Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0089 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0525 | 0.6529 | 0.6529 |
Echinococcus multilocularis | acetylcholinesterase | 0.0525 | 0.6529 | 0.6529 |
Loa Loa (eye worm) | hypothetical protein | 0.0525 | 0.6529 | 1 |
Brugia malayi | HSF-type DNA-binding domain containing protein | 0.0194 | 0.1571 | 0.2405 |
Loa Loa (eye worm) | hypothetical protein | 0.0525 | 0.6529 | 1 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.0461 | 0.0706 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.0194 | 0.1571 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0089 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0089 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0525 | 0.6529 | 0.6529 |
Onchocerca volvulus | Heat shock factor protein 2 homolog | 0.0194 | 0.1571 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0525 | 0.6529 | 0.6529 |
Echinococcus granulosus | acetylcholinesterase | 0.0525 | 0.6529 | 0.6529 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.0194 | 0.1571 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1571 | 0.2405 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0525 | 0.6529 | 0.6529 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0525 | 0.6529 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0525 | 0.6529 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0758 | 1 | 1 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.0194 | 0.1571 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0525 | 0.6529 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0089 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0089 | 0 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0758 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.0461 | 0.0706 |
Echinococcus multilocularis | acetylcholinesterase | 0.0525 | 0.6529 | 0.6529 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.0461 | 0.0706 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0525 | 0.6529 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.