Detailed information for compound 913506

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 749.939 | Formula: C38H47N5O7S2
  • H donors: 2 H acceptors: 7 LogP: 4.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1C)nc(cc2O[C@@H]1C[C@@H]2[C@@H](C1)C(=O)N(C)CCCC/C=C\[C@H]1[C@](NC2=O)(C1)C(=O)NS(=O)(=O)C1CC1)c1scc(n1)C(C)C
  • InChi: 1S/C38H47N5O7S2/c1-21(2)30-20-51-35(40-30)29-18-32(26-13-14-31(49-5)22(3)33(26)39-29)50-24-16-27-28(17-24)36(45)43(4)15-9-7-6-8-10-23-19-38(23,41-34(27)44)37(46)42-52(47,48)25-11-12-25/h8,10,13-14,18,20-21,23-25,27-28H,6-7,9,11-12,15-17,19H2,1-5H3,(H,41,44)(H,42,46)/b10-8-/t23-,24-,27-,28-,38-/m1/s1
  • InChiKey: JTZZSQYMACOLNN-VDWJNHBNSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Nonstructural protein NS3-4A Starlite/ChEMBL References
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL No references
Homo sapiens cathepsin S Starlite/ChEMBL References
Hepatitis C virus Hepatitis C virus serine protease, NS3/NS4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii ATP-dependent helicase ddx8 Get druggable targets OG5_126599 All targets in OG5_126599
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative Get druggable targets OG5_126599 All targets in OG5_126599
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Babesia bovis RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania mexicana pre-mRNA splicing factor, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis pre-mRNA splicing factor ATP-dependent RNA helicase Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii pre-mRNA splicing factor ATP-dependent RNA helicase-like protein-related Get druggable targets OG5_126599 All targets in OG5_126599
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma brucei pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus DSS1 SEM1 domain containing protein Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis pre-mRNA splicing factor, putative Get druggable targets OG5_126599 All targets in OG5_126599
Cryptosporidium parvum PRP43 involved in spliceosome disassembly mRNA splicing Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing Get druggable targets OG5_126599 All targets in OG5_126599
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania major pre-mRNA splicing factor, putative Get druggable targets OG5_126599 All targets in OG5_126599
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania infantum pre-mRNA splicing factor, putative Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-mRNA splicing factor ATP-dependent RNA helicase F56D2.6 Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii ATP-dependent RNA helicase-like protein Get druggable targets OG5_126599 All targets in OG5_126599
Cryptosporidium parvum Prp16p pre-mRNA splicing factor. HrpA family SFII helicase Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus pre mRNA splicing factor ATP dependent RNA Get druggable targets OG5_126599 All targets in OG5_126599
Candida albicans potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Candida albicans DEAH box helicase involved in pre-mRNA splicing Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis pre mRNA splicing factor ATP dependent Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative Get druggable targets OG5_126599 All targets in OG5_126599
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni ATP-dependent RNA Helicase Get druggable targets OG5_126599 All targets in OG5_126599
Theileria parva RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Theileria parva RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative Get druggable targets OG5_126599 All targets in OG5_126599
Babesia bovis DEAH box RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii pre-mRNA-splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Toxoplasma gondii helicase associated domain (ha2) protein Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma cruzi pre-mRNA-splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) sex determination protein MOG-1 Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) pre-mRNA splicing factor ATP-dependent RNA helicase Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni ATP-dependent RNA Helicase Get druggable targets OG5_126599 All targets in OG5_126599
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Candida albicans DEAH box helicase involved in pre-mRNA splicing Get druggable targets OG5_126599 All targets in OG5_126599
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Probable pre-mRNA splicing factor ATP-dependent RNA helicase mog-1 Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans DEAH box helicase involved in pre-mRNA splicing Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Candida albicans potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing Get druggable targets OG5_126599 All targets in OG5_126599
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Entamoeba histolytica helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis DSS1 (SEM1) domain containing protein Get druggable targets OG5_126599 All targets in OG5_126599
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus pre mRNA splicing factor ATP dependent Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis pre mRNA splicing factor ATP dependent Get druggable targets OG5_126599 All targets in OG5_126599
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania donovani pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ATP dependent RNA helicase DHX8 Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania infantum pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania major pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense pre-mRNA-splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Neospora caninum hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) DEAH box polypeptide 8 Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania donovani pre-mRNA-splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Schistosoma mansoni ATP-dependent RNA Helicase Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus granulosus ATP dependent RNA helicase DHX8 Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei pre-mRNA-splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis RNA helicase Get druggable targets OG5_126599 All targets in OG5_126599
