Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0147 | 0.15 | 0.2218 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.2897 |
Onchocerca volvulus | 0.0377 | 0.4461 | 1 | |
Echinococcus granulosus | ectonucleotide | 0.0147 | 0.15 | 0.2218 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0175 | 0.1854 | 0.3669 |
Brugia malayi | intermediate filament protein | 0.0057 | 0.0343 | 0.0769 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0139 | 0.1397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1541 | 0.3455 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0057 | 0.0343 | 0.0769 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.2897 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.15 | 0.3363 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1854 | 0.4156 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1732 | 0.3373 |
Schistosoma mansoni | hypothetical protein | 0.0377 | 0.4461 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0175 | 0.1854 | 0.3669 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0105 | 0.0956 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.2897 |
Echinococcus granulosus | Endonuclease G | 0.0105 | 0.0956 | 0.1174 |
Trypanosoma cruzi | endonuclease G, putative | 0.0105 | 0.0956 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.2897 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0463 | 0.5559 | 0.5402 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.1565 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.033 | 0.0739 |
Echinococcus granulosus | geminin | 0.0165 | 0.1732 | 0.2663 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0139 | 0.1397 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0377 | 0.4461 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0463 | 0.5559 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0463 | 0.5559 | 0.5402 |
Trypanosoma brucei | endonuclease G, putative | 0.0105 | 0.0956 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0057 | 0.0343 | 0.0769 |
Echinococcus multilocularis | ectonucleotide | 0.0147 | 0.15 | 0.1198 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1854 | 0.4156 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0175 | 0.1854 | 0.4156 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0105 | 0.0956 | 0.2142 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0285 | 0.3275 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.1565 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0105 | 0.0956 | 0.5 |
Onchocerca volvulus | 0.0175 | 0.1854 | 0.3669 | |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1854 | 0.4156 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0343 | 0.0769 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1732 | 0.1439 |
Loa Loa (eye worm) | intermediate filament protein | 0.0057 | 0.0343 | 0.0769 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0139 | 0.1397 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0105 | 0.0956 | 0.5 |
Brugia malayi | hypothetical protein | 0.0151 | 0.1541 | 0.3455 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0285 | 0.3275 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.1565 |
Leishmania major | endonuclease G, putative | 0.0105 | 0.0956 | 0.5 |
Onchocerca volvulus | 0.0151 | 0.1541 | 0.2909 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Schistosoma mansoni | endonuclease related | 0.0105 | 0.0956 | 0.1488 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.2897 |
Echinococcus granulosus | neuropeptide s receptor | 0.0463 | 0.5559 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.1565 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0147 | 0.15 | 0.1198 |
Trypanosoma brucei | endonuclease G, putative | 0.0105 | 0.0956 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0175 | 0.1854 | 0.3669 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1732 | 0.3373 |
Onchocerca volvulus | 0.0175 | 0.1854 | 0.3669 | |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0175 | 0.1854 | 0.3669 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0377 | 0.4461 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0105 | 0.0956 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0285 | 0.3275 | 0.5 |
Echinococcus multilocularis | Endonuclease G | 0.0105 | 0.0956 | 0.0634 |
Trypanosoma cruzi | endonuclease G, putative | 0.0105 | 0.0956 | 0.5 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0105 | 0.0956 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0175 | 0.1854 | 0.1565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.