Detailed view for TGME49_233520
Basic information
TDR Targets ID: 263393
Toxoplasma gondii, ATP-dependent RNA helicase
Source Database / ID: ToxoDB
Toxoplasma gondii, ATP-dependent RNA helicase
Source Database / ID: ToxoDB
pI: 7.672 |
Length (AA): 801 |
MW (Da): 88865 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
Mouse over links to read term descriptions.
GO:0003676
nucleic acid binding GO:0000166 nucleotide binding
GO:0017111 nucleoside-triphosphatase activity
GO:0005524 ATP binding
GO:0004386 helicase activity
Metabolic Pathways
Spliceosome (KEGG)
Structural information
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 35 | 777 | 2xau (A) | 3 | 749 | 57.00 | 0 | 1 | 1.67249 | -1 |
| 99 | 786 | 5d0u (A) | 71 | 764 | 60.00 | 0 | 1 | 1.63583 | -1.02 |
| 516 | 759 | 3i4u (A) | 951 | 1192 | 43.00 | 0 | 1 | 0.892719 | -1.29 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | VEG Tachyzoite, ME49 Tachyzoite. | Gregory |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 60-80% percentile | ME49 merozoite, ME49 Bradyzoite. | Hehl AB Sibley/Greg |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Lower 20-40% percentile | ME49 Oocyst. | Fritz HM |
-
Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. -
Gregory ToxoDB -
Sibley/Greg ToxoDB -
Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
Orthologs
Ortholog group members (OG5_126599)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT4G16680 | putative RNA helicase |
| Arabidopsis thaliana | AT1G32490 | DEAH RNA helicase homolog PRP2 |
| Arabidopsis thaliana | AT2G47250 | putative pre-mRNA-splicing factor ATP-dependent RNA helicase |
| Arabidopsis thaliana | AT3G26560 | probable pre-mRNA-splicing factor ATP-dependent RNA helicase |
| Arabidopsis thaliana | AT5G13010 | RNA helicase family protein |
| Arabidopsis thaliana | AT3G62310 | RNA helicase family protein |
| Arabidopsis thaliana | AT2G35340 | protein MATERNAL EFFECT EMBRYO ARREST 29 |
| Babesia bovis | BBOV_I002940 | RNA helicase, putative |
| Babesia bovis | BBOV_IV011160 | RNA helicase, putative |
| Babesia bovis | BBOV_IV002560 | DEAH box RNA helicase, putative |
| Babesia bovis | BBOV_I004340 | pre-mRNA splicing factor RNA helicase, putative |
| Brugia malayi | Bm1_28720 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Brugia malayi | Bm1_50870 | ATP-dependent helicase DHX8 |
| Brugia malayi | Bm1_46020 | Probable pre-mRNA splicing factor ATP-dependent RNA helicase mog-1 |
| Brugia malayi | Bm1_46075 | Pre-mRNA splicing factor ATP-dependent RNA helicase F56D2.6 |
| Candida albicans | CaO19.9255 | potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing |
| Candida albicans | CaO19.11516 | DEAH box helicase involved in pre-mRNA splicing |
| Candida albicans | CaO19.5865 | potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step |
| Candida albicans | CaO19.2818 | DEAH box helicase involved in pre-mRNA splicing |
| Candida albicans | CaO19.10336 | DEAH box helicase involved in pre-mRNA splicing |
| Candida albicans | CaO19.1687 | potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing |
| Candida albicans | CaO19.4033 | DEAH box helicase involved in pre-mRNA splicing |
| Candida albicans | CaO19.13287 | potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step |
| Caenorhabditis elegans | CELE_K03H1.2 | Protein MOG-1 |
| Caenorhabditis elegans | CELE_F56D2.6 | Protein F56D2.6, isoform B |
| Caenorhabditis elegans | CELE_C04H5.6 | Protein MOG-4 |
| Caenorhabditis elegans | CELE_EEED8.5 | Protein MOG-5 |
| Cryptosporidium hominis | Chro.10299 | hypothetical protein |
| Cryptosporidium hominis | Chro.60176 | pre-mRNA splicing factor ATP-dependent RNA helicase |
| Cryptosporidium hominis | Chro.80471 | RNA helicase |
| Cryptosporidium hominis | Chro.70079 | DEAH-box RNA helicase |
| Cryptosporidium parvum | cgd7_640 | Prp16p pre-mRNA splicing factor. HrpA family SFII helicase |
| Cryptosporidium parvum | cgd8_4100 | PRP43 involved in spliceosome disassembly mRNA splicing |
| Cryptosporidium parvum | cgd1_2650 | hypothetical protein |
| Cryptosporidium parvum | cgd6_1410 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Dictyostelium discoideum | DDB_G0270110 | DEAD/DEAH box helicase |
| Dictyostelium discoideum | DDB_G0291183 | DEAD/DEAH box helicase |
| Dictyostelium discoideum | DDB_G0285937 | DEAD/DEAH box helicase |
| Dictyostelium discoideum | DDB_G0285843 | DEAD/DEAH box helicase |
| Dictyostelium discoideum | DDB_G0285213 | DEAD/DEAH box helicase |
| Drosophila melanogaster | Dmel_CG8241 | peanuts |
