Detailed information for compound 895768

Basic information

Technical information
  • TDR Targets ID: 895768
  • Name: 3-(4-methoxyphenyl)-1-morpholin-4-yl-2-phenyl octan-3-ol
  • MW: 397.55 | Formula: C25H35NO3
  • H donors: 1 H acceptors: 1 LogP: 4.61 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC(C(c1ccccc1)CN1CCOCC1)(c1ccc(cc1)OC)O
  • InChi: 1S/C25H35NO3/c1-3-4-8-15-25(27,22-11-13-23(28-2)14-12-22)24(21-9-6-5-7-10-21)20-26-16-18-29-19-17-26/h5-7,9-14,24,27H,3-4,8,15-20H2,1-2H3
  • InChiKey: FREHESDPKBIAIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methoxyphenyl)-1-morpholino-2-phenyl-octan-3-ol
  • 3-(4-methoxyphenyl)-1-morpholino-2-phenyloctan-3-ol
  • 3-(4-methoxyphenyl)-1-morpholin-4-yl-2-phenyl-octan-3-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0283 0.1655
Brugia malayi hypothetical protein 0.0021 0.0238 0.0193
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0588 0.4191
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0493 0.1973
Treponema pallidum nicotinate phosphoribosyltransferase 0.0065 0.1288 0.7573
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.1701 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0468 0.0482
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1038 0.7921
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.1027 0.1181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2166 0.2608
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0588 0.4191
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0283 0.1655
Schistosoma mansoni rab6-interacting 0.0021 0.0238 0.0193
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0493 0.3397
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0493 0.1973
Loa Loa (eye worm) hypothetical protein 0.0025 0.0333 0.0363
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1038 0.7921
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0468 0.0482
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0495 0.0415
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0495 0.0415
Schistosoma mansoni protein kinase 0.0032 0.0495 0.0515
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.0244
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0588 0.4191
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0084 0.0492
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0495 0.0515
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0495 0.0565
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0468 0.0482
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0495 0.0515
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.1701 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Loa Loa (eye worm) hypothetical protein 0.003 0.0468 0.0532
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.1701 0.2026
Schistosoma mansoni loxhd1 0.0021 0.0238 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2158 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.1701 0.2491
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.1701 1
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0495 0.1981
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.1701 0.2026
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0418 0.0338
Schistosoma mansoni rab6-interacting 0.0021 0.0238 0.0193
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0238 0.0193
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.1038 0.7921
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0493 0.3397
Loa Loa (eye worm) hypothetical protein 0.0032 0.0495 0.0565
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0493 0.3397
Leishmania major glucose transporter, lmgt3 0.0031 0.0493 0.3397
Entamoeba histolytica protein kinase, putative 0.0032 0.0495 0.2106
Schistosoma mansoni lipoxygenase 0.0058 0.1125 0.1305
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0283 0.0201
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0065 0.1288 0.1215
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0283 0.0201
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0283 0.025
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0495 0.0415
Echinococcus multilocularis General substrate transporter 0.0087 0.1819 0.2173
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0084 0.0492
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2158 0.2598
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.0244
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0495 0.0515
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0495 0.0515
Schistosoma mansoni hypothetical protein 0.0101 0.2158 0.2598
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0065 0.1288 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0588 0.4191
Trypanosoma brucei protein kinase, putative 0.0054 0.1038 0.7921
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0495 0.0634
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.1038 0.7921
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0495 0.0415
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0588 0.4191
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2158 0.2598
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.1125 0.1305
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.1027 0.783
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.1038 0.7921
Schistosoma mansoni hypothetical protein 0.0021 0.0238 0.0193
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2158 0.2598
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0438 0.0443
Loa Loa (eye worm) sugar transporter 0.0014 0.0084 0.0053
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0493 0.1973
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0495 0.0515
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0495 0.0515
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0438 0.0443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2166 0.2608
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.2166 0.2647
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0495 0.0515
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.1701 0.2491
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0588 0.0509
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.1701 0.1631
Plasmodium falciparum protein kinase 7 0.0287 0.6575 0.6546
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0468 0.4033
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0238 0.0193
Leishmania major glucose transporter, lmgt2 0.0031 0.0493 0.3397
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.1038 0.1195
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0495 0.0634
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0217 0.0641
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.2166 0.2608
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.1038 0.1195
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0065 0.1288 0.1509
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0588 0.0509
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0065 0.1288 1
Trypanosoma brucei glucose transporter 2A 0.0031 0.0493 0.3397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0493 0.1973
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2166 0.2608
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0283 0.1655
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0202 0.0981
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0065 0.1288 0.5806
Schistosoma mansoni protein kinase 0.0032 0.0495 0.0515
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0418 0.2459
Echinococcus granulosus RUN 0.0021 0.0238 0.0193
Schistosoma mansoni glucose transport protein 0.0101 0.2158 0.2598
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0495 0.0515
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0084 0.0492
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0495 0.0415
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3656 0.3602
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0065 0.1288 0.1509
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0283 0.209