Brugia malayi pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ATP-dependent helicase DHX8 Get druggable targets OG5_126599 All targets in OG5_126599
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi pre-mRNA-splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Candida albicans potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania major pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) dead box protein 15 Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Giardia lamblia RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus pre mRNA splicing factor ATP dependent Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum ATP-dependent helicase (hrpA) Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva splicing factor, putative Get druggable targets OG5_126599 All targets in OG5_126599
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis DEAH-box RNA helicase Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense pre-mRNA splicing factor ATP-dependent RNA helicase, putative,RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium knowlesi pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative Get druggable targets OG5_126599 All targets in OG5_126599
Babesia bovis pre-mRNA splicing factor RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Dhx8 protein Get druggable targets OG5_126599 All targets in OG5_126599
Toxoplasma gondii pre-mRNA-processing protein 8, putative Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium yoelii Unknown protein Get druggable targets OG5_126599 All targets in OG5_126599
Leishmania braziliensis pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative Get druggable targets OG5_126599 All targets in OG5_126599
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense RNA helicase Prp43 Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Toxoplasma gondii ATP-dependent RNA helicase Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans DEAH box helicase involved in pre-mRNA splicing Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma brucei gambiense pre-mRNA splicing factor ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum hypothetical protein Get druggable targets OG5_126599 All targets in OG5_126599
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative Get druggable targets OG5_126599 All targets in OG5_126599
Trypanosoma brucei RNA helicase Prp43 Get druggable targets OG5_126599 All targets in OG5_126599
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis pre mRNA splicing factor ATP dependent RNA Get druggable targets OG5_126599 All targets in OG5_126599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-dependent RNA helicase, putative Get druggable targets OG5_126599 All targets in OG5_126599
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei expression site-associated gene 3 (ESAG3)-like protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 49 aa 28.6 %
Echinococcus granulosus 60S ribosomal protein L8 Hepatitis C virus serine protease, NS3/NS4A   54 aa 48 aa 33.3 %
Mycobacterium ulcerans Maf-like protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 44 aa 38.6 %
Entamoeba histolytica hypothetical protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 52 aa 23.1 %
Trypanosoma brucei hypothetical protein, conserved Hepatitis C virus serine protease, NS3/NS4A   54 aa 55 aa 30.9 %
Toxoplasma gondii hypothetical protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 50 aa 28.0 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Schistosoma japonicum expressed protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 44 aa 29.5 %
Trypanosoma congolense WD40 repeats, putative Hepatitis C virus serine protease, NS3/NS4A   54 aa 46 aa 28.3 %
Leishmania braziliensis hypothetical protein, conserved Hepatitis C virus serine protease, NS3/NS4A   54 aa 46 aa 26.1 %
Schistosoma mansoni hypothetical protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 44 aa 29.5 %
Trypanosoma brucei gambiense expression site-associated gene 3 (ESAG3)-like protein, putative Hepatitis C virus serine protease, NS3/NS4A   54 aa 49 aa 28.6 %
Mycobacterium tuberculosis Membrane-associated phospholipase C 2 PlcB Hepatitis C virus serine protease, NS3/NS4A   54 aa 49 aa 32.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 1 1
Echinococcus granulosus eukaryotic initiation factor 4A 0.003 1 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.7759 0.7759
Brugia malayi Cathepsin L-like precursor 0.0027 0.7759 0.7759
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.003 1 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.003 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Loa Loa (eye worm) ctsf protein 0.0027 0.7759 0.7759
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.003 1 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.7759 0.7759
Onchocerca volvulus 0.0027 0.7759 0.7759
Onchocerca volvulus 0.0027 0.7759 0.7759
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.7759 0.7759
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.7759 0.7759
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.003 1 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 1 1
Onchocerca volvulus 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 1 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.7759 0.7759
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Onchocerca volvulus Cathepsin L homolog 0.0027 0.7759 0.7759
Echinococcus granulosus eukaryotic initiation factor 4A III 0.003 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Echinococcus multilocularis eukaryotic initiation factor 4A 0.003 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Brugia malayi Cathepsin L-like precursor 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Plasmodium falciparum eukaryotic initiation factor 4A 0.003 1 1
