Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0021 | 0.0247 | 0.1379 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Leishmania major | trypanothione reductase | 0.0061 | 0.1793 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0061 | 0.1793 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0016 | 0.003 | 0.0165 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0028 | 0.0498 | 0.1622 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0247 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0021 | 0.0247 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0061 | 0.1793 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0021 | 0.0247 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0061 | 0.1793 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0061 | 0.1793 | 0.576 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0061 | 0.1793 | 0.576 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0021 | 0.0247 | 0.1379 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0021 | 0.0247 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0021 | 0.0247 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0021 | 0.0247 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0021 | 0.0247 | 0.1379 |
Schistosoma mansoni | beta-galactosidase | 0.0091 | 0.2931 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2931 | 0.2931 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0061 | 0.1793 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0021 | 0.0247 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0061 | 0.1793 | 0.1793 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0247 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0061 | 0.1793 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0021 | 0.0247 | 0.1379 |
Echinococcus granulosus | beta galactosidase | 0.0091 | 0.2931 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0021 | 0.0247 | 0.1379 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0021 | 0.0247 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0061 | 0.1793 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.0091 | 0.2931 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0061 | 0.1793 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0498 | 0.1622 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0016 | 0.003 | 0.0165 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0021 | 0.0247 | 0.1379 |
Brugia malayi | glutathione reductase | 0.0061 | 0.1793 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0021 | 0.0247 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0061 | 0.1793 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0021 | 0.0247 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0061 | 0.1793 | 0.1793 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0021 | 0.0247 | 0.1379 |
Brugia malayi | Thioredoxin reductase | 0.0061 | 0.1793 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0021 | 0.0247 | 0.1379 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0021 | 0.0247 | 0.1379 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 0.8 uM | Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method | ChEMBL. | 24948565 |
MIC50 (functional) | = 0.5 ug ml-1 | Antifungal activity against Candida albicans by broth macrodilution method | ChEMBL. | 24948565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.