TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.476 | Formula: C21H31NO3
H donors: 2 H acceptors: 3 LogP: 4.16 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCCN1CC/C(=C\c2cc(c(c(c2)C(C)(C)C)O)C(C)(C)C)/C1=O
InChi: 1S/C21H31NO3/c1-20(2,3)16-12-14(13-17(18(16)24)21(4,5)6)11-15-7-8-22(9-10-23)19(15)25/h11-13,23-24H,7-10H2,1-6H3/b15-11+
InChiKey: VLZAWALSZLBIIH-RVDMUPIBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0527	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0088	0.017
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0445	0.0493
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.001	0.002
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.009	0.0174
Onchocerca volvulus		0.003	0.0019	0.0034
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0046	0.0051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0942	0.1813
Schistosoma mansoni	hypothetical protein	0.0032	0.0046	0.0051
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0046	0.0089
Loa Loa (eye worm)	glutaminase	0.0284	0.3356	0.6459
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0019	0.0038
Echinococcus multilocularis	protein patched	0.0041	0.0172	0.0172
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0172	0.033
Leishmania major	guanosine monophosphate reductase	0.0424	0.5196	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.009	0.01
Trypanosoma cruzi	GMP reductase	0.0424	0.5196	0.5
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0159	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0243	0.0467
Schistosoma mansoni	hypothetical protein	0.0032	0.0046	0.0051
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.042	0.5137	1
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0424	0.5196	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.1835	0.5172
Brugia malayi	glutaminase DH11.1	0.0284	0.3356	0.6459
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0445	0.0857
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.1258	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0172	0.033
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0424	0.5196	1
Schistosoma mansoni	microtubule-associated protein tau	0.0717	0.9035	1
Trypanosoma cruzi	GMP reductase	0.0424	0.5196	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.1258	0.2421
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.299	0.8764
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0172	0.019
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0159	0.0159
Echinococcus multilocularis	snurportin 1	0.03	0.3567	0.3567
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.143	0.1583
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0091	0.0101
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0095	0.0873	0.0966
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.001	0.0012
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0234	0.2704	0.5146
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Schistosoma mansoni	hypothetical protein	0.0506	0.6264	0.6933
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.143	0.143
Schistosoma mansoni	hypothetical protein	0.004	0.0152	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0029	0.001	0.002
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0424	0.5196	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0414	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0527	0.1015
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0424	0.5196	1
Brugia malayi	jmjC domain containing protein	0.0095	0.0873	0.168
Plasmodium vivax	SET domain protein, putative	0.003	0.0019	0.0038
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0243	0.0467
Schistosoma mansoni	hypothetical protein	0.0068	0.0527	0.0584
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0424	0.5196	0.5
Echinococcus granulosus	microtubule associated protein 2	0.0717	0.9035	1
Echinococcus multilocularis	geminin	0.0506	0.6264	0.6264
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0234	0.2704	0.497
Schistosoma mansoni	hypothetical protein	0.004	0.0152	0.0168
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0019	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0095	0.0873	0.0873
Brugia malayi	TAR-binding protein	0.0062	0.0445	0.0857
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.001	0.002
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0046	0.0089
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0445	0.0493
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.1835	0.5172
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.001	0.0012
Onchocerca volvulus	Putative GMP reductase	0.0186	0.2064	0.7601
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0445	0.0493
Schistosoma mansoni	patched 1	0.0041	0.0172	0.019
Loa Loa (eye worm)	hypothetical protein	0.0096	0.089	0.1713
Onchocerca volvulus	Glucosylceramidase homolog	0.0168	0.1835	0.6754
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0046	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0088	0.017
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.3387	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.3567	0.6865
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0088	0.0172
Brugia malayi	RNA, U transporter 1	0.008	0.068	0.1308
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.1466	0.2698
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.001	0.002
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0618	0.0684
Plasmodium falciparum	phd finger protein, putative	0.0029	0.001	0.002
Giardia lamblia	Fructose-bisphosphate aldolase	0.0287	0.3387	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0005	0.0006
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.019	0.2123	0.3983
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0424	0.5196	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0243	0.0303
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0019	0.0019
Trypanosoma brucei	GMP reductase	0.0424	0.5196	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0256	0.299	0.5754
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0243	0.0459
Echinococcus multilocularis	microtubule associated protein 2	0.0717	0.9035	0.9035
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0424	0.5196	1
Loa Loa (eye worm)	GMP reductase	0.0186	0.2064	0.3972
Mycobacterium ulcerans	glutaminase	0.0284	0.3356	0.6398
Schistosoma mansoni	hypothetical protein	0.004	0.0152	0.0168
Schistosoma mansoni	glutaminase	0.0284	0.3356	0.3715
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0424	0.5196	0.5751
Brugia malayi	PHD-finger family protein	0.0029	0.001	0.002
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0243	0.0467
Echinococcus multilocularis	peregrin	0.0029	0.001	0.001
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.2338	0.4499
Brugia malayi	Pre-SET motif family protein	0.0206	0.2338	0.4499
Onchocerca volvulus		0.0235	0.2712	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0019	0.0022
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.299	0.8764
Brugia malayi	RNA binding protein	0.0062	0.0445	0.0857
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.019	0.2123	0.3796
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0243	0.0459
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.009	0.009
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0243	0.0303
Loa Loa (eye worm)	hypothetical protein	0.005	0.0281	0.0541
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0445	0.0857
Echinococcus granulosus	geminin	0.0506	0.6264	0.6933
