TDR Targets

Basic information

Technical information

TDR Targets ID: 873194
Name: 4-[[3-[(3-fluorophenyl)methyl]imidazo[5,4-b]p yridin-2-yl]sulfanylmethyl]-N-propylbenzamide
MW: 434.529 | Formula: C24H23FN4OS
H donors: 1 H acceptors: 3 LogP: 4.91 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(=O)c1ccc(cc1)CSc1nc2c(n1Cc1cccc(c1)F)nccc2
InChi: 1S/C24H23FN4OS/c1-2-12-27-23(30)19-10-8-17(9-11-19)16-31-24-28-21-7-4-13-26-22(21)29(24)15-18-5-3-6-20(25)14-18/h3-11,13-14H,2,12,15-16H2,1H3,(H,27,30)
InChiKey: CYMFLPCKKNEXGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[3-[(3-fluorophenyl)methyl]imidazo[5,4-b]pyridin-2-yl]sulfanylmethyl]-N-propyl-benzamide
4-[[[3-[(3-fluorophenyl)methyl]-2-imidazo[5,4-b]pyridinyl]thio]methyl]-N-propylbenzamide
4-[[[3-(3-fluorobenzyl)imidazo[5,4-b]pyridin-2-yl]thio]methyl]-N-propyl-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0341	0.0344	0.0344
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0341	0.0344	0.0341
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0341	0.0344	0.0341
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0341	0.0344	0.0572
Echinococcus multilocularis	integrin beta 2	0.0226	0.0216	0.0213
Echinococcus multilocularis	neuropeptide receptor A26	0.0453	0.0469	0.0466
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0341	0.0344	0.1883
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Leishmania major	tyrosine specific protein phosphatase, putative	0.0341	0.0344	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0341	0.0344	0.0341
Onchocerca volvulus		0.0341	0.0344	0.0491
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Brugia malayi	hypothetical protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0029	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.5372	0.5973	1
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0341	0.0344	0.0344
Schistosoma mansoni	hypothetical protein	0.0166	0.0148	0.0148
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0017	0.0017
Schistosoma mansoni	integrin beta subunit	0.018	0.0164	0.0164
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.8971	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.5372	0.5973	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0046	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Schistosoma mansoni	protein tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus granulosus	integrin beta 2	0.0226	0.0216	0.0213
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0029	1
Onchocerca volvulus		0.5372	0.5973	1
Onchocerca volvulus	4.1 G protein, putative homolog	0.0341	0.0344	0.0491
Onchocerca volvulus		0.0341	0.0344	0.0491
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0029	0.0044
Trichomonas vaginalis	pten, drome, putative	0.0341	0.0344	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0341	0.0344	0.0341
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0341	0.0344	0.0344
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0341	0.0344	0.0344
Schistosoma mansoni	pcd6 interacting protein-related	0.0341	0.0344	0.0344
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0341	0.0344	0.0344
Brugia malayi	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.3716	0.412	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0341	0.0344	0.0341
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0341	0.0344	0.0341
Brugia malayi	hypothetical protein	0.0341	0.0344	0.0344
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0341	0.0344	0.0344
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.5372	0.5973	1
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0003	0.0003
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0003	0.0003
Brugia malayi	Inositol-1	0.0036	0.0003	0.0003
Onchocerca volvulus		0.0341	0.0344	0.0491
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.5372	0.5973	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Brugia malayi	hypothetical protein	0.0046	0.0015	0.0015
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Brugia malayi	Kelch motif family protein	0.0046	0.0015	0.0015
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.5372	0.5973	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0029	0.0029
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0341	0.0344	0.0341
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.5372	0.5973	0.5973
Onchocerca volvulus		0.0341	0.0344	0.0491
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Onchocerca volvulus		0.0341	0.0344	0.0491
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0341	0.0344	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0017	0.0017
Loa Loa (eye worm)	integrin beta-2	0.0305	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Brugia malayi	Protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.1656	0.1815	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.8971	1	1
Onchocerca volvulus		0.0341	0.0344	0.0491
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0017	0.0017
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0054	0.0054
Schistosoma mansoni	protein tyrosine phosphatase	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0341	0.0344	0.0344
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0029	0.0144
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.0054	0.0051
Onchocerca volvulus		0.0341	0.0344	0.0491
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1656	0.1815	0.3036
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0341	0.0344	0.0341
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.5372	0.5973	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.5372	0.5973	1
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Echinococcus multilocularis		0.0341	0.0344	0.0341
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0341	0.0344	0.1883
Brugia malayi	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Echinococcus multilocularis	hypothetical protein	0.0341	0.0344	0.0341
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0341	0.0344	0.0572
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Onchocerca volvulus		0.0341	0.0344	0.0491
Echinococcus multilocularis	neuropeptide s receptor	0.0453	0.0469	0.0466
Schistosoma mansoni	protein tyrosine phosphatase	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Echinococcus granulosus	neuropeptide s receptor	0.0453	0.0469	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Onchocerca volvulus		0.0341	0.0344	0.0491
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.0054	0.0054
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0341	0.0344	0.0341
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0341	0.0344	0.0344
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Trypanosoma cruzi	hypothetical protein, conserved	0.1656	0.1815	1
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0341	0.0344	0.0344
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0341	0.0344	0.1883
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0341	0.0344	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.0054	0.0051
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Onchocerca volvulus		0.0341	0.0344	0.0491
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	inositol-1	0.0036	0.0003	0.0003
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.5372	0.5973	0.5973
Brugia malayi	Protein-tyrosine phosphatase 1	0.0341	0.0344	0.0344
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0341	0.0344	0.0341
Echinococcus multilocularis	geminin	0.0166	0.0148	0.0145
Onchocerca volvulus		0.0341	0.0344	0.0491
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0029	0.0026
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0341	0.0344	0.0341
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0341	0.0344	0.0344
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.5372	0.5973	1
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0341	0.0344	0.1883
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus granulosus	neuropeptide receptor A26	0.0453	0.0469	0.0466
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0029	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Trypanosoma cruzi	hypothetical protein, conserved	0.1656	0.1815	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0794	0.0851	0.0848
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0341	0.0344	0.0341
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0341	0.0344	0.0344
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Echinococcus granulosus	geminin	0.0166	0.0148	0.0145
Schistosoma mansoni	hypothetical protein	0.0166	0.0148	0.0148
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0341	0.0344	0.0341
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0341	0.0344	0.0572
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Leishmania major	hypothetical protein, conserved	0.1656	0.1815	1
Onchocerca volvulus		0.0341	0.0344	0.0491
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1656	0.1815	0.3036
Brugia malayi	Protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0341	0.0344	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Brugia malayi	Integrin beta pat-3 precursor	0.0305	0.0304	0.0304
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0341	0.0344	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0015	0.0015
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0341	0.0344	0.0341
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.5372	0.5973	1
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0341	0.0344	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.0344	0.0344
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0341	0.0344	0.0341
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.8971	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0341	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0344	0.0344
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.0054	0.0054
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.8971	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0029	0.0026
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0017	0.0017
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.5372	0.5973	1
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0341	0.0344	0.0344

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 873194