Detailed information for compound 904456

Basic information

Technical information
  • TDR Targets ID: 904456
  • Name: 2-(4-nitrophenoxy)-N-(2-phenylethyl)acetamide
  • MW: 300.309 | Formula: C16H16N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccc(cc1)[N+](=O)[O-])NCCc1ccccc1
  • InChi: 1S/C16H16N2O4/c19-16(17-11-10-13-4-2-1-3-5-13)12-22-15-8-6-14(7-9-15)18(20)21/h1-9H,10-12H2,(H,17,19)
  • InChiKey: WZIQVHAZCSPVOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-nitrophenoxy)-N-(2-phenylethyl)ethanamide
  • Oprea1_555632
  • ZINC00123893
  • ST5181987
  • CBDivE_006874

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0057 0.0347 0.0538
Echinococcus granulosus GPCR family 2 0.0018 0.0053 0.0153
Echinococcus multilocularis protein dispatched 1 0.0056 0.0335 0.0519
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0118 0.0184
Loa Loa (eye worm) steroid hormone receptor 0.0057 0.0347 0.2037
Brugia malayi Fli-1 protein 0.0237 0.1702 0.235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0057 0.0347 0.0538
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0506 0.2975
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0143 0.0411
Echinococcus multilocularis geminin 0.0195 0.1391 0.2157
Echinococcus granulosus geminin 0.0195 0.1391 0.3999
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0053 0.0153
Plasmodium falciparum telomerase reverse transcriptase 0.0364 0.2669 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0353 0.0488
Echinococcus multilocularis expressed conserved protein 0.0107 0.072 0.1117
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Schistosoma mansoni hypothetical protein 0.0047 0.0269 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0692 0.3746
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Schistosoma mansoni retinoic acid receptor RXR 0.0057 0.0347 0.0997
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.084
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0057 0.0347 0.0997
Brugia malayi chromobox protein homolog 3 0.0044 0.0246 0.034
Schistosoma mansoni kinase 0.0106 0.0713 0.205
Schistosoma mansoni zinc finger protein 0.0027 0.0118 0.0341
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0272 0.1432
Schistosoma mansoni RAR-like nuclear receptor 0.0057 0.0347 0.0997
Trypanosoma brucei telomerase reverse transcriptase 0.0364 0.2669 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0353 0.2075
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0143 0.084
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.1485 0.8112
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0068 0.0312
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0118 0.0164
Echinococcus granulosus chromobox protein 1 0.0078 0.0506 0.1456
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0347 0.0479
Echinococcus multilocularis chromobox protein 2 0.0013 0.0011 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0246 0.1293
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0053 0.0083
Brugia malayi conserved hypotetical protein 0.0027 0.0118 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0347 0.0479
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0057 0.0347 0.0538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0312
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0053 0.0314
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0143 0.0197
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.0503 0.1448
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0347 0.0997
Brugia malayi hypothetical protein 0.0027 0.0118 0.0164
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Brugia malayi CHD4 protein 0.0015 0.0026 0.0035
Schistosoma mansoni chromobox protein 0.0078 0.0506 0.1456
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.084
Schistosoma mansoni ets-related 0.0237 0.1702 0.4896
Echinococcus multilocularis cpg binding protein 0.0035 0.0179 0.0278
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0118 0.0107
Loa Loa (eye worm) hypothetical protein 0.006 0.0365 0.2146
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.0503 0.0781
Brugia malayi nuclear receptor NHR-67 0.0027 0.0118 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0706 0.2029
Brugia malayi CHE-14 protein 0.0049 0.0283 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.1485 0.8112
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.084
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0011 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0347 0.0997
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.0706 0.4145
Echinococcus multilocularis Chromo domain 0.0013 0.0011 0.0018
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0153
Giardia lamblia Telomerase catalytic subunit 0.0364 0.2669 1
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0011 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0454 0.1306
Echinococcus multilocularis FTZ F1 alpha 0.0057 0.0347 0.0538
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0118 0.0164
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0347 0.0538
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0314
Schistosoma mansoni gabp alpha 0.0078 0.0503 0.1448
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0118 0.0164
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.1485 0.4271
Brugia malayi steroid hormone receptor 0.0057 0.0347 0.0479
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0692 0.3746
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0057 0.0347 0.0479
Plasmodium vivax telomerase reverse transcriptase, putative 0.0364 0.2669 1
Onchocerca volvulus 0.0045 0.0257 0.0246
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Brugia malayi SET domain containing protein 0.0015 0.0026 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0057 0.0347 0.0997
Toxoplasma gondii RNA-directed DNA polymerase 0.0364 0.2669 1
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0347 0.0479
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0283 0.0438
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0312
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0026 0.0074
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0011 0.0033
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0001 0.0005
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0118 0.0164
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0706 0.1095
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0118 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0246 0.1293
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0364 0.2669 1
Onchocerca volvulus 0.0034 0.0175 0.0163
Schistosoma mansoni chromobox protein 0.0013 0.0011 0.0033
Schistosoma mansoni hypothetical protein 0.0047 0.0269 0.0775
Brugia malayi ecdysone receptor 0.0027 0.0118 0.0164
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0118 0.0696
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0118 0.0184
