Detailed information for compound 870656

Basic information

Technical information
  • TDR Targets ID: 870656
  • Name: ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-4,6,7, 8-tetrahydrochromene-3-carboxylate
  • MW: 347.793 | Formula: C18H18ClNO4
  • H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(N)OC2=C(C1c1ccc(cc1)Cl)C(=O)CCC2
  • InChi: 1S/C18H18ClNO4/c1-2-23-18(22)16-14(10-6-8-11(19)9-7-10)15-12(21)4-3-5-13(15)24-17(16)20/h6-9,14H,2-5,20H2,1H3
  • InChiKey: NAOZUHXAJDKWOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(4-chlorophenyl)-5-oxo-4,6,7,8-tetrahydrochromene-3-carboxylic acid ethyl ester
  • 2-amino-4-(4-chlorophenyl)-5-keto-4,6,7,8-tetrahydrochromene-3-carboxylic acid ethyl ester
  • Oprea1_500609
  • Oprea1_791582
  • ST5005732
  • BAS 00898967

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.4321 0.658
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.4321 0.6732
Loa Loa (eye worm) hypothetical protein 0.0009 0.02 0.0311
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.3199 0.4823
Brugia malayi P-glycoprotein-like protein 0.001 0.0285 0.0444
Brugia malayi Protein kinase domain containing protein 0.0037 0.5389 0.8397
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.4321 0.4321
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0322 0.0322
Plasmodium vivax hypothetical protein, conserved 0.002 0.2113 0.2981
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0042 0.6418 0.6418
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.6313 0.6238
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Loa Loa (eye worm) ABC transporter 0.001 0.0285 0.0444
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.4235 0.4235
Loa Loa (eye worm) hypothetical protein 0.0031 0.4235 0.6599
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.001 0.0322 0.0038
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0042 0.6418 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.02 0.0311
Schistosoma mansoni atypical protein kinase C 0.0012 0.0665 0.0665
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Brugia malayi ABC transporter family protein 0.001 0.0285 0.0444
Echinococcus granulosus Glutaredoxin protein 5 0.0023 0.2721 0.2721
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.001 0.0285 0.0285
Echinococcus multilocularis nervana 2 0.0023 0.2721 0.2721
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.0665 0.1036
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Brugia malayi ABC transporter 0.001 0.0285 0.0444
Trypanosoma brucei ATP-binding cassette protein, putative 0.001 0.0322 0.0038
Entamoeba histolytica protein kinase, putative 0.0037 0.5389 0.8345
Entamoeba histolytica ABC transporter, putative 0.001 0.0285 0.0137
Entamoeba histolytica protein kinase, putative 0.0035 0.496 0.7654
Trichomonas vaginalis AGC family protein kinase 0.0014 0.1095 0.0914
Toxoplasma gondii hypothetical protein 0.002 0.2113 0.2205
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0042 0.6418 0.6313
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Brugia malayi protein kinase C II. 0.0012 0.0665 0.1036
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Schistosoma mansoni multidrug resistance protein 0.0031 0.4321 0.4321
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.4235 0.4235
Entamoeba histolytica P-glycoprotein-2 0.0031 0.4321 0.6627
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0012 0.0665 0.1036
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Brugia malayi ABC transporter 0.0009 0.02 0.0311
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0042 0.6418 0.6418
Echinococcus multilocularis 0.001 0.0285 0.0285
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0042 0.6418 0.6418
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 1 1
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0665 0.0475
Loa Loa (eye worm) ABC transporter 0.001 0.0285 0.0444
Giardia lamblia Multidrug resistance-associated protein 1 0.001 0.0285 0.0333
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis protein kinase c iota type 0.0012 0.0665 0.0665
Echinococcus granulosus multidrug resistance associated protein 1 0.001 0.0285 0.0285
Entamoeba histolytica P-glycoprotein 6, putative 0.001 0.0285 0.0137
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.4321 0.6627
Loa Loa (eye worm) AGC/NDR protein kinase 0.0012 0.0665 0.1036
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0012 0.0617 0.0426
Loa Loa (eye worm) hypothetical protein 0.001 0.0285 0.0444
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0012 0.0665 0.1036
Brugia malayi ABC transporter transmembrane region family protein 0.001 0.0285 0.0444
Entamoeba histolytica P-glycoprotein-1 0.0031 0.4321 0.6627
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0322 0.0322
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0322 0.0322
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.6313 0.6205
Loa Loa (eye worm) AGC/PKN protein kinase 0.0012 0.0665 0.1036
Trichomonas vaginalis taga, putative 0.0031 0.4321 0.4205
Leishmania major p-glycoprotein 0.0031 0.4321 0.4154
Brugia malayi multidrug resistance related protein 1 0.001 0.0285 0.0444
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Schistosoma mansoni smdr1 0.001 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0012 0.0665 0.1036
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.4321 0.4867
Mycobacterium ulcerans putative regulatory protein 0.002 0.2113 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Plasmodium vivax ABC transporter G family member 2, putative 0.001 0.0322 0.006
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0322 0.0322
Mycobacterium ulcerans putative regulatory protein 0.002 0.2113 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.001 0.0285 0.0444
Loa Loa (eye worm) hypothetical protein 0.0031 0.4321 0.6732
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Schistosoma mansoni smdr2 0.0031 0.4321 0.4321
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0322 0.02
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0665 0.0475
Echinococcus granulosus ATP binding cassette sub family B 0.001 0.0285 0.0285
