TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 749.939 | Formula: C38H47N5O7S2
H donors: 2 H acceptors: 7 LogP: 4.81 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc2c(c1C)nc(cc2O[C@@H]1C[C@@H]2[C@@H](C1)C(=O)N(C)CCCC/C=C\[C@H]1[C@](NC2=O)(C1)C(=O)NS(=O)(=O)C1CC1)c1scc(n1)C(C)C
InChi: 1S/C38H47N5O7S2/c1-21(2)30-20-51-35(40-30)29-18-32(26-13-14-31(49-5)22(3)33(26)39-29)50-24-16-27-28(17-24)36(45)43(4)15-9-7-6-8-10-23-19-38(23,41-34(27)44)37(46)42-52(47,48)25-11-12-25/h8,10,13-14,18,20-21,23-25,27-28H,6-7,9,11-12,15-17,19H2,1-5H3,(H,41,44)(H,42,46)/b10-8-/t23-,24-,27-,28-,38-/m1/s1
InChiKey: JTZZSQYMACOLNN-VDWJNHBNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus serine protease, NS3/NS4A	Starlite/ChEMBL	No references
Hepatitis C virus	Nonstructural protein NS3-4A	Starlite/ChEMBL	References
Hepatitis C virus	Hepatitis C virus NS3 protease/helicase	Starlite/ChEMBL	No references
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	RNA helicase Prp43	Get druggable targets OG5_126599	All targets in OG5_126599
Schistosoma japonicum	Eukaryotic initiation factor 4A-III, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Toxoplasma gondii	ATP-dependent RNA helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related	Get druggable targets OG5_126984	All targets in OG5_126984
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Dhx8 protein	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	Get druggable targets OG5_126984	All targets in OG5_126984
Echinococcus granulosus	pre mRNA splicing factor ATP dependent RNA	Get druggable targets OG5_126599	All targets in OG5_126599
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium yoelii	pre-mRNA splicing factor ATP-dependent RNA helicase-like protein-related	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	DEAD/DEAH box helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Babesia bovis	RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Theileria parva	RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	DEAH box polypeptide 8	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	eukaryotic initiation factor 4A (eIF4A) (eIF-4A)	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	ATP-dependent helicase ddx8	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	RNA helicase-1, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	ATP-dependent RNA Helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	pre mRNA splicing factor ATP dependent	Get druggable targets OG5_126599	All targets in OG5_126599
Brugia malayi	Probable pre-mRNA splicing factor ATP-dependent RNA helicase mog-1	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	ATP-dependent RNA Helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Entamoeba histolytica	helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Treponema pallidum	ATP-dependent helicase (hrpA)	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium knowlesi	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania major	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium falciparum	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	Prp16p pre-mRNA splicing factor. HrpA family SFII helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	pre-mRNA splicing factor, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma cruzi	pre-mRNA-splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium vivax	RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Trichomonas vaginalis	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Brugia malayi	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	pre-mRNA splicing factor, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Schistosoma japonicum	ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Toxoplasma gondii	helicase associated domain (ha2) protein	Get druggable targets OG5_126599	All targets in OG5_126599
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	splicing factor, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium falciparum	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	ATP-dependent RNA helicase-like protein	Get druggable targets OG5_126599	All targets in OG5_126599
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Babesia bovis	eukaryotic translation initiation factor 4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	eukaryotic initiation factor 4A III	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma brucei gambiense	pre-mRNA splicing factor ATP-dependent RNA helicase, putative,RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania mexicana	pre-mRNA splicing factor, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	sex determination protein MOG-1	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	pre mRNA splicing factor ATP dependent	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	Unknown protein	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Babesia bovis	RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Cryptosporidium hominis	RNA helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	pre-mRNA-splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	pre-mRNA splicing factor ATP-dependent RNA helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus granulosus	ATP dependent RNA helicase DHX8	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma cruzi	pre-mRNA-splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Schistosoma japonicum	ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative	Get druggable targets OG5_126599	All targets in OG5_126599
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma brucei	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Schistosoma japonicum	ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus multilocularis	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	pre-mRNA-splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania major	pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Neospora caninum	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania donovani	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania mexicana		Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	pre mRNA splicing factor ATP dependent RNA	Get druggable targets OG5_126599	All targets in OG5_126599
