Detailed information for compound 883719

Basic information

Technical information
  • TDR Targets ID: 883719
  • Name: butyl 2-[[4-(2,5-dimethylphenyl)piperazine-1- carbonyl]amino]benzoate
  • MW: 409.521 | Formula: C24H31N3O3
  • H donors: 1 H acceptors: 2 LogP: 5.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)c1ccccc1NC(=O)N1CCN(CC1)c1cc(C)ccc1C
  • InChi: 1S/C24H31N3O3/c1-4-5-16-30-23(28)20-8-6-7-9-21(20)25-24(29)27-14-12-26(13-15-27)22-17-18(2)10-11-19(22)3/h6-11,17H,4-5,12-16H2,1-3H3,(H,25,29)
  • InChiKey: VBIAWZJKZQELIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[[4-(2,5-dimethylphenyl)-1-piperazinyl]-oxomethyl]amino]benzoic acid butyl ester
  • 2-[[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]amino]benzoic acid butyl ester
  • butyl 2-[[4-(2,5-dimethylphenyl)piperazin-1-yl]carbonylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0557 0.0456
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0076 0.0953 0.5729
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0465 0.2155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.0056
Loa Loa (eye worm) cyclin domain-containing protein 0.0035 0.0175 0.0026
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.0269 0.0112
Brugia malayi Fibronectin type III domain containing protein 0.0055 0.0541 0.1766
Echinococcus granulosus tyrosine protein kinase Lyn 0.0057 0.0596 0.0503
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0037 0.0212 0.0925
Schistosoma mansoni cell adhesion molecule 0.0062 0.0688 0.1314
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0069 0.0822 0.0683
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0055 0.0541 0.0904
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0546
Trichomonas vaginalis cyclin B, putative 0.0056 0.0575 0.3281
Toxoplasma gondii propionate-CoA ligase 0.0037 0.0205 0.4227
Loa Loa (eye worm) hypothetical protein 0.0068 0.0802 0.0663
Loa Loa (eye worm) hypothetical protein 0.0125 0.1881 0.1758
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0072 0.0871 0.0832
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0111 0.1612 1
Echinococcus multilocularis roundabout 2 0.0068 0.0802 0.155
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.0205 0.0546
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0557 0.0456
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0055 0.0541 0.0938
Echinococcus multilocularis Immunoglobulin 0.0055 0.0541 0.0904
Trichomonas vaginalis cyclins, putative 0.0056 0.0575 0.3281
Brugia malayi protein-tyrosine kinase 0.0048 0.0415 0.1157
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0557 0.0456
Schistosoma mansoni nephrin 0.0061 0.0656 0.1232
Trichomonas vaginalis cyclin B, putative 0.0056 0.0575 0.3281
Brugia malayi Immunoglobulin I-set domain containing protein 0.0069 0.0822 0.3125
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0125 0.1881 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0205 0.0056
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0111 0.1612 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0088 0.1183 0.5905
Leishmania major cyclin 0.0056 0.0575 0.2212
Loa Loa (eye worm) hypothetical protein 0.0055 0.0541 0.0397
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.1881 1
Loa Loa (eye worm) oxidoreductase 0.0037 0.0205 0.0056
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.0205 0.0546
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.1612 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0465 0.0716
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0546
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0209 0.3466 0.3934
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0205 0.0377
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.028 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.1881 1
Echinococcus granulosus tyrosine kinase 0.0048 0.0415 0.0286
Brugia malayi Immunoglobulin I-set domain containing protein 0.0125 0.1876 0.8215
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0557 0.0943
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0055 0.0541 0.0938
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0465 0.1697
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0557 0.0456
Trichomonas vaginalis cyclin D, putative 0.0035 0.0175 0.0688
Loa Loa (eye worm) hypothetical protein 0.0055 0.0541 0.0397
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.1184 0.6071
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.1881 1
Echinococcus granulosus neuroglian 0.0061 0.0656 0.0574
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0465 0.2564
Giardia lamblia G2/mitotic-specific cyclin B 0.0056 0.0575 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.1881 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0051 0.0465 0.032
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0037 0.0212 0.0193
Giardia lamblia Hypothetical protein 0.0035 0.0175 0.3046
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.1881 1
Trichomonas vaginalis cyclin A, putative 0.0056 0.0575 0.3281
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0205 0.0142
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0546
Loa Loa (eye worm) hypothetical protein 0.0097 0.1337 0.1206
Plasmodium falciparum acyl-CoA synthetase 0.0094 0.1281 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.1281 0.1149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0557 0.0943
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0055 0.0557 0.0456
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0205 0.0377
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0209 0.3466 0.8135
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.0056
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0119 0.1761 0.392
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.0205 0.0546
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0125 0.1881 1
Brugia malayi SRC-1 0.0055 0.0557 0.1843
