Detailed information for compound 906360

Basic information

Technical information
  • TDR Targets ID: 906360
  • Name: N'-(4-chlorophenyl)-N-[2-[1-(4-fluoro-2-methy lphenyl)sulfonylpiperidin-2-yl]ethyl]oxamide
  • MW: 481.968 | Formula: C22H25ClFN3O4S
  • H donors: 2 H acceptors: 4 LogP: 4.01 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)C(=O)NCCC1CCCCN1S(=O)(=O)c1ccc(cc1C)F
  • InChi: 1S/C22H25ClFN3O4S/c1-15-14-17(24)7-10-20(15)32(30,31)27-13-3-2-4-19(27)11-12-25-21(28)22(29)26-18-8-5-16(23)6-9-18/h5-10,14,19H,2-4,11-13H2,1H3,(H,25,28)(H,26,29)
  • InChiKey: CMYAQXFQXGUDLE-UHFFFAOYSA-N  

Network

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Synonyms

  • N'-(4-chlorophenyl)-N-[2-[1-(4-fluoro-2-methyl-phenyl)sulfonyl-2-piperidyl]ethyl]oxamide
  • N'-(4-chlorophenyl)-N-[2-[1-(4-fluoro-2-methylphenyl)sulfonyl-2-piperidinyl]ethyl]oxamide
  • N'-(4-chlorophenyl)-N-[2-[1-(4-fluoro-2-methyl-phenyl)sulfonylpiperidin-2-yl]ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0429 0.0429
Echinococcus multilocularis muscleblind protein 0.0147 0.9512 0.9512
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.2155 1
Mycobacterium ulcerans heat shock protein 90 0.0026 0.1036 0.2024
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3722 0.3722
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0429 0.0442
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.1036 0.2024
Plasmodium vivax endoplasmin, putative 0.0032 0.149 0.2911
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0422 0.0435
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.1036 0.2024
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.3618 0.3618
Brugia malayi jmjC domain containing protein 0.0017 0.0422 0.0422
Brugia malayi jmjC domain containing protein 0.0017 0.0422 0.0422
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.149 0.2911
Giardia lamblia Grp94/Hsp90 0.0026 0.1036 0.4808
Treponema pallidum methionine aminopeptidase (map) 0.0084 0.512 1
Echinococcus multilocularis endoplasmin 0.0026 0.1036 0.1036
Toxoplasma gondii heat shock protein HSP90 0.0032 0.149 0.2911
Trypanosoma brucei methionine aminopeptidase, putative 0.0084 0.512 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.3722 0.3722
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Brugia malayi Hsp90 protein 0.0013 0.0174 0.0174
Trichomonas vaginalis heat shock protein, putative 0.0032 0.149 0.6163
Brugia malayi heat shock protein 90 0.0032 0.149 0.149
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0174 0.0174
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.3618 0.373
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.149 0.2911
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.3618 0.3618
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.149 0.2911
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.3618 0.3618
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Schistosoma mansoni heat shock protein 0.0032 0.149 0.149
Loa Loa (eye worm) hypothetical protein 0.0036 0.1785 0.1785
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0174 1
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0174 0.0339
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0422 0.0435
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.2418 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0084 0.512 0.512
Schistosoma mansoni hypothetical protein 0.0036 0.1785 0.1785
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.3618 0.3618
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0084 0.512 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0422 0.0824
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.2418 0.4723
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0174 0.0174
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0422 0.0422
Echinococcus granulosus tar DNA binding protein 0.0064 0.3722 0.3837
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.149 0.2911
Trichomonas vaginalis endoplasmin, putative 0.002 0.0628 0.2597
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Echinococcus granulosus phd:f box containing protein 0.0017 0.0422 0.0435
Mycobacterium ulcerans methionine aminopeptidase 0.0084 0.512 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.149 0.2911
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.2155 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0084 0.512 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 1 1
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0084 0.512 1
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0174 0.0339
Loa Loa (eye worm) methionine aminopeptidase type I 0.0084 0.512 0.512
Loa Loa (eye worm) endoplasmin 0.0032 0.149 0.149
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Trichomonas vaginalis heat shock protein, putative 0.002 0.0628 0.2597
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.149 0.6916
Trichomonas vaginalis heat shock protein, putative 0.0026 0.1036 0.4285
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0084 0.512 1
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.149 0.2911
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3722 0.3722
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0422 0.0824
Loa Loa (eye worm) hypothetical protein 0.0017 0.0422 0.0422
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0422 0.0422
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0422 0.0824
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0422 0.0422
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0429 0.0429
Plasmodium falciparum endoplasmin, putative 0.002 0.0628 0.1227
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0422 0.0422
Schistosoma mansoni endoplasmin 0.0032 0.149 0.149
Treponema pallidum heat shock protein 90 0.0026 0.1036 0.2024
Schistosoma mansoni heat shock protein 0.0032 0.149 0.149
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0084 0.512 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.1036 0.4285
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1785 0.1785
Echinococcus granulosus GPCR family 2 0.0017 0.0429 0.0442
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0084 0.512 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.9512 0.9512
Leishmania major heat shock protein, putative 0.0013 0.0174 0.0339
Schistosoma mansoni hypothetical protein 0.0017 0.0429 0.0429
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0084 0.512 1
Loa Loa (eye worm) acetyltransferase 0.0154 1 1
Leishmania major hypothetical protein, conserved 0.0017 0.0422 0.0824
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0084 0.512 1
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0422 0.0422
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0084 0.512 1
Brugia malayi Methionine aminopeptidase protein type I 0.0084 0.512 0.512
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.3722 0.3722
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.2954 0.2954
Plasmodium vivax heat shock protein 86, putative 0.0032 0.149 0.2911
