322 0.0322
Plasmodium falciparum ABC transporter G family member 2 0.001 0.0322 0.006
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Mycobacterium leprae conserved hypothetical protein 0.002 0.2113 1
Schistosoma mansoni multidrug resistance protein 0.0031 0.4321 0.4321
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Brugia malayi multidrug resistance related protein 1 0.001 0.0285 0.0444
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.001 0.0285 0.0444
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6313
Trichomonas vaginalis abcb9, putative 0.0031 0.4321 0.4205
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Loa Loa (eye worm) ABC transporter 0.001 0.0285 0.0444
Brugia malayi ABC transporter family protein 0.001 0.0285 0.0444
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Brugia malayi multidrug resistance protein 3 0.0031 0.4321 0.6732
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0285 0.0087
Echinococcus granulosus protein kinase c iota type 0.0012 0.0665 0.0665
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.2113 0.453
Schistosoma mansoni smdr1 0.001 0.0285 0.0285
Echinococcus multilocularis protein kinase c iota type 0.0012 0.0665 0.0665
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Entamoeba histolytica multidrug resistance protein, putative 0.001 0.0285 0.0137
Brugia malayi ABC transporter transmembrane region family protein 0.001 0.0285 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.8577 0.8548
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.3199 0.3199
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.4321 0.4321
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0665 0.0475
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.2113 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0012 0.0617 0.0426
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Trypanosoma cruzi ATP-binding cassette protein, putative 0.001 0.0322 0.0038
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.6313 0.6205
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.3536 0.5509
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.2547 0.2547
Brugia malayi P-glycoprotein-like protein 0.001 0.0285 0.0444
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0012 0.0665 0.1036
Echinococcus granulosus serine threonine protein kinase nrc 0.0023 0.2769 0.2769
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6313
Schistosoma mansoni atypical protein kinase C 0.0012 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.001 0.0285 0.0444
Brugia malayi ABC transporter transmembrane region family protein 0.0009 0.02 0.0311
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.4321 0.6732
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.3199 0.3199
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0012 0.0665 0.0665
Entamoeba histolytica protein kinase 2, putative 0.0023 0.2769 0.4131
Entamoeba histolytica P-glycoprotein 6, putative 0.001 0.0285 0.0137
Brugia malayi Protein kinase domain containing protein 0.0037 0.5389 0.8397
Mycobacterium ulcerans putative regulatory protein 0.002 0.2113 1
Onchocerca volvulus 0.0031 0.4321 1
Entamoeba histolytica P-glycoprotein-2 0.0031 0.4321 0.6627
Entamoeba histolytica ABC transporter, putative 0.001 0.0285 0.0137
Entamoeba histolytica ABC transporter, putative 0.001 0.0322 0.0196
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0035 0.496 0.7727
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0023 0.2721 0.2721
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.4321 1
Brugia malayi ABC transporter 0.001 0.0285 0.0444
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.2113 0.2981
Echinococcus multilocularis 0.001 0.0285 0.0285
Giardia lamblia MRP-like ABC transporter 0.001 0.0285 0.0333
Loa Loa (eye worm) hypothetical protein 0.0009 0.02 0.0311
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.001 0.0322 0.0044
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.4321 0.6627
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6345
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0665 0.0475
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Schistosoma mansoni serine/threonine kinase 0.0012 0.0665 0.0665
Brugia malayi hypothetical protein 0.001 0.0285 0.0444
Echinococcus granulosus Protein kinase C brain isozyme 0.0012 0.0665 0.0665
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.001 0.0322 0.0038
Echinococcus multilocularis nervana 2 0.0023 0.2721 0.2721
Brugia malayi ABC transporter transmembrane region family protein 0.001 0.0285 0.0444
Loa Loa (eye worm) hypothetical protein 0.001 0.0285 0.0444
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0322 0.0322
Brugia malayi ABC transporter family protein 0.001 0.0285 0.0444
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 1 1
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Leishmania major p-glycoprotein 0.0031 0.4321 0.4154
Echinococcus granulosus nervana 2 0.0023 0.2721 0.2721
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0322 0.0322
Echinococcus granulosus NDR protein kinase 0.0012 0.0665 0.0665
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.3536 0.3536
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis serine threonine protein kinase 0.0012 0.0665 0.0665
Brugia malayi ABC transporter family protein 0.0031 0.4321 0.6732
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.001 0.0322 0.0038
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0322 0.02
Loa Loa (eye worm) ABC transporter 0.001 0.0285 0.0444
Toxoplasma gondii hypothetical protein 0.0054 0.8577 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Brugia malayi Protein kinase domain containing protein 0.0012 0.0665 0.1036
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.4321 0.4154
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0042 0.6418 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.001 0.0285 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0061 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.0665 0.0665
Entamoeba histolytica P-glycoprotein 6, putative 0.001 0.0285 0.0137
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.4321 0.6627
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0023 0.2769 0.2769
Brugia malayi ABC transporter 0.0009 0.02 0.0311
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.6313 0.6238
Echinococcus granulosus multidrug resistance associated protein 1 0.001 0.0285 0.0285
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0023 0.2769 0.405
Trypanosoma brucei ABC transporter, putative 0.001 0.0322 0.0038
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.001 0.0285 0.5
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0009 0.02 0.02
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.0665 0.0665
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.2547 0.2547
Entamoeba histolytica protein kinase, putative 0.0035 0.496 0.7654
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus Glutaredoxin protein 5 0.0023 0.2721 0.2721
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0035 0.496 0.7727
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.2113 0.453
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0009 0.02 0.02
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.3536 0.3404
Loa Loa (eye worm) ABC transporter 0.001 0.0285 0.0444
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0042 0.6418 0.6313
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.4321 0.6732
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.3199 0.2999
Plasmodium vivax ABC transporter G family member 2, putative 0.001 0.0322 0.006
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0042 0.6418 0.6418
Echinococcus granulosus protein kinase C gamma type 0.0012 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0031 0.4321 0.6732
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0322 0.02
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.2547 0.2396
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0023 0.2769 0.405
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.4321 0.5
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Brugia malayi Protein kinase domain containing protein 0.0012 0.0665 0.1036
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.4321 0.658
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.001 0.0285 0.5
Entamoeba histolytica P-glycoprotein-1 0.0031 0.4321 0.6627
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.3536 0.3404
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.4321 0.6627
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Entamoeba histolytica hypothetical protein 0.001 0.0285 0.0137
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0042 0.6418 0.6313
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.4321 0.4321
Echinococcus granulosus multidrug resistance associated protein 7 0.001 0.0285 0.0285
Loa Loa (eye worm) AGC/PKN protein kinase 0.0012 0.0665 0.1036
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0322 0.0322

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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