Entamoeba histolytica protein kinase, putative 0.0012 0.0665 0.0748
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.4321 0.4321
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Echinococcus granulosus ATP binding cassette sub family B 0.001 0.0285 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0035 0.496 0.7727
Toxoplasma gondii GAF domain-containing protein 0.002 0.2113 0.2205
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.2547 0.2547
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.4321 0.658
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0042 0.6418 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0012 0.0665 0.1036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.3199 0.4823
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0665 0.0665
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Brugia malayi ABC transporter transmembrane region family protein 0.001 0.0285 0.0444
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.0665 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.8577 0.8548
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.0665 0.0665
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.2547 0.2547
Loa Loa (eye worm) ABC transporter 0.0009 0.0043 0.0067
Echinococcus multilocularis Glutaredoxin protein 5 0.0023 0.2721 0.2721
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.2547 0.2547
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.8577 0.8548
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.4321 0.4321
Toxoplasma gondii hypothetical protein 0.002 0.2113 0.2205
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0023 0.2769 0.405
Trichomonas vaginalis abcb9, putative 0.0031 0.4321 0.4205
Echinococcus granulosus serine threonine protein kinase nrc 0.0023 0.2769 0.2769
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Echinococcus granulosus protein kinase c iota type 0.0012 0.0665 0.0665
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0042 0.6418 0.7397
Schistosoma mansoni multidrug resistance protein 0.0031 0.4321 0.4321
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0023 0.2769 0.2769
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Trypanosoma brucei ABC transporter, putative 0.001 0.0322 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.2113 0.3293
Echinococcus multilocularis serine threonine protein kinase 0.0012 0.0665 0.0665
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0012 0.0665 0.0665
Echinococcus granulosus NDR protein kinase 0.0012 0.0665 0.0665
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0012 0.0665 0.0665
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Loa Loa (eye worm) hypothetical protein 0.001 0.0285 0.0444
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.3536 0.3404
Echinococcus granulosus nervana 2 0.0023 0.2721 0.2721
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.3199 0.2999
Schistosoma mansoni serine/threonine kinase 0.0012 0.0665 0.0665
Echinococcus granulosus Protein kinase C brain isozyme 0.0012 0.0665 0.0665
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Entamoeba histolytica protein kinase 2, putative 0.0023 0.2769 0.4131
Brugia malayi ABC transporter transmembrane region family protein 0.0009 0.02 0.0311
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0322 0.02
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.4321 0.4205
Trypanosoma cruzi ABC transporter, putative 0.001 0.0322 0.0038
Entamoeba histolytica P-glycoprotein 6, putative 0.001 0.0285 0.0137
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0023 0.2721 0.2721
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.4321 0.6627
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Trichomonas vaginalis conserved hypothetical protein 0.002 0.2113 0.1953
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.3199 0.3199
Entamoeba histolytica hypothetical protein 0.001 0.0285 0.0137
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0009 0.02 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.2113 0.453
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.2547 0.2396
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.3536 0.3404
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0322 0.0322
Giardia lamblia Kinase, AGC PKA 0.0023 0.2769 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.001 0.0322 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0012 0.0665 0.0665
Entamoeba histolytica P-glycoprotein-5 0.0031 0.4321 0.6627
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0042 0.6418 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Brugia malayi ABC transporter family protein 0.001 0.0285 0.0444
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Plasmodium falciparum ABC transporter G family member 2 0.001 0.0322 0.006
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.2113 0.2981
Schistosoma mansoni ABC transporter 0.0009 0.0043 0.0043
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Echinococcus granulosus ATP binding cassette sub family B 0.0009 0.02 0.02
Giardia lamblia ABC transporter 0.001 0.0236 0.0142
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.001 0.0285 0.5
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6345
Giardia lamblia Multidrug resistance-associated protein 1 0.001 0.0285 0.0333
Entamoeba histolytica P-glycoprotein-2 0.0031 0.4321 0.6627
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.4321 0.4321
Echinococcus multilocularis nervana 2 0.0023 0.2721 0.2721
Echinococcus multilocularis multidrug resistance associated protein 7 0.001 0.0285 0.0285
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.6313 0.6238
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Brugia malayi p70 ribosomal S6 kinase beta 0.0035 0.496 0.7727
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.8577 0.8548
Toxoplasma gondii AGC kinase 0.0035 0.496 0.5637
Loa Loa (eye worm) hypothetical protein 0.0031 0.4321 0.6732
Loa Loa (eye worm) ABC transporter 0.001 0.0285 0.0444
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.4321 0.4205
Echinococcus granulosus protein kinase C gamma type 0.0012 0.0665 0.0665
