Detailed information for compound 908950

Basic information

Technical information
  • TDR Targets ID: 908950
  • Name: (5E)-5-[(3-fluorophenyl)methylidene]-1,3-thia zolidine-2,4-dione
  • MW: 223.224 | Formula: C10H6FNO2S
  • H donors: 1 H acceptors: 2 LogP: 2.3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)/C(=C/c2cccc(c2)F)/S1
  • InChi: 1S/C10H6FNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5+
  • InChiKey: FHRKKLBIQCOIMF-VMPITWQZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-5-[(3-fluorophenyl)methylene]thiazolidine-2,4-dione
  • (5E)-5-(3-fluorobenzylidene)thiazolidine-2,4-quinone
  • (5E)-5-(3-Fluorobenzylidene)-1,3-thiazolidine-2,4-dione
  • Thiazolidine-2,4-dione, 5-(3-fluorobenzylideno)-
  • ZINC01231366

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0103 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0301 0.1907 0.1907
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0369 0.2362 0.4553
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.079 0.5169 1
Brugia malayi MH1 domain containing protein 0.0103 0.0584 0.0584
Echinococcus granulosus smad 0.0103 0.0584 0.3061
Brugia malayi Probable ClpP-like protease 0.0082 0.0445 0.0445
Loa Loa (eye worm) isocitrate dehydrogenase 0.0129 0.0756 0.0756
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0017 0.0042
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0017 0.0031
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0107 0.061 0.32
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.079 0.5169 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0129 0.0756 0.1396
Leishmania major hypothetical protein, conserved 0.0239 0.1489 0.9792
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0046 0.0203 0.0362
Echinococcus multilocularis Smad4 0.0103 0.0584 0.1078
Brugia malayi hypothetical protein 0.0018 0.0017 0.0017
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0017 0.0017
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.3965
Loa Loa (eye worm) MH2 domain-containing protein 0.0046 0.0203 0.0203
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0017 0.0017
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0017 0.0031
Brugia malayi hypothetical protein 0.0239 0.1489 0.1489
Echinococcus granulosus TGF beta signal transducer SmadC 0.0103 0.0584 0.3061
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0017 0.0042
Brugia malayi DIX domain containing protein 0.0018 0.0017 0.0017
Echinococcus granulosus mothers against decapentaplegic 5 0.0103 0.0584 0.3061
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0445 0.2876
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.079 0.5169 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0046 0.0203 0.0203
Schistosoma mansoni smad 0.0046 0.0203 0.0511
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Loa Loa (eye worm) hypothetical protein 0.0046 0.0203 0.0203
Schistosoma mansoni smad1 5 8 and 0.0103 0.0584 0.147
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0243 0.1521 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.1396
Loa Loa (eye worm) hypothetical protein 0.0369 0.2362 0.2362
Echinococcus granulosus mothers against decapentaplegic 6 0.0046 0.0203 0.1065
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0045
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0756 0.4893
Schistosoma mansoni smad 0.0103 0.0584 0.147
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.1396
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0017 0.0017
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0017 0.0031
Onchocerca volvulus 0.079 0.5169 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0445 0.2908
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0283 0.1783 0.3292
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0107 0.061 0.1127
Brugia malayi hypothetical protein 0.0018 0.0017 0.0017
Loa Loa (eye worm) MH1 domain-containing protein 0.0103 0.0584 0.0584
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.079 0.5169 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0827 0.5416 1
Loa Loa (eye worm) Smad1 0.0103 0.0584 0.0584
Schistosoma mansoni Smad4 0.0046 0.0203 0.0511
Schistosoma mansoni dishevelled 0.0018 0.0017 0.0042
Leishmania major hypothetical protein, conserved 0.0243 0.1521 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0129 0.0756 0.1903
Echinococcus multilocularis muscleblind protein 0.0301 0.1907 0.3522
Schistosoma mansoni Smad4 0.0046 0.0203 0.0511
Schistosoma mansoni smad1 5 8 and 0.0103 0.0584 0.147
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0256 0.0722
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0243 0.1521 0.2943
Schistosoma mansoni dep domain containing protein 0.0018 0.0017 0.0042
Brugia malayi Protein kinase domain containing protein 0.0193 0.1184 0.1184
Trypanosoma brucei PAB1-binding protein , putative 0.0239 0.1489 0.9788
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0017 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.1396
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0256 0.5745
Echinococcus multilocularis mothers against decapentaplegic 5 0.0103 0.0584 0.1078
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0129 0.0756 0.4999
Brugia malayi MH2 domain containing protein 0.0046 0.0203 0.0203
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0059
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0129 0.0756 0.4999
Brugia malayi Isocitrate dehydrogenase 0.0129 0.0756 0.0756
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.0045
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0085 0.0418
Loa Loa (eye worm) latrophilin receptor protein 2 0.0283 0.1783 0.1783
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0193 0.1184 0.2186
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0445 0.2908
Brugia malayi MH1 domain containing protein 0.0057 0.0276 0.0276
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0256 0.1341
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Schistosoma mansoni Smad4 0.0103 0.0584 0.147
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0756 0.4972
Echinococcus granulosus mothers against decapentaplegic 2 0.0046 0.0203 0.1065
Plasmodium falciparum ataxin-2 like protein, putative 0.0239 0.1489 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.0045
Brugia malayi hypothetical protein 0.0154 0.0924 0.0924
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.079 0.5169 1
Brugia malayi MH1 domain containing protein 0.0057 0.0276 0.0276
Schistosoma mansoni smad1 5 8 and 0.0103 0.0584 0.147
