TDR Targets

Basic information

Technical information

TDR Targets ID: 893502
Name: 5-amino-3-[2-(4-bromo-3-nitrophenyl)-1-cyanoe thenyl]-1-phenylpyrazole-4-carbonitrile
MW: 435.234 | Formula: C19H11BrN6O2
H donors: 1 H acceptors: 5 LogP: 4.15 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#CC(=Cc1ccc(c(c1)[N+](=O)[O-])Br)c1nn(c(c1C#N)N)c1ccccc1
InChi: 1S/C19H11BrN6O2/c20-16-7-6-12(9-17(16)26(27)28)8-13(10-21)18-15(11-22)19(23)25(24-18)14-4-2-1-3-5-14/h1-9H,23H2/b13-8+
InChiKey: YSPWLWFIDPKSJY-MDWZMJQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-amino-3-[(Z)-2-(4-bromo-3-nitrophenyl)-1-cyanoethenyl]-1-phenylpyrazole-4-carbonitrile
5-amino-3-[2-(4-bromo-3-nitro-phenyl)-1-cyano-vinyl]-1-phenyl-pyrazole-4-carbonitrile
5-amino-3-[(Z)-2-(4-bromo-3-nitro-phenyl)-1-cyano-vinyl]-1-phenyl-pyrazole-4-carbonitrile
5-amino-3-[2-(4-bromo-3-nitrophenyl)-1-cyanovinyl]-1-phenyl-4-pyrazolecarbonitrile
5-amino-3-[(Z)-2-(4-bromo-3-nitrophenyl)-1-cyanovinyl]-1-phenyl-4-pyrazolecarbonitrile
5-amino-3-[(Z)-2-(4-bromo-3-nitro-phenyl)-1-cyano-ethenyl]-1-phenyl-pyrazole-4-carbonitrile
5-amino-3-[2-(4-bromo-3-nitro-phenyl)-1-cyano-ethenyl]-1-phenyl-pyrazole-4-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0047	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Onchocerca volvulus		0.0047	0.0063	0.0211
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0063	0.0186
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0336	0.1366	0.1366
Echinococcus granulosus	synaptic vesicle 2 protein	0.0047	0.0063	0.0063
Toxoplasma gondii	sugar transporter ST2	0.0047	0.0063	0.0186
Schistosoma mansoni	sugar transporter	0.0047	0.0063	0.0147
Schistosoma mansoni	sugar transporter	0.0047	0.0063	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.032	0.2122
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Onchocerca volvulus		0.0047	0.0063	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Brugia malayi	Cache domain containing protein	0.0452	0.1893	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0047	0.0063	0.0063
Brugia malayi	hypothetical protein	0.0047	0.0063	0.0269
Brugia malayi	major facilitator superfamily protein	0.0047	0.0063	0.0269
Treponema pallidum	76K protein	0.0042	0.0038	0.5
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0336	0.1366	0.1366
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.003	0.003
Loa Loa (eye worm)	sugar transporter	0.0047	0.0063	0.0292
Brugia malayi	hypothetical protein	0.0047	0.0063	0.0269
Leishmania major	telomerase reverse transcriptase, putative	0.0082	0.0221	0.6145
Schistosoma mansoni	serine-rich repeat protein	0.0528	0.2234	0.5222
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0047	0.0063	0.5
Onchocerca volvulus		0.0047	0.0063	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Toxoplasma gondii	sugar transporter ST3	0.0047	0.0063	0.0186
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0082	0.0221	0.1376
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0047	0.0063	0.5
Echinococcus granulosus	solute carrier family 22	0.0047	0.0063	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Brugia malayi	hypothetical protein	0.0047	0.0063	0.0269
Entamoeba histolytica	hypothetical protein, conserved	0.0042	0.0038	0.5
Treponema pallidum	hypothetical protein	0.0042	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.006	0.0121	0.0621
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.006	0.0121	0.0621
Echinococcus multilocularis	serotonin receptor	0.0282	0.1125	0.1125
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Onchocerca volvulus		0.0047	0.0063	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0104	0.032	0.2122
Onchocerca volvulus		0.0047	0.0063	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	CUTiclin family member	0.0042	0.0038	0.0166
Trypanosoma cruzi	hexose transporter, putative	0.0057	0.0107	0.1706
Onchocerca volvulus		0.0047	0.0063	0.0211
Trichomonas vaginalis	glucose transporter, putative	0.0104	0.032	0.2122
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0301	0.1209	1
Schistosoma mansoni	calcium-activated potassium channel	0.0467	0.1961	0.4583
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0047	0.0063	0.0063
Giardia lamblia	Telomerase catalytic subunit	0.0082	0.0221	1
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0082	0.0221	0.6145
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Echinococcus multilocularis	General substrate transporter	0.0288	0.1153	0.1153
Leishmania major	glucose transporter, lmgt2	0.0104	0.032	1
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trypanosoma brucei	telomerase reverse transcriptase	0.0082	0.0221	0.6145
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0336	0.1366	0.1366
Mycobacterium ulcerans	integral membrane transport protein	0.0047	0.0063	0.5
Onchocerca volvulus		0.0047	0.0063	0.0211
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0042	0.0038	0.0138
