Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0534 | 0.9614 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0338 | 0.5567 | 0.5567 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0094 | 0.0558 | 0.0558 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0204 | 0.2819 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0204 | 0.2819 | 0.5 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0094 | 0.0558 | 0.0558 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Echinococcus granulosus | serotonin transporter | 0.0553 | 1 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0204 | 0.2819 | 0.5 |
Brugia malayi | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Echinococcus granulosus | voltage gated potassium channel | 0.0098 | 0.0638 | 0.0638 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0094 | 0.0558 | 0.0558 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0094 | 0.0558 | 0.0558 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0136 | 0.1432 | 0.0965 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0553 | 1 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0094 | 0.0558 | 0.0558 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0338 | 0.5567 | 0.5567 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0136 | 0.1432 | 0.1432 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0136 | 0.1432 | 0.0965 |
Chlamydia trachomatis | peptide deformylase | 0.0534 | 0.9614 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0136 | 0.1432 | 0.1432 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0094 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0098 | 0.0638 | 0.0638 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0369 | 0.6204 | 0.6204 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0094 | 0.0558 | 0.0558 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0136 | 0.1432 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0369 | 0.6204 | 0.6204 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0315 | 0.511 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.0638 | 0.0638 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0553 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0136 | 0.1432 | 0.2802 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0094 | 0.0558 | 0.0558 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0553 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0094 | 0.0558 | 0.0558 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0098 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0136 | 0.1432 | 0.2802 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Plasmodium vivax | peptide deformylase, putative | 0.0534 | 0.9614 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0094 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0638 | 0.0638 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0534 | 0.9614 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0101 | 0.0705 | 0.1379 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0338 | 0.5567 | 0.5567 |
Onchocerca volvulus | 0.0553 | 1 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0098 | 0.0638 | 0.0638 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1432 | 0.1432 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0204 | 0.2819 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0094 | 0.0558 | 0.0558 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0094 | 0.0558 | 0.0558 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0136 | 0.1432 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0094 | 0.0558 | 0.0558 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0094 | 0.0558 | 0.0558 |
Mycobacterium ulcerans | peptide deformylase | 0.0534 | 0.9614 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0136 | 0.1432 | 0.2802 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0094 | 0.0558 | 0.0558 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0534 | 0.9614 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0094 | 0.0558 | 0.0558 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0315 | 0.511 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0553 | 1 | 1 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0136 | 0.1432 | 0.1432 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0136 | 0.1432 | 0.1432 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0204 | 0.2819 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0553 | 1 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0204 | 0.2819 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0338 | 0.5567 | 0.5567 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0094 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0558 | 0.0558 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0136 | 0.1432 | 0.1432 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.0638 | 0.0638 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0094 | 0.0558 | 0.0558 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0204 | 0.2819 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0094 | 0.0558 | 0.0558 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0094 | 0.0558 | 0.0558 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0098 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | serotonin transporter b | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0094 | 0.0558 | 0.0558 |
Plasmodium falciparum | peptide deformylase | 0.0534 | 0.9614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.465 | 0.465 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.0705 | 0.0162 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0553 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0534 | 0.9614 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.