Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0083 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1428 | 1 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0083 | 0 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0083 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0083 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0185 | 0.0762 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0185 | 0.0762 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0083 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0083 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0083 | 0 | 0.5 |
Onchocerca volvulus | 0.0083 | 0 | 0.5 | |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1428 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0083 | 0 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0083 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0185 | 0.0762 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0083 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0083 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1178 | 0.8143 | 0.8143 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1428 | 1 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1428 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0083 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1428 | 1 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0083 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1428 | 1 | 1 |
Echinococcus multilocularis | 0.0083 | 0 | 0.5 | |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0083 | 0 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0083 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1178 | 0.8143 | 0.8143 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0185 | 0.0762 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0083 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0185 | 0.0762 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0083 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1095 | 0.7526 | 0.7526 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.