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Leishmania major	glucose transporter, lmgt1	0.0104	0.032	1
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0046	0.0108
Echinococcus granulosus	solute carrier family 22	0.0047	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0071	0.0332
Onchocerca volvulus		0.0047	0.0063	0.0211
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Plasmodium vivax	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0104	0.032	0.2122
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0336	0.1366	0.1366
Onchocerca volvulus		0.0047	0.0063	0.0211
Brugia malayi	Telomerase reverse transcriptase	0.0219	0.0837	0.4387
Loa Loa (eye worm)	glutamate receptor	0.004	0.0029	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0336	0.1366	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Loa Loa (eye worm)	sugar transporter	0.0336	0.1366	0.6958
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Trypanosoma cruzi	hexose transporter, putative	0.0104	0.032	1
Toxoplasma gondii	RNA-directed DNA polymerase	0.0082	0.0221	0.1376
Brugia malayi	Major Facilitator Superfamily protein	0.0047	0.0063	0.0269
Schistosoma mansoni	amine GPCR	0.0364	0.1492	0.3488
Schistosoma mansoni	hypothetical protein	0.0042	0.0038	0.0089
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0045	0.0054	0.0126
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.003	0.0122
Echinococcus granulosus	solute carrier family 22	0.0047	0.0063	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0282	0.1125	0.5724
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0336	0.1366	0.1366
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trypanosoma brucei	glucose transporter 1E	0.0104	0.032	1
Schistosoma mansoni	hypothetical protein	0.0042	0.0038	0.0089
Schistosoma mansoni	glucose transporter	0.0047	0.0063	0.0147
Onchocerca volvulus		0.0047	0.0063	0.0211
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0336	0.1366	0.1366
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0063	0.0186
Schistosoma mansoni	hypothetical protein	0.0336	0.1366	0.3193
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0047	0.0063	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0104	0.032	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0336	0.1366	0.1366
Echinococcus granulosus	solute carrier family 22	0.0047	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Schistosoma mansoni	hypothetical protein	0.0467	0.1961	0.4583
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0063	0.0063
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.098	0.4278	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Schistosoma mansoni	hypothetical protein	0.0528	0.2234	0.5222
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trypanosoma cruzi	hexose transporter, putative	0.0104	0.032	1
Trichomonas vaginalis	sugar transport protein, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0063	0.0186
Onchocerca volvulus		0.0047	0.0063	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Brugia malayi	von Willebrand Factor	0.0042	0.0038	0.0138
Trypanosoma cruzi	hexose transporter, putative	0.0104	0.032	1
Loa Loa (eye worm)	hypothetical protein	0.0234	0.0908	0.4615
Plasmodium falciparum	hexose transporter	0.0336	0.1366	1
Loa Loa (eye worm)	hypothetical protein	0.0467	0.1961	1
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.032	0.2122
Echinococcus granulosus	General substrate transporter	0.0288	0.1153	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0336	0.1366	0.1366
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.1022	0.4466	0.4466
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0104	0.032	1
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Onchocerca volvulus		0.0047	0.0063	0.0211
Onchocerca volvulus		0.0047	0.0063	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Schistosoma mansoni	sugar transporter	0.0047	0.0063	0.0147
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Toxoplasma gondii	facilitative glucose transporter GT1	0.0336	0.1366	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Schistosoma mansoni	calcium-activated potassium channel	0.0444	0.1858	0.4343
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.004	0.003	0.0092
Loa Loa (eye worm)	hypothetical protein	0.021	0.0799	0.406
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0494	0.2082	0.4867
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	CUTiclin-Like family member	0.0042	0.0038	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0452	0.1893	0.9656
Echinococcus granulosus	collagen alpha 1VII chain	0.0042	0.0038	0.0038
Brugia malayi	Major Facilitator Superfamily protein	0.0047	0.0063	0.0269
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0047	0.0063	0.5
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.003	0.003
Trypanosoma brucei	glucose transporter, putative	0.0104	0.032	1
