Detailed information for compound 896585

Basic information

Technical information
  • TDR Targets ID: 896585
  • Name: 3-amino-4-dimethylaminochromen-2-one
  • MW: 204.225 | Formula: C11H12N2O2
  • H donors: 1 H acceptors: 1 LogP: 1.28 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1oc2ccccc2c(c1N)N(C)C
  • InChi: 1S/C11H12N2O2/c1-13(2)10-7-5-3-4-6-8(7)15-11(14)9(10)12/h3-6H,12H2,1-2H3
  • InChiKey: RMILQQGLPHOCSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-Amino-4-dimethylamino-chromen-2-one
  • 3-amino-4-dimethylamino-2-chromenone
  • 3-amino-4-dimethylamino-coumarin
  • BAS 01256122
  • MLS000712979
  • AH-262/31958010
  • Oprea1_066627
  • SMR000282746
  • ZINC00247548
  • ChemDiv2_000021
  • Oprea1_803765

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0108 0.0746 0.0883
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0374 0.2623
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0035 0.0106
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0038 0 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0205 0.066
Loa Loa (eye worm) beta-lactamase 0.0041 0.0035 0.0114
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.035 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0182 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0182 0.0216
Echinococcus multilocularis aminopeptidase N 0.0368 0.3506 0.3506
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0182 0.052
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0108 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0041 0.0035 0.0114
Brugia malayi beta-lactamase 0.0041 0.0035 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0059 0.0793
Trichomonas vaginalis esterase, putative 0.0041 0.0035 0.0106
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1427 0.587
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.035 0.0414
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0374 0.0443
Brugia malayi hypothetical protein 0.0108 0.0746 0.2129
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0108 0.0746 0.0883
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0035 0.0106
Onchocerca volvulus 0.0108 0.0746 0.2129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0374 0.2623
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0059 0.0177
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0108 0.0746 1
Onchocerca volvulus 0.0041 0.0035 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1686 0.1686
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0059 0.0059
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.007 0.0342 0.4578
Schistosoma mansoni alpha-glucosidase 0.0169 0.1395 0.1651
Loa Loa (eye worm) hypothetical protein 0.0039 0.0012 0.0038
Onchocerca volvulus 0.0041 0.0035 0.0101
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0035 0.0101
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0374 0.5017
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0374 0.0374
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0059 0.0177
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0035 0.0042
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0059 0.0177
Loa Loa (eye worm) hypothetical protein 0.0041 0.0035 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0374 0.2623
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0108 0.0746 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0035 0.0114
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1686 0.5436
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0059 0.0177
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0035 0.0247
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0182 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0182 0.0216
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3345 0.5
Echinococcus multilocularis geminin 0.0205 0.177 0.177
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.007 0.0342 0.0404
Loa Loa (eye worm) hypothetical protein 0.0057 0.0205 0.066
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3345 1
Schistosoma mansoni jumonji domain containing protein 0.0071 0.035 0.0414
Trypanosoma cruzi aminopeptidase, putative 0.0108 0.0746 1
Brugia malayi jmjC domain containing protein 0.0071 0.035 0.0998
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0059 0.0177
Brugia malayi beta-lactamase family protein 0.0041 0.0035 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0205 0.0583
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0108 0.0746 0.0883
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0059 0.1581
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0035 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0059 0.0177
Brugia malayi beta-lactamase family protein 0.0041 0.0035 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0059 0.0191
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0035 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0059 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0035 0.0106
Onchocerca volvulus 0.0114 0.0804 0.2295
Loa Loa (eye worm) hypothetical protein 0.0041 0.0035 0.0114
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0038 0 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0035 0.0106
Echinococcus granulosus geminin 0.0205 0.177 0.2094
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.035 0.0414
Brugia malayi Peptidase family M1 containing protein 0.0108 0.0746 0.2129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.035 0.0414
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.0342 0.0342
Mycobacterium ulcerans lipase LipD 0.0041 0.0035 0.0247
Loa Loa (eye worm) hypothetical protein 0.033 0.3101 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0108 0.0746 0.0883
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.035 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0035 0.0473
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1686 0.1995
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3345 1
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0035 0.0473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Schistosoma mansoni hypothetical protein 0.0205 0.177 0.2094
Trypanosoma brucei Aminopeptidase M1, putative 0.0108 0.0746 1
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0012 0.0034
Schistosoma mansoni hypothetical protein 0.0039 0.0012 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0205 0.0583
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0059 0.0793
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0035 1
Brugia malayi Peptidase family M1 containing protein 0.0368 0.3506 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0108 0.0746 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.845 1
Mycobacterium ulcerans hypothetical protein 0.0041 0.0035 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0059 0.0793
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3345 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0182 0.0182
Leishmania major hypothetical protein, conserved 0.0041 0.0035 0.0473
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0059 0.0177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0342 0.1102
Onchocerca volvulus 0.0368 0.3506 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.1395 0.1651
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0108 0.0746 0.2231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0182 0.0182
Trypanosoma brucei Aminopeptidase M1, putative 0.0108 0.0746 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1686 0.1686
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.035 0.0414
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0108 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0041 0.0035 0.0114
Loa Loa (eye worm) aminopeptidase N 0.0108 0.0746 0.2407
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.845 0.845
Loa Loa (eye worm) hypothetical protein 0.007 0.0342 0.1102
Schistosoma mansoni hypothetical protein 0.0205 0.177 0.2094
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1427 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0059 0.007
Brugia malayi jmjC domain containing protein 0.0071 0.035 0.0998
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1686 0.4809
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0059 0.0177
Mycobacterium ulcerans aminopeptidase N PepN 0.0108 0.0746 0.5229
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0374 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0182 0.0216
Schistosoma mansoni alpha glucosidase 0.0044 0.0059 0.007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0035 0.0114
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0374 0.0443
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.035 0.1129
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0035 0.0473
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0059 0.0177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0182 0.0588
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1427 1
Echinococcus granulosus aminopeptidase N 0.0368 0.3506 0.4149
Onchocerca volvulus 0.0041 0.0035 0.0101
Toxoplasma gondii ABC1 family protein 0.0041 0.0035 0.0943
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0035 0.0042
Mycobacterium ulcerans beta-lactamase 0.0041 0.0035 0.0247
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0108 0.0746 0.0746
Trypanosoma brucei glucosidase, putative 0.0044 0.0059 0.0793
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0108 0.0746 0.0746
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0108 0.0746 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0108 0.0746 0.0746
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0108 0.0746 0.0746
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0108 0.0746 0.0883
Loa Loa (eye worm) hypothetical protein 0.0041 0.0035 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3345 1
Entamoeba histolytica aminopeptidase, putative 0.0108 0.0746 0.2091
Loa Loa (eye worm) hypothetical protein 0.026 0.2355 0.7593
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0374 0.0443
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0035 0.0247
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.845 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0108 0.0746 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.2406 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0035 0.0106
Loa Loa (eye worm) peptidase family M1 containing protein 0.0298 0.2759 0.8898
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0108 0.0746 0.2231
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0108 0.0746 0.0883
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0374 0.143

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.