TDR Targets

Basic information

Technical information

TDR Targets ID: 873872
Name: 1-(3,4-difluorophenyl)-3-[(4-methoxyphenyl)me thylamino]pyrazin-2-one
MW: 343.327 | Formula: C18H15F2N3O2
H donors: 1 H acceptors: 1 LogP: 2.51 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CNc1nccn(c1=O)c1ccc(c(c1)F)F
InChi: 1S/C18H15F2N3O2/c1-25-14-5-2-12(3-6-14)11-22-17-18(24)23(9-8-21-17)13-4-7-15(19)16(20)10-13/h2-10H,11H2,1H3,(H,21,22)
InChiKey: GEQDMCHVPGVOEM-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

1-(3,4-difluorophenyl)-3-[(4-methoxyphenyl)methylamino]-2-pyrazinone
1-(3,4-difluorophenyl)-3-[(4-methoxybenzyl)amino]pyrazin-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0632	0.3321	0.3321
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0632	0.3321	0.3321
Brugia malayi	EGF-like domain containing protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Echinococcus granulosus	neural cadherin	0.0309	0.0028	0.006
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Brugia malayi	notch-like transmembrane receptor	0.0309	0.0028	0.0028
Echinococcus granulosus	fibropellin Ia	0.0309	0.0028	0.006
Brugia malayi	EGF-like domain containing protein	0.0309	0.0028	0.0028
Echinococcus granulosus	slit 2 protein	0.0309	0.0028	0.006
Echinococcus granulosus	Tolloid protein 1	0.0632	0.3321	0.7162
Echinococcus multilocularis	laminin	0.0632	0.3321	0.7162
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Onchocerca volvulus		0.1287	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1287	1	1
Echinococcus multilocularis	enteropeptidase	0.0761	0.4637	1
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0632	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1287	1	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0632	0.3321	0.7166
Echinococcus granulosus	neurogenic locus notch protein 4	0.0309	0.0028	0.006
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Echinococcus multilocularis	tissue type plasminogen activator	0.0759	0.4623	0.9971
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Echinococcus multilocularis	protein jagged 1	0.0309	0.0028	0.006
Toxoplasma gondii	PAN domain-containing protein	0.0488	0.1858	0.3981
Plasmodium falciparum	cysteine repeat modular protein 1	0.0759	0.4623	0.5
Onchocerca volvulus	Arrow homolog	0.0632	0.3321	0.3302
Echinococcus granulosus	glycoprotein Antigen 5	0.0761	0.4637	1
Echinococcus granulosus	neurogenic locus notch protein	0.0309	0.0028	0.006
Loa Loa (eye worm)	hypothetical protein	0.0632	0.3321	0.3321
Echinococcus multilocularis	slit 2 protein	0.0309	0.0028	0.006
Echinococcus granulosus	protein jagged 2	0.0309	0.0028	0.006
Schistosoma mansoni	hypothetical protein	0.0759	0.4623	0.4608
Brugia malayi	Cadherin domain containing protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0632	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Brugia malayi	EGF-like domain containing protein	0.0309	0.0028	0.0028
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0309	0.0028	0.006
Brugia malayi	Cadherin domain containing protein	0.0309	0.0028	0.0028
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0309	0.0028	0.006
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0632	0.3321	0.3321
Echinococcus multilocularis	Mastin	0.0761	0.4637	1
Brugia malayi	GCC2 and GCC3 family protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	notch protein	0.0309	0.0028	0.0028
Brugia malayi	Calcium binding EGF domain containing protein	0.0632	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Giardia lamblia	High cysteine protein	0.0309	0.0028	0.5
Echinococcus granulosus	protein jagged 2	0.0309	0.0028	0.006
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0632	0.3321	0.3302
Echinococcus multilocularis	neurogenic locus protein delta	0.0309	0.0028	0.006
Echinococcus granulosus	neurogenic locus notch protein	0.0309	0.0028	0.006
Brugia malayi	EGF-like domain containing protein	0.0309	0.0028	0.0028
Echinococcus granulosus	Mastin	0.0761	0.4637	1
Echinococcus multilocularis	fibrillin 1	0.0632	0.3321	0.7162
Schistosoma mansoni	voltage-gated potassium channel	0.0334	0.0286	0.0259
Echinococcus granulosus	tissue type plasminogen activator	0.0759	0.4623	0.9971
Echinococcus multilocularis	Tolloid protein 1	0.0632	0.3321	0.7162
Echinococcus multilocularis	notch	0.0309	0.0028	0.006
Toxoplasma gondii	PAN domain-containing protein	0.0488	0.1858	0.3981
Echinococcus multilocularis	glycoprotein Antigen 5	0.0761	0.4637	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0759	0.4623	0.5
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0759	0.4623	0.5
Loa Loa (eye worm)	hypothetical protein	0.1287	1	1
Onchocerca volvulus		0.0759	0.4623	0.4608
Echinococcus multilocularis	neurogenic locus notch protein	0.0309	0.0028	0.006
Toxoplasma gondii	kringle domain-containing protein	0.0759	0.4623	1
Brugia malayi	EGF-like domain containing protein	0.0309	0.0028	0.0028
Brugia malayi	Calcium binding EGF domain containing protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0632	0.3321	0.7166
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0761	0.4637	0.4622
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0632	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	TK/ROR protein kinase	0.0759	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Brugia malayi	EGF-like domain containing protein	0.0309	0.0028	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0759	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Brugia malayi	Delta serrate ligand family protein	0.0309	0.0028	0.0028
Brugia malayi	Kringle domain containing protein	0.0759	0.4623	0.4623
Echinococcus granulosus	neurogenic locus protein delta	0.0309	0.0028	0.006
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Brugia malayi	EGF-like domain containing protein	0.0309	0.0028	0.0028
Echinococcus multilocularis	fibropellin Ia	0.0309	0.0028	0.006
Loa Loa (eye worm)	Notch2	0.0309	0.0028	0.0028
Leishmania major	hypothetical protein, conserved	0.0759	0.4623	0.5
Echinococcus multilocularis	protein jagged 1	0.0309	0.0028	0.006
Schistosoma mansoni	voltage-gated potassium channel	0.0334	0.0286	0.0259
Brugia malayi	Muscle positioning protein 4	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0759	0.4623	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Brugia malayi	Calcium binding EGF domain containing protein	0.0309	0.0028	0.0028
Brugia malayi	Fibulin-1 precursor	0.0632	0.3321	0.3321
Brugia malayi	Calcium binding EGF domain containing protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Echinococcus multilocularis	neural cadherin	0.0309	0.0028	0.006
Onchocerca volvulus		0.0991	0.6989	0.698
Echinococcus granulosus	notch	0.0309	0.0028	0.006
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.1287	1	1
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0632	0.3321	0.3321
Echinococcus granulosus	protein jagged 1	0.0309	0.0028	0.006
Echinococcus granulosus	laminin	0.0632	0.3321	0.7162
Echinococcus multilocularis	neurogenic locus notch protein	0.0309	0.0028	0.006
Echinococcus multilocularis	neurogenic locus protein delta	0.0309	0.0028	0.006
Echinococcus granulosus	protein jagged 1	0.0309	0.0028	0.006
Schistosoma mansoni	egf-like domain protein	0.0632	0.3321	0.3302
Echinococcus multilocularis	protein jagged 2	0.0309	0.0028	0.006
Echinococcus granulosus	delta-like protein 1	0.0309	0.0028	0.006
Echinococcus granulosus	enteropeptidase	0.0761	0.4637	1
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0632	0.3321	0.3321

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 873872