Cryptosporidium hominis	DEAH-box RNA helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Babesia bovis	DEAH box RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	PRP43 involved in spliceosome disassembly mRNA splicing	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	ATP-dependent RNA Helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	DEAH box helicase involved in pre-mRNA splicing	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	ATP dependent RNA helicase DHX8	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus multilocularis	DSS1 (SEM1) domain containing protein	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	RNA helicase Prp43	Get druggable targets OG5_126599	All targets in OG5_126599
Candida albicans	DEAH box helicase involved in pre-mRNA splicing	Get druggable targets OG5_126599	All targets in OG5_126599
Candida albicans	potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	ATP-dependent helicase DHX8	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	pre mRNA splicing factor ATP dependent	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus granulosus	pre mRNA splicing factor ATP dependent	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing	Get druggable targets OG5_126599	All targets in OG5_126599
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus granulosus	DSS1 SEM1 domain containing protein	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Echinococcus granulosus	eukaryotic initiation factor 4A III	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma cruzi	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Treponema pallidum	ATP-dependent RNA helicase	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma japonicum	ATP-dependent RNA helicase eIF4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	pre-mRNA-splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania major	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Entamoeba histolytica	helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	DEAH box helicase involved in pre-mRNA splicing	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	eukaryotic initiation factor 4A (eIF4A) (eIF-4A)	Get druggable targets OG5_126984	All targets in OG5_126984
Brugia malayi	Pre-mRNA splicing factor ATP-dependent RNA helicase F56D2.6	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Translation initiation factor eIF-4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium falciparum	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus		Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Eukaryotic initiation factor 4A-II, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	dead box protein 15	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Toxoplasma gondii	pre-mRNA-processing protein 8, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	RNA helicase-1, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	pre-mRNA splicing factor ATP-dependent RNA helicase	Get druggable targets OG5_126599	All targets in OG5_126599
Trichomonas vaginalis	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma cruzi	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium knowlesi	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Babesia bovis	pre-mRNA splicing factor RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Leishmania braziliensis	pre-mRNA splicing factor, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium yoelii	RNA helicase-1	Get druggable targets OG5_126984	All targets in OG5_126984
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	pre-mRNA-splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Candida albicans	potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing	Get druggable targets OG5_126599	All targets in OG5_126599
Candida albicans	DEAH box helicase involved in pre-mRNA splicing	Get druggable targets OG5_126599	All targets in OG5_126599
Plasmodium berghei	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	pre-mRNA splicing factor ATP-dependent RNA helicase, putative	Get druggable targets OG5_126599	All targets in OG5_126599
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma japonicum	ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative	Get druggable targets OG5_126599	All targets in OG5_126599
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative	Get druggable targets OG5_126599	All targets in OG5_126599

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	hypothetical protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	44 aa	29.5 %
Trypanosoma congolense	WD40 repeats, putative	Hepatitis C virus serine protease, NS3/NS4A	54 aa	46 aa	28.3 %
Mycobacterium ulcerans	Maf-like protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	44 aa	38.6 %
Trypanosoma brucei	hypothetical protein, conserved	Hepatitis C virus serine protease, NS3/NS4A	54 aa	55 aa	30.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Toxoplasma gondii	hypothetical protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	50 aa	28.0 %
Trypanosoma brucei	expression site-associated gene 3 (ESAG3)-like protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	49 aa	28.6 %
Mycobacterium tuberculosis	Membrane-associated phospholipase C 2 PlcB	Hepatitis C virus serine protease, NS3/NS4A	54 aa	49 aa	32.7 %
Schistosoma japonicum	expressed protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	44 aa	29.5 %
Entamoeba histolytica	hypothetical protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	52 aa	23.1 %
Leishmania braziliensis	hypothetical protein, conserved	Hepatitis C virus serine protease, NS3/NS4A	54 aa	46 aa	26.1 %
Trypanosoma brucei gambiense	expression site-associated gene 3 (ESAG3)-like protein, putative	Hepatitis C virus serine protease, NS3/NS4A	54 aa	49 aa	28.6 %
Echinococcus granulosus	60S ribosomal protein L8	Hepatitis C virus serine protease, NS3/NS4A	54 aa	48 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.7759	0.7759
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.7759	0.7759
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.003	1	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Leishmania major	eukaryotic initiation factor 4a, putative	0.003	1	1
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.003	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Loa Loa (eye worm)	fibroinase	0.0027	0.7759	0.7759
Brugia malayi	Cathepsin L-like precursor	0.0027	0.7759	0.7759
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.7759	0.7759
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.7759	0.7759