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3722 0.3722
Toxoplasma gondii methionine aminopeptidase 0.0084 0.512 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3722 0.3722
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.149 0.6916
Loa Loa (eye worm) TAR-binding protein 0.0064 0.3722 0.3722
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.149 0.2911
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Brugia malayi Endoplasmin precursor 0.0032 0.149 0.149
Echinococcus multilocularis GPCR, family 2 0.0017 0.0429 0.0429
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0084 0.512 0.5279
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.149 0.6916
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.1036 0.2024
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.1036 0.2024
Echinococcus multilocularis heat shock protein 0.0032 0.149 0.149
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0084 0.512 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0429 0.0442
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.2155 0.4209
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Echinococcus multilocularis heat shock protein 90 0.0032 0.149 0.149
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0576 0.1126
Brugia malayi Muscleblind-like protein 0.0147 0.9512 0.9512
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.2418 0.2493
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.2418 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0174 0.0806
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0422 0.0422
Chlamydia trachomatis methionine aminopeptidase 0.0084 0.512 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0422 0.0422
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0174 0.0339
Echinococcus granulosus heat shock protein 90 0.0026 0.1036 0.1068
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0422 0.0422
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Brugia malayi jmjC domain containing protein 0.0017 0.0422 0.0422
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0174 0.0339
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 1 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.9512 0.9512
Brugia malayi jmjC domain containing protein 0.0063 0.3618 0.3618
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0429 0.0429
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0084 0.512 0.512
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.1036 0.4808
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0084 0.512 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.1036 0.1068
Loa Loa (eye worm) RNA binding protein 0.0064 0.3722 0.3722
Brugia malayi jmjC domain containing protein 0.0017 0.0422 0.0422
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.1036 0.2024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.2954 0.2954
Echinococcus granulosus heat shock protein 90 0.0032 0.149 0.1537
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0422 0.0422
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0422 0.0435
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0429 0.0429
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0084 0.512 1
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0422 0.0824
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.1036 0.2024
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.2954 0.2954
Brugia malayi RNA binding protein 0.0064 0.3722 0.3722
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0174 0.0339
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0084 0.512 0.512
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0429 0.0429
Echinococcus granulosus endoplasmin 0.0026 0.1036 0.1068
Echinococcus multilocularis heat shock protein 90 0.0026 0.1036 0.1036
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0174 0.0339
Echinococcus granulosus muscleblind protein 0.0147 0.9512 0.9807
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.3618 0.3618
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0084 0.512 1
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0422 0.0435
Loa Loa (eye worm) heat shock protein 90 0.0032 0.149 0.149
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Loa Loa (eye worm) hypothetical protein 0.0017 0.0422 0.0422
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.3722 0.3722
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.149 0.2911
Plasmodium vivax heat shock protein, putative 0.0013 0.0174 0.0339
Toxoplasma gondii methionine aminopeptidase 0.0084 0.512 1
Brugia malayi TAR-binding protein 0.0064 0.3722 0.3722
Schistosoma mansoni jumonji domain containing protein 0.0063 0.3618 0.3618
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0422 0.0422
Schistosoma mansoni endoplasmin 0.0032 0.149 0.149
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0422 0.0422
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.2418 0.4723
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0084 0.512 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0422 0.0824
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.9699 1
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0084 0.512 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.149 0.2911
Leishmania major heat shock protein 83-1 0.0032 0.149 0.2911
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0174 0.0179
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0084 0.512 0.512
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0422 0.0422
Plasmodium falciparum heat shock protein 90 0.0032 0.149 0.2911
Schistosoma mansoni hypothetical protein 0.0017 0.0429 0.0429
Schistosoma mansoni hypothetical protein 0.0017 0.0429 0.0429
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0422 0.0422
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0084 0.512 1
Plasmodium vivax JmjC domain containing protein 0.0017 0.0422 0.0824
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.149 0.2911
Brugia malayi jmjC domain containing protein 0.0063 0.3618 0.3618
Echinococcus multilocularis muscleblind protein 1 0.0147 0.9512 0.9512
Loa Loa (eye worm) hypothetical protein 0.0017 0.0429 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3722 0.3722
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.3618 0.373
Schistosoma mansoni hypothetical protein 0.0017 0.0429 0.0429
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0422 0.0422
Trichomonas vaginalis heat shock protein, putative 0.0026 0.1036 0.4285
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0174 0.0339
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0174 0.0719
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.2418 0.4723
Echinococcus granulosus heat shock protein 0.0032 0.149 0.1537
Schistosoma mansoni heat shock protein 0.0013 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0053 0.2954 0.2954
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0422 0.0824

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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