| Drosophila melanogaster | Dmel_CG10689 | lethal (2) 37Cb |
| Drosophila melanogaster | Dmel_CG11107 | CG11107 gene product from transcript CG11107-RA |
| Drosophila melanogaster | Dmel_CG32604 | lethal (1) G0007 |
| Escherichia coli | b1413 | putative ATP-dependent helicase |
| Escherichia coli | b0148 | putative ATP-dependent helicase |
| Echinococcus granulosus | EgrG_000904900 | pre mRNA splicing factor ATP dependent RNA |
| Echinococcus granulosus | EgrG_000904800 | DSS1 SEM1 domain containing protein |
| Echinococcus granulosus | EgrG_001199400 | pre mRNA splicing factor ATP dependent |
| Echinococcus granulosus | EgrG_001027700 | ATP dependent RNA helicase DHX8 |
| Echinococcus granulosus | EgrG_000214600 | pre mRNA splicing factor ATP dependent |
| Entamoeba histolytica | EHI_184530 | helicase, putative |
| Entamoeba histolytica | EHI_148930 | helicase, putative |
| Entamoeba histolytica | EHI_122790 | helicase, putative |
| Entamoeba histolytica | EHI_096230 | helicase, putative |
| Echinococcus multilocularis | EmuJ_001199400 | pre mRNA splicing factor ATP dependent |
| Echinococcus multilocularis | EmuJ_000214600 | pre mRNA splicing factor ATP dependent |
| Echinococcus multilocularis | EmuJ_001027700 | ATP dependent RNA helicase DHX8 |
| Echinococcus multilocularis | EmuJ_000904800 | DSS1 (SEM1) domain containing protein |
| Echinococcus multilocularis | EmuJ_000904900 | pre mRNA splicing factor ATP dependent RNA |
| Giardia lamblia | GL50803_15930 | RNA helicase, putative |
| Giardia lamblia | GL50803_17539 | RNA helicase, putative |
| Homo sapiens | ENSG00000109606 | DEAH (Asp-Glu-Ala-His) box helicase 15 |
| Homo sapiens | ENSG00000204560 | DEAH (Asp-Glu-Ala-His) box polypeptide 16 |
| Homo sapiens | ENSG00000067596 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
| Homo sapiens | ENSG00000140829 | DEAH (Asp-Glu-Ala-His) box polypeptide 38 |
| Leishmania braziliensis | LbrM.34.1120 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Leishmania braziliensis | LbrM.35.3050 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative |
| Leishmania braziliensis | LbrM.24.1110 | pre-mRNA splicing factor, putative |
| Leishmania donovani | LdBPK_351210.1 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Leishmania donovani | LdBPK_241120.1 | pre-mRNA-splicing factor ATP-dependent RNA helicase, putative |
| Leishmania donovani | LdBPK_362970.1 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Leishmania infantum | LinJ.24.1120 | pre-mRNA splicing factor, putative |
| Leishmania infantum | LinJ.36.2970 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative |
| Leishmania infantum | LinJ.35.1210 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Leishmania major | LmjF.36.2830 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative |
| Leishmania major | LmjF.24.1100 | pre-mRNA splicing factor, putative |
| Leishmania major | LmjF.35.1200 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Leishmania mexicana | LmxM.24.1100 | pre-mRNA splicing factor, putative |
| Leishmania mexicana | LmxM.36.2830 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative |
| Leishmania mexicana | LmxM.34.1200 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Loa Loa (eye worm) | LOAG_02619 | dead box protein 15 |
| Loa Loa (eye worm) | LOAG_14297 | DEAH box polypeptide 8 |
| Loa Loa (eye worm) | LOAG_01737 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_03362 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_11401 | Dhx8 protein |
| Loa Loa (eye worm) | LOAG_07948 | sex determination protein MOG-1 |
| Loa Loa (eye worm) | LOAG_06523 | pre-mRNA splicing factor ATP-dependent RNA helicase |
| Mus musculus | ENSMUSG00000037993 | DEAH (Asp-Glu-Ala-His) box polypeptide 38 |
| Mus musculus | ENSMUSG00000029169 | DEAH (Asp-Glu-Ala-His) box polypeptide 15 |
| Mus musculus | ENSMUSG00000034931 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
| Mus musculus | ENSMUSG00000024422 | DEAH (Asp-Glu-Ala-His) box polypeptide 16 |
| Neospora caninum | NCLIV_026800 | hypothetical protein |
| Neospora caninum | NCLIV_024300 | hypothetical protein |
| Neospora caninum | NCLIV_033280 | hypothetical protein |
| Neospora caninum | NCLIV_055860 | hypothetical protein |
| Oryza sativa | 4345304 | Os08g0335000 |
| Oryza sativa | 9266959 | Os11g0515900 |
| Oryza sativa | 4343339 | Os07g0508000 |
| Oryza sativa | 4340964 | Os06g0343100 |
| Oryza sativa | 4329095 | Os02g0301500 |
| Oryza sativa | 9268581 | Os03g0282700 |
| Oryza sativa | 4332645 | Os03g0314100 |
