Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide | 0.0477 | 0.1101 | 0.2342 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Onchocerca volvulus | 0.1221 | 0.2986 | 1 | |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.034 | 0.0755 | 0.3414 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0477 | 0.1101 | 0.4983 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.0254 | 0.0137 |
Trypanosoma brucei | endonuclease G, putative | 0.034 | 0.0755 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.1221 | 0.2986 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0477 | 0.1101 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.1327 | 0.4211 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0549 | 0.1284 | 0.581 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Brugia malayi | hypothetical protein | 0.0177 | 0.0341 | 0.0775 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0341 | 0.0775 |
Schistosoma mansoni | hypothetical protein | 0.1221 | 0.2986 | 0.2902 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0914 | 0.221 | 0.2116 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.1221 | 0.2986 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0565 | 0.1327 | 0.1222 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.1327 | 0.4211 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.034 | 0.0755 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.0914 | 0.221 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.6002 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.034 | 0.0755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.1327 | 0.4211 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0914 | 0.221 | 0.4987 |
Onchocerca volvulus | 0.0565 | 0.1327 | 0.4211 | |
Leishmania major | endonuclease G, putative | 0.034 | 0.0755 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0314 | 0.0691 | 1 |
Onchocerca volvulus | 0.0177 | 0.0341 | 0.0775 | |
Trypanosoma brucei | endonuclease G, putative | 0.034 | 0.0755 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0549 | 0.1284 | 0.2778 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0089 | 0.0119 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.034 | 0.0755 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.0254 | 0.0322 |
Trypanosoma cruzi | endonuclease G, putative | 0.034 | 0.0755 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0154 | 0.0283 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.2879 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.0244 | 0.1106 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.2879 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.6002 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0565 | 0.1327 | 0.1222 |
Schistosoma mansoni | endonuclease related | 0.034 | 0.0755 | 0.0643 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.2879 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.0356 | 0.0239 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.2879 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.034 | 0.0755 | 0.5 |
Onchocerca volvulus | 0.0565 | 0.1327 | 0.4211 | |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.2879 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.2879 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0565 | 0.1327 | 0.4211 |
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.0254 | 0.0471 |
Echinococcus multilocularis | Endonuclease G | 0.034 | 0.0755 | 0.1515 |
Echinococcus granulosus | ectonucleotide | 0.0477 | 0.1101 | 0.4983 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.0356 | 0.0239 |
Echinococcus granulosus | Endonuclease G | 0.034 | 0.0755 | 0.3414 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.1101 | 0.3425 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1744 | 0.4312 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Echinococcus granulosus | gpi ethanolamine phosphate transferase 3 | 0.0089 | 0.0119 | 0.054 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0914 | 0.221 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.034 | 0.0755 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Echinococcus multilocularis | geminin | 0.0182 | 0.0356 | 0.0564 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.6002 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.6002 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0565 | 0.1327 | 0.1222 |
Echinococcus granulosus | neuropeptide s receptor | 0.0549 | 0.1284 | 0.581 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.0254 | 0.0471 |
Echinococcus granulosus | geminin | 0.0182 | 0.0356 | 0.1611 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0549 | 0.1284 | 0.2778 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0314 | 0.0691 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0565 | 0.1327 | 0.6002 |
Echinococcus granulosus | transferase | 0.0089 | 0.0119 | 0.054 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0089 | 0.0119 | 0.054 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0565 | 0.1327 | 0.1222 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0154 | 0.0283 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 0.0691 | 1 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.034 | 0.0755 | 0.2216 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0154 | 0.0283 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.