TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.29 | Formula: C20H20Cl2N2O3
H donors: 3 H acceptors: 3 LogP: 4.32 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N[C@H]1C[C@@H](Nc2c1c(Cl)cc(c2)Cl)C(=O)O)CCCc1ccccc1
InChi: 1S/C20H20Cl2N2O3/c21-13-9-14(22)19-15(10-13)23-17(20(26)27)11-16(19)24-18(25)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-10,16-17,23H,4,7-8,11H2,(H,24,25)(H,26,27)/t16-,17+/m0/s1
InChiKey: DBAWGZLWFPLLGA-DLBZAZTESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	Glutamate (NMDA) receptor subunit zeta 1	938 aa	822 aa	23.2 %
Drosophila melanogaster	NMDA receptor 2	Glutamate (NMDA) receptor subunit zeta 1	938 aa	878 aa	27.4 %
Drosophila melanogaster	Glutamate receptor IA	Glutamate (NMDA) receptor subunit zeta 1	938 aa	979 aa	23.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0159	0.0595
Onchocerca volvulus		0.0015	0.0135	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0533	0.1987
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0533	0.0617
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0104	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2201	0.8208
Schistosoma mansoni	sugar transporter	0.0015	0.0135	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0333	0.1369
Onchocerca volvulus		0.0015	0.0135	0.5
Entamoeba histolytica	protein kinase, putative	0.0032	0.0533	1
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0333	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0518	0.2128
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.2201	0.8208
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0333	0.1243
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0533	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0518	0.2128
Schistosoma mansoni	sugar transporter	0.0015	0.0135	0.0595
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0533	0.1987
Onchocerca volvulus		0.0015	0.0135	0.5
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0533	0.219
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0533	0.1927
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0518	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0333	1
Onchocerca volvulus		0.0015	0.0135	0.5
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0533	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0159	0.0655
Entamoeba histolytica	protein kinase, putative	0.0032	0.0533	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.2201	0.3201
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0518	0.1932
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0533	0.1987
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0533	0.0404
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0135	0.0502
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0518	0.2287
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0023	0.0318	0.9458
Brugia malayi	major facilitator superfamily protein	0.0015	0.0135	0.0553
Leishmania major	glucose transporter, lmgt3	0.0033	0.0542	0.8107
Chlamydia trachomatis	glutamine binding protein	0.0023	0.0318	0.9458
Schistosoma mansoni	sugar transporter	0.0015	0.0135	0.0595
Brugia malayi	major facilitator superfamily protein	0.0015	0.0135	0.0553
Onchocerca volvulus		0.0015	0.0135	0.5
Onchocerca volvulus		0.0015	0.0135	0.5
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0533	0.0404
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0637	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0159	0.0595
Leishmania major	protein kinase, putative	0.0032	0.0533	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0581	0.2386
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0333	0.1243
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0135	0.0502
Onchocerca volvulus		0.0015	0.0135	0.5
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0135	0.0502
Schistosoma mansoni	sugar transporter	0.0015	0.0135	0.0595
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0135	0.2954
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0518	0.2128
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0159	0.0655
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0637	0.051
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0135	0.2954
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0333	0.0201
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0542	0.1973
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0023	0.0318	1
Brugia malayi	MH2 domain containing protein	0.0116	0.2433	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Echinococcus granulosus	General substrate transporter	0.0091	0.1863	0.6947
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0104	0.0389
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0104	0.0389
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0135	0.0553
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0533	0.0404
Schistosoma mansoni	protein kinase	0.0032	0.0533	0.2353
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0487	0.1817
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0487	0.1817
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0542	0.8107
Schistosoma mansoni	glutamate receptor NMDA	0.0109	0.2264	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0104	0.0389
Brugia malayi	hypothetical protein	0.0015	0.0135	0.0553
Schistosoma mansoni	hypothetical protein	0.0106	0.2201	0.972
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0135	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0135	0.0502
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0533	0.0404
Plasmodium vivax	CDK-related protein kinase 6, putative	0.045	1	1
Echinococcus granulosus	glutamate receptor 2	0.0014	0.0104	0.0389
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0014	0.0104	0.0389
Brugia malayi	Sugar transporter family protein	0.0015	0.0135	0.0553
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0637	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0533	0.0404
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0135	0.0553
Brugia malayi	Sugar transporter family protein	0.0106	0.2201	0.9044
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0135	0.0502
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0542	0.8107
Onchocerca volvulus		0.0015	0.0135	0.5
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Schistosoma mansoni	hypothetical protein	0.0016	0.0159	0.0704
Brugia malayi	Cam kinase protein 1	0.0032	0.0533	0.219
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0542	0.1973
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0518	0.1855
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0637	0.0779
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0533	0.1987
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0542	0.8107
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0014	0.0104	0.0389
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2201	0.8208
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0159	0.0595
Onchocerca volvulus		0.0015	0.0135	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0159	0.0655
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0333	0.3046
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0023	0.0318	0.9458
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2201	0.8208
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0533	0.1987
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Echinococcus granulosus	solute carrier family 22	0.0015	0.0135	0.0502
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Echinococcus granulosus	solute carrier family 22	0.0015	0.0135	0.0502
Schistosoma mansoni	hypothetical protein	0.0016	0.0159	0.0704
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0333	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0159	0.0595
Onchocerca volvulus	Putative transporter	0.0015	0.0135	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Schistosoma mansoni	glucose transporter	0.0015	0.0135	0.0595
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0171	0.3681	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0135	0.0553
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Onchocerca volvulus		0.0015	0.0135	0.5