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0118 0.0341
Echinococcus granulosus ecdysone induced protein 78C 0.0057 0.0347 0.0997
Loa Loa (eye worm) helicase 0.0013 0.0011 0.0067
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0272 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0283 0.1493
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0706 0.2029
Entamoeba histolytica serine/threonine protein kinase, putative 0.0208 0.1485 1
Onchocerca volvulus 0.0253 0.1828 0.1819
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.0503 0.2957
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0165 0.0968
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0785 0.2259
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0057 0.0347 0.0997
Schistosoma mansoni hypothetical protein 0.004 0.0214 0.0617
Brugia malayi hypothetical protein 0.003 0.0143 0.0197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0053 0.0074
Brugia malayi nuclear hormone receptor 0.0057 0.0347 0.0479
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0057 0.0347 0.0336
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.084
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0118 0.0341
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0026 0.004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0118 0.0341
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.1485 0.8112
Loa Loa (eye worm) hypothetical protein 0.004 0.0214 0.126
Echinococcus multilocularis chromobox protein 1 0.0078 0.0506 0.0786
Onchocerca volvulus 0.0027 0.0118 0.0107
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0118 0.0184
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0057 0.0347 0.0997
Loa Loa (eye worm) hypothetical protein 0.0067 0.0418 0.2456
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0057 0.0347 0.0479
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0057 0.0347 0.0538
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0053 0.0153
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.084
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0118 0.0696
Brugia malayi Heterochromatin protein 1 0.0078 0.0506 0.0699
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0143 0.0197
Echinococcus granulosus FTZ F1 alpha 0.0057 0.0347 0.0997
Echinococcus multilocularis chromobox protein 1 0.0078 0.0506 0.0786
Brugia malayi Ets-domain containing protein 0.0078 0.0503 0.0695
Schistosoma mansoni coup transcription factor 0.0057 0.0347 0.0997
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.0772 0.222
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.114 0.1769
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0706 0.2029
Brugia malayi Pre-SET motif family protein 0.0033 0.0161 0.0222
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.114 0.3279
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0118 0.0696
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0057 0.0347 0.0997
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0161 0.0249
Onchocerca volvulus 0.0057 0.0347 0.0336
Schistosoma mansoni steroid hormone receptor ad4bp 0.0057 0.0347 0.0997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0057 0.0347 0.2037
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0161 0.0462
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.1596 0.9378
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0353 0.0488
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0706 0.1095
Brugia malayi hypothetical protein 0.0027 0.0118 0.0164
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0011 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.1485 0.8112
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0149 0.076
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0001
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0118 0.0164
Schistosoma mansoni hypothetical protein 0.0047 0.0269 0.0775
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0246 0.0235
Brugia malayi hypothetical protein 0.003 0.0143 0.0197
Brugia malayi Ets-domain containing protein 0.0078 0.0503 0.0695
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0353 0.2075
Brugia malayi Telomerase reverse transcriptase 0.097 0.7245 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0053 0.0083
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0067
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0864 0.6446 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0011 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0057 0.0347 0.2037
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0118 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0057 0.0347 0.2037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0057 0.0347 0.0479
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0312
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0068 0.0312
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0118 0.0184
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0283 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0347 0.0479
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Leishmania major telomerase reverse transcriptase, putative 0.0364 0.2669 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0347 0.0479
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0118 0.0341
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0118 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.1485 0.8112
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.0772 0.1198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0347 0.0479
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.0706 0.0974
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.1485 0.8112
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0067
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0053 0.0083
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0143 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0057 0.0347 0.2037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0057 0.0347 0.0479
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0347 0.0997
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0011 0.0033
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0506 0.2724
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0149 0.076
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Schistosoma mansoni hypothetical protein 0.0047 0.0269 0.0775
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0312
Schistosoma mansoni chromobox protein 0.0013 0.0011 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0057 0.0347 0.0479
Echinococcus multilocularis protein patched 0.0049 0.0283 0.0438
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0214 0.0296
Schistosoma mansoni nuclear receptor 0.0027 0.0118 0.0341
Loa Loa (eye worm) hypothetical protein 0.0034 0.0175 0.1026
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0943
Loa Loa (eye worm) hypothetical protein 0.0044 0.0246 0.1447