Onchocerca volvulus		0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.003	1	0.5
Onchocerca volvulus		0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Onchocerca volvulus		0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Onchocerca volvulus		0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.003	1	1
Plasmodium falciparum	eukaryotic initiation factor 4A	0.003	1	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.7759	0.7759
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.003	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.7759	0.7759
Brugia malayi	Cathepsin L-like precursor	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.003	1	1
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.003	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.7759	0.7759
Treponema pallidum	ATP-dependent RNA helicase	0.003	1	0.5
Brugia malayi	Cathepsin L-like precursor	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Onchocerca volvulus		0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Leishmania major	eukaryotic initiation factor 4a, putative	0.003	1	1
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.003	1	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.7759	0.7759
Brugia malayi	Cathepsin L-like precursor	0.0027	0.7759	0.7759
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.003	1	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.003	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.7759	0.7759
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.003	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.7759	0.7759
Entamoeba histolytica	cysteine protease, putative	0.0027	0.7759	0.7759
Loa Loa (eye worm)	ctsf protein	0.0027	0.7759	0.7759
Onchocerca volvulus		0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.003	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.7759	0.7759
Echinococcus granulosus	cathepsin l1	0.0027	0.7759	0.7759
Loa Loa (eye worm)	hypothetical protein	0.003	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.7759	0.7759
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.003	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.003	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.7759	0.7759
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.7759	0.7759
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.003	1	1
Onchocerca volvulus		0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.7759	0.7759
Echinococcus granulosus	eukaryotic initiation factor 4A	0.003	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.7759	0.7759
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.003	1	1
Plasmodium vivax	RNA helicase-1, putative	0.003	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.7759	0.7759
Loa Loa (eye worm)	cysteine protease	0.0027	0.7759	0.7759

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	= 16 uM	Cytotoxicity against human MT4 cells after 3 to 4 days by resazurin proliferation assay	ChEMBL.	19171797
CC50 (ADMET)	= 16 uM	Cytotoxicity against human MRC5 cells after 3 to 4 days by resazurin proliferation assay	ChEMBL.	19171797
CC50 (ADMET)	= 16 uM	Cytotoxicity against human HT1080 cells after 3 to 4 days by resazurin proliferation assay	ChEMBL.	19171797
CC50 (ADMET)	= 33 uM	Cytotoxicity against staphylococcal enterotoxin B-stimulated human PBMC cells	ChEMBL.	19171797
CS50 (ADMET)	= 10 uM	Cytostatic activity against human PBMC cells assessed as incorporation of [3H]thymidine	ChEMBL.	19171797
CS50 (ADMET)	>= 10 uM	Cytostatic activity against staphylococcal enterotoxin B-stimulated human PBMC assessed as decrease in cell proliferation after 7 hrs by [3H]thymidine incorporation assay	ChEMBL.	24446688
IC50 (binding)	= 0.8 uM	Inhibition of human cathepsin S in human JY cells assessed as p10 accumulation by fluorescence-based assay	ChEMBL.	19171797
Ki (binding)	= 0.36 nM	Inhibition of HCV genotype 1a NS3/4A protease using Ac-DED(Edans)EEAbu-psi[COO]ASK(Dabcyl)-NH2 as substrate by FRET assay	ChEMBL.	25456385
Ki (binding)	= 0.5 nM	BindingDB_Patents: Inhibition Assay. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate, Ac-DED(Edans)EEAbu[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (Ake Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348]. The enzyme (1 nM) was incubated in 50 mM HEPES, pH 7.5, 10 mM DTT, 40% glycerol, 0.1% n-octyl-D-glucoside, with 25 µM NS4A cofactor and inhibitor at 30 C. for 10 min, whereupon the reaction was initiated by addition of 0.5 µM substrate. Inhibitors were dissolved in DMSO, sonicated for 30 sec. and vortexed.	ChEMBL.	No reference
Ki (binding)	= 0.5 nM	BindingDB_Patents: Enzymatic Assay. The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay provides an indication of how effective compounds of the present invention would be in inhibiting HCV NS3/4A proteolytic activity. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate,Â Ac-DED(Edans)EEAbuÃ[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (Ã¢ Â«ke Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348].	ChEMBL.	No reference
Ki (binding)	= 0.5 nM	BindingDB_Patents: Enzymatic Assay. The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay provides an indication of how effective compounds of the present invention would be in inhibiting HCV NS3/4A proteolytic activity. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate,Â Ac-DED(Edans)EEAbuÃ[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (Ã¢ Â«ke Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348].	ChEMBL.	No reference
Ki (binding)	= 0.5 nM	BindingDB_Patents: Inhibition Assay. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate, Ac-DED(Edans)EEAbu[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (Ake Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348]. The enzyme (1 nM) was incubated in 50 mM HEPES, pH 7.5, 10 mM DTT, 40% glycerol, 0.1% n-octyl-D-glucoside, with 25 µM NS4A cofactor and inhibitor at 30 C. for 10 min, whereupon the reaction was initiated by addition of 0.5 µM substrate. Inhibitors were dissolved in DMSO, sonicated for 30 sec. and vortexed.	ChEMBL.	No reference
Papp (ADMET)	= 8.4 cm/s	Apparent permeability from apical to basolateral side of the human Caco-2 cells	ChEMBL.	18678486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL501849

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 913506