| Oryza sativa | 4338675 | Os05g0389800 |
| Onchocerca volvulus | OVOC7027 |
|
| Plasmodium berghei | PBANKA_1140200 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative |
| Plasmodium berghei | PBANKA_0514100 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative |
| Plasmodium berghei | PBANKA_0818600 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative |
| Plasmodium falciparum | PF3D7_1030100 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative |
| Plasmodium falciparum | PF3D7_1364300 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 |
| Plasmodium falciparum | PF3D7_0917600 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative |
| Plasmodium knowlesi | PKNH_0614800 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative |
| Plasmodium knowlesi | PKNH_0715600 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative |
| Plasmodium knowlesi | PKNH_1107000 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative |
| Plasmodium vivax | PVX_111220 | RNA helicase, putative |
| Plasmodium vivax | PVX_099300 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative |
| Plasmodium vivax | PVX_115175 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative |
| Plasmodium yoelii | PY04108 | ATP-dependent helicase ddx8 |
| Plasmodium yoelii | PY00835 | pre-mRNA splicing factor ATP-dependent RNA helicase-like protein-related |
| Plasmodium yoelii | PY04107 | Unknown protein |
| Plasmodium yoelii | PY06080 | ATP-dependent RNA helicase-like protein |
| Saccharomyces cerevisiae | YER013W | DEAH-box ATP-dependent RNA helicase PRP22 |
| Saccharomyces cerevisiae | YNR011C | DEAH-box RNA-dependent ATPase PRP2 |
| Saccharomyces cerevisiae | YGL120C | DEAH-box ATP-dependent RNA helicase PRP43 |
| Saccharomyces cerevisiae | YKR086W | DEAH-box RNA helicase PRP16 |
| Schistosoma japonicum | Sjp_0057890 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
| Schistosoma japonicum | Sjp_0053360 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
| Schistosoma japonicum | Sjp_0013210 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
| Schistosoma japonicum | Sjp_0008450 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
| Schistosoma mansoni | Smp_027970 | ATP-dependent RNA Helicase |
| Schistosoma mansoni | Smp_156060 | hypothetical protein |
| Schistosoma mansoni | Smp_169650 | ATP-dependent RNA Helicase |
| Schistosoma mansoni | Smp_157510 | ATP-dependent RNA Helicase |
| Schmidtea mediterranea | mk4.000675.10 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase |
| Schmidtea mediterranea | mk4.001502.00 | |
| Schmidtea mediterranea | mk4.000204.00 | |
| Schmidtea mediterranea | mk4.017785.00 | |
| Schmidtea mediterranea | mk4.000856.08 | |
| Schmidtea mediterranea | mk4.000214.11 | |
| Schmidtea mediterranea | mk4.003302.02 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 |
| Schmidtea mediterranea | mk4.005198.00 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 |
| Schmidtea mediterranea | mk4.008785.02 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 |
| Schmidtea mediterranea | mk4.000566.04 | Putative atp-dependent RNA helicase |
| Schmidtea mediterranea | mk4.017941.02 | |
| Schmidtea mediterranea | mk4.002075.00 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 |
| Schmidtea mediterranea | mk4.002357.02 | |
| Schmidtea mediterranea | mk4.002125.02 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase |
| Schmidtea mediterranea | mk4.005392.03 | |
| Schmidtea mediterranea | mk4.034582.00 | |
| Schmidtea mediterranea | mk4.001355.04 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 |
| Trypanosoma brucei gambiense | Tbg972.10.8930 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative,RNA helicase, putative |
| Trypanosoma brucei gambiense | Tbg972.5.1620 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma brucei | Tb927.5.1150 | RNA helicase Prp43 |
| Trypanosoma brucei | Tb927.11.5730 | pre-mRNA-splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma brucei | Tb927.10.7280 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma congolense | TcIL3000.11.6100 | pre-mRNA-splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma congolense | TcIL3000_5_1020 | RNA helicase Prp43 |
| Trypanosoma congolense | TcIL3000_5_1050 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma cruzi | TcCLB.503911.20 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma cruzi | TcCLB.507681.220 | pre-mRNA splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma cruzi | TcCLB.506203.70 | pre-mRNA-splicing factor ATP-dependent RNA helicase, putative |