Echinococcus granulosus Chromo domain 0.0013 0.0011 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0347 0.0997
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0364 0.2669 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0397 0.1452
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0347 0.0538
Onchocerca volvulus 0.0027 0.0118 0.0107
Brugia malayi photoreceptor-specific nuclear receptor 0.0057 0.0347 0.0479
Brugia malayi CXXC zinc finger family protein 0.0033 0.0165 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0057 0.0347 0.0479
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0506 0.2724
Onchocerca volvulus Bile acid receptor homolog 0.0057 0.0347 0.0336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0038 0.0145
Brugia malayi Protein cec-1. 0.0013 0.0011 0.0016
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.0772 0.1066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0057 0.0347 0.0997
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0053 0.0074
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0118 0.0341
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0042 0.0167
Echinococcus granulosus expressed conserved protein 0.0107 0.072 0.2071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0118 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0462
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0462
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0026 0.0074
Schistosoma mansoni cpg binding protein 0.0033 0.0165 0.0474
Brugia malayi tailless protein 0.0027 0.0118 0.0164
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0011 0.0016
Brugia malayi nuclear receptor NHR-88 0.0027 0.0118 0.0164
Onchocerca volvulus Serine\/threonine kinase homolog 0.0208 0.1485 0.1475
Echinococcus multilocularis dnaJ subfamily B 0.0471 0.3477 0.5394
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0011 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0347 0.0997
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0057 0.0347 0.0479
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0067
Brugia malayi nuclear receptor RXR 0.003 0.0143 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0706 0.2029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0161 0.0249
Loa Loa (eye worm) fli-1 protein 0.0237 0.1702 1
Loa Loa (eye worm) DR-78 0.0027 0.0118 0.0696
Schistosoma mansoni patched 1 0.0049 0.0283 0.0813
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0161 0.0561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0462
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0011 0.0033
Schistosoma mansoni nuclear receptor 0.0027 0.0118 0.0341
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0347 0.0997
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0208 0.1485 0.4271
Echinococcus granulosus chromobox protein 1 0.0078 0.0506 0.1456
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0118 0.0341
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0257 0.074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0706 0.2029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0146 0.042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0067
Onchocerca volvulus Protein ultraspiracle homolog 0.0057 0.0347 0.0336
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0208 0.1485 0.8723
Brugia malayi serine/threonine-protein kinase plk-2 0.0208 0.1485 0.205
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0067
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0118 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0312
Brugia malayi nuclear hormone receptor 0.0027 0.0118 0.0164
Plasmodium vivax SET domain protein, putative 0.0033 0.0161 0.0561
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0347 0.0479
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0283 0.166
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0057 0.0347 0.0997
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0026 0.0151
Brugia malayi hypothetical protein 0.0013 0.0011 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0057 0.0347 0.0997
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0118 0.0341
Loa Loa (eye worm) hypothetical protein 0.0113 0.0772 0.4536
Schistosoma mansoni cpg binding protein 0.0035 0.0179 0.0515
Schistosoma mansoni chromobox protein 0.0078 0.0506 0.1456
Schistosoma mansoni cpg binding protein 0.0035 0.0179 0.0515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0057 0.0347 0.0997
Brugia malayi Steroid receptor seven-up type 2 0.0057 0.0347 0.0479
Brugia malayi nuclear receptor NHR-88 0.0057 0.0347 0.0479
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0067
Onchocerca volvulus 0.0013 0.0011 0.000000010083
Echinococcus multilocularis thyroid hormone receptor alpha 0.0057 0.0347 0.0538
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0153
Brugia malayi nuclear receptor RXR 0.0027 0.0118 0.0164
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0057 0.0347 0.2037
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0283 0.0813
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0272 0.1432
Schistosoma mansoni hypothetical protein 0.0195 0.1391 0.3999
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0118 0.0341
Loa Loa (eye worm) hypothetical protein 0.0049 0.0283 0.166
Echinococcus granulosus chromobox protein 2 0.0013 0.0011 0.0033
Trichomonas vaginalis set domain proteins, putative 0.0253 0.1828 1
Brugia malayi ecdysteroid receptor 0.0057 0.0347 0.0479
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0143 0.0411
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0118 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0312
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.2037
Onchocerca volvulus 0.0033 0.0165 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.1485 0.8112
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0143 0.0411
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0118 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0057 0.0347 0.2037
Schistosoma mansoni hypothetical protein 0.0471 0.3477 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0067
Echinococcus granulosus dnaJ subfamily B 0.0471 0.3477 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0208 0.1485 0.2304
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0696
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.0772 0.5162
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0057 0.0347 0.0997
Schistosoma mansoni hypothetical protein 0.0195 0.1391 0.3999
Echinococcus multilocularis ecdysone induced protein 78C 0.0057 0.0347 0.0538
Echinococcus granulosus cpg binding protein 0.0035 0.0179 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0042 0.0167
Brugia malayi Pre-SET motif family protein 0.0223 0.1596 0.2203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0057 0.0347 0.2037
Echinococcus granulosus Chromobox protein 3 0.0013 0.0011 0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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