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.1281 0.6421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0125 0.1881 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0094 0.1281 1
Brugia malayi hypothetical protein 0.0055 0.0541 0.1766
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.1881 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0546
Echinococcus multilocularis tyrosine protein kinase Abl 0.0112 0.1625 0.3583
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0465 0.032
Loa Loa (eye worm) hypothetical protein 0.0094 0.1281 0.1149
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0037 0.0212 0.0094
Echinococcus granulosus cyclin dependent kinase 0.0051 0.0465 0.0346
Loa Loa (eye worm) hypothetical protein 0.0125 0.1881 0.1758
Trichomonas vaginalis cyclins, putative 0.0035 0.0175 0.0688
Loa Loa (eye worm) hypothetical protein 0.0072 0.0871 0.0732
Trichomonas vaginalis cyclin B3, putative 0.0035 0.0175 0.0688
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0054 0.0523 0.9097
Echinococcus multilocularis neuroglian 0.0061 0.0656 0.1188
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.0205 0.0546
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0557 0.0943
Trypanosoma cruzi cyclin, putative 0.0056 0.0575 0.2911
Brugia malayi Protein kinase domain containing protein 0.0051 0.0465 0.1398
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0205 0.0056
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.0415 0.0286
Loa Loa (eye worm) hypothetical protein 0.0048 0.0425 0.028
Trichomonas vaginalis cyclin D, putative 0.0035 0.0175 0.0688
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0205 0.0142
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0465 0.032
Brugia malayi AMP-binding enzyme family protein 0.0125 0.1881 0.824
Echinococcus multilocularis cyclin dependent kinase 6 0.0191 0.3133 0.7313
Trichomonas vaginalis cyclins, putative 0.0056 0.0575 0.3281
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0205 0.0879
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0205 0.0142
Loa Loa (eye worm) SRC-1 0.0055 0.0557 0.0413
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.0101
Loa Loa (eye worm) TK/ABL protein kinase 0.0249 0.4221 0.4133
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0094 0.1281 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0249 0.4221 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0205 0.0142
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0209 0.3466 0.8438
Schistosoma mansoni tyrosine kinase 0.0119 0.1761 0.4066
Mycobacterium ulcerans hypothetical protein 0.0125 0.1881 1
Onchocerca volvulus 0.0125 0.1881 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0249 0.4221 0.4836
Brugia malayi AMP-binding enzyme family protein 0.0125 0.1881 0.824
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0051 0.0465 0.1551
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0037 0.0205 0.4227
Loa Loa (eye worm) hypothetical protein 0.0062 0.0688 0.0546
Schistosoma mansoni tyrosine kinase 0.0241 0.4075 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0119 0.1761 0.392
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.1881 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0098 0.1361 0.573
Plasmodium vivax protein kinase Crk2 0.0051 0.0465 0.2416
Entamoeba histolytica protein kinase, putative 0.004 0.0269 0.055
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0051 0.0465 0.0346
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0212 0.0177
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0465 0.8077
Brugia malayi Cyclin, N-terminal domain containing protein 0.0056 0.0575 0.1933
Trichomonas vaginalis cyclin B, putative 0.0035 0.0175 0.0688
Loa Loa (eye worm) hypothetical protein 0.0094 0.1281 0.1149
Loa Loa (eye worm) phosphatidylinositol 3 0.0186 0.3036 0.293
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.0415 0.0286
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0051 0.0465 1
Trichomonas vaginalis cyclin B, putative 0.0056 0.0575 0.3281
Loa Loa (eye worm) TK protein kinase 0.0125 0.1876 0.1753
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0125 0.1881 1
Onchocerca volvulus 0.0056 0.0575 0.2212
Brugia malayi AMP-binding enzyme family protein 0.0125 0.1881 0.824
Trypanosoma cruzi cyclin 6, putative 0.0056 0.0575 0.2911
Echinococcus granulosus fibroblast growth factor receptor 4 0.0119 0.1761 0.1896
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0465 0.0716
Plasmodium falciparum protein kinase 5 0.0051 0.0465 0.2618
Loa Loa (eye worm) hypothetical protein 0.0055 0.0541 0.0397
Brugia malayi Tyrosine-protein kinase abl-1 0.0145 0.2246 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0465 0.2564
Brugia malayi Cyclin, N-terminal domain containing protein 0.0056 0.0575 0.1933
Schistosoma mansoni tyrosine kinase 0.0055 0.0557 0.0978
Echinococcus granulosus cyclin dependent kinase 1 0.0051 0.0465 0.0346
Trypanosoma brucei mitotic cyclin 6 0.0056 0.0575 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0125 0.1881 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0055 0.0557 0.0943
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0055 0.0557 0.0456
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0205 0.0142
Echinococcus granulosus cyclin dependent kinase 6 0.0191 0.3133 0.3537
Loa Loa (eye worm) hypothetical protein 0.0055 0.0541 0.0397
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0465 0.2564
Trypanosoma cruzi CYC2-like cyclin, putative 0.0056 0.0575 0.2911
Trypanosoma brucei cdc2-related kinase 3 0.0051 0.0465 0.7015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0541 0.1766
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0049 0.0441 0.1558
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.1184 0.6071
Loa Loa (eye worm) TK protein kinase 0.004 0.0269 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.1612 0.6942