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0333	0.0201
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0023	0.0318	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0127	0.2681	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2201	0.8208
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0637	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0518	0.2287
Brugia malayi	Sugar transporter family protein	0.0015	0.0135	0.0553
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0542	0.8107
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0135	0.5
Echinococcus multilocularis	glutamate receptor 2	0.0014	0.0104	0.0389
Mycobacterium ulcerans	sugar transporter	0.0015	0.0135	0.2954
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0542	0.1973
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0104	0.0389
Schistosoma mansoni	hypothetical protein	0.0016	0.0159	0.0704
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0533	0.2353
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0333	0.395
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0518	0.2128
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0943	0.3877
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0581	0.2386
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0032	0.0521	0.1944
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0135	0.0595
Schistosoma mansoni	hypothetical protein	0.0035	0.0581	0.2564
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0159	0.0595
Schistosoma mansoni	protein kinase	0.0032	0.0533	0.2353
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2201	0.8208
Loa Loa (eye worm)	sugar transporter	0.0106	0.2201	0.9044
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0171	0.3681	0.3595
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0518	0.1932
Schistosoma mansoni	hypothetical protein	0.0016	0.0159	0.0704
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0518	0.9253
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0159	0.0655
Echinococcus granulosus	solute carrier family 22	0.0015	0.0135	0.0502
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0542	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2201	0.8208
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0333	0.5182
Echinococcus granulosus	glutamate receptor NMDA	0.0095	0.1956	0.7297
Brugia malayi	hypothetical protein	0.0015	0.0135	0.0553
Onchocerca volvulus		0.0015	0.0135	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0533	0.1987
Echinococcus multilocularis	nmda type glutamate receptor	0.01	0.2061	0.7686
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0135	0.0502
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0533	0.0617
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0533	0.1987
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0542	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0383	0.1572
Echinococcus granulosus	nmda type glutamate receptor	0.01	0.2061	0.7686
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0533	0.0617
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0533	0.0404
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0333	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0943	0.3877
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0533	0.0404
Echinococcus multilocularis	General substrate transporter	0.0091	0.1863	0.6947
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0542	0.8107
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0533	0.219
Plasmodium falciparum	protein kinase 7	0.03	0.6589	0.6542
Echinococcus granulosus	nmda type glutamate receptor	0.0127	0.2681	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0637	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0542	0.1973
Onchocerca volvulus		0.0015	0.0135	0.5
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0637	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0542	0.1973
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.2201	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0171	0.3681	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0533	0.219
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Onchocerca volvulus		0.0015	0.0135	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.2433	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0542	0.8107
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0637	0.051
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.2433	1
Schistosoma mansoni	glucose transport protein	0.0106	0.2201	0.972
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0943	0.3877
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0135	0.0502
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0159	0.0595
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0267	0.0641
Plasmodium falciparum	hexose transporter	0.0106	0.2201	0.2094
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0333	0.395
Echinococcus multilocularis	glutamate receptor NMDA	0.0095	0.1956	0.7297
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0518	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Brugia malayi	hypothetical protein	0.0015	0.0135	0.0553
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0333	0.0961
Onchocerca volvulus		0.0015	0.0135	0.5
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0252	0.6421
Leishmania major	glucose transporter, lmgt1	0.0033	0.0542	0.8107
Loa Loa (eye worm)	sugar transporter	0.0015	0.0135	0.0553
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0533	0.0404
Plasmodium vivax	hexose transporter	0.0106	0.2201	0.2094
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0333	0.1472
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0093	0.0381
Schistosoma mansoni	glucose transport protein	0.0106	0.2201	0.972
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0135	0.0553
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0204	0.1383
Trypanosoma cruzi	hexose transporter	0.0033	0.0542	0.8107
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0533	0.219
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0542	0.8107
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0333	1
Onchocerca volvulus		0.0015	0.0135	0.5
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0135	0.2954
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0542	0.8107
Schistosoma mansoni	glucose transport protein	0.0106	0.2201	0.972
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0135	0.0502
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0333	0.395
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0252	0.6421
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0104	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0135	0.0553
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0333	0.1472
Schistosoma mansoni	protein kinase	0.0032	0.0533	0.2353
Onchocerca volvulus		0.0015	0.0135	0.5
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0542	0.8107
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0023	0.0318	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0135	0.0502
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0943	0.3877
Leishmania major	glucose transporter, lmgt2	0.0033	0.0542	0.8107
Toxoplasma gondii	protein kinase, putative	0.03	0.6589	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0542	0.1973
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0533	0.1987
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2201	0.8208

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.17 uM	Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.	ChEMBL.	1534584
IC50 (binding)	= 0.17 uM	Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.	ChEMBL.	1534584
Kb (functional)	= 1.7 uM	Compound was evaluated for antagonism of depolarizations due to NMDA in a rat cortical slice preparation	ChEMBL.	1534584
Kb (functional)	= 1.7 uM	Compound was evaluated for antagonism of depolarizations due to NMDA in a rat cortical slice preparation	ChEMBL.	1534584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL57937

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 87343