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.4321 0.6627
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.3536 0.3536
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.2113 0.453
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.4321 0.4205
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 1 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.001 0.0285 0.0444
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.3536 0.3536
Echinococcus granulosus nervana 2 0.0023 0.2721 0.2721
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.2769 0.2557
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.3199 0.3199
Loa Loa (eye worm) AGC/AKT protein kinase 0.0037 0.5389 0.8397
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.4321 0.5
Onchocerca volvulus 0.0031 0.4321 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6313
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0665 0.0665
Schistosoma mansoni multidrug resistance protein 0.0009 0.02 0.02
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0012 0.0665 0.0665
Brugia malayi ABC transporter family protein 0.0031 0.4321 0.6732
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0322 0.0322
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0012 0.0665 0.0665
Trypanosoma cruzi Protein kinase B 0.0025 0.3199 0.2999
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.3199 0.3199
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis abcb9, putative 0.0031 0.4321 0.4205
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Brugia malayi ABC transporter family protein 0.001 0.0285 0.0444
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0023 0.2769 0.405
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.2113 1
Trypanosoma cruzi ATP-binding cassette protein, putative 0.001 0.0322 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.3536 0.5509
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0023 0.2721 0.2721
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.001 0.0322 0.0038
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.001 0.0285 0.0444
Toxoplasma gondii hypothetical protein 0.0054 0.8577 1
Echinococcus granulosus multidrug resistance associated protein 7 0.001 0.0285 0.0285
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0285 0.0087
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.4321 0.6732
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0285 0.0285
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Brugia malayi Protein kinase domain containing protein 0.0012 0.0665 0.1036
Schistosoma mansoni multidrug resistance protein 0.0031 0.4321 0.4321
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0023 0.2769 0.2769
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Echinococcus multilocularis multidrug resistance associated protein 1 0.001 0.0285 0.0285
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.4321 0.4321
Brugia malayi Hr1 repeat family protein 0.0012 0.0665 0.1036
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.3536 0.3404
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0042 0.6418 1
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Brugia malayi ABC transporter family protein 0.0009 0.0043 0.0067
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.4321 0.4321
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.4321 1
Brugia malayi Protein kinase domain containing protein 0.0012 0.0665 0.1036
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 1 1
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0665 0.0475
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Brugia malayi hypothetical protein 0.001 0.0285 0.0444
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.4321 0.4867
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0665 0.0665
Giardia lamblia ABC transporter, putative 0.001 0.0285 0.0333
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0012 0.0665 0.0665
Mycobacterium leprae conserved hypothetical protein 0.002 0.2113 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0037 0.5389 0.5254
Entamoeba histolytica ABC transporter, putative 0.001 0.0322 0.0196
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0012 0.0665 0.0665
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.3199 0.3199
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.4321 0.4321
Trichomonas vaginalis abcb9, putative 0.0031 0.4321 0.4205
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.3536 0.3536
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0322 0.0322
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6345
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0042 0.6418 0.6313
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0322 0.02
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0042 0.6418 0.6313
Schistosoma mansoni multidrug resistance protein 0.001 0.0285 0.0285
Brugia malayi multidrug resistance protein 3 0.0031 0.4321 0.6732
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 1 1
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.001 0.0285 0.5
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 1 1
Entamoeba histolytica multidrug resistance protein, putative 0.001 0.0285 0.0137
Entamoeba histolytica protein kinase, putative 0.0037 0.5389 0.8345
Entamoeba histolytica ATP-binding cassette protein, putative 0.001 0.0285 0.0137
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0012 0.0665 0.0665
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 1 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.3536 0.5509
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.4321 0.4154
Trichomonas vaginalis AGC family protein kinase 0.0037 0.5389 0.5296
Trichomonas vaginalis ABC transporter, putative 0.0031 0.4321 0.4205
Trichomonas vaginalis conserved hypothetical protein 0.0061 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.3536 0.5509
Echinococcus multilocularis serine:threonine protein kinase 38 0.0012 0.0665 0.0665
Giardia lamblia MRP-like ABC transporter 0.001 0.0285 0.0333

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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