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0063	0.0186
Trichomonas vaginalis	glucose transporter, putative	0.0047	0.0063	0.0186
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0104	0.032	1
Echinococcus granulosus	voltage dependent calcium channel subunit	0.1022	0.4466	0.4466
Trichomonas vaginalis	glucose transporter, putative	0.0104	0.032	0.2122
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Echinococcus multilocularis	serotonin receptor	0.0282	0.1125	0.1125
Entamoeba histolytica	hypothetical protein	0.0042	0.0038	0.5
Brugia malayi	von Willebrand factor type A domain containing protein	0.0042	0.0038	0.0138
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0063	0.0063
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0047	0.0063	0.0292
Schistosoma mansoni	glucose transport protein	0.0336	0.1366	0.3193
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0282	0.1125	0.2629
Schistosoma mansoni	glucose transport protein	0.0336	0.1366	0.3193
Echinococcus multilocularis	small conductance calcium activated potassium	0.0467	0.1961	0.1961
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0049	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Schistosoma mansoni	sugar transporter	0.0047	0.0063	0.0147
Onchocerca volvulus		0.0047	0.0063	0.0211
Toxoplasma gondii	transporter, major facilitator family protein	0.0047	0.0063	0.0186
Plasmodium falciparum	telomerase reverse transcriptase	0.0082	0.0221	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Leishmania major	glucose transporter, lmgt3	0.0104	0.032	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0104	0.032	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0282	0.1125	0.1125
Onchocerca volvulus		0.0047	0.0063	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	von Willebrand factor type A domain-containing protein	0.0042	0.0038	0.0166
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0046	0.0108
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0047	0.0063	0.0147
Brugia malayi	Sugar transporter family protein	0.0336	0.1366	0.7196
Trypanosoma cruzi	hexose transporter	0.0104	0.032	1
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Brugia malayi	Sugar transporter family protein	0.0047	0.0063	0.0269
Brugia malayi	Zona pellucida-like domain containing protein	0.0042	0.0038	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Entamoeba histolytica	hypothetical protein, conserved	0.0042	0.0038	0.5
Brugia malayi	Major Facilitator Superfamily protein	0.0047	0.0063	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Toxoplasma gondii	sugar transporter ST1	0.0047	0.0063	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Brugia malayi	major facilitator superfamily protein	0.0047	0.0063	0.0269
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Echinococcus multilocularis	collagen alpha 1(VII) chain	0.0042	0.0038	0.0038
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0049	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0282	0.1125	0.5724
Echinococcus granulosus	small conductance calcium activated potassium	0.0467	0.1961	0.1961
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Schistosoma mansoni	glucose transport protein	0.0336	0.1366	0.3193
Brugia malayi	Zona pellucida-like domain containing protein	0.0042	0.0038	0.0138
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0047	0.0063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0063	0.0186
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0047	0.0063	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Trichomonas vaginalis	myo-inositol transporter, putative	0.0047	0.0063	0.0186
Plasmodium vivax	hexose transporter	0.0336	0.1366	1
Onchocerca volvulus	Putative transporter	0.0047	0.0063	0.0211
Brugia malayi	Metabotropic glutamate receptor precursor.	0.004	0.0029	0.009
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0063	0.0292
Loa Loa (eye worm)	von Willebrand factor domain-containing protein	0.0042	0.0038	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0038	0.0166
Entamoeba histolytica	elongation factor-2 kinase, putative	0.0042	0.0038	0.5
Onchocerca volvulus		0.0047	0.0063	0.0211
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0063	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0063	0.0186
Mycobacterium ulcerans	sugar transporter	0.0047	0.0063	0.5
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0082	0.0221	0.6145
Brugia malayi	Sugar transporter family protein	0.0047	0.0063	0.0269
Brugia malayi	hypothetical protein	0.0042	0.0038	0.0138
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.2247	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0104	0.032	0.2122
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0042	0.0038	0.0138
Trypanosoma brucei	glucose transporter 2A	0.0104	0.032	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 893502