TDR Targets

Basic information

Technical information

TDR Targets ID: 876354
Name: N-(4-bromophenyl)-4-pyrimidin-2-ylpiperazine- 1-carboxamide
MW: 362.224 | Formula: C15H16BrN5O
H donors: 1 H acceptors: 3 LogP: 2.01 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCN(CC1)c1ncccn1)Nc1ccc(cc1)Br
InChi: 1S/C15H16BrN5O/c16-12-2-4-13(5-3-12)19-15(22)21-10-8-20(9-11-21)14-17-6-1-7-18-14/h1-7H,8-11H2,(H,19,22)
InChiKey: QDQGRYAIINYPJR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-bromophenyl)-4-pyrimidin-2-yl-piperazine-1-carboxamide
N-(4-bromophenyl)-4-(2-pyrimidinyl)-1-piperazinecarboxamide
Oprea1_379450

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.228	1	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0375	0.1531	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0058	0.012	0.0228
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase	0.0058	0.012	0.012
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1217	0.5273	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1217	0.5273	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0058	0.012	0.012
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1217	0.5273	1
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0058	0.012	0.012
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase 1	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0058	0.012	0.012
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.228	1	1
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1217	0.5273	0.5273
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.228	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0011	0.0011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Schistosoma mansoni	hypothetical protein	0.0164	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0058	0.012	0.012
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0058	0.012	0.012
Mycobacterium tuberculosis	Probable oxidoreductase	0.121	0.5243	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0058	0.012	0.012
Onchocerca volvulus		0.1217	0.5273	1
Echinococcus multilocularis	geminin	0.0164	0.0592	0.0592
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.012	0.012
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0375	0.1531	0.2738
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Trypanosoma cruzi	hypothetical protein, conserved	0.0375	0.1531	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0375	0.1531	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Schistosoma mansoni	pcd6 interacting protein-related	0.0058	0.012	0.012
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.228	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0079	0.0079
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0375	0.1531	0.2738
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Leishmania major	hypothetical protein, conserved	0.0375	0.1531	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0058	0.012	0.012
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Schistosoma mansoni	protein tyrosine phosphatase	0.0058	0.012	0.012
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1217	0.5273	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0058	0.012	0.012
Brugia malayi	hypothetical protein	0.0058	0.012	0.012
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0058	0.012	0.011
Brugia malayi	hypothetical protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0058	0.012	0.012
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0058	0.012	0.012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase	0.0058	0.012	0.012
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0058	0.012	0.012
Brugia malayi	hypothetical protein	0.0058	0.012	0.012
Echinococcus multilocularis		0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0079	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Brugia malayi	hypothetical protein	0.0058	0.012	0.012
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0058	0.012	0.012
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1217	0.5273	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Schistosoma mansoni	hypothetical protein	0.0033	0.0011	0.0011
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0058	0.012	0.011
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0058	0.012	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0058	0.012	0.011
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1217	0.5273	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1217	0.5273	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0058	0.012	0.0228
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0058	0.012	0.012
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0058	0.012	0.012
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Echinococcus granulosus	geminin	0.0164	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0058	0.012	0.012
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0058	0.012	0.012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Brugia malayi	hypothetical protein	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1217	0.5273	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0079	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1217	0.5273	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0058	0.012	0.011
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0058	0.012	0.012
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0058	0.012	0.012
Echinococcus multilocularis	hypothetical protein	0.0058	0.012	0.012
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1217	0.5273	0.5268
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.012	0.012
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1217	0.5273	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Schistosoma mansoni	hypothetical protein	0.0164	0.0592	0.0592
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.012	0.012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.012	0.011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.012	0.011
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.012	0.012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0058	0.012	0.012
Schistosoma mansoni	protein tyrosine phosphatase	0.0058	0.012	0.012
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0058	0.012	0.012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 876354