Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0518 | 0.0824 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0041 | 0.0017 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3111 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.0518 | 0.0869 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1868 | 0.5945 | 0.5945 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.0334 | 0.0496 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0041 | 0.0041 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0518 | 0.0869 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.0191 | 0.8342 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1868 | 0.5945 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0031 | 0.0049 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0031 | 0.0031 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.0229 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1868 | 0.5945 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0782 | 0.0782 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0782 | 0.1313 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.2569 | 0.4292 |
Brugia malayi | hypothetical protein | 0.0148 | 0.0334 | 0.0334 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3111 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0518 | 0.0824 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.0191 | 0.8342 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.2569 | 0.432 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1868 | 0.5945 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0031 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0782 | 0.0782 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.0191 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.0229 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.0229 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1868 | 0.5945 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.0229 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3111 | 1 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1868 | 0.5945 | 0.5945 |
Loa Loa (eye worm) | hypothetical protein | 0.159 | 0.5038 | 0.5038 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.0191 | 0.8342 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.0334 | 0.0496 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0031 | 0.0031 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0031 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0041 | 0.0017 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.2569 | 0.432 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0782 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0334 | 0.0334 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0031 | 0.0049 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.0191 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0334 | 0.0334 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.0191 | 0.8342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0079 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.