Trypanosoma cruzi hypothetical protein, conserved 0.0243 0.1521 1
Echinococcus multilocularis smad 0.0103 0.0584 0.1078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Echinococcus granulosus muscleblind protein 0.0301 0.1907 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0023 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.1184 0.298
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0756 0.4893
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0085 0.1455
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0445 0.0822
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0445 0.2334
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0017 0.0088
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0103 0.0584 0.1078
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0283 0.1783 0.9347
Brugia malayi MH2 domain containing protein 0.0103 0.0584 0.0584
Brugia malayi MH2 domain containing protein 0.0103 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0301 0.1907 0.1907
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0017 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0129 0.0756 0.1396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0283 0.1783 0.3292
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0584 0.0584
Schistosoma mansoni dishevelled 0.0018 0.0017 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0129 0.0756 0.4893
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0193 0.1184 0.6208
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0283 0.1783 0.9347
Brugia malayi latrophilin 2 splice variant baaae 0.0611 0.3973 0.3973
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.1184 0.1184
Echinococcus multilocularis mothers against decapentaplegic 2 0.0046 0.0203 0.0375
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.079 0.5169 0.5169
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0045
Echinococcus granulosus GPCR family 2 0.0283 0.1783 0.9347
Trypanosoma cruzi PAB1-binding protein , putative 0.0239 0.1489 0.9788
Loa Loa (eye worm) transcription factor SMAD2 0.1514 1 1
Toxoplasma gondii hypothetical protein 0.0028 0.0085 0.0462
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0193 0.1184 0.1184
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0283 0.1783 0.1783
Loa Loa (eye worm) hypothetical protein 0.0283 0.1783 0.1783
Schistosoma mansoni hypothetical protein 0.0611 0.3973 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0256 0.0722
Loa Loa (eye worm) hypothetical protein 0.0611 0.3973 0.3973
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0445 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0276 0.0276
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0893 0.5861 0.5861
Brugia malayi mothers against decapentaplegic homolog 3 0.0046 0.0203 0.0203
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0256 0.0472
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0017 0.0031
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.2876
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0193 0.1184 0.2266
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.1184 0.1184
Plasmodium falciparum ataxin-2 like protein, putative 0.0239 0.1489 1
Plasmodium vivax ataxin-2 like protein, putative 0.0239 0.1489 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0023 0.0528
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0023 0.0066
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0243 0.1521 1
Brugia malayi N-terminal motif family protein 0.0369 0.2362 0.2362
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0017 0.0088
Schistosoma mansoni hypothetical protein 0.0107 0.061 0.1536
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0017 0.0031
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0017 0.0017
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0017 0.0088
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.0861
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0043
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0017 0.0088
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.079 0.5169 1
Brugia malayi isocitrate dehydrogenase 0.0129 0.0756 0.0756
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0085 0.1906
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0445 0.112
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0129 0.0756 0.4893
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0243 0.1521 0.2943
Loa Loa (eye worm) nuclear factor I 0.0057 0.0276 0.0276
Brugia malayi Muscleblind-like protein 0.0301 0.1907 0.1907
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.079 0.5169 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0123
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.079 0.5169 0.5169
Brugia malayi Calcitonin receptor-like protein seb-1 0.0893 0.5861 0.5861
Echinococcus multilocularis GPCR, family 2 0.0283 0.1783 0.3292
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.0756 0.5021
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0017 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0239 0.1489 1
Brugia malayi Smad1 0.0103 0.0584 0.0584
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0085 0.0418
Trypanosoma cruzi PAB1-binding protein , putative 0.0239 0.1489 0.9788
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0129 0.0756 0.2134
Echinococcus multilocularis muscleblind protein 1 0.0301 0.1907 0.3522
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0154
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0546 0.3543 1
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.0756 0.5021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0893 0.5861 0.5861
Brugia malayi Latrophilin receptor protein 2 0.0283 0.1783 0.1783
Loa Loa (eye worm) MH2 domain-containing protein 0.1514 1 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.079 0.5169 1
Loa Loa (eye worm) hypothetical protein 0.0893 0.5861 0.5861
Loa Loa (eye worm) hypothetical protein 0.0239 0.1489 0.1489
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Echinococcus multilocularis mothers against decapentaplegic 6 0.0046 0.0203 0.0375
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0103 0.0584 0.147
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0445 0.0445
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.079 0.5169 1
Echinococcus granulosus Smad4 0.0103 0.0584 0.3061
Entamoeba histolytica protein tyrosine phosphatase, putative 0.079 0.5169 1
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0059

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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