Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | iron superoxide dismutase A, mitochondrial | 0.0053 | 0.1474 | 0.1445 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0031 | 0.0105 | 0.0158 |
Trypanosoma brucei | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0108 | 0.4923 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0045 | 0.0963 | 0.2117 |
Trypanosoma brucei | iron superoxide dismutase | 0.0053 | 0.1474 | 0.1445 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0095 | 0.4158 | 1 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0086 | 0.3579 | 0.7237 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0031 | 0.0105 | 0.0213 |
Schistosoma mansoni | adenosine deaminase-related | 0.0095 | 0.4158 | 0.8427 |
Echinococcus granulosus | adenosine deaminase | 0.0095 | 0.4158 | 0.8427 |
Entamoeba histolytica | iron-containing superoxide dismutase | 0.0053 | 0.1474 | 0.3379 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0086 | 0.3579 | 0.3557 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0051 | 0.1363 | 0.277 |
Trypanosoma cruzi | iron superoxide dismutase, putative | 0.0053 | 0.1474 | 0.1445 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0056 | 0.1705 | 0.0954 |
Plasmodium falciparum | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0158 |
Trypanosoma brucei | cAMP-specific phosphodiesterase, putative | 0.0188 | 1 | 1 |
Trypanosoma brucei | iron superoxide dismutase | 0.0053 | 0.1474 | 0.1445 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0101 | 0.452 | 1 |
Trypanosoma cruzi | cAMP-specific phosphodiesterase, putative | 0.0188 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.0108 | 0.4923 | 0.4905 |
Brugia malayi | GMP reductase | 0.0045 | 0.0963 | 0.1857 |
Plasmodium falciparum | adenosine deaminase | 0.0095 | 0.4158 | 0.9191 |
Brugia malayi | adenosine monophosphate deaminase | 0.0031 | 0.0105 | 0.0093 |
Mycobacterium ulcerans | adenosine deaminase | 0.0095 | 0.4158 | 0.7849 |
Trypanosoma brucei | iron superoxide dismutase A, mitochondrial | 0.0053 | 0.1474 | 0.1445 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0095 | 0.4158 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0031 | 0.0105 | 0.0071 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.005 | 0.1306 | 0.2563 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0108 | 0.4923 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.1363 | 0.2681 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0108 | 0.4923 | 0.4905 |
Trypanosoma brucei | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Leishmania major | guanosine monophosphate reductase | 0.0108 | 0.4923 | 0.4905 |
Onchocerca volvulus | Superoxide dismutase [Mn], mitochondrial homolog | 0.0053 | 0.1474 | 0.3379 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0045 | 0.0963 | 0.1857 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0086 | 0.3579 | 0.7211 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0108 | 0.4923 | 0.4905 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0086 | 0.3579 | 0.7237 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0095 | 0.4133 | 0.8377 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.005 | 0.1306 | 0.2653 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0031 | 0.0105 | 0.0071 |
Trypanosoma cruzi | iron superoxide dismutase, putative | 0.0036 | 0.0418 | 0.0385 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0086 | 0.3579 | 0.3557 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0095 | 0.4158 | 0.7849 |
Trypanosoma cruzi | GMP reductase | 0.0108 | 0.4923 | 0.4905 |
Leishmania major | iron superoxide dismutase | 0.0053 | 0.1474 | 0.1445 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0065 | 0.2214 | 0.4498 |
Schistosoma mansoni | adenosine deaminase | 0.0095 | 0.4158 | 0.8427 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.133 | 0.2611 |
Brugia malayi | methionyl-tRNA synthetase | 0.0065 | 0.2214 | 0.443 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0095 | 0.4158 | 0.8412 |
Plasmodium vivax | superoxide dismutase [Fe], putative | 0.0053 | 0.1474 | 0.3211 |
Echinococcus granulosus | manganese superoxide dismutase | 0.0053 | 0.1474 | 0.2909 |
Loa Loa (eye worm) | GMP reductase | 0.0045 | 0.0963 | 0.1857 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0045 | 0.0963 | 0.1857 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0095 | 0.4158 | 0.8412 |
Onchocerca volvulus | Superoxide dismutase [Mn], mitochondrial homolog | 0.0036 | 0.0418 | 0.0772 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0065 | 0.2214 | 0.443 |
Treponema pallidum | adenosine deaminase | 0.0095 | 0.4158 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0095 | 0.4158 | 0.8446 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0086 | 0.3579 | 0.3557 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.4158 | 0.8427 |
Leishmania major | iron superoxide dismutase, putative | 0.0053 | 0.1474 | 0.1445 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0065 | 0.2214 | 0.5205 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Toxoplasma gondii | superoxide dismutase SOD3 | 0.0053 | 0.1474 | 0.2843 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0056 | 0.1705 | 0.0667 |
Toxoplasma gondii | superoxide dismutase SOD2 | 0.0053 | 0.1474 | 0.2843 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0095 | 0.4158 | 0.7781 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.22 | 0.44 |
