TDR Targets

Basic information

Technical information

TDR Targets ID: 906317
Name: N-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2- yl]ethyl]-N'-(3-methylphenyl)oxamide
MW: 459.558 | Formula: C23H29N3O5S
H donors: 2 H acceptors: 4 LogP: 3.26 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)S(=O)(=O)N1CCCCC1CCNC(=O)C(=O)Nc1cccc(c1)C
InChi: 1S/C23H29N3O5S/c1-17-6-5-7-18(16-17)25-23(28)22(27)24-14-13-19-8-3-4-15-26(19)32(29,30)21-11-9-20(31-2)10-12-21/h5-7,9-12,16,19H,3-4,8,13-15H2,1-2H3,(H,24,27)(H,25,28)
InChiKey: KNAYFHYWUYMIJN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[1-(4-methoxyphenyl)sulfonyl-2-piperidyl]ethyl]-N'-(3-methylphenyl)oxamide
N-[2-[1-(4-methoxyphenyl)sulfonyl-2-piperidinyl]ethyl]-N'-(3-methylphenyl)oxamide
N-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]ethyl]-N'-(3-methylphenyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0086	0.0085
Toxoplasma gondii	cathepsin B	0.3803	0.663	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2235	0.3879	0.3879
Echinococcus multilocularis	cathepsin L	0.1303	0.2244	0.2244
Echinococcus multilocularis	cathepsin b	0.5723	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0668	0.1129	0.0064
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.2235	0.3879	0.3879
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Entamoeba histolytica	cysteine proteinase 1, putative	0.1303	0.2244	0.577
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0668	0.1129	0.1129
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2235	0.3879	1
Onchocerca volvulus		0.16	0.2764	0.7126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0086	0.0085
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0668	0.1129	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0001	0.0001
Brugia malayi	cathepsin L precursor	0.0668	0.1129	0.1129
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0032	0.0014	0.0013
Loa Loa (eye worm)	intermediate filament protein	0.0025	0.0001	0.0001
Plasmodium vivax	serine-repeat antigen (SERA)	0.0668	0.1129	0.0205
Brugia malayi	Papain family cysteine protease containing protein	0.0668	0.1129	0.1129
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0668	0.1129	0.1129
Brugia malayi	Cathepsin L-like precursor	0.16	0.2764	0.2764
Loa Loa (eye worm)	hypothetical protein	0.0668	0.1129	0.1129
Echinococcus granulosus	cysteine protease	0.1303	0.2244	0.2244
Loa Loa (eye worm)	hypothetical protein	0.0668	0.1129	0.1129
Brugia malayi	Cathepsin L-like precursor	0.16	0.2764	0.2764
Onchocerca volvulus		0.2235	0.3879	1
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Loa Loa (eye worm)	hypothetical protein	0.0635	0.1072	0.1072
Trypanosoma cruzi	cysteine proteinase, putative	0.1303	0.2244	0.1313
Trypanosoma cruzi	cysteine peptidase, putative	0.4574	0.7984	0.7742
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0668	0.1129	0.0205
Schistosoma mansoni	hypothetical protein	0.0032	0.0014	0.0013
Plasmodium vivax	unspecified product	0.1303	0.2244	0.4176
Entamoeba histolytica	cysteine protease, putative	0.0668	0.1129	0.2886
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2235	0.3879	0.3879
Echinococcus granulosus	cathepsin l1	0.16	0.2764	0.2764
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Leishmania major	cathepsin L-like protease	0.4574	0.7984	1
Brugia malayi	Cathepsin L-like precursor	0.2235	0.3879	0.3879
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0086	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0668	0.1129	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Trypanosoma cruzi	cysteine proteinase, putative	0.1303	0.2244	0.1313
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1303	0.2244	0.2244
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Plasmodium vivax	unspecified product	0.0668	0.1129	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0635	0.1072	0.1072
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Brugia malayi	Papain family cysteine protease containing protein	0.0668	0.1129	0.1129
Entamoeba histolytica	cysteine protease, putative	0.0668	0.1129	0.2886
Brugia malayi	Cathepsin L-like cysteine proteinase	0.16	0.2764	0.2764
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2235	0.3879	0.3879
Toxoplasma gondii	cathepsin CPL	0.2235	0.3879	0.4999
Plasmodium vivax	vivapain-2	0.2235	0.3879	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.3803	0.663	0.7641
Loa Loa (eye worm)	hypothetical protein	0.16	0.2764	0.2764
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0668	0.1129	0.1129
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5723	1	1
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.5723	1	1
Echinococcus granulosus	tar DNA binding protein	0.0073	0.0086	0.0085
Brugia malayi	cathepsin L-like precursor	0.16	0.2764	0.2764
Trypanosoma cruzi	cysteine peptidase, putative	0.2235	0.3879	0.3144
Plasmodium vivax	vivapain-1	0.1303	0.2244	0.4176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Schistosoma mansoni	cathepsin C	0.0668	0.1129	0.1129
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0668	0.1129	0.1129
Onchocerca volvulus		0.2235	0.3879	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2235	0.3879	0.3879
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.3803	0.663	0.6701
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0668	0.1129	0.1129
