Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0059 | 0.0031 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0043 | 0.0083 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0108 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.1617 | 0.5092 | 0.5092 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0174 | 0.0174 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0059 | 0.0114 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0059 | 0.0031 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0059 | 0.0055 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0174 | 0.0255 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0043 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0041 | 0.0041 |
Brugia malayi | hypothetical protein | 0.0228 | 0.0685 | 0.0681 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0059 | 0.0031 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.027 | 0.0818 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0059 | 0.0059 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0059 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0059 | 0.0059 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1642 | 0.5173 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.027 | 0.0818 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0043 | 0.0083 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1642 | 0.5173 | 0.5173 |
Echinococcus granulosus | lamin | 0.0026 | 0.0043 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0685 | 0.0685 |
Onchocerca volvulus | 0.0047 | 0.0108 | 0.0127 | |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0043 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0043 | 0.0043 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3163 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3163 | 1 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1642 | 0.5173 | 0.5171 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0043 | 0.0043 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.0685 | 0.1324 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0272 | 0.0272 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.0685 | 0.1324 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0043 | 0.0083 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0108 | 0.0127 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0059 | 0.0114 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1642 | 0.5173 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0174 | 0.0169 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0059 | 0.0031 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3163 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0043 | 0.0083 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1642 | 0.5173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0272 | 0.0272 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0108 | 0.0127 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0059 | 0.0055 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0272 | 0.0268 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0272 | 0.0268 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0059 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.3163 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0059 | 0.0114 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0043 | 0.0038 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0059 | 0.0114 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1642 | 0.5173 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.