| Trypanosoma cruzi | TcCLB.508643.9 | pre-mRNA-splicing factor ATP-dependent RNA helicase, putative |
| Toxoplasma gondii | TGME49_233530 | hypothetical protein |
| Toxoplasma gondii | TGME49_312280 | pre-mRNA-splicing factor ATP-dependent RNA helicase, putative |
| Toxoplasma gondii | TGME49_263650 | pre-mRNA-processing protein 8, putative |
| Toxoplasma gondii | TGME49_260200 | helicase associated domain (ha2) protein |
| Toxoplasma gondii | TGME49_233520 | ATP-dependent RNA helicase |
| Treponema pallidum | TP0526 | ATP-dependent helicase (hrpA) |
| Theileria parva | TP03_0394 | splicing factor, putative |
| Theileria parva | TP01_1019 | ATP-dependent RNA helicase, putative |
| Theileria parva | TP01_0544 | RNA helicase, putative |
| Theileria parva | TP01_0641 | RNA helicase, putative |
| Trichomonas vaginalis | TVAG_299100 | ATP-dependent RNA helicase, putative |
| Trichomonas vaginalis | TVAG_119590 | ATP-dependent RNA helicase, putative |
| Trichomonas vaginalis | TVAG_198940 | ATP-dependent RNA helicase, putative |
| Trichomonas vaginalis | TVAG_353500 | ATP-dependent RNA helicase, putative |
| Trichomonas vaginalis | TVAG_291440 | ATP-dependent RNA helicase, putative |
| Trichomonas vaginalis | TVAG_231410 | ATP-dependent RNA helicase, putative |
| Trichomonas vaginalis | TVAG_100850 | ATP-dependent RNA helicase, putative |
Essentiality
TGME49_233520 has direct evidence of essentiality
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.10.7280 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.10.7280 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.10.7280 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.10.7280 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb11.02.3460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb11.02.3460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb11.02.3460 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb11.02.3460 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb927.5.1150 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.5.1150 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.5.1150 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.5.1150 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| b0148 | Escherichia coli | non-essential | goodall |
| CELE_K03H1.2 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K03H1.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K03H1.2 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_C04H5.6 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_C04H5.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C04H5.6 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_C04H5.6 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_C04H5.6 | Caenorhabditis elegans | sterile | wormbase |
| CELE_EEED8.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_EEED8.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_EEED8.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_EEED8.5 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F56D2.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F56D2.6 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F56D2.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F56D2.6 | Caenorhabditis elegans | sterile | wormbase |
| YKR086W | Saccharomyces cerevisiae | inviable | yeastgenome |
| YNR011C | Saccharomyces cerevisiae | inviable | yeastgenome |
| YER013W | Saccharomyces cerevisiae | inviable | yeastgenome |
| YGL120C | Saccharomyces cerevisiae | inviable | yeastgenome |
| PBANKA_0514100 | Plasmodium berghei | Essential | plasmo |
| PBANKA_0818600 | Plasmodium berghei | Essential | plasmo |
| TGME49_312280 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_263650 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_233520 this record | Toxoplasma gondii | Probably essential | sidik |
| TGME49_260200 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_233530 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_312280 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_263650 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_233520 this record | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_260200 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_233530 | Toxoplasma gondii | Probably non-essential | sidik |
-
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Hepatitis C virus | Nonstructural protein NS3-4A | Compounds | References |
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
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