Mycobacterium leprae | Probable superoxide dismutase SodA | 0.0053 | 0.1474 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1474 | 0.2909 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.22 | 0.44 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0095 | 0.4158 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0086 | 0.3579 | 0.727 |
Echinococcus granulosus | AMP deaminase 2 | 0.0031 | 0.0105 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.22 | 0.44 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.133 | 0.2611 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0051 | 0.1363 | 0.2681 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0065 | 0.2214 | 0.443 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0108 | 0.4923 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0095 | 0.4158 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0086 | 0.3579 | 0.7902 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0108 | 0.4923 | 1 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0054 | 0.1567 | 0.3098 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.133 | 0.2611 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0095 | 0.4133 | 0.8377 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0031 | 0.0105 | 0.0071 |
Brugia malayi | Superoxide dismutase, mitochondrial precursor, putative | 0.0053 | 0.1474 | 0.2909 |
Leishmania major | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0086 | 0.3579 | 0.3557 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0108 | 0.4923 | 1 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.005 | 0.1306 | 0.2563 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0086 | 0.3579 | 0.7237 |
Schistosoma mansoni | AMP deaminase | 0.0031 | 0.0105 | 0.0093 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0101 | 0.452 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0095 | 0.4133 | 0.8377 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0086 | 0.3579 | 0.727 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0108 | 0.4923 | 1 |
Mycobacterium ulcerans | superoxide dismutase [Fe] SodA | 0.0053 | 0.1474 | 0.0307 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0108 | 0.4923 | 1 |
Trypanosoma cruzi | iron superoxide dismutase, putative | 0.0053 | 0.1474 | 0.1445 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0031 | 0.0105 | 0.0071 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0108 | 0.4923 | 0.4905 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0101 | 0.452 | 0.8869 |
Toxoplasma gondii | IMP dehydrogenas | 0.0108 | 0.4923 | 1 |
Loa Loa (eye worm) | PDE1B protein | 0.0086 | 0.3579 | 0.7237 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0105 | 0.0093 |
Echinococcus multilocularis | insulin receptor | 0.003 | 0.006 | 0.0122 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0108 | 0.4923 | 0.4905 |
Trypanosoma cruzi | iron superoxide dismutase, putative | 0.0053 | 0.1474 | 0.1445 |
Loa Loa (eye worm) | AMP deaminase | 0.0031 | 0.0105 | 0.0093 |
Plasmodium vivax | adenosine deaminase, putative | 0.0095 | 0.4158 | 0.9191 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.005 | 0.1306 | 0.2563 |
Leishmania major | adenine aminohydrolase | 0.0095 | 0.4158 | 0.4138 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0086 | 0.3579 | 0.7211 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.005 | 0.1306 | 0.2563 |
Trypanosoma cruzi | iron superoxide dismutase A, mitochondrial | 0.0053 | 0.1474 | 0.1445 |
Echinococcus multilocularis | manganese superoxide dismutase | 0.0053 | 0.1474 | 0.2995 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0095 | 0.4133 | 0.8397 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0086 | 0.3579 | 0.7237 |
Onchocerca volvulus | Superoxide dismutase [Mn], mitochondrial homolog | 0.0053 | 0.1474 | 0.3379 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.2214 | 0.443 |
Toxoplasma gondii | superoxide dismutase | 0.0053 | 0.1474 | 0.2843 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0095 | 0.4158 | 0.8427 |
Schistosoma mansoni | tyrosine kinase | 0.0095 | 0.4133 | 0.8377 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0108 | 0.4923 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Trypanosoma cruzi | GMP reductase | 0.0108 | 0.4923 | 0.4905 |
Leishmania major | iron superoxide dismutase, putative | 0.0053 | 0.1474 | 0.1445 |
Plasmodium falciparum | superoxide dismutase [Fe] | 0.0053 | 0.1474 | 0.3211 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0108 | 0.4923 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.003 | 0.006 | 0.0122 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0095 | 0.4158 | 1 |
Brugia malayi | glycyl-tRNA synthetase | 0.005 | 0.1306 | 0.2563 |
Trypanosoma brucei | AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.1363 | 0.2681 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0031 | 0.0105 | 0.0071 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0108 | 0.4923 | 0.4905 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.005 | 0.1306 | 0.2563 |
Schistosoma mansoni | superoxide dismutase [mn] | 0.0053 | 0.1474 | 0.2909 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0105 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.22 | 0.44 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0065 | 0.2214 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0051 | 0.1363 | 0.2681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.