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.0415 0.0592
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.0205 0.0073
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.0205 0.0546
Echinococcus granulosus roundabout 2 0.0068 0.0802 0.075
Schistosoma mansoni vesicular amine transporter 0.0055 0.0541 0.0938
Echinococcus granulosus Immunoglobulin 0.0055 0.0541 0.0437
Trichomonas vaginalis cyclins, putative 0.0056 0.0575 0.3281
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0037 0.0212 0.0214
Trichomonas vaginalis cyclins, putative 0.0056 0.0575 0.3281
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.1881 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.0269 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0465 0.0742
Trypanosoma cruzi cyclin, putative 0.0056 0.0575 0.2911
Schistosoma mansoni cyclin B 0.0056 0.0575 0.1026
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.1612 1
Entamoeba histolytica hypothetical protein 0.0088 0.1183 0.5905
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0465 0.2155
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.0205 0.0035
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0108 0.155 0.8059
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0056 0.0575 0.2212
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0072 0.0871 0.172
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.0205 0.0142
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0037 0.0212 0.0426
Loa Loa (eye worm) hypothetical protein 0.0055 0.0541 0.0397
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0051 0.0465 0.1551
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0465 0.2155
Loa Loa (eye worm) TK protein kinase 0.0048 0.0415 0.0269
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0076 0.0953 0.5729
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0119 0.1761 0.1896
Loa Loa (eye worm) hypothetical protein 0.0068 0.0802 0.0663
Echinococcus multilocularis cyclin B 0.0056 0.0575 0.0989
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0205 0.0879
Entamoeba histolytica cyclin, putative 0.0056 0.0575 0.2346
Echinococcus multilocularis Immunoglobulin 0.0055 0.0541 0.0904
Loa Loa (eye worm) hypothetical protein 0.0055 0.0541 0.0397
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0415 0.0592
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0205 0.0377
Brugia malayi cell division control protein 2 homolog 0.0051 0.0465 0.1398
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0557 0.0943
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0037 0.0212 0.0925
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0037 0.0212 0.0214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0072 0.0871 0.336
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.1184 0.6071
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0205 0.0377
Loa Loa (eye worm) hypothetical protein 0.0094 0.1281 0.1149
Echinococcus multilocularis cyclin dependent kinase 0.0051 0.0465 0.0716
Schistosoma mansoni tyrosine kinase 0.0055 0.0557 0.0978
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0055 0.0557 0.0943
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0055 0.0557 0.0943
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0125 0.1881 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.0205 0.0546
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0477 0.854 1
Echinococcus granulosus defective proboscis extension response 0.0055 0.0541 0.0437
Giardia lamblia Cyclin A 0.0035 0.0175 0.3046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.1184 0.6071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.1881 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0112 0.1625 0.7002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0037 0.0205 0.4227
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0125 0.1881 1
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.0205 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.3133 0.7586
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.028 0.0125
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0055 0.0557 0.0943
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0055 0.0557 0.0943
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.1612 0.8424
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.1881 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0051 0.0465 0.0716
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.0415 0.0592
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0037 0.0212 0.0925
Trichomonas vaginalis cyclin B, putative 0.0056 0.0575 0.3281
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0465 0.1697
Loa Loa (eye worm) hypothetical protein 0.0125 0.1881 0.1758
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0465 0.0742
Trypanosoma brucei cdc2-related kinase 1 0.0051 0.0465 0.7015
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0037 0.0205 0.0266
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.1612 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.0205 0.0546
Loa Loa (eye worm) hypothetical protein 0.0056 0.0575 0.0432
Echinococcus granulosus tyrosine protein kinase Src64B 0.0055 0.0557 0.0456
Loa Loa (eye worm) hypothetical protein 0.0056 0.0575 0.0432
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.0205 0.0172
Echinococcus granulosus cyclin dependent kinase 5 0.0051 0.0465 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0175 0.0688
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0062 0.0688 0.0612
Echinococcus granulosus twitchin 0.0063 0.0695 0.0622
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0465 0.2155
Loa Loa (eye worm) hypothetical protein 0.0094 0.1281 0.1149
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0094 0.1281 0.6617
Echinococcus granulosus cyclin B 0.0056 0.0575 0.0478
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0465 0.8077

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.