TDR Targets

Basic information

Technical information

TDR Targets ID: 875333
Name: N-[5-(diethylsulfamoyl)-1,3,4-thiadiazol-2-yl ]-3-methylbenzamide
MW: 354.448 | Formula: C14H18N4O3S2
H donors: 1 H acceptors: 5 LogP: 2.11 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(S(=O)(=O)c1nnc(s1)NC(=O)c1cccc(c1)C)CC
InChi: 1S/C14H18N4O3S2/c1-4-18(5-2)23(20,21)14-17-16-13(22-14)15-12(19)11-8-6-7-10(3)9-11/h6-9H,4-5H2,1-3H3,(H,15,16,19)
InChiKey: CQNYFPJBQOKZIF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[5-(diethylsulfamoyl)-1,3,4-thiadiazol-2-yl]-3-methyl-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0022	0.0472	0.0472
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.0472	0.0472
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.5179	0.6991
Schistosoma mansoni	nuclear hormone receptor	0.0047	0.1628	0.2108
Leishmania major	cathepsin L-like protease	0.0016	0.0203	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.0472	0.0472
Schistosoma mansoni	thyroid hormone receptor	0.0169	0.7368	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.0472	0.0533
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Loa Loa (eye worm)	hypothetical protein	0.0094	0.3869	0.3869
Brugia malayi	ecdysone receptor	0.0022	0.0472	0.0472
Onchocerca volvulus		0.0094	0.3869	1
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0472	0.0518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Echinococcus granulosus	Ankyrin	0.0014	0.01	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.0472	0.0472
Schistosoma mansoni	hypothetical protein	0.0066	0.2551	0.3377
Onchocerca volvulus		0.0047	0.1628	0.4063
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0472	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0014	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Schistosoma mansoni	nuclear receptor	0.0022	0.0472	0.0518
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0596	0.0689
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Brugia malayi	Common central domain of tyrosinase family protein	0.0094	0.3869	0.3869
Schistosoma mansoni	retinoic acid receptor RXR	0.0142	0.6123	0.8288
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0047	0.1628	0.2108
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0203	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0472	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0095	0.000000053742
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.0472	0.0533
Schistosoma mansoni	hypothetical protein	0.0164	0.7167	0.9723
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0047	0.1628	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.0472	0.0472
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0071	0.2797	0.3821
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.0472	0.0533
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0203	0.5
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.5179	0.719
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0047	0.1628	0.1628
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Echinococcus granulosus	FTZ F1 alpha	0.0047	0.1628	0.2168
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0047	0.1628	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0079	0.3163	0.3163
Leishmania major	cathepsin L-like protease	0.0016	0.0203	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Brugia malayi	nuclear receptor RXR	0.0025	0.0596	0.0596
Brugia malayi	nuclear receptor RXR	0.0022	0.0472	0.0472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0203	0.0286
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.01	0.0008
Echinococcus multilocularis	FTZ F1 alpha	0.0047	0.1628	0.2108
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0047	0.1628	0.2108
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0472	0.0533
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0203	0.0148
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0047	0.1628	0.4063
Onchocerca volvulus		0.0094	0.3869	1
Loa Loa (eye worm)	DR-78	0.0022	0.0472	0.0472
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0472	0.0518
Brugia malayi	bZIP transcription factor family protein	0.0081	0.3268	0.3268
Leishmania major	cathepsin L-like protease	0.0016	0.0203	0.0863
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.0472	0.0518
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0071	0.2797	0.3715
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Echinococcus multilocularis	jun protein	0.0081	0.3268	0.4363
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.0472	0.0518
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0203	0.0203
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0472	0.0472
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0203	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Brugia malayi	nuclear receptor NHR-67	0.0022	0.0472	0.0472
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0142	0.6123	0.8524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Onchocerca volvulus		0.0016	0.0203	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Loa Loa (eye worm)	STAT protein	0.0161	0.7037	0.7037
Brugia malayi	hypothetical protein	0.0022	0.0472	0.0472
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0169	0.7368	1
Brugia malayi	nuclear hormone receptor	0.0047	0.1628	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.2096	0.8925
Brugia malayi	Death domain containing protein	0.0014	0.0095	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.3869	0.3869
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.2348	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0047	0.1628	0.1628
Brugia malayi	nuclear hormone receptor	0.0022	0.0472	0.0472
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0095	0.000000052255
Plasmodium vivax	vivapain-2	0.0016	0.0203	0.5
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0203	0.0203
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0047	0.1628	0.1628
Brugia malayi	Uncoordinated protein 44	0.0014	0.0095	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Loa Loa (eye worm)	fibroinase	0.0016	0.0203	0.0203
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0472	0.0518
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0047	0.1628	0.1628
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0047	0.1628	0.1628
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0094	0.3869	0.3869
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0203	0.0148
Onchocerca volvulus	Bile acid receptor homolog	0.0047	0.1628	0.4063
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0472	0.0518
Brugia malayi	hypothetical protein	0.0064	0.2446	0.2446
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0047	0.1628	0.1628
Schistosoma mansoni	zinc finger protein	0.0022	0.0472	0.0518
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0203	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0203	0.0148
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0047	0.1628	0.1628
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0224	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0047	0.1628	0.2108
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0047	0.1628	0.1628
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0203	0.0863
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0047	0.1628	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.0596
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0047	0.1628	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0203	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0081	0.3268	0.4363
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0047	0.1628	0.1628
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0025	0.0596	0.0689
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0047	0.1628	0.2108
Onchocerca volvulus		0.0016	0.0203	0.0286
Schistosoma mansoni	hypothetical protein	0.0122	0.5179	0.6991
Onchocerca volvulus		0.0016	0.0203	0.0286
Onchocerca volvulus		0.0064	0.2446	0.623
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0081	0.3268	0.4487
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0047	0.1628	0.1628
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0472	0.0518