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Onchocerca volvulus	Cathepsin L homolog	0.0668	0.1129	0.291
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0086	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.16	0.2764	0.2973
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0124	0.0123
Giardia lamblia	Cathepsin B precursor	0.3803	0.663	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.0124	0.0124
Entamoeba histolytica	cysteine proteinase, putative	0.1303	0.2244	0.577
Trypanosoma cruzi	cysteine peptidase, putative	0.4574	0.7984	0.7742
Entamoeba histolytica	cysteine protease, putative	0.0668	0.1129	0.2886
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2235	0.3879	0.3879
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0668	0.1129	0.1129
Entamoeba histolytica	cysteine proteinase, putative	0.1303	0.2244	0.577
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0668	0.1129	0.1129
Brugia malayi	cathepsin F-like cysteine proteinase	0.0668	0.1129	0.1129
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.0086	0.0085
Brugia malayi	Papain family cysteine protease containing protein	0.1303	0.2244	0.2244
Schistosoma mansoni	cathepsin F (C01 family)	0.16	0.2764	0.2764
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0668	0.1129	0.1129
Loa Loa (eye worm)	fibroinase	0.2235	0.3879	0.3879
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0668	0.1129	0.1129
Echinococcus granulosus	geminin	0.0152	0.0224	0.0223
Brugia malayi	Papain family cysteine protease containing protein	0.0668	0.1129	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2235	0.3879	0.4999
Loa Loa (eye worm)	cathepsin B	0.3803	0.663	0.663
Echinococcus granulosus	cathepsin l1	0.2235	0.3879	0.3879
Brugia malayi	hypothetical protein	0.0032	0.0014	0.0013
Brugia malayi	Cathepsin L-like precursor	0.2235	0.3879	0.3879
Echinococcus multilocularis	geminin	0.0152	0.0224	0.0223
Loa Loa (eye worm)	hypothetical protein	0.5723	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0668	0.1129	0.0205
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1303	0.2244	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1303	0.2244	0.2027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Brugia malayi	RNA binding protein	0.0073	0.0086	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.1303	0.2244	0.1313
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Schistosoma mansoni	hypothetical protein	0.0152	0.0224	0.0223
Loa Loa (eye worm)	hypothetical protein	0.16	0.2764	0.2764
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0635	0.1072	0.1071
Echinococcus multilocularis	cathepsin b	0.5723	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0668	0.1129	0.0205
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0124	0.0123
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0668	0.1129	0.0205
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0668	0.1129	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0124	0.0123
Echinococcus granulosus	cathepsin L	0.1303	0.2244	0.2244
Echinococcus multilocularis	cysteine protease	0.2235	0.3879	0.3879
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Echinococcus granulosus	cathepsin b	0.5723	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Echinococcus multilocularis	cathepsin L	0.0668	0.1129	0.1129
Onchocerca volvulus		0.2235	0.3879	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0124	0.0123
Echinococcus granulosus	cathepsin L	0.0668	0.1129	0.1129
Leishmania major	cathepsin L-like protease	0.4574	0.7984	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0668	0.1129	0.1129
Schistosoma mansoni	hypothetical protein	0.0152	0.0224	0.0223
Schistosoma mansoni	lipoxygenase	0.0096	0.0125	0.0124
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1303	0.2244	0.1313
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5723	1	1
Brugia malayi	Cathepsin L-like precursor	0.2235	0.3879	0.3879
Onchocerca volvulus	Cathepsin L homolog	0.2235	0.3879	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0668	0.1129	0.2886
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2235	0.3879	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.3939	0.6869	0.6493
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1303	0.2244	0.2244
Entamoeba histolytica	hypothetical protein	0.0668	0.1129	0.2886
Onchocerca volvulus		0.2235	0.3879	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Loa Loa (eye worm)	hypothetical protein	0.0668	0.1129	0.1129
Brugia malayi	Cathepsin L-like precursor	0.2235	0.3879	0.3879
Trypanosoma cruzi	cysteine peptidase, putative	0.4574	0.7984	0.7742
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0668	0.1129	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.0086	0.0085
Entamoeba histolytica	cysteine protease, putative	0.2235	0.3879	1
Entamoeba histolytica	cysteine protease, putative	0.0668	0.1129	0.2886
Brugia malayi	Papain family cysteine protease containing protein	0.2235	0.3879	0.3879
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.0124	0.0123
Brugia malayi	Cathepsin L-like precursor	0.0635	0.1072	0.1071
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0137	0.0197	0.0196
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2235	0.3879	0.3879
Echinococcus multilocularis	cathepsin L cysteine protease	0.2235	0.3879	0.3879
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0668	0.1129	0.0205