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0186	0.2064	0.3972
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0256	0.299	0.5754
Echinococcus granulosus	GPCR family 2	0.0032	0.0046	0.0051
Trichomonas vaginalis	glutaminase, putative	0.0284	0.3356	0.9904
Brugia malayi	Pre-SET motif family protein	0.003	0.0019	0.0038
Schistosoma mansoni	hypothetical protein	0.03	0.3567	0.3948
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0243	0.0467
Echinococcus granulosus	peregrin	0.0029	0.001	0.0012
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.1835	0.5172
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0019	0.0019
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0243	0.0303
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0839	0.1616
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.001	0.002
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0091	0.0101
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.299	0.8764
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0243	0.0467
Schistosoma mansoni	hypothetical protein	0.0029	0.001	0.0012
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0424	0.5196	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0046	0.0051
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.089	0.089
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.001	0.001
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.089	0.1713
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0019	0.0022
Schistosoma mansoni	hypothetical protein	0.0506	0.6264	0.6933
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0839	0.0929
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.1835	0.5172
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0942	0.1813
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0172	0.019
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0243	0.035
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0243	0.0303
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1953	0.5541
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0046	0.0089
Treponema pallidum	fructose-bisphosphate aldolase	0.0287	0.3387	0.5
Brugia malayi	Bromodomain containing protein	0.0029	0.001	0.002
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.1835	0.5172
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0839	0.0839
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.009	0.01
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0243	0.0303
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0186	0.2064	0.3972
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0243	0.0303
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0445	0.0493
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0088	0.0049
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0172	0.0172
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0942	0.1813
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0046	0.0046
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0839	0.0839
Schistosoma mansoni	hypothetical protein	0.0035	0.0091	0.0101
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.042	0.5137	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0046	0.0051
Loa Loa (eye worm)	glutaminase 2	0.0284	0.3356	0.6459
Echinococcus granulosus	expressed conserved protein	0.009	0.0814	0.0901
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0564
Toxoplasma gondii	IMP dehydrogenas	0.0424	0.5196	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.009	0.01
Brugia malayi	GMP reductase	0.0186	0.2064	0.3972
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.299	0.8764
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0248	0.0248
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.2712	0.7899
Brugia malayi	hypothetical protein	0.0035	0.0091	0.0176
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0046	0.0046
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.1835	0.5172
Brugia malayi	MH2 domain containing protein	0.0124	0.1258	0.2421
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0942	0.1813
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0424	0.5196	0.5196
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.089	0.2424
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0424	0.5196	1
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0424	0.5196	0.5
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.089	0.0985
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0445	0.0857
Echinococcus granulosus	snurportin 1	0.03	0.3567	0.3948
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0839	0.0929
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0019	0.0022
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0046	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0088	0.017
Brugia malayi	jmjC domain containing protein	0.0035	0.009	0.0174
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0243	0.035
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.299	0.8764
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.1953	0.5541
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0088	0.017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0839	0.0929
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0243	0.0303
Loa Loa (eye worm)	hypothetical protein	0.003	0.0019	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0088	0.017
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0019	0.0022
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.299	0.8764
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.014	0.1466	0.247
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.042	0.5137	0.9884
Onchocerca volvulus		0.0047	0.0243	0.086
Brugia malayi	CHE-14 protein	0.0041	0.0172	0.033
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.1835	0.5172
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0243	0.0467
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0445	0.0857
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0243	0.0303
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.3387	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0839	0.1616
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0424	0.5196	0.5751
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0445	0.0493
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0839	0.0929
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0243	0.0459
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0445	0.0445
Echinococcus multilocularis	expressed conserved protein	0.009	0.0814	0.0814
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0088	0.0172
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0046	0.0046
Schistosoma mansoni	hypothetical protein	0.004	0.0152	0.0168
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3387	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.091	0.1007
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0088	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0445	0.0493
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0424	0.5196	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0091	0.0091
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0839	0.0929
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.1466	0.2733

Activities

Activity type	Activity value	Assay description	Source	Reference
Min ED (functional)	= 10 mg kg-1	Antiinflammatory activity expressed as minimum effective dose was screened by using adjuvant-induced local hyperthermia in rats	ChEMBL.	3118023

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 89817