Brugia malayi	nuclear receptor NHR-88	0.0047	0.1628	0.1628
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Brugia malayi	conserved hypotetical protein	0.0022	0.0472	0.0472
Loa Loa (eye worm)	ctsf protein	0.0016	0.0203	0.0203
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0596	0.0596
Brugia malayi	tailless protein	0.0022	0.0472	0.0472
Brugia malayi	photoreceptor-specific nuclear receptor	0.0047	0.1628	0.1628
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.3869	0.3869
Schistosoma mansoni	jun-related protein	0.0066	0.2551	0.3377
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0203	0.0286
Onchocerca volvulus	Protein ultraspiracle homolog	0.0047	0.1628	0.4063
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0047	0.1628	0.2108
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0203	0.0203
Brugia malayi	ecdysteroid receptor	0.0047	0.1628	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0203	0.0203
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0047	0.1628	0.2168
Plasmodium vivax	vivapain-2	0.0016	0.0203	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0047	0.1628	0.1628
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0047	0.1628	0.2108
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0161	0.7037	0.7037
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0472	0.0999
Schistosoma mansoni	RAR-like nuclear receptor	0.0047	0.1628	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Leishmania major	cathepsin L-like protease	0.0062	0.2348	1
Brugia malayi	hypothetical protein	0.0025	0.0596	0.0596
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0025	0.0596	0.0596
Echinococcus granulosus	geminin	0.0164	0.7167	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0095	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0203	0.5
Schistosoma mansoni	coup transcription factor	0.0047	0.1628	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0095	0.0095
Echinococcus multilocularis	cysteine protease	0.0016	0.0203	0.0148
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0025	0.0596	0.0708
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0203	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Echinococcus multilocularis	Ankyrin	0.0014	0.01	0.0008
Loa Loa (eye worm)	tyrosinase 1	0.0094	0.3869	0.3869
Brugia malayi	Nuclear hormone receptor-like 1	0.0047	0.1628	0.1628
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.0472	0.0472
Brugia malayi	ShTK domain containing protein	0.0094	0.3869	0.3869
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0047	0.1628	0.2108
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0095	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0047	0.1628	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Onchocerca volvulus		0.0016	0.0203	0.0286
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.3869	0.3869
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0596	0.0596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0047	0.1628	0.1628
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0203	0.0863
Brugia malayi	hypothetical protein	0.0025	0.0596	0.0596
Onchocerca volvulus		0.0094	0.3869	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0047	0.1628	0.2108
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0203	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0047	0.1628	0.1628
Leishmania major	cathepsin L-like protease	0.0062	0.2348	1
Brugia malayi	Steroid receptor seven-up type 2	0.0047	0.1628	0.1628
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.0472	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0047	0.1628	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0203	0.5
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0025	0.0596	0.0689
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0047	0.1628	0.2108
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2348	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0047	0.1628	0.1628
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0095	0.000000052255
Loa Loa (eye worm)	cysteine protease	0.0016	0.0203	0.0203
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Onchocerca volvulus		0.0016	0.0203	0.0286
Onchocerca volvulus		0.0094	0.3869	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.0472	0.0472
Leishmania major	cathepsin L-like protease	0.0062	0.2348	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0047	0.1628	0.2168
Leishmania major	cathepsin L-like protease	0.0016	0.0203	0.0863
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2348	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0203	0.0203
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2348	1
Echinococcus granulosus	cathepsin l1	0.0016	0.0203	0.0153
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.3869	0.3869
Echinococcus multilocularis	geminin	0.0164	0.7167	0.9723
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0047	0.1628	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0203	0.0203
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.1725	0.7348
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.0472	0.0518
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0047	0.1628	0.2108
Schistosoma mansoni	tyrosinase precursor	0.0094	0.3869	0.5188
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0047	0.1628	0.2108
Leishmania major	cathepsin L-like protease	0.0016	0.0203	0.0863
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Schistosoma mansoni	thyroid hormone receptor	0.0169	0.7368	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0117	0.4967	0.6698
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.0596
Toxoplasma gondii	cathepsin CPL	0.0016	0.0203	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2348	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0203	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.0472	0.0518
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0472	0.0472
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0047	0.1628	0.1628
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0203	0.0203
Loa Loa (eye worm)	steroid hormone receptor	0.0047	0.1628	0.1628
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0203	0.5
Schistosoma mansoni	hypothetical protein	0.0164	0.7167	0.9723
Onchocerca volvulus		0.0016	0.0203	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0094	0.3869	0.3869
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0203	0.0148
Brugia malayi	steroid hormone receptor	0.0047	0.1628	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0472	0.0533
Schistosoma mansoni	nuclear receptor	0.0022	0.0472	0.0518
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0203	0.0203
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0203	0.0153
Echinococcus multilocularis	ecdysone induced protein 78C	0.0047	0.1628	0.2108
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.3869	0.3869
Onchocerca volvulus		0.0022	0.0472	0.0999
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0047	0.1628	0.1628
Echinococcus granulosus	ecdysone induced protein 78C	0.0047	0.1628	0.2168
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0203	0.0153
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0047	0.1628	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1628	0.1628
Echinococcus multilocularis	cysteine protease	0.0016	0.0203	0.0148
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0472	0.0533
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0203	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.0596
Onchocerca volvulus		0.0022	0.0472	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0472	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.0596
Onchocerca volvulus		0.0016	0.0203	0.0286
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0203	0.0148
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0047	0.1628	0.2168
Schistosoma mansoni	tyrosinase precursor	0.0094	0.3869	0.5188
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0047	0.1628	0.2168
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0203	0.0148
Echinococcus granulosus	jun protein	0.0081	0.3268	0.4487

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875333