Treponema pallidum ATP-dependent RNA helicase 0.003 1 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Brugia malayi Cathepsin L-like precursor 0.0027 0.7759 0.7759
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.003 1 1
Leishmania major eukaryotic initiation factor 4a, putative 0.003 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Plasmodium vivax RNA helicase-1, putative 0.003 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Onchocerca volvulus 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.7759 0.7759
Loa Loa (eye worm) hypothetical protein 0.0027 0.7759 0.7759
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.7759 0.7759
Brugia malayi Cathepsin L-like precursor 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Onchocerca volvulus 0.0027 0.7759 0.7759
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.7759 0.7759
Giardia lamblia Translation initiation factor eIF-4A, putative 0.003 1 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.7759 0.7759
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.7759 0.7759
Loa Loa (eye worm) fibroinase 0.0027 0.7759 0.7759
Leishmania major eukaryotic initiation factor 4a, putative 0.003 1 1
Loa Loa (eye worm) hypothetical protein 0.003 1 1
Onchocerca volvulus 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.7759 0.7759
Onchocerca volvulus 0.0027 0.7759 0.7759
Entamoeba histolytica cysteine protease, putative 0.0027 0.7759 0.7759
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.7759 0.7759
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 1 1
Echinococcus granulosus cathepsin l1 0.0027 0.7759 0.7759
Onchocerca volvulus Cathepsin F homolog 0.0027 0.7759 0.7759
Brugia malayi Cathepsin L-like precursor 0.0027 0.7759 0.7759
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.003 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.7759 0.7759
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.7759 0.7759
Brugia malayi Cathepsin L-like precursor 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Loa Loa (eye worm) cysteine protease 0.0027 0.7759 0.7759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.7759 0.7759
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 1 1

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 16 uM Cytotoxicity against human MT4 cells after 3 to 4 days by resazurin proliferation assay ChEMBL. 19171797
CC50 (ADMET) = 16 uM Cytotoxicity against human MRC5 cells after 3 to 4 days by resazurin proliferation assay ChEMBL. 19171797
CC50 (ADMET) = 16 uM Cytotoxicity against human HT1080 cells after 3 to 4 days by resazurin proliferation assay ChEMBL. 19171797
CC50 (ADMET) = 33 uM Cytotoxicity against staphylococcal enterotoxin B-stimulated human PBMC cells ChEMBL. 19171797
CS50 (ADMET) = 10 uM Cytostatic activity against human PBMC cells assessed as incorporation of [3H]thymidine ChEMBL. 19171797
CS50 (ADMET) >= 10 uM Cytostatic activity against staphylococcal enterotoxin B-stimulated human PBMC assessed as decrease in cell proliferation after 7 hrs by [3H]thymidine incorporation assay ChEMBL. 24446688
IC50 (binding) = 0.8 uM Inhibition of human cathepsin S in human JY cells assessed as p10 accumulation by fluorescence-based assay ChEMBL. 19171797
Ki (binding) = 0.36 nM Inhibition of HCV genotype 1a NS3/4A protease using Ac-DED(Edans)EEAbu-psi[COO]ASK(Dabcyl)-NH2 as substrate by FRET assay ChEMBL. 25456385
Ki (binding) = 0.5 nM BindingDB_Patents: Inhibition Assay. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate, Ac-DED(Edans)EEAbu[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (Ake Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348]. The enzyme (1 nM) was incubated in 50 mM HEPES, pH 7.5, 10 mM DTT, 40% glycerol, 0.1% n-octyl-D-glucoside, with 25 µM NS4A cofactor and inhibitor at 30 C. for 10 min, whereupon the reaction was initiated by addition of 0.5 µM substrate. Inhibitors were dissolved in DMSO, sonicated for 30 sec. and vortexed. ChEMBL. No reference
Ki (binding) = 0.5 nM BindingDB_Patents: Enzymatic Assay. The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay provides an indication of how effective compounds of the present invention would be in inhibiting HCV NS3/4A proteolytic activity. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate,  Ac-DED(Edans)EEAbuÏ[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (â «ke Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348]. ChEMBL. No reference
Ki (binding) = 0.5 nM BindingDB_Patents: Enzymatic Assay. The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay provides an indication of how effective compounds of the present invention would be in inhibiting HCV NS3/4A proteolytic activity. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate,  Ac-DED(Edans)EEAbuÏ[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (â «ke Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348]. ChEMBL. No reference
Ki (binding) = 0.5 nM BindingDB_Patents: Inhibition Assay. The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification 25 363 371. Briefly, the hydrolysis of a depsipeptide substrate, Ac-DED(Edans)EEAbu[COO]ASK(Dabcyl)-NH2 (AnaSpec, San Jose, USA), was measured spectrofluorometrically in the presence of a peptide cofactor, KKGSVVIVGRIVLSGK (Ake Engstrom, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden). [Landro, 1997 #Biochem 36 9340-9348]. The enzyme (1 nM) was incubated in 50 mM HEPES, pH 7.5, 10 mM DTT, 40% glycerol, 0.1% n-octyl-D-glucoside, with 25 µM NS4A cofactor and inhibitor at 30 C. for 10 min, whereupon the reaction was initiated by addition of 0.5 µM substrate. Inhibitors were dissolved in DMSO, sonicated for 30 sec. and vortexed. ChEMBL. No reference
Papp (ADMET) = 8.4 cm/s Apparent permeability from apical to basolateral side of the human Caco-2 cells ChEMBL. 18678486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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