Entamoeba histolytica	cysteine protease, putative	0.0668	0.1129	0.2886
Plasmodium vivax	vivapain-3	0.1303	0.2244	0.4176
Leishmania major	cathepsin L-like protease	0.4574	0.7984	1
Brugia malayi	Papain family cysteine protease containing protein	0.1303	0.2244	0.2244
Entamoeba histolytica	cysteine proteinase, putative	0.2235	0.3879	1
Loa Loa (eye worm)	RNA binding protein	0.0073	0.0086	0.0086
Echinococcus granulosus	cathepsin L cysteine protease	0.1303	0.2244	0.2244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.16	0.2764	0.2973
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0668	0.1129	0.1129
Onchocerca volvulus		0.2235	0.3879	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2235	0.3879	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Schistosoma mansoni	lipoxygenase	0.0137	0.0197	0.0196
Schistosoma mansoni	transcription factor LCR-F1	0.0032	0.0014	0.0013
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2235	0.3879	0.3879
Loa Loa (eye worm)	hypothetical protein	0.0668	0.1129	0.1129
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5723	1	1
Giardia lamblia	Cathepsin B precursor	0.3803	0.663	1
Giardia lamblia	Cathepsin B precursor	0.3803	0.663	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.5723	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0635	0.1072	0.1072
Onchocerca volvulus		0.2235	0.3879	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Echinococcus granulosus	cathepsin b	0.5723	1	1
Onchocerca volvulus		0.0668	0.1129	0.291
Plasmodium vivax	serine-repeat antigen (SERA)	0.0668	0.1129	0.0205
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0124	0.0123
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0124	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0668	0.1129	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1303	0.2244	0.2027
Entamoeba histolytica	cysteine proteinase 2	0.1303	0.2244	0.577
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Entamoeba histolytica	cysteine proteinase, putative	0.1303	0.2244	0.577
Brugia malayi	TAR-binding protein	0.0073	0.0086	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1303	0.2244	0.2244
Brugia malayi	cathepsin L-like cysteine proteinase	0.0668	0.1129	0.1129
Entamoeba histolytica	cysteine proteinase, putative	0.1303	0.2244	0.577
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0668	0.1129	0.1129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4574	0.7984	1
Loa Loa (eye worm)	hypothetical protein	0.0635	0.1072	0.1072
Onchocerca volvulus	Cathepsin F homolog	0.2235	0.3879	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Loa Loa (eye worm)	hypothetical protein	0.16	0.2764	0.2764
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Schistosoma mansoni	cathepsin S (C01 family)	0.0668	0.1129	0.1129
Echinococcus multilocularis	cysteine protease	0.2235	0.3879	0.3879
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0124	0.0123
Onchocerca volvulus		0.2235	0.3879	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0137	0.0197	0.0196
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2235	0.3879	0.4999
Entamoeba histolytica	cysteine protease, putative	0.0668	0.1129	0.2886
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0668	0.1129	0.0205
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3803	0.663	0.6629
Brugia malayi	Cathepsin L-like precursor	0.2235	0.3879	0.3879
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0668	0.1129	0.0205
Trypanosoma cruzi	major cysteine proteinase, putative	0.3007	0.5234	0.4662
Loa Loa (eye worm)	ctsf protein	0.2235	0.3879	0.3879
Brugia malayi	fibroinase precursor	0.0668	0.1129	0.1129
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.3803	0.663	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0032	0.0014	0.0013
Plasmodium vivax	vivapain-2	0.2235	0.3879	1
Brugia malayi	Cathepsin L-like precursor	0.2235	0.3879	0.3879
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0668	0.1129	0.2886
Onchocerca volvulus	Cathepsin L homolog	0.2235	0.3879	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2235	0.3879	0.4999
Echinococcus multilocularis	cathepsin L cysteine protease	0.2235	0.3879	0.3879
Loa Loa (eye worm)	hypothetical protein	0.0668	0.1129	0.1129
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Brugia malayi	cathepsin F-like cysteine proteinase	0.0635	0.1072	0.1071
Schistosoma mansoni	cathepsin s	0.0635	0.1072	0.1071
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0668	0.1129	0.1129
Schistosoma mansoni	cathepsin B (C01 family)	0.0668	0.1129	0.1129
Trypanosoma cruzi	cysteine protease, putative	0.1303	0.2244	0.1313
Entamoeba histolytica	cysteine protease, putative	0.1303	0.2244	0.577
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0668	0.1129	0.0205
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0025	0.0001	0.0001
Schistosoma mansoni	cathepsin F (C01 family)	0.2235	0.3879	0.3879
Entamoeba histolytica	cysteine proteinase, putative	0.16	0.2764	0.7116
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2235	0.3879	0.4999
Entamoeba histolytica	cysteine proteinase, putative	0.2235	0.3879	1
Loa Loa (eye worm)	cysteine protease	0.2235	0.3879	0.3879
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3803	0.663	0.6225
Trypanosoma cruzi	cruzipain precursor, putative	0.4574	0.7984	0.7742

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906317