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0283 0.025
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.1701 0.1631
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.1701 1
Brugia malayi Probable ClpP-like protease 0.0082 0.1701 0.2026
Toxoplasma gondii protein kinase, putative 0.0287 0.6575 1
Brugia malayi Pre-B cell enhancing factor precursor 0.035 0.8067 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0283 0.1664
Schistosoma mansoni glucose transport protein 0.0101 0.2158 0.2598
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.5539 0.685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2166 0.2608
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0065 0.1288 1
Echinococcus granulosus General substrate transporter 0.0087 0.1819 0.2173
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0283 0.025
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0493 0.1973
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0283 0.1664
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0065 0.1288 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.1701 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0468 0.0482
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.1701 0.2026
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0495 0.0415
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0202 0.0981
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0495 0.0515
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0283 0.0542
Brugia malayi Cam kinase protein 1 0.0032 0.0495 0.0515
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.1038 0.147
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0468 0.1778
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0283 0.1664
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0238 0.0193
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0065 0.1288 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0495 0.0415
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0238 0.0193
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1038 0.4599
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0468 0.0482
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.1038 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.1038 0.1195
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0495 0.0565
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.1038 0.1195
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0283 0.0307
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2158 0.2598
Onchocerca volvulus 0.0021 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Toxoplasma gondii hypothetical protein 0.0028 0.0418 0.0516
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.1038 0.1241
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0495 0.0634
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2158 0.3195
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0283 0.0961
Trypanosoma brucei glucose transporter 1E 0.0031 0.0493 0.3397
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0493 0.3397
Echinococcus multilocularis RUN 0.0021 0.0238 0.0193
Brugia malayi Doublecortin family protein 0.0021 0.0238 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0493 0.1973
Loa Loa (eye worm) pre-B cell enhancing factor 0.035 0.8067 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0238 0.0193
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.1701 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.1027 0.5503
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1038 0.4599
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1038 0.1195
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2166 0.2608
Loa Loa (eye worm) hypothetical protein 0.003 0.0468 0.0532
Plasmodium vivax CDK-related protein kinase 6, putative 0.0431 1 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0468 0.0482
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0238 0.0155
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2158 0.2598
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0238 0.0193
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0084 0.0053
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3656 0.5503
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0153 0.058
Brugia malayi Sugar transporter family protein 0.0101 0.2158 0.2598
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.1701 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0283 0.025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Brugia malayi hypothetical protein 0.0021 0.0238 0.0193
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0084 0.0053
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3656 0.3602
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0495 0.0415
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0588 0.0778
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0495 0.0515
Leishmania major protein kinase, putative 0.0032 0.0495 0.3412
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0065 0.1288 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2158 0.2598
Schistosoma mansoni glucose transport protein 0.0101 0.2158 0.2598
Schistosoma mansoni protein kinase 0.0032 0.0495 0.0515
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0493 0.3397
Schistosoma mansoni polycystin 1-related 0.0021 0.0238 0.0193
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0493 0.3397
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.1038 0.7921
Plasmodium vivax hexose transporter 0.0101 0.2158 0.2092
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0053
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0495 0.3412
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0468 0.1855
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.1027 0.1181
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.035 0.8067 1
Schistosoma mansoni lipoxygenase 0.0021 0.0238 0.0193
Plasmodium falciparum hexose transporter 0.0101 0.2158 0.2092
Loa Loa (eye worm) hypothetical protein 0.0082 0.1701 0.2067
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.1027 0.783
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2166 0.2608
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0493 0.1973
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.1038 0.7921
Onchocerca volvulus 0.0021 0.0238 1
Loa Loa (eye worm) sugar transporter 0.0101 0.2158 0.2637
Loa Loa (eye worm) hypothetical protein 0.0023 0.0283 0.0301
Mycobacterium ulcerans sugar transporter 0.0014 0.0084 0.0492
Leishmania major glucose transporter, lmgt1 0.0031 0.0493 0.3397
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1038 0.4599
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.035 0.8067 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0468 0.1844
Brugia malayi MAP kinase sur-1 0.0054 0.1038 0.1195
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0495 0.0415
Entamoeba histolytica protein kinase, putative 0.0032 0.0495 0.2106
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0238 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2166 0.2608
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0283 0.025
Trypanosoma cruzi hexose transporter 0.0031 0.0493 0.3397
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0238 0.0244
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1038 0.4599
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2158 0.2598
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.035 0.8067 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.1125 0.1305
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0418 0.0338
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2158 0.2598
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0493 0.3397
Trypanosoma brucei glucose transporter, putative 0.0031 0.0493 0.3397
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0418 0.1444
Brugia malayi follicle stimulating hormone receptor 0.0243 0.5539 0.6833

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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