Detailed information for compound 908950

Basic information

Technical information
  • TDR Targets ID: 908950
  • Name: (5E)-5-[(3-fluorophenyl)methylidene]-1,3-thia zolidine-2,4-dione
  • MW: 223.224 | Formula: C10H6FNO2S
  • H donors: 1 H acceptors: 2 LogP: 2.3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)/C(=C/c2cccc(c2)F)/S1
  • InChi: 1S/C10H6FNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5+
  • InChiKey: FHRKKLBIQCOIMF-VMPITWQZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5E)-5-[(3-fluorophenyl)methylene]thiazolidine-2,4-dione
  • (5E)-5-(3-fluorobenzylidene)thiazolidine-2,4-quinone
  • (5E)-5-(3-Fluorobenzylidene)-1,3-thiazolidine-2,4-dione
  • Thiazolidine-2,4-dione, 5-(3-fluorobenzylideno)-
  • ZINC01231366

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0103 0.0584 0.0584
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0017 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0584 0.0584
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0085 0.1906
Brugia malayi Probable ClpP-like protease 0.0082 0.0445 0.0445
Loa Loa (eye worm) MH1 domain-containing protein 0.0046 0.0203 0.0203
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.1184 0.1184
Echinococcus granulosus muscleblind protein 0.0301 0.1907 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0123
Brugia malayi Isocitrate dehydrogenase 0.0129 0.0756 0.0756
Brugia malayi MH1 domain containing protein 0.0103 0.0584 0.0584
Brugia malayi MH2 domain containing protein 0.0046 0.0203 0.0203
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.0756 0.5021
Brugia malayi hypothetical protein 0.0239 0.1489 0.1489
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0046 0.0203 0.0362
Brugia malayi Latrophilin receptor protein 2 0.0283 0.1783 0.1783
Loa Loa (eye worm) hypothetical protein 0.0301 0.1907 0.1907
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.079 0.5169 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.1489 0.1489
Loa Loa (eye worm) MH1 domain-containing protein 0.0103 0.0584 0.0584
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0193 0.1184 0.6208
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0243 0.1521 0.2943
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Onchocerca volvulus 0.079 0.5169 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0256 0.5745
Leishmania major hypothetical protein, conserved 0.0239 0.1489 0.9792
Echinococcus multilocularis muscleblind protein 0.0301 0.1907 0.3522
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0893 0.5861 0.5861
Echinococcus multilocularis muscleblind protein 1 0.0301 0.1907 0.3522
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0023 0.0066
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0107 0.061 0.1127
Brugia malayi isocitrate dehydrogenase 0.0129 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.0861
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0017 0.0031
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0129 0.0756 0.4999
Brugia malayi Calcitonin receptor-like protein seb-1 0.0893 0.5861 0.5861
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0445 0.2908
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0103 0.0584 0.1078
Echinococcus granulosus TGF beta signal transducer SmadC 0.0103 0.0584 0.3061
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0017 0.0017
Echinococcus granulosus mothers against decapentaplegic 5 0.0103 0.0584 0.3061
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0023 0.0528
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0017 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0239 0.1489 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0045
Loa Loa (eye worm) isocitrate dehydrogenase 0.0129 0.0756 0.0756
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0154
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0017 0.0088
Trypanosoma brucei PAB1-binding protein , putative 0.0239 0.1489 0.9788
Plasmodium vivax ataxin-2 like protein, putative 0.0239 0.1489 1
Schistosoma mansoni smad1 5 8 and 0.0103 0.0584 0.147
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.079 0.5169 0.5169
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0017 0.0017
Brugia malayi DIX domain containing protein 0.0018 0.0017 0.0017
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0085 0.1455
Brugia malayi MH2 domain containing protein 0.0103 0.0584 0.0584
Echinococcus granulosus Smad4 0.0103 0.0584 0.3061
Echinococcus granulosus GPCR family 2 0.0283 0.1783 0.9347
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0256 0.0722
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.079 0.5169 1
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0017 0.0042
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0129 0.0756 0.4999
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.1396
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0827 0.5416 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0129 0.0756 0.1396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0283 0.1783 0.3292
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.0045
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.079 0.5169 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0043
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0017 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0046 0.0203 0.0203
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.1396
Leishmania major hypothetical protein, conserved 0.0243 0.1521 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0445 0.0445
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0129 0.0756 0.4893
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0193 0.1184 0.2186
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0756 0.4893
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.079 0.5169 1
Trypanosoma cruzi hypothetical protein, conserved 0.0243 0.1521 1
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.0861
Loa Loa (eye worm) MH2 domain-containing protein 0.1514 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0129 0.0756 0.1903
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0445 1
Brugia malayi latrophilin 2 splice variant baaae 0.0611 0.3973 0.3973
Trypanosoma cruzi hypothetical protein, conserved 0.0243 0.1521 1
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0017 0.0088
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0103 0.0584 0.147
Brugia malayi hypothetical protein 0.0018 0.0017 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0283 0.1783 0.1783
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.1396
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0129 0.0756 0.3965
Brugia malayi Smad1 0.0103 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0017 0.0017
Schistosoma mansoni dep domain containing protein 0.0018 0.0017 0.0042
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.1184 0.1184
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0445 0.0822
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0017 0.0088
Schistosoma mansoni Smad4 0.0046 0.0203 0.0511
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Brugia malayi MH1 domain containing protein 0.0057 0.0276 0.0276
Echinococcus multilocularis isocitrate dehydrogenase 0.0129 0.0756 0.1396
Echinococcus granulosus mothers against decapentaplegic 6 0.0046 0.0203 0.1065
Schistosoma mansoni smad1 5 8 and 0.0103 0.0584 0.147
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.079 0.5169 1
Schistosoma mansoni hypothetical protein 0.0283 0.1783 0.4487
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0085 0.0418
Loa Loa (eye worm) hypothetical protein 0.0301 0.1907 0.1907
Loa Loa (eye worm) hypothetical protein 0.0046 0.0203 0.0203
Echinococcus multilocularis GPCR, family 2 0.0283 0.1783 0.3292
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0017 0.0017
Echinococcus granulosus smad 0.0103 0.0584 0.3061
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0017 0.0031
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.079 0.5169 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.079 0.5169 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0129 0.0756 0.2134
Plasmodium falciparum ataxin-2 like protein, putative 0.0239 0.1489 1
Schistosoma mansoni smad 0.0046 0.0203 0.0511
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0107 0.061 0.32
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0243 0.1521 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0756 0.4893
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0045
Loa Loa (eye worm) hypothetical protein 0.0369 0.2362 0.2362
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0256 0.0722
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.1184 0.298
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0283 0.1783 0.3292
Brugia malayi Protein kinase domain containing protein 0.0193 0.1184 0.1184
Brugia malayi hypothetical protein 0.0154 0.0924 0.0924
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0369 0.2362 0.4553
Schistosoma mansoni hypothetical protein 0.0107 0.061 0.1536
Echinococcus multilocularis mothers against decapentaplegic 2 0.0046 0.0203 0.0375
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0193 0.1184 0.2266
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0017 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0239 0.1489 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0023 0.0045
Schistosoma mansoni hypothetical protein 0.0611 0.3973 1
Schistosoma mansoni Smad4 0.0046 0.0203 0.0511
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0256 0.0472
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0059
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0017 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0129 0.0756 0.4893
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0017 0.0031
Schistosoma mansoni smad1 5 8 and 0.0103 0.0584 0.147
Toxoplasma gondii hypothetical protein 0.0028 0.0085 0.0462
Entamoeba histolytica protein tyrosine phosphatase, putative 0.079 0.5169 1
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.0756 0.5021
Brugia malayi mothers against decapentaplegic homolog 3 0.0046 0.0203 0.0203
Entamoeba histolytica protein tyrosine phosphatase, putative 0.079 0.5169 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.1783 0.1783
Schistosoma mansoni dishevelled 0.0018 0.0017 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0283 0.1783 0.1783
Brugia malayi Muscleblind-like protein 0.0301 0.1907 0.1907
Loa Loa (eye worm) nuclear factor I 0.0057 0.0276 0.0276
Trypanosoma cruzi PAB1-binding protein , putative 0.0239 0.1489 0.9788
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0445 0.2334
Loa Loa (eye worm) Smad1 0.0103 0.0584 0.0584
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.079 0.5169 0.5169
Echinococcus multilocularis smad 0.0103 0.0584 0.1078
Echinococcus multilocularis Smad4 0.0103 0.0584 0.1078
Loa Loa (eye worm) hypothetical protein 0.0611 0.3973 0.3973
Schistosoma mansoni dishevelled 0.0018 0.0017 0.0042
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0193 0.1184 0.1184
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0256 0.1341
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.0045
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0017 0.0031
Brugia malayi N-terminal motif family protein 0.0369 0.2362 0.2362
Schistosoma mansoni Smad4 0.0103 0.0584 0.147
Schistosoma mansoni smad 0.0103 0.0584 0.147
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0283 0.1783 0.9347
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0546 0.3543 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0445 0.112
Echinococcus multilocularis mothers against decapentaplegic 5 0.0103 0.0584 0.1078
Brugia malayi MH1 domain containing protein 0.0057 0.0276 0.0276
Brugia malayi MH2 domain containing protein 0.0103 0.0584 0.0584
Echinococcus granulosus mothers against decapentaplegic 2 0.0046 0.0203 0.1065
Trypanosoma cruzi PAB1-binding protein , putative 0.0239 0.1489 0.9788
Brugia malayi hypothetical protein 0.0018 0.0017 0.0017
Echinococcus multilocularis mothers against decapentaplegic 6 0.0046 0.0203 0.0375
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0085 0.0418
Loa Loa (eye worm) transcription factor SMAD2 0.1514 1 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0243 0.1521 0.2943
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0445 0.2876
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0017 0.0088
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.079 0.5169 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0445 0.2876
Loa Loa (eye worm) hypothetical protein 0.0057 0.0276 0.0276
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0445 0.2908
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.0756 0.4972
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0893 0.5861 0.5861
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0283 0.1783 0.9347
Loa Loa (eye worm) hypothetical protein 0.0893 0.5861 0.5861

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.