Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.5999 | 0.6857 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.1547 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0943 | 0.1335 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.5999 | 0.849 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.7066 | 0.7346 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0381 | 0.0436 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.8749 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.051 | 0.199 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0224 | 0.9619 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.051 | 0.5 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0224 | 0.9619 | 1 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0224 | 0.9619 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.2565 | 0.363 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.1392 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0991 | 0.6407 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0381 | 0.1487 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.051 | 0.0722 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.1547 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.051 | 0.0531 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.1355 | 0.1917 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.1392 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0991 | 0.4637 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0224 | 0.9619 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.2565 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.1547 | 0.2189 |
Echinococcus granulosus | geminin | 0.0166 | 0.7066 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0991 | 0.1403 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0381 | 0.0436 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.2565 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0991 | 0.1133 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0381 | 0.1487 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.051 | 0.0531 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0991 | 0.103 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.1547 | 0.1092 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.051 | 0.0583 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.5822 | 0.824 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.051 | 0.33 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.2565 | 0.2931 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.8749 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.051 | 0.0531 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.051 | 0.0583 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.051 | 0.0531 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0991 | 0.1403 |
Leishmania major | cytochrome p450-like protein | 0.0016 | 0.0381 | 0.1487 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.5999 | 0.6237 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0224 | 0.9619 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0991 | 0.103 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0016 | 0.0381 | 0.0396 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.051 | 0.199 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.2565 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.2565 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.2565 | 0.2666 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0991 | 0.1133 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.051 | 0.199 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.1355 | 0.1917 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.7066 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0381 | 0.0436 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0991 | 0.103 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.2565 | 0.2931 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0991 | 0.103 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.2565 | 0.363 |
Trypanosoma brucei | cytochrome P450, putative | 0.0016 | 0.0381 | 0.1487 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0073 | 0.0084 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.051 | 0.199 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0381 | 0.0436 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0991 | 0.1403 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.1547 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.051 | 0.0722 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.1392 | 0.4293 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.7066 | 0.7346 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.5999 | 0.6857 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.2565 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0381 | 0.